• The Korean Journal of Pain
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• 제35권3호
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• pp.291-302
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• 2022

Background: Spinal cord injury (SCI) is one of the most debilitating disorders throughout the world, causing persistent sensory-motor dysfunction, with no effective treatment. Oxidative stress and inflammatory responses play key roles in the secondary phase of SCI. Naringenin (NAR) is a natural flavonoid with known anti-inflammatory and antioxidative properties. This study aims at evaluating the effects of intrathecal NAR administration on sensory-motor disability after SCI. Methods: Animals underwent a severe compression injury using an aneurysm clip. About 30 minutes after surgery, NAR was injected intrathecally at the doses of 5, 10, and 15 mM in 20 µL volumes. For the assessment of neuropathic pain and locomotor function, acetone drop, hot plate, inclined plane, and Basso, Beattie, Bresnahan tests were carried out weekly till day 28 post-SCI. Effects of NAR on matrix metalloproteinase (MMP)-2 and MMP-9 activity was appraised by gelatin zymography. Also, histopathological analyses and serum levels of glutathione (GSH), catalase and nitrite were measured in different groups. Results: NAR reduced neuropathic pain, improved locomotor function, and also attenuated SCI-induced weight loss weekly till day 28 post-SCI. Zymography analysis showed that NAR suppressed MMP-9 activity, whereas it increased that of MMP-2, indicating its anti-neuroinflammatory effects. Also, intrathecal NAR modified oxidative stress related markers GSH, catalase, and nitrite levels. Besides, the neuroprotective effect of NAR was corroborated through increased survival of sensory and motor neurons after SCI. Conclusions: These results suggest intrathecal NAR as a promising candidate for medical therapeutics for SCI-induced sensory and motor dysfunction.

• 대한기계학회논문집A
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• 제36권6호
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• pp.665-672
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• 2012

면외 기계적 하중 및 면내 전기적 하중하의 횡등방성 이종 압전재료에 대한 계면균열문제를 해석하였다. 복소함수를 도입하여 문제를 수식화 하고, 이로부터 Hilbert 문제를 구성하였다. Hilbert 문제를 풀므로써, 일반해를 얻었다. 일반해를 사용하여, 반무한 균열 혹은 한 개 유한균열 및 두 개 유한균열에 대한 폐형 해를 각각 구하였다. 이때 하중은 한 개의 집중 기계하중 및 전기적하중이 균열면에 작용한다. 이 문제는 기하조건만 동일하면, 임의의 하중에 대해서도 해를 얻을 수 있는 Green 함수로서 사용될 수 있다.

• Steel and Composite Structures
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• 제10권1호
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• pp.87-108
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• 2010

A Steel Plate Shear Wall (SPSW) is a lateral load resisting system consisting of an infill plate located within a frame. When buckling occurs in the infill plate of a SPSW, a diagonal tension field is formed through the plate. The study of the tension field behavior regarding the distribution and orientation patterns of principal stresses can be useful, for instance to modify the basic strip model to predict the behavior of SPSW more accurately. This paper investigates the influence of torsional and out-of-plane flexural rigidities of boundary members (i.e. beams and columns) on the buckling coefficient as well as on the distribution and orientation patterns of principal stresses associated with the buckling modes. The linear buckling equations in the sense of von-Karman have been solved in conjunction with various boundary conditions, by using the Ritz method. Also, in this research the effects of symmetric and anti-symmetric buckling modes and complete anchoring of the tension field due to lacking of in-plane bending of the beams as well as the aspect ratio of plate on the behavior of tension field and buckling coefficient have been studied.

• 대한기계학회논문집A
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• 제34권6호
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• pp.701-708
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• 2010

면외평면전단하중과 면내전기하중을 받는 직교이방성 압전재료에서 전기투과형 전파균열장을 해석하였다. 압전재료에서 전파하는 균열의 운동방정식이 유도되었으며 근접해법을 통하여 응력장과 변위장의 해를 얻었다. 압전상수 및 유전율 등이 균열선단의 응력장과 변위장에 미치는 영향을 명확히 나타내었다. 본 연구에서 유도된 응력장과 변위장을 사용하여 압전재료에서 전파하는 균열선단부근의 응력과 변위의 특성에 대하여 논의하였다.

