• 대한치과교정학회지
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• 제54권3호
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• pp.160-170
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• 2024

Objective: Owing to the availability of 3D software, scanners, and printers, clinicians are encouraged to produce in-office aligners. Recently, a new direct-printing resin (Tera Harz TC-85DAC) has been introduced. Studies on its mechanical characteristics and biological effects have been published; however, evidence on its efficacy in orthodontic treatment remains scarce. This pilot study aimed to investigate the accuracy of teeth movement achieved with direct-printed aligners. Methods: Seventeen patients (eight males and nine females) with a mean age of 27.67 ± 8.95 years, presenting with dental rotations < 30° and spaces/crowding < 5 mm, were recruited for this study. The teeth movement was planned starting from a T0 digital dental cast. The 3D direct-printed aligners were produced using Tera Harz TC-85DAC resin. Once the orthodontic treatment was completed, a final digital cast was obtained (T1). The planned teeth positions were then superimposed onto the T0 and T1 digital models. The differences between the programmed movements and the achieved overall torque, tip, rotation, and transverse dimensions were assessed using the paired t test or Wilcoxon's signed rank test. Results: The overall accuracies for torque, tip, and rotation were 67.6%, 64.2%, and 72.0%, respectively. The accuracy of the change in transverse diameter was 99.6%. Conclusions: Within the limits of the present pilot study (difficulties with abnormally shaped teeth and use of attachments), it can be concluded that 3D printed aligners can be successfully printed in-house and utilized for mildly crowded cases, with a comparable accuracy of tooth movement to that of other aligners.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6871-6876
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• 2015

Background: The meningeal hemangiopericytoma (MHPC) is a vascular tumor arising from pericytes. Most intracranial MHPCs resemble meningiomas (MNGs) in their clinical presentation and histological features and may therefore be misdiagnosed, despite important differences in prognosis. Materials and Methods: We report 8 cases of MHPC and 5 cases of MNG collected from 2007 to 2011 from the Neuro-Surgery and Histopathology departments. All 13 samples were re reviewed by two independent pathologists and investigated by immunohistochemistry (IHC) using mesenchymal, epithelial and neuro-glial markers. Additionally, we screened all tumors for a large panel of chromosomal alterations using multiplex ligation probe amplification (MLPA). Presence of the NAB2-STAT6 fusion gene was inferred by immunohistochemical staining for STAT6. Results: Compared with MNG, MHPCs showed strong VIM (100% of cases), CD99 (62%), bcl-2 (87%), and p16 (75%) staining but only focal positivity with EMA (33%) and NSE (37%). The p21 antibody was positive in 62% of MHPC and less than 1% in all MNGs. MLPA data did not distinguish HPC from MNG, with PTEN loss and ERBB2 gain found in both. By contrast, STAT6 nuclear staining was observed in 3 MHPC cases and was absent from MNG. Conclusions: MNG and MHPC comprise a spectrum of tumors that cannot be easily differentiated based on histopathology. The presence of STAT6 nuclear positivity may however be a useful diagnostic marker.

• Journal of Genetic Medicine
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• 제16권2호
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• pp.67-70
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• 2019

Limb-girdle muscular dystrophy (LGMD) is a group of muscular dystrophies that has extremely heterogeneous clinical features and genetic background. The caveolin-3 gene (CAV3) is one of the causative genes. LGMD appears as a clinical continuum, from isolated skeletal muscle involvement to long QT syndrome. Here we report two patients without apparent muscle weakness in a family with CAV3 mutation. A 7-month-old Korean boy visited our muscle clinic because of an incidental finding of elevated serum creatine kinase (CK) concentration (680 IU/L, reference range, 20-270 IU/L) without clinical symptoms. The patient was born after an uneventful pregnancy and showed normal developmental milestones. He developed pseudohypertrophy of his calf muscle during the follow-up. We obtained a muscle biopsy at age 14 months, which showed size variations and degenerating/regenerating myofibers with endomysial fibrosis and immunohistochemical evidence of normal dystrophin. Under the impression of LGMD, we performed target panel sequencing and identified a heterozygous in-frame mutation of CAV3, c.307_312delGTGGTG (p.Val103_Val104del). Immunohistochemical staining of muscle indicated complete loss of caveolin-3 compared with normal control muscle, which supported the variant's pathogenicity. We performed segregation analysis and found that the patient's mother had the same variant with elevated serum CK level (972 IU/L). We report on autosomal dominant familial caveolinopathy caused by a pathogenic variant in CAV3, which was asymptomatic until the fourth decade. This case highlights the utility of next generation sequencing in the diagnosis of muscular dystrophies and the additive role of muscle biopsy to confirm the variants.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2597-2603
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• 2016

