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Anti-apoptosis Engineering  

Kim, Eun-Jeong (School of Chemical Engineering and Institute of Chemical Processes, Seoul National University)
Park, Tai-Hyun (School of Chemical Engineering and Institute of Chemical Processes, Seoul National University)
Publication Information
Biotechnology and Bioprocess Engineering:BBE / v.8, no.2, 2003 , pp. 76-82 More about this Journal
Abstract
An increased understanding of apoptosis makes anti-apoptosis engineering possible, which is an approach used to inhibit apoptosis for the purpose of therapeutic, or industrial applications in the treatment of the diseases associated with increased apoptosis, or to improve the productivity of animal cell cultures, respectively. Some known anti-apoptosis proteins are the Bcl-2 family, IAP (inhibitor of apoptosis) and Hsps (heat shock proteins), with which anti-apoptosis engineering has progressed. This article reviews anti-apoptosis engineering using known anti-apoptosis compounds, and introduces a 30 K protein, isolated from silkworm hemolymph, as a novel anti-apoptotic protein, that Shows no homology with other known anti-apoptotic proteins. The regulation of apoptosis, using anti-apoptotic proteins and genes originating from the silkworm, Bombyx mori, may provide a new strategy in this field.
Keywords
apoptosis; anti-apoptosis engineering; Bcl-2 family; IAP; Hsps; 30K protein;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 28  (Related Records In Web of Science)
Times Cited By SCOPUS : 26
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