• 대한기계학회논문집A
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• 제36권9호
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• pp.985-996
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• 2012

면외 기계적하중과 면내 전기적하중을 받는 압전재료에서 비정상적으로 전파하는 전기투과형 균열에 대하여 연구하였다. 비정상적으로 전파하는 균열에 대한 평형방정식을 개발하였고 근접해법으로 투과형균열에 대한 응력장 및 변위장을 얻었다. 압전상수, 유전율 그리고 균열선단속도 및 응력확대계수의 시간 변화율이 비정상적으로 전파하는 균열선단부근의 응력 및 변위장에 미치는 영향을 명확히 나타내었다. 이러한 응력장과 변위장을 사용하여 비정상적으로 전파하는 균열선단의 응력장 및 변위장의 특성에 대하여 토론하였다.

• Earthquakes and Structures
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• 제5권2호
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• pp.161-205
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• 2013

We study seismically induced, anti-plane strain wave motion in a non-homogeneous geological region containing tunnels. Two different scenarios are considered: (a) The first models two tunnels in a finite geological region embedded within a laterally inhomogeneous, layered geological profile containing a seismic source. For this case, labelled as the first boundary-value problem (BVP 1), an efficient hybrid technique comprising the finite difference method (FDM) and the boundary element method (BEM) is developed and applied. Since the later method is based on the frequency-dependent fundamental solution of elastodynamics, the hybrid technique is defined in the frequency domain. Then, an inverse fast Fourier transformation (FFT) is used to recover time histories; (b) The second models a finite region with two tunnels, is embedded in a homogeneous half-plane, and is subjected to incident, time-harmonic SH-waves. This case, labelled as the second boundary-value problem (BVP 2), considers complex soil properties such as anisotropy, continuous inhomogeneity and poroelasticity. The computational approach is now the BEM alone, since solution of the surrounding half plane by the FDM is unnecessary. In sum, the hybrid FDM-BEM technique is able to quantify dependence of the signals that develop at the free surface to the following key parameters: seismic source properties and heterogeneous structure of the wave path (the FDM component) and near-surface geological deposits containing discontinuities in the form of tunnels (the BEM component). Finally, the hybrid technique is used for evaluating the seismic wave field that develops within a key geological cross-section of the Metro construction project in Thessaloniki, Greece, which includes the important Roman-era historical monument of Rotunda dating from the 3rd century A.D.

• 대한기계학회논문집
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• 제16권5호
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• pp.838-848
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• 1992

본 연구에서는 김성호등의 형상모델인 Fig.1(b)에서 전단하중이 작용하는 경 우에 대한, 복합재료의 탄성층 내부(레진층)에 존재하는 중앙균열의 응력확대계수 산 출을 위하여 균열부위를 제외하고는 섬유층과 레진층이 완전히 접착되었다고 가정한 모델을 다음과 같이 설정 하였다. 접착레진을 주로하는 탄성층(resin rich layer)을 중심으로 상하 각1개의 섬유층(fiber rich layer)과 균질한 특성을 갖는 복합재료의 층으로 단순화하였으며, 복합재료는 레진층이나 섬유층에 비하여 무한히 두꺼우므로 반무한체로 이상화 하였다. 선형탄 이론에 의한 혼합경계조건문제(mixed boundary value problem)로 부터 제2종 Fredholm 적분방정식(fredholm integral equation of a second kind)을 유도하였으며 수치해석적인 방법에 의하여 응력확대계수를 구하였다. 또한, 복합재료의 재료물성 및 균열길이, 섬유두께등이 기하학적 변수에 대하여 응력 확대계수를 산출하였다.

