• 한국작물학회:학술대회논문집
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• 한국작물학회 2003년도 추계 학술발표회 요지
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• pp.214-215
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• 2003

• 한국영양학회:학술대회논문집
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• 한국영양학회 2003년도 추계학술대회 및 정기총회
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• pp.164-164
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• 2003

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.1008-1008
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• 2005

• 한국작물학회:학술대회논문집
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• 한국작물학회 1999년도 춘계 학술대회지
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• pp.188-189
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• 1999

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2003년도 제40회 국제학술심포지움
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• pp.149-150
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• 2003

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.94-94
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• 2003

Tea is the most popular beverage in the world, especially green tea (Camellia sinensis) is daily taken by Asian people including Japanese. In last two decades, a variety of biological effects of tea components such as antioxidative, antimutagenic, anticarcinogenic, antibacterial and radical scavenging activities on bacteria, cultured cells and mammals have been elucidated.(omitted)

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2000년도 제29회 국제학술심포지움 및 추계학술대회
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• pp.26-26
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• 2000

• Journal of Nutrition and Health
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• 제34권1호
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• pp.14-22
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• 2001

In this study, we examined the effects of dietary fatty acids and vitamin E supplementation on antioxidant systems in the rat brain regions. The Sprague Dawley rats were fed the experimental diets 3-4 wks prior to the conception. Experimental diet consisted of 10% fat(wt/wt) which were safflower oil(SO, poor in $\omega$3 fatty acids), mixed oil(MO, P/M/S ratio=1.03:1.45:1,$\omega$6/$\omega$3 ratio=6.3) and mixed oil supplemented with vitamin E(ME:MO+500mg vitamin E/kg diet). At 3 and 9 weeks of age of the newborn rats, frontal cortex(FC), corpus striatum(CS), hippocampus(H) cerebellum(CB) were dissected out from the whole brain. Activities of glutathione peroxidase(GSH-P(sub)x, superoxide dismutase(SOD) concentrations of malondialdehyde(MDA) were mesaured. Dietary fatty acids were not effective in antioxidative system for rat brain. However, when vitamin E was supplemented to the diet(ME), the activities of GSH-P(suh)x tended to increase in comparison to MO group. Therefore, the activites of GSH-P(suh)x of FC and H at the age of 3 weeks showed significant differences(p<0.05). The activities of Total-SOD tended to decrease in ME group compared to MO group. There were significant differences(p<0.05) in FC and CS at the age of 3 weeks. The activities of Mn-SOD tended to increase and Cu, Zn-SOD tended to decrease when vitamin E was supplemented. The activity levels of antioxidative enzymes at the age of 3 weeks and 9 weeks were similar. This suggested that the activity level of antioxidative enzymes reached to the adult level at the age of 3 weeks which is the end point of lactation period. The concentrations of MDA were not altered by experimental diets. When the activities of antioxidant enzymes were compared, the activities of antioxidant enzymes were the lowest in H and FC. In conclusion, the antioxidative system were not altered by dietary fatty acid at the age of 3 weeks and 9 weeks, but the supplementation of vitamin E altered the antioxidative systems. Therefore, these findings should be considered comprehensively in scope of the balance of various antioxidative systems and their interactions(Korean J Nutrition 34(1):14-22, 2001)

• 한국식품과학회지
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• 제31권5호
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• pp.1371-1377
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• 1999

본 연구에서는 백미의 돌연변이 억제 활성 물질의 분포 및 정제를 위한 기초자료를마련하고, 세포외 작용기작의 하나인 항산화활성과의 상관성을 살펴보기 위해 일품벼를 도정분획별로 분획한 다음 돌연변이 억제활성 및 항산화 활성을 조사하였다. Salmonella typhimurium reversion assay를 이용하여 Trp-P-2로 유도된 변이원성에 대해 도정분획별 돌연변이 억제활성을 살펴본 결과, 미강에서는 외층으로 갈수록. 백비에서는 내층으로 갈수록 더 강한 돌연변이 억제 활성을 보였다. 과산화물가(POV) 측정에 의한 항산화 활성은 배아와 미강 부분이 백미보다 더 활성이 강한 것으로, TBA치로 측정한 항산화 활성은 백미의 경우 $6{\sim}20%$로 낮았으며 배아, 미강, 배유는 거의 활성이 없었다. 전자공여능(EDA) 측정으로 살펴본 항산화 활성은 배아(45%), 미강$(35{\sim}40%)$보다는 백미$(41{\sim}65%)$에서, 도정 율이 낮을수록 더 강한 활성을 나타내었다. 돌연변이 억제활성은 전자공여작용과는 양의 상관성(r=0.609)을 과산화물가와는 음의 상관성(r=-0.471)을 나타내었고 TBA치 측정에 의한 항산화 활성과는 유의적인 상관성이 없었다. 도정분획별 페놀산 및 SH함량은 미강 및 배아가 백미에 비해 높았고, 백미에서는 내층으로 갈수록 함량이 낮아 돌연변이 억제활성과 음의 상관성을 보였다.

• 생약학회지
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• 제33권3호통권130호
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• pp.177-181
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• 2002

This study was carried out to investigate the antioxidative activities of Rosa davurica Pall for the purpose of development of novel antioxidant from natural products. Antioxidant activities of four different parts of Rosa davurica Pall such as fruit, leaf, stem and root were examined by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The methanol extract from the root of Rosa davurica Pall showed the highest antioxidative activity among 16 samples tested. And, we also tested radical scavenging effects of 5 different extract compartments(Hexane, $CHCl_3$, EtOAc, BuOH and $H_2O$ fraction). EtOAc and BuOH fractions from the root of Rosa davurica Pall exhibited antioxidative activities higher to those of natural, ${\alpha}-tocopherol$ or synthetic antioxidants, BHT. The antioxidative substance of EtOAc fraction from the root of Rosa davurica Pall was successively purified with silica gel adsorption column chromatography and Sephadex LH-20 column chromatography. The purified active substance was isolated as crystal and identified as (+)-catechin by $^{l}H-NMR$ and $^{13}C-NMR$. This compound exhibited DPPH radical scavenging activity with the $IC_50$ value of $1.7\;{\mu}g/ml$. In the analysis of catechin content, the leaf extracts contained the highest catechin, and fruit extracts contained the lowest catechin. Considering antioxidative activity on DPPH assay, the extracts of Rosa davurica Pall showed a possibility to be used as a new material for natural antioxidant and functional food.