• Journal of the Korea Society for Simulation
• /
• v.32 no.3
• /
• pp.55-66
• /
• 2023

In recent years, naval vessels have been developed to fulfill a variety of missions by being equipped with various cutting-edge equipment and ICT technologies. One of the main missions of Korean naval vessels is anti-ballistic missile warfare to defend key units and areas against the growing threat of ballistic missiles. Because the process of detection and interception is too complex and the cost of failure is much high, a lot of preparation is required to effectively conduct anti-ballistic missile warfare. This paper describes the development of a simulation model of anti-ballistic missile warfare with combat systems and equipment to be installed on future naval vessels. In particular, the DEVS formalism providing a modular and hierarchical modeling manner was applied to the simulation model, which can be utilized to efficiently represent various anti-ballistic missile warfare situations. In the simulation results presented, experiments were conducted to analyze the effectiveness of the model for effective detection resource management in anti-ballistic missile warfare. This study is expected to be utilized as a variety of analysis tools necessary to determine the optimal deployment and configuration of combat resources and operational tactics required for effective anti-ballistic missile warfare of ships in the future.

• Korean Journal of Pharmacognosy
• /
• v.29 no.4
• /
• pp.384-390
• /
• 1998

The methanol extract of Torilis Fructus showed potent anti-edematous effect in carrageenan-induced paw edema in rats. Systematic fractionation of the extract with hexane, chloroform, ethyl acetate and butanol resulted in potent anti-edematous action only in hexane fraction at an oral dose of 237 mg/kg which is corresponding to 4.8 g of raw Fructus. This hexane fraction showed inhibitory effects at 77 mg/kg p.o on vascular permeability in mice, at 8mg/pouch on leucocyte emigration in rats, and at 120 mg/kg p.o. on adjuvant arthritis model in rats. These results demonstrate that hexane fraction of the extract possesses potent anti-inflammatory effect which may support its traditional uses.

• Korean Journal of Pharmacognosy
• /
• v.47 no.2
• /
• pp.165-171
• /
• 2016

Corylopsis gotoana (Hamamelidaceae) has been used as a traditional medicine for the treatment various diseases including cold, edema and vomiting. However, previous studies regarding component analysis and pharmacological actions of C. gotoana are extremely limited until now. In this study, we investigated anti-inflammatory activities of the methanolic extract of the twigs of Corylopsis gotoana (MCG) both in vitro and in vivo. MCG effectively inhibited excessive NO production in IFN-${\gamma}$ and LPS-stimulated mouse peritoneal macrophages without notable cytotoxicity. In addition, we also found that MCG could attenuate the expression of inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). We further tested in vivo anti-inflammatory activity of MCG using paw edema mouse model. Herein, MCG demonstrated significant suppression on the paw edema induced by both of trypsin and carrageenan. These results indicated that MCG has potent anti-inflammatory potential and may be useful for prevention and treatments of inflammatory diseases.

• Archives of Pharmacal Research
• /
• v.28 no.5
• /
• pp.509-517
• /
• 2005

A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4- chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analygesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.

• Journal of National Security and Military Science
• /
• s.2
• /
• pp.201-235
• /
• 2004

This paper provides a simple microeconomic model of terrorist attcks and anti-terrorism policies. The terrorists can be characterised as rational actors, choosing between legal activities and terrorist activities to promote their political goals. Since their resources are limited, one can think of anti-terrorist policies by examining how such policies affect the objectives and constraints of terrorists. Deterrence policy seeks to reduce terrorist attacks by raising the cost of undertaking terrorist acts. Proactive policy aims at preventing attacks by destroying terrorists' resources (fund, personnel, leadership). This paper suggests another type of anti-terrorist policy which is to reduce the benefits of (or in other words, raising the opportunity costs of) terrorist acts. Such a policy is based on decentralisation in political decision-making and economic power.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.22 no.6
• /
• pp.815-823
• /
• 2019

A naval surface-to-air missile is an effective countermeasure against increasing threats of anti-ship missiles. Optimal operation is imperative for high survivability due to limited defense resources of a warship. This paper addresses a problem of optimal engagement to maximize the overall probability of intercept under Shoot-Look-Shoot tactics. The problem is formulated and analyzed with consideration of a realistic single-shoot probability model. The analysis shows that a global solution is achieved for some engagement scenarios. A numerical algorithm to optimize the overall probability of intercept is suggested. An illustrative example is provided to verify our results.