Ovarian cancer is a highly malignant neoplasm with high mortality rates. Research to identify markers facilitating early detection has been pursued for many years. Currently, diagnosis is based on the CA 125 and HE4 markers, as well as the ROMA algorithm. The search continues for new proteins that meet the criteria of good markers A total of 90 patients were included in the present study, allocated into: group 1, ovarian cancer, with 29 patients; group 2, endometrial cysts, with 30s; and group 3, simple ovarian cysts, with 31. Following histopathological verification, the CA 125, HE4, and metalloproteinase 3 (MMP3) levels were determined and the ROMA algorithm was calculated for all patients. The mean concentrations of all determined proteins, CA 125, HE4, and MMP3, as well as the ROMA values, were significantly higher in group 1 (ovarian cancer) compared to group 3 (simple ovarian cysts). The highest significant differences for the CA 125 levels (p<0.000001) and ROMA (p<0.000001) values were observed in postmenopausal women. For HE4, statistical significance was at the level of p=0.00001 compared to p=0.002 for MMP3. For the differentiation between ovarian cancer and endometrial cysts, the respective AUC ratios were obtained for CA 125, HE4, and MMP3 levels, as well as the ROMA values ( 0,93 / 0,96 / 0,75 / 0,98). After removing the post-menopausal patients, the MMP3 AUC value for ovarian cancer vs. benign ovarian cysts increased to 0.814. For post-menopausal women, the MMP3 AUC value for ovarian cancer vs. endometrial cysts was 0.843. As suggested by the results above, both the CA 125 and HE4 markers, as well as the ROMA algorithm, meet the criteria of a good diagnostic test for ovarian cancer. MMP3 seems to meet the criteria of a good diagnostic test, particularly in postmenopausal women; however, it is not superior to the tests used to date.

• 생명과학회지
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• 제24권5호
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• pp.498-504
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• 2014

HAase는 신체의 연골, 피부, 눈의 초자체 등에 포함된 고분자 다당류의 HA를 분해하는 효소로서 상처나 염증질환 시 활성화되어 염증, 알레르기 유발과 관련된 효소이다. 본 연구는 500종 식물에서 각 종당 한 식물체로부터 한 천연물의 메탄올 추출물(500추출물)을 이용하여 생물학적으로 기능이 다양하고 산업적으로 활용 가능성이 많은 HAase 저해제를 검색하였다. 그 결과 HAase 저해효과가 가장 우수한 천연물 추출물은 때죽나무 줄기 추출물 57.28%, 매화말발도리 줄기 추출물 53.50%의 저해효과를 나타내었다. 이 같은 추출물들의 농도 별 저해효과를 확인한 결과 농도 의존적으로 저해율이 증가하였다. 이 같은 결과로 볼 때 때죽나무, 매화말발도리 추출물은 HAase 효소의 저해효과가 우수하여 향후 HA 분해와 관련된 항염증 및 항 알레르기 연구에 이용될 수 있다.

