• Journal of the Korean Society of Safety
• /
• v.26 no.5
• /
• pp.13-16
• /
• 2011

The vibration and shock of the opto-electronic protective device was induced mechanical failure or fail to work correctly. In order to identify the exciting frequency components of vibration and shock, vibration signals are measured and analyzed from the mechanical power press. In addition, the modal test for the opto-electronic protective device was performed to investigate the dynamic characteristics. Some FEM simulations were carried out and then anti vibration mount was made for opto-electronic protective device. Based on the results of simulations, some kind of rubber mounts were tested to demonstrate the reduction of vibration and shock. It was verified by the test that a considerable amount of vibration and shock were reduced.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.43 no.4
• /
• pp.362-369
• /
• 2007

This paper was studied on the characteristics of acid resistance and thermal shock for epoxy coatings in the strong acidic environment. The exhaust gas system, such as a air preheater, desulfurization equipment, for industrial boiler is damaged by dew point corrosion. To protect the acid corrosion, the coating using nonmetal was applied. The electrochemical polarization test, acid resistance and thermal shock test for epoxy coatings were carried out. And the acid resistance and thermal shock characteristics, aspect, and electrochemical anti-corrosion characteristics for epoxy coatings in the strong acidic environment were considered. The main results are as followings: As the epoxy glass flake coating by acidic thermal shock was damaged to the crack, blistering and elution etc., the current density of epoxy glass flake coating is high. But the damage of epoxy metal complex coating by acidic thermal shock was not occurred. Therefore the characteristics of acid resistance and thermal shock for epoxy metal complex coating is better than those for epoxy glass flake coating.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.21 no.2
• /
• pp.152-165
• /
• 2008

Purpose: It is the purpose of this study to investigate the anti-inflammatory effects and mechanism of cheukbaekjurpihwan(CBJPH) extract on LPS (lipopolysaccharide)-induced inflammatory mediators in murine peritoneal macrophages. Methods: To evaluate anti-inflammatory effects of CBJPH extract, the production of cytokines(TNF-${\alpha}$(tumor necrosis factor-alpha), IL(interleukin)-6, IL-12) and NO(nitric oxide) was measured in vitro and in vivo. And western blot analysis has been done to look into the mechanism. Results: CBJPH extract reduced LPS-induced NO, TNF-${\alpha}$ and IL-6, IL-12 productions in peritoneal macrophages. CBJPH extract inhibited the activation of JNK(c-Jun N-terminal kinase), but didn't inhibit the activation of MAPKs (mitogen-activated protein kinases) such as p38, ERK1/2(extracelluar signal-regulated kinase1/2) and the degradation of $I_{\kappa}B-{\alpha}$(inhibitory kappa B-alpha) in the LPS-stimulated peritoneal macrophages. CBJPH extract suppressed LPS-induced endotoxin shock and the productions of TNF-${\alpha}$, but not of IL-6, after an oral administration of CBJPH extract Conclusion: CBJPH extract suppressed the productions of LPS-induced NO and cytokines by preventing JNK from phosphorylation, which may provide a clinical basis for anti-inflammatory properties of CBJPH.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.22 no.2
• /
• pp.307-314
• /
• 2008

Handayeolso-Tang(HDT) has been used as traditional medicine for the treatment of Taeumin TaeYang-Hanguel. The present study was conducted to investigate the anti-allergic activity of Handayeolso-Tang(HDT). We investigated the anti-allergic effects of HDT in RBL-2H3 basophilic leukemia cells by compound48/80, a mast cell degranulator and compound 48/80 induced anaphylactic shock in mice. HDT significantly inhibited ${\beta}-hexosaminidase$ and histamine release from compound 48/80 stimulated RBL-2H3 cells. In addition, HDT effectively inhibited anaphylactic shock in mice by 45% at a dose 120 mg/mouse versus PBS treated control after the I.p injection(8 mg/kg) of compound 48/80. The in vitro anti-inflammatory activities of HDT in LPS-stimulated RAW 264.7 cells were investigated. HDT inhibited NO production in LPS-stimulated RAW 264.7 cells and effectively dowregulated the expression of iNOS mRNA and iNOS protein expression in LPS -stimulated RAW 264.7 cells. These result provide evidences that HDT may be beneficial in the treatment of allergic inflammtory disease.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2014.10a
• /
• pp.975-977
• /
• 2014

Recently, As portability of storage device has been increased, it is important to analyze the precise anti-shock analysis. For non-operational shock analysis, the accuracy of non-operational shock simulation has been improved. However, because operational shock analysis includes nonlinear process, it is hard to get clear result from operational shock simulation. In this paper, by using Lagrange multiplier method, the FE model including ramp-disk contact of nonlinear process will be analyzed. Through this, we find ramp-disk contact affect the dynamic of slider. Additionally, for the more accurate analysis, we should include ramp-disk contact process at the FE model.

