• 대한기계학회논문집A
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• 제20권4호
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• pp.1164-1176
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• 1996

A magnetically levitated micro-positioner is implemented to avoid mechanical friction and increase precision. Since magnetic levitation system is inherently unstable, most concern is focused on a magnetic circuit design to increase the system dynamic stability. For this, the proposed levitation system is constructed by using an antagonistic structure which permits a simple design and robust stability. From the dynamic equations of motion, it is verified that the proposed magnetically levitated system is decoupled in 6 degree-of-freedom motion. Experimental results are presented in terms of time response and accuracy.

• Smart Structures and Systems
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• 제14권4호
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• pp.643-658
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• 2014

This paper presents the design, modelling and, simulation and experimental results of a shape memory alloy (SMA) actuator based critical motion control application. Dynamic performance of SMA and its ability in replacing servo motor is studied for which the famous open loop unstable balancing ball and beam system direct driven by antagonistic SMA is designed and developed. Simulation uses the mathematical model of ball and beam structure derived from the first principles and model estimated for the SMA actuator by system identification. A PID based cascade control system consisting of two loops is designed and control of ball trajectory for various target positions with settling time as control parameter is verified experimentally. The results demonstrate the performance of SMA for a complicated i.e., under actuated, highly nonlinear unstable system, and thereby it's dynamic behaviour. Control strategies bring out the effectiveness of the actuator and its possible application to much more complex applications such as in aerospace control and robotics.

• 한국엔터테인먼트산업학회논문지
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• 제14권7호
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• pp.309-318
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• 2020

지금까지의 미야자키 하야오 작품 연구의 경향은 작품의 미학적 분석 및 사회적 의의에 치중되어 왔다. 본 논문은 3막 구조, 혹은 8 시퀀스 구조라고 불리는 내러티브 구조 및 주요 등장인물의 갈등을 유발하는 대립자 등 할리우드의 규범적 스토리텔링의 요소를 변주하여 차용하는 미야자키 하야오의 스토리텔링 전략에 대한 구체적인 분석을 수행하고, 이와 같은 변칙적인 스토리텔링으로 인해 야기될 수 있는 서사상의 단점이 해당 작품의 설화적, 그리고 동화적 성격으로 인해 상호보완 된 사례를 살핌으로써 미야자키 하야오 작품 연구의 다각화에 기여하고자 한다. 이를 위해 본 논문은 주인공의 목표를 방해하는 특정 대립자의 존재 없이 상황과 인물 관계의 설정만으로 이에 상응하는 극적 효과를 성취한 <이웃집 토토로>와 첫 번째 대립자가 극의 중간점 전후로 아군으로 돌아서는 <하울의 움직이는 성>과 <센과 치히로의 행방불명>의 대안적 대립 운용의 사례를 살펴보았다. 또한 해당 작품들의 내러티브 전개가 서사 구조상의 구획을 축약하고 확장하는 등, 8 시퀀스 구조의 재구성을 통해 관객을 흥미를 효과적으로 유발하는 설화적 스토리텔링의 구조를 성취한 사례의 구체적인 분석을 수행하였다.

• Mycobiology
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• 제40권1호
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• pp.59-65
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• 2012

Antagonistic microorganisms against $Rhizoctonia$ $solani$ were isolated and their antifungal activities were investigated. Two hundred sixteen bacterial isolates were isolated from various soil samples and 19 isolates were found to antagonize the selected plant pathogenic fungi with varying degrees. Among them, isolate C9 was selected as an antagonistic microorganism with potential for use in further studies. Treatment with the selected isolate C9 resulted in significantly reduced incidence of stem-segment colonization by $R.$ $solani$ AG2-2(IV) in Zoysia grass and enhanced growth of grass. Through its biochemical, physiological, and 16S rDNA characteristics, the selected bacterium was identified as $Bacillus$ $subtilis$ subsp. $subtilis$. Mannitol (1%) and soytone (1%) were found to be the best carbon and nitrogen sources, respectively, for use in antibiotic production. An antibiotic compound, designated as DG4, was separated and purified from ethyl acetate extract of the culture broth of isolate C9. On the basis of spectral data, including proton nuclear magneric resonance ($^1H$ NMR), carbon nuclear magneric resonance ($^{13}C$ NMR), and mass analyses, its chemical structure was established as a stereoisomer of acetylbutanediol. Application of the ethyl acetate extract of isolate C9 to several plant pathogens resulted in dose-dependent inhibition. Treatment with the purified compound (an isomer of acetylbuanediol) resulted in significantly inhibited growth of tested pathogens. The cell free culture supernatant of isolate C9 showed a chitinase effect on chitin medium. Results from the present study demonstrated the significant potential of the purified compound from isolate C9 for use as a biocontrol agent as well as a plant growth promoter with the ability to trigger induced systemic resistance of plants.