• 대한수의학회지
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• 제52권1호
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• pp.33-38
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• 2012

Germanium biotite, a natural mineral, has been used as a feed supplement to reinforce innate immune ability. The aim of the present study was to evaluate the effects of germanium biotite on the adsorptive and inhibition of growth abilities against Escherichia (E.) coli and Salmonella spp. in vitro. Two strains of enterotoxigenic E. coli and four strains of two Salmonella serotypes (Salmonella Derby and Salmonella Typhimurium), major bacterial diarrheal pathogens, were used for this experiment. The absorptive ability of germanium biotite against most Salmonella used in present experiment was observed weakly. The germanium biotite, however, showed significant effect of bacterial growth inhibition in most experiment bacteria. These results suggest that the use of the germanium biotite as feed supplement could alleviate diarrhea following inhibition of bacteria growth. It is also presumed that antibiotics usage for farm animals, considered as causes of antibiotic residue in meat and emerging antibiotic resistance, could be reduced through the use of germanium biotite as a feed supplement, in place of antibiotics used for the prevention of diarrhea.

• Journal of Electrical Engineering and Technology
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• 제10권4호
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• pp.1621-1625
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• 2015

Power quality has always been a concern of power engineers. Certainly an argument can be successfully made that most parts of power engineering have the ultimate objective to improve power quality. AC motors were widely used in industrial and domestic applications. Generally, AC motors were of two types: Induction and Synchronous motors. In motor many parameters like different load cycling, switching, working in hot weather and unbalances creates harmonics which creates major reasons for temperature rise of the motors. Due to high peak value of voltage, harmonics can weaken insulation in cables, windings and capacitors and different electronic components. Higher value of harmonics increase the motor current and decrease the power factor which will reduce the life time of the motor and increase the overall rating of all electrical equipments. Harmonics reduction of all the motors in India will save more power. Coating of windings of the motor with nano fillers will reduce the amount of harmonics in the motor. Based on the previous project works, actions were taken to use the enamel filled with various nano fillers for the coating of the windings of the different AC motors. Ball mill method was used to convert the micro particles of Al₂O₃, SiO₂, TiO₂, ZrO₂ and ZnO into nano particles. SEM, TEM and XRD were used to augment the particle size of the powder. The synthesized nano powders were mixed with the enamel by using ultrasonic vibrator. Then the enamel mixed with the nano fillers was coated to the windings of the several AC motors. Harmonics were measured in terms of various indices like THD, VHD, CHD and DIN by using Harmonic analyzer. There are many other measures and indices to describe power quality, but none is applicable in all cases and in many instances, these indices may hide more than they show. Sometimes power quality indices were used as a basis of comparison and standardization. The efficiency of the motors was increased by 5 – 10 %. The thermal withstanding capacity of the motor was increased by 5º to 15º C. The harmonics of the motors were reduced by 10 – 50%.

• Biomolecules & Therapeutics
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• 제28권3호
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• pp.272-281
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• 2020

Environmental agents, including viral and bacterial infectious agents, are involved in the alteration of physicochemical and biological parameters in the nasal epithelium. Hyaluronan (HA) has an important role in the regulation of tissue healing properties. High molecular weight HA (HMW-HA) shows greater anti-inflammatory responses than medium molecular weight HA (MMW-HA) and low molecular weight HA (LMW-HA). We investigated the effect of HMW-HA, MMW-HA and LMW-HA on the regulation of physicochemical and biological parameters in an "in vitro" model that might mimic viral infections of the nasal epithelium. Human nasal epithelial cell line RPMI2650 was stimulated with double-stranded RNA (dsRNA) Poly(I:C) for 5 days in air-liquid-interface (ALI) culture (3D model of airway tissue). dsRNA Poly(I:C) treatment significantly decreased transepithelial electrical resistance (TEER) in the stratified nasal epithelium of RPMI2650 and increased pH values, rheological parameters (elastic G' and viscous G''), and Muc5AC and Muc5B production in the apical wash of ALI culture of RPMI2650 in comparison to untreated cells. RPMI2650 treated with dsRNA Poly(I:C) in the presence of HMW-HA showed lower pH values, Muc5AC and Muc5B production, and rheological parameters, as well as increased TEER values in ALI culture, compared to cells treated with Poly(I:C) alone or pretreated with LMW-HA and MMW-HA. Our 3D "in vitro" model of epithelium suggests that HMW-HA might be a coadjuvant in the pharmacological treatment of viral infections, allowing for the control of some physicochemical and biological properties affecting the epithelial barrier of the nose during infection.