• Transactions of the Society of Information Storage Systems
• /
• v.5 no.2
• /
• pp.76-81
• /
• 2009

Mobile devices have become an important part of daily life. This is especially true of laptop PCs, which are portable enough to be used almost anywhere. Laptop PCs, however, cannot be nomadic if each component is not robust enough to endure rugged laptop operating environment. Generally, external shock makes collision on head-disk interface and damage to read-write performance. To minimize the likelihood of failure, shock analysis must be incorporated into the design of hard disk drive in laptop. This research explores the structure modification of laptop HDD base, for improving shock performance using finite element analysis which considers the flexibility of whole HDD structure. FE model is verified by modal test and finely tuned. Then we obtained the transmitted acceleration of spindle and pivot and the relative displacement between disk and slider head as shock response. Based on shock simulation, the structural dynamics modification is performed and the primary design parameters are extracted.

• Biotechnology and Bioprocess Engineering:BBE
• /
• v.8 no.2
• /
• pp.76-82
• /
• 2003

An increased understanding of apoptosis makes anti-apoptosis engineering possible, which is an approach used to inhibit apoptosis for the purpose of therapeutic, or industrial applications in the treatment of the diseases associated with increased apoptosis, or to improve the productivity of animal cell cultures, respectively. Some known anti-apoptosis proteins are the Bcl-2 family, IAP (inhibitor of apoptosis) and Hsps (heat shock proteins), with which anti-apoptosis engineering has progressed. This article reviews anti-apoptosis engineering using known anti-apoptosis compounds, and introduces a 30 K protein, isolated from silkworm hemolymph, as a novel anti-apoptotic protein, that Shows no homology with other known anti-apoptotic proteins. The regulation of apoptosis, using anti-apoptotic proteins and genes originating from the silkworm, Bombyx mori, may provide a new strategy in this field.

• The Korean Journal of Physiology and Pharmacology
• /
• v.22 no.4
• /
• pp.457-465
• /
• 2018

The expression of BCL-2 interacting cell death suppressor (BIS), an anti-stress or anti-apoptotic protein, has been shown to be regulated at the transcriptional level by heat shock factor 1 (HSF1) upon various stresses. Recently, HSF1 was also shown to bind to BIS, but the significance of these protein-protein interactions on HSF1 activity has not been fully defined. In the present study, we observed that complete depletion of BIS using a CRISPR/Cas9 system in A549 non-small cell lung cancer did not affect the induction of heat shock protein (HSP) 70 and HSP27 mRNAs under various stress conditions such as heat shock, proteotoxic stress, and oxidative stress. The lack of a functional association of BIS with HSF1 activity was also demonstrated by transient downregulation of BIS by siRNA in A549 and U87 glioblastoma cells. Endogenous BIS mRNA levels were significantly suppressed in BIS knockout (KO) A549 cells compared to BIS wild type (WT) A549 cells at the constitutive and inducible levels. The promoter activities of BIS and HSP70 as well as the degradation rate of BIS mRNA were not influenced by depletion of BIS. In addition, the expression levels of the mutant BIS construct, in which 14 bp were deleted as in BIS-KO A549 cells, were not different from those of the WT BIS construct, indicating that mRNA stability was not the mechanism for autoregulation of BIS. Our results suggested that BIS was not required for HSF1 activity, but was required for its own expression, which involved an HSF1-independent pathway.

• Natural Product Sciences
• /
• v.6 no.1
• /
• pp.49-51
• /
• 2000

The anti-allergy activity of Cinnamomum cassia cortex extract and its fractions were investigated in mice. The extract exhibited potent anaphylactic shock and Arthus reaction. Among the fractions obtained in the successive fractionation with n-hexane, butanol and acetone, the butanol insoluble portion was shown to have the activities.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.7 no.2 s.17
• /
• pp.118-125
• /
• 2004

In anti-ship missile, the seeker and guidance control units are located in front of warhead. When the missile hits target, these structures play an important role to warhead structure like a shock absorber Because the shock waves are attenuated, the survival probability of warhead increases which guarantees the explosive train. In this thesis the role of frontal sections is studies. The theoretical analysis and numerical analyses using LS-DYNA code are performed. To prove the effect of shock absorber, the penetration test using subscale prototype warhead are executed.