• Geomechanics and Engineering
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• 제14권2호
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• pp.195-202
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• 2018

Many laboratory experiments on crack propagation under uniaxial loading and biaxial loading have been conducted in the past using transparent materials such as resin, polymethyl methacrylate (PMMA), etc. However, propagation behaviors of three-dimensional (3D) cracks in rock or rock-like materials under tri-axial loading are often considerably different. In this study, a series of true tri-axial loading tests on the rock-like material with two semi-ellipse pre-existing cracks were performed in laboratory to investigate the acoustic emission (AE) characteristics and propagation characteristics of 3D crack groups influenced by intermediate principal stress. Compared with previous experiments under uniaxial loading and biaxial loading, the tests under true tri-axial loading showed that shear cracks, anti-wing cracks and secondary cracks were the main failure mechanisms, and the initiation and propagation of tensile cracks were limited. Shear cracks propagated in the direction parallel to pre-existing crack plane. With the increase of intermediate principal stress, the critical stress of crack initiation increased gradually, and secondary shear cracks may no longer coalesce in the rock bridge. Crack aperture decreased with the increase of intermediate principal stress, and the failure is dominated by shear fracturing. There are two stages of fracture development: stable propagation stage and unstable failure stage. The AE events occurred in a zone parallel to pre-existing crack plane, and the AE zone increased gradually with the increase of intermediate principal stress, eventually forming obvious shear rupture planes. This shows that shear cracks initiated and propagated in the pre-existing crack direction, forming a shear rupture plane inside the specimens. The paths of fracturing inside the specimens were observed using the Computerized Tomography (CT) scanning and reconstruction.

• Structural Engineering and Mechanics
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• 제90권4호
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• pp.391-401
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• 2024

The present study focuses on the effect of extension-bending coupling on the elastic stability (buckling) of laminated composite plates. These plates will be loaded under uni-axial or bi-axial in-plane mechanical loads, especially in the orthotropic or anti-symmetric cross-angle cases. The main objective is to find a limit where we can approximate the elastic stability behavior of angularly crossed anti-symmetric plates by the simple behavior of specially orthotropic plates. The contribution of my present study is to predict the explicit effect of extension-flexion coupling on the elastic stability of this type of panel. Critically, a parametric study is carried out, involving the search for the critical buckling load as a function of deformation mode, aspect ratio, plate anisotropy ratio and finally the study of the effect of lamination angle and number of layers on the contribution of extension-flexure coupling in terms of plate buckling stability. We use first-order shear deformation theory (FSDT) with a correction factor of 5/6. Simply supported conditions along the four boundaries are adopted where we can develop closed-form analytical solutions obtained by a Navier development.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2002년도 추계학술발표대회 논문집
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• pp.88-91
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• 2002

The two dimensional size effect of specimen gauge section (length x width) was investigated on the compressive behavior of a T300/924 [45/-45/0/90]3s, carbon fiber-epoxy laminate. A modified ICSTM compression test fixture was used together with an anti-buckling device to test 3mm thick specimens with a 30$\times$30, 50$\times$50, 70$\times$70, and 90mm$\times$90mm gauge length by width section. In all cases failure was sudden and occurred mainly within the gauge length. Post failure examination suggests that $0^{\circ}$ fiber microbuckling is the critical damage mechanism that causes final failure. This is the matrix dominated failure mode and its triggering depends very much on initial fiber waviness. It is suggested that manufacturing process and quality may play a significant role in determining the compressive strength. When the anti-buckling device was used on specimens, it was showed that the compressive strength with the device was slightly greater than that without the device due to surface friction between the specimen and the device by pretoque in bolts of the device. In the analysis result on influence of the anti-buckling device using the finite element method, it was found that the compressive strength with the anti-buckling device by loaded bolts was about 7% higher than actual compressive strength. Additionally, compressive tests on specimen with an open hole were performed. The local stress concentration arising from the hole dominates the strength of the laminate rather than the stresses in the bulk of the material. It is observed that the remote failure stress decreases with increasing hole size and specimen width but is generally well above the value one might predict from the elastic stress concentration factor. This suggests that the material is not ideally brittle and some stress relief occurs around the hole. X-ray radiography reveals that damage in the form of fiber microbuckling and delamination initiates at the edge of the hole at approximately 80% of the failure load and extends stably under increasing load before becoming unstable at a critical length of 2-3mm (depends on specimen geometry). This damage growth and failure are analysed by a linear cohesive zone model. Using the independently measured laminate parameters of unnotched compressive strength and in-plane fracture toughness the model predicts successfully the notched strength as a function of hole size and width.