• Natural Product Sciences
• /
• v.4 no.4
• /
• pp.234-237
• /
• 1998

To evaluate the anti-diarrheal potential of the leaves of Bauhinia purpurea Linn., investigations were performed on different animal models e.g. castor oil induced diarrhea in rats and gastrointestinal motility test by using charcoal meal. In both the models the ethanolic extract of the leaves showed significant activity when compared to control group. The group treated with standard anti-diarrheal agent also showed significant activity comparing with control. Thus this study establishes the efficacy of Bauhinia purpurea Linn. Leaves as an anti-diarrheal as claimed in folklore.

• International Journal of Computer Science & Network Security
• /
• v.21 no.12spc
• /
• pp.719-725
• /
• 2021

The main purpose of the study is to determine the main aspects of information support for anti-crisis management in the context of ensuring national security. In modern conditions, under the influence of COVID-19, it becomes important to develop a modern paradigm for the transformation of anti-crisis management, based on the determination of the laws of state development on the basis of the imperative of national interests and territorial integrity. These are, firstly, the patterns of development of the state system of public administration, secondly, the patterns of development of a complex of state interests, and thirdly, patterns of development of the modern model of the country's territorial integrity. As a result of the study, the key aspects of the anti-crisis management system were identified in the context of ensuring the security of national interests.

• East Asian Economic Review
• /
• v.26 no.2
• /
• pp.95-117
• /
• 2022

This paper empirically examines what factors affected the termination of anti-dumping measures in Korea during the 2006-2019 period. Employing a meticulous literature review, the paper investigates the WTO's and Korea's rules on the termination of anti-dumping measures and sets up the related variables in the Cox proportional hazards model. The empirical results show that the GDP growth rate, employment, and trade competitiveness in domestic industries had positive effects on the hazard of the termination of AD measures, while free trade agreements had negative effects. By industry, the hazard of the termination of AD measures was less prominent in the steel industry, while it was more prominent in the machinery industry. These results imply that AD measures in Korea had the properties of a proper trade remedy policy and, at the same time, a protectionism tool to sustain its domestic industries, depending on industrial characteristics and other trade policies.

• IMMUNE NETWORK
• /
• v.4 no.1
• /
• pp.44-52
• /
• 2004

Background: As a potent antigen presenting cell and a powerful inducer of antigen specific immunity, dendritic cells (DCs) are being considered as a promising anti-tumor therapeutic module. The expected therapeutic effect of DCs in renal cell carcinoma was tested in the mouse model. Established late-stage tumor therapeutic (E-T) and minimal residual disease (MRD) model was considered in the in vivo experiments. Methods: Syngeneic renal cell carcinoma cells (RENCA) were inoculated either subcutaneously (E-T) or intravenously (MRD) into the Balb/c mouse. Tumor cell lysate pulsed-DCs were injected twice in two weeks. Intraperitoneal DC injection was started 3 week (E-T model) or one day (MRD model) after tumor cell inoculation. Two weeks after the final DC injection, the tumor growth and the systemic immunity were observed. Therapeutic DCs were cultured from the bone marrow myeloid lineage cells with GM-CSF and IL-4 for 7 days and pulsed with RENCA cell lysate for 18 hrs. Results: Compared to the saline treated group, tumor growth (E-T model) or formation (MRD model) was suppressed in pulsed-DC treated group. RENCA specific lymphocyte proliferation was observed in the RENCA tumor-bearing mice treated with pulsed-DCs. Primary cytotoxic T cell activity against RENCA cells was increased in pulsed-DC treated group. Conclusion: The data suggest the possible anti-tumor effect of cultured DCs in established or minimal residual disease/metastasis state of renal cell carcinoma. Systemic tumor specific immunity including cytotoxic T cell activity was modulated also in pulsed-DC treated group.