• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.32-32
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• 2003

Recent, a problem about an animal-experimentation were seriously stated with bright development of human science. Safety of chemical materials is evaluated on the basis of the various toxicity data that used an animal-experimentation. However, an toxicity test used by animal is covered with limit and criticism. A problem of toxicity test by animal can try to approach in ethic a few side and usefulness.(omitted)

• Journal of Korean Biological Nursing Science
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• v.17 no.4
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• pp.324-330
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• 2015

Purpose: The purpose of this study was to analyze the trends in Korea of nursing research using animals. Methods: 45 articles were reviewed with descriptive statistics from 2000 to 2015. Results: Nearly 50% of the studies were supported by research funds. Most of the animal species in the studies were rats (81.1%) and mice (15.6%). The major animal models for human disease were cerebrovascular diseases (24.4%), skin problems (17.8%), and nerve injuries (15.5%). Immunohistochemistry (24.3%) was mainly used as an experimental technique. The main intervention and treatments used in the studies were chemical treatments, exercise and surgery. Conclusion: In this review, relevant results were described to identify the trends of nursing research using animal experimentation in Korea. Expansion of various nursing research using animal models can be required for gaining knowledge applicable to the same conditions in humans.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.7
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• pp.1142-1151
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• 1999

Today, laboratory animal production has decreased world-wide to half the number estimated in 1970 of more than 100 Mio. This is due to the cell-biological assays which replaced animal experimentation as a first allround method to solve biomedical problems. Animal experimentation remains the most significant experimental method for the study of higher organized physiological systems and their multifactorial connections. This requires maximal uniformity of all quantitative traits among the animals used for such studies (mainly mice and rats) and stability of these traits for reproducing such studies at any time world-wide. The success of the developed methods for the standardization of laboratory animals was analyzed and were found only partly be acceptable. Getting a higher degree of uniformity among standardized inbred animals is blocked by "intangible variance". This is caused by influences of ooplasm, shown by experimental twin and clone studies. Manipulation of this component of variance is essential in the future. - Genetic drifts impair the necessary stability of biological traits. There are a few disadvantages associated with the cryopreservation of embryos and other methods are required. - Dogs and cats were replaced by pigs as laboratory animals. A new line of animal production will evolve over the next 25 years with similarities to the present laboratory animal production, because in future pigs were used as donors for xenotransplants for men.

• Toxicological Research
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• v.25 no.1
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• pp.9-15
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• 2009

Historically, research in toxicology has utilized non-human mammalian species, particularly rats and mice, to study in vivo the effects of toxic exposure on physiology and behavior. However, ethical considerations and the overwhelming increase in the number of chemicals to be screened has led to a shift away from in vivo work. The decline in in vivo experimentation has been accompanied by an increase in alternative methods for detecting and predicting detrimental effects: in vitro experimentation and in silico modeling. Yet, these new methodologies can not replace the need for in vivo work on animal physiology and behavior. The development of new, non-mammalian model systems shows great promise in restoring our ability to use behavioral endpoints in toxicological testing. Of these systems, the zebrafish, Danio rerio, is the model organism for which we are accumulating enough knowledge in vivo, in vitro, and in silico to enable us to develop a comprehensive, high-throughput toxicology screening system.

• Archives of Plastic Surgery
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• v.40 no.4
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• pp.327-329
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• 2013

As a technically demanding skill, microsurgery is taught in the lab, in the form of a course of variable length (depending on the centre). Microsurgical training courses usually use a mixture of non-living and live animal simulation models. In the literature, a plethora of microsurgical training models have been described, ranging from low to high fidelity models. Given the high costs associated with live animal models, cheaper alternatives are coming into vogue. In this paper we describe the use of the chicken aorta as a simple and cost effective low fidelity microsurgical simulation model for training.

• Asian-Australasian Journal of Animal Sciences
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• v.11 no.6
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• pp.769-773
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• 1998

Genetic advances, changes in housing systems and new management strategies have made it necessary to thoroughly review conventional nutritional programs. The approach has changed from one of feeding to permit gradual depletion of fat and protein tissues to one of feeding to maintain long-term nutritional balance. Increasingly the sow is viewed as a dynamic system that can be described by a mathematical model. There is opportunity to improve the initial models through research to provide a better understanding of metabolism and key physiological events in the sow's reproductive life. Direct experimentation remains a very important tool for defining nutritional requirements. Recent data supports increases in amino acid recommendations during lactation. Voluntary feed intake remains an intractable problem during lactation.