• 만화애니메이션 연구
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• 통권44호
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• pp.57-84
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• 2016

그동안 보수적 성향을 고수하던 디즈니가 애니메이션 <겨울왕국>에서 보여준 여성상은 파격이었다. <겨울왕국>의 두 공주는 전통적 성역할과 남성 의존에서 벗어난 주체적 여성으로 그려졌다. 이러한 이유로 <겨울왕국>을 페미니즘 작품으로 해석하는 경향이 있다. 주체적 여성상의 캐릭터는 페미니즘 작품을 규정하는 데에 중요한 지표가 될 수 있으나 이것만으로 작품 성향을 규정하는 것은 무리가 있다. 이에 본 연구는 <겨울왕국>이 페미니즘 작품으로서 타당한가를 검토하였다. 우선, <겨울왕국>의 주제의식인 '자매애'에는 자매간의 우정 이외에 '여성 연대'라는 페미니즘적 개념이 내포되어 있었다. 여성연대의 핵심 개념인 차이, 공감과 연대를 중심으로 <겨울왕국>을 분석했을 때, <겨울왕국>은 서사와 캐릭터, 이미지 등에서 '차이'를 반영하고 있었다. 그리고 진정한 사랑으로 오해와 갈등의 원인이 된 자매의 차이를 인정하자 공감과 연대가 형성되는 과정을 그리고 있었다. 공감과 희생으로 맺어진 엘사와 안나의 연대는 적대자를 물리치는 힘이 되었을 뿐 아니라, 다시 봄을 찾아 재 건립된 아델렌처럼 상생의 공동체를 이룬다는 페미니즘적 가치를 반영하고 있었다. 따라서 <겨울왕국>을 페미니즘 작품으로 해석하는 것이 가능함을 확인할 수 있었다.

• 한국콘텐츠학회논문지
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• 제18권5호
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• pp.566-578
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• 2018

본 연구는 국내 게이미피케이션 연구의 동향과 성과를 고찰하고, 연구방향에 대해 제언하는 것을 목적으로 한다. 이를 위해 체계적 문헌고찰 방법을 통해 선정된 논문 131편을 대상으로 연구시기, 연구목적, 연구 유형, 연구방법, 연구결과에 따라 분석을 실시하였다. 그 결과 국내에서도 관련 연구가 꾸준히 증가하는 추세를 보이면서, 2015년 이후부터 다양한 비게임 분야의 학술적 논의가 보다 활발하게 이루어지고 있음을 알 수 있었다. 연구목적별로는 게이미피케이션 전략 프로그램 디자인의 활용 효과를 검증하고자 하는 평가 목적의 연구가 가장 많았다. 연구시기별 연구목적 분포의 경우 게이미피케이션 논의 초창기에는 소개 분석 목적의 연구가, 2014년 이후부터는 게이미피케이션 전략 개발과 효과 검증을 다루는 연구들이 증가하였다. 연구유형별로는 솔루션, 평가, 포지션페이퍼, 타당화 연구 순이었다. 연구방법별로는 문헌연구가 가장 많았으며 양적연구, 질적연구, 혼합연구의 순이었다. 연구결과를 보고한 45편의 논문에 대한 연구결과별 분석에서는 심리적 효과를 다룬 논문이 21편, 행동적 효과를 다룬 논문이 17편, 심리적, 행동적 효과를 모두 다룬 논문이 7편인 것으로 나타났다. 이러한 분석결과를 바탕으로 향후 연구방향을 제안하였다.