• 한국병원경영학회지
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• 제12권1호
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• pp.100-127
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• 2007

The purpose of this study is to reform the productive industrial relations in hospital. Because the industrial relations of hospital is antagonistic each other and this problem cause a low productivity. In Korea, hospitals maintain their ownership structure, strategy is controlled by government, short process of management, and culture of grade. The executive of hospital doesn't gain the confidence of union. This circumstances is related with the antagonistic industrial relations. This research is to analyze hospital management system through experiential and literature study, and is to present a reform strategies for cooperative industrial relations of improving productivity in hospital. As a results, if the hospital manager hopes to improve productivity, they should introduce expert management system rather than ownership and management system. And it is need to execute the hospital initiative strategy rather than to depend on the government. Moreover, the hospital can achieve productive industrial relations as a middle-long term visions in management process and horizontal organization culture. Although this study is limited by literature research, it will contribute to settle productive industrial relations in hospital and to accomplish the additional study.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1998년도 The Third Asian Fuzzy Systems Symposium
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• pp.395-398
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• 1998

In this paper, a method for the improvement of learning speed and convergence rate was proposed applied it to physiological neural structure with the advantages of artificial neural networks and fuzzy theory to physiological neuron structure, To compare the proposed method with conventional the single layer perception algorithm, we applied these algorithms bit parity problem and pattern recognition containing noise. The simulation result indicated that our learning algorithm reduces the possibility of local minima more than the conventional single layer perception does. Furthermore we show that our learning algorithm guarantees the convergence.

• 한국융합학회논문지
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• 제8권1호
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• pp.115-121
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• 2017

AHR(Aryl Hydrocarbon Receptor, 방향성탄화수소 수용체)은 리간드에 의해 활성화되어 체내 외래물질의 대사를 조절하는 전사인자다. 생체 내에서 AHR의 생리학적 역할은 오랜 기간 연구되어 왔으나 antagonist를 비롯한 적절한 화학적 도구의 부재로 그 역할 규명이 제한되어 있다. AHR이 암을 비롯한 여러 질병의 발병기전에 관여되어 있다는 것이 밝혀짐에 따라 유효한 약물 표적으로 간주되나 화학적 도구의 부재로 인해 치료용 약물 개발 역시 제한되어 있다. 기존 antagonist 들은 저농도에서는 활성이 있으나 높은 농도에서는 AHR의 활성화를 유도하는 부분적 antagonist이므로 순수 저해활성을 가지는 신규 antagonist의 개발이 필요하다. 본 연구에서는 2-methyl-4-(2-methylphenyldiazenyl)phenyl picolinamide의 o-toluidinyl 고리구조의 변경하여 활성을 평가하는 유기화학과 분자생물학의 융합연구를 통하여 o-toluidinyl 구조를 최적화하였다.

• 디지털융복합연구
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• 제17권1호
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• pp.443-447
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• 2019

방향성탄화수소 수용체(Arylhydrocarbon Receptor, AhR)은 리간드에 의해 활성화되어 체내 외래물질의 대사를 조절하는 전사인자다. 생체 내에서 AhR의 생리학적 역할은 오랜 기간 연구되어 왔으나 활성화를 유발하지 않는 길항제를 비롯하여 유효한 화학적 도구가 아직 개발되지 않아 기능 연구가 제한적이다. AhR이 다양한 질병의 발병기전에서 중요한 역할을 수행한다는 것이 보고됨에 따라 약물 표적으로서 유효하다고 판단되나 치료나 예방을 위한 유효한 약물은 아직 개발되지 않았다. 길항제로 알려진 화합물들은 낮은 농도에서는 활성이 있어 연구 목적으로 활용되고 있으나 높은 농도에서는 방향성 탄화수소를 활성화하는 부분적 agonist로 작용한다. 이에 AhR 활성화를 유도하지 않는 순수한 길항제의 개발이 필요하다. 본 연구에서는 이미 알려진 AhR 길항제의 골격인 phenyldiazenylphenylpicolinamide의 세 고리구조 중 두 고리구조에 존재하는 메틸 기들을 변형하여 활성을 평가하는 구조-활성 관계 연구를 통하여 새로운 길항제를 개발하고자 하였다.

• Journal of information and communication convergence engineering
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• 제1권3호
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• pp.104-108
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• 2003

A biologically inspired fuzzy multilayer perceptron is proposed in this paper. The proposed algorithm is established under consideration of biological neuronal structure as well as fuzzy logic operation. We applied this suggested learning algorithm to benchmark problem in neural network such as exclusive OR and 3-bit parity, and to digit image recognition problems. For the comparison between the existing and proposed neural networks, the convergence speed is measured. The result of our simulation indicates that the convergence speed of the proposed learning algorithm is much faster than that of conventional backpropagation algorithm. Furthermore, in the image recognition task, the recognition rate of our learning algorithm is higher than of conventional backpropagation algorithm.

• Natural Product Sciences
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• 제20권4호
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• pp.281-284
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• 2014

In this study, twenty-one oleanane-type triterpenoid saponins were isolated from a methanol extract of the roots of Pulsatilla koreana. Antagonistic activities were measured in these compounds by the aequorin based cellular functional assay system for the corticotropin releasing factor receptor (CRF1). Of them, compounds 7 - 10 showed the highest degree of CRF1 inhibition further at the concentration of $10{\mu}M$. Moreover, by the analysis based on the structure-activity relationship of isolated saponins, a sugar chain at C-3 and a carboxyl group at C-28, as well as a methyl group at C-23 seems to be key functional elements. To our knowledge, this is the first report on CRF1 inhibition of saponins from P. koreana.