• Journal of Korean Medicine for Obesity Research
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• v.22 no.1
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• pp.54-76
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• 2022

Objectives: The purpose of this study is to analyze the research trends of herbal medicine for obesity in animal experiments over the past 5 years. Methods: 5 Databases (Science on, Oriental Medicine Advanced Searching Integrated System, Research Information Sharing Service, PubMed, Cochrane) were searched from 2017 to 2021. Results: A total of 50 studies were selected and analyzed. 21 single herbs and 25 complex formula were used in the studies. The most commonly used herbal material was Poria cocos. As a result, there were significant improvements in the indicators related to obesity or metabolic abnormalities accompanied by obesity in all studies. Conclusions: These results suggest the efficacy and mechanism of herbal medicine for obesity treatment in animal models. Also, there should be more clinical trials in the future, based on this study.

• The Korean Journal of Physiology
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• v.17 no.1
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• pp.29-35
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• 1983

The most popular way to get the animal to be co-operative for the animal experimentation is by using some kinds of general anesthetic agents. One of the most important point to take care of is, however, whether the agent(s) to be used is hinder the experimentation itself. There have been many contradictory reports of the general anesthetic agents on the renal function. Moreover, little information on the changes of the renal function by anesthesia has been available. We have done experiments to clarify and compare the effects of anesthesia induced by several general anesthetic agents on renal function in unanesthetized rabbits. Nembutal anesthesia(30 mg/kg, iv.) caused a decrease in free-water clearance, and increase in sodium and chloride excretion without significance. Thiopental anesthesia$(20{\sim}30\;mg/kg,\;iv.)$ suppressed all renal parameters tested. Chloralose(50 mg/kg, iv.) and chloral hydrate(75 mg/kg, iv.) did not change renal functions except for glomerular filtration rate, which parameter was suppressed only for a short period just after agent administration. Urethane(1 g/kg), administered by the route of either subcutaneously or intraperitoneally, suppressed renal functions lasted for the duration of experimental anesthesia. The above data suggest that it is very important to chose an appropriate anesthetic agents for a given experiment, especially experiment involved with renal function, and to interprete the data obtained from the anesthetized animal model for the expected results.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2072-2077
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• 2003

Animal-like robots are serving an important role as a linkage between biology and engineering. So, in this paper, we aim to develop a biomimetic microrobot that mimics the locomotion mechanism of a gastropod. This microrobot has 3 DOF (x, y translation and rotation), and has small size, unlimited traveling range, high resolution and low cost. Its movement can be made using propagation wave that is generated by the controllable sinusoidal voltage source and piezoelectric effects. This soft motion that can be generated by propagation wave and piezoelectric mechanism would be useful for the motion on the slippery surface. So we modeled the propagation wave mechanism including piezoelectric effect and friction on the contact surface, and could know the velocity of the microrobot is dependent on the driving frequency, input voltage peak, propagation wavelength and surface friction coefficient. With these results we design the microrobot, and accomplish its fabrication and experimentation. The development of this microrobot shall be aimed to design an autonomous moving actuator like animal. Also it can be used from micromanipulation system technology to biology and medicine.

• Animal Bioscience
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• v.35 no.8
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• pp.1174-1183
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• 2022

Objective: This study was conducted to evaluate the effects of the provision of a protein-rich supplement on productive performance, and metabolic profile on grazing suckling female beef calves in tropical conditions during 150 d of experimentation. Methods: Fifty-six Nellore suckling female calves, and their respective dams were distributed in a completely randomised design and made to undergo two treatments as follows: UNS (without supplementation), and SUP (supplementation with 5 g/kg body weight [BW] of a protein supplement). Throughout the experiment, animal performance and metabolic profile were evaluated. Also, ureagenesis and gluconeogenesis were assessed for gene expression. Results: SUP female calves showed a higher voluntary intake (p≤0.03) of the diet components evaluated, digestibility of organic matter (p≤0.02) and microbial nitrogen production (MICN; p≤0.02) compared to UNS female calves. In its turn, serum urea nitrogen (p≤0.01) and insulin-like growth factor-1 (p≤0.03) levels and ureagenesis (p≤0.04) increased in SUP female calves compared to UNS female calves. Blood glucose and triglyceride levels were not affected by supplementation. The average daily gain (ADG) from SUP female calves was higher (p≤0.02) compared with UNS female calves. However, supplementation did not affect the body measures of the animals. Conclusion: In summary, provision of a protein-rich supplement improves the intake and nutrients digestibility, ADG and final BW and increases metabolic indicators of the protein status in grazing suckling female beef calves in tropical conditions.