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Use of Animals for Nursing Research in Korea

동물 실험을 적용한 국내 간호 연구 동향 분석

  • 유해영 (중앙대학교 적십자간호대학)
  • Received : 2015.09.30
  • Accepted : 2015.10.27
  • Published : 2015.11.30

Abstract

Purpose: The purpose of this study was to analyze the trends in Korea of nursing research using animals. Methods: 45 articles were reviewed with descriptive statistics from 2000 to 2015. Results: Nearly 50% of the studies were supported by research funds. Most of the animal species in the studies were rats (81.1%) and mice (15.6%). The major animal models for human disease were cerebrovascular diseases (24.4%), skin problems (17.8%), and nerve injuries (15.5%). Immunohistochemistry (24.3%) was mainly used as an experimental technique. The main intervention and treatments used in the studies were chemical treatments, exercise and surgery. Conclusion: In this review, relevant results were described to identify the trends of nursing research using animal experimentation in Korea. Expansion of various nursing research using animal models can be required for gaining knowledge applicable to the same conditions in humans.

Keywords

References

  1. Holden JE. Putting the bio in biobehavioral: Animal models. Western Journal of Nursing Research. 2011;33(8):1017-1029. http://dx.doi.org/10.1177/01939459 11403776
  2. Page GG. The importance of animal research to nursing science. Nursing Outlook. 2004;52(2):102-107. http://dx.doi.org/10.1016/j.outlook.2003.10.011
  3. Holden JE. Physiological research is nursing research. Nursing Research. 1996;45(5):312-313. http://dx.doi.org/10.1097/00006199-199609000-00011
  4. Cowan MJ, Heinrich J, Lucas M, Sigmon H, Hinshaw AS. Integration of biological and nursing sciences: A 10-year plan to enhance research and training. Research in Nursing and Health. 1993;16(1):3-9. http://dx.doi.org/10.1002/nur.4770160103
  5. Rudy E, Grady P. Biological researchers: Building nursing science. Nursing Outlook. 2005;53(2):88-94. http://dx.doi.org/10.1016/j.outlook.2004.09.006
  6. Heitkemper MM, Bond EF. State of nursing science: On the edge. Biological Research for Nursing. 2003;4(3):151-162. http://dx.doi.org/10.1177/10998004022 39725
  7. Choe MA, Kim NC, Kim KM, Kim SJ, Park KS, Byeon YS, et al. Trends in nursing research in Korea: Research trends for studies published from the inaugural issue to 2010 in the Journal of Korean Academy of Nursing and the journals published by member societies under Korean Academy of Nursing Science. Journal of Korean Academy of Nursing. 2014;44(5):484-494. http://dx.doi.org/10.4040/jkan.2014.44.5.484
  8. Shin HS, Hyun MS, Ku MO, Cho MO, Kim, SY, Jeong, JS, et al. Analysis of research papers published in the Journal of Korean Academy of Nursing-focused on research trends; Intervention studies, and level of evidence in the research. Journal of Korean Academy of Nursing. 2010;40(1):139-149. http://dx.doi.org/10.4040/jkan.2010.40.1.139
  9. Lee KE, Park YR, Cho KJ, Park MJ. Research trends in the Korean Biological Nursing Science-Based on analysis of the research papers published in the Journal of Korean Biological Nursing Science from 1999 to 2010-. Journal Korean Biological Nursing Science. 2011;13(2):81-93.
  10. Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernaldes-Suarez XM, Flint J, et al. Progress and prospects in rat genetics: a community view. Nature Genetics. 2008;40(5):516-522. http://dx.doi.org/10.1038/ng.147
  11. Ginsgerg MD, Busto R. Rodent models of cerebral ischemia. Stroke. 1989;20: 1627-1642. http://dx.doi.org/10.1161/01.str.20.12.1627
  12. Lee YK, Choe MA, An GJ. Effects of isometric contraction training by electrostimulation on type I and II hindlimb muscles in cerebral ischemia model rats. Journal of Korean Academy of Nursing. 2006;36(7):1232-1241. https://doi.org/10.4040/jkan.2006.36.7.1232
  13. Choe MA, An GJ. Effects of exercise before steroid treatment on type I and type II hindlimb muscles in a rat model. Journal of Korean Academy of Nursing. 2007;37(1):81-90. https://doi.org/10.4040/jkan.2007.37.1.81
  14. Choe MA, An GJ. Effect of DHEA administration alone or exercise combined with DHEA before steroid treatment on rat hindlimb muscle. Journal of Korean Academy of Nursing. 2009;39(3):321-328. http://dx.doi.org/10.4040/jkan. 2009.39.3.321
  15. Kim JI, Choe MA. Effects of unilateral sciatic nerve injury on unaffected hindlimb muscles of rats. Journal of Korean Academy of Nursing. 2009;39(3):393-400. http://dx.doi.org/10.4040/jkan.2009.39.3.393
  16. Choe MA, Shin GS, An GJ, Choi JA, Lee YK. Effect of regular exercise during recovery period following steroid treatment on the atrophied type II muscles induced by steroid in young rats. Journal of Korean Academy of Nursing. 2002;32(4):550-559. https://doi.org/10.4040/jkan.2002.32.4.550
  17. Choe MA, Shin GS, An GJ, Lee EJ. Effect of DHEA administration before, during and after dexamethasone treatment on body weight and mass of type I, II muscles in rats. Journal of Korean Academy of Nursing. 2002;32(5):727-734. https://doi.org/10.4040/jkan.2002.32.5.727
  18. Kim Y, Choe MA. Effect of decreased locomotor activity on hindlimb muscles in a rat model of parkinson's disease. Journal of Korean Academy of Nursing. 2010;40(4):580-588. http://dx.doi.org/10.4040/jkan.2010.40.4.580
  19. Na YK, Hong HS. The effects of the ulmus root-bark dressing in tissue regeneration of induced pressure ulcers in rats. Journal of Korean Academy of Nursing. 2006;36(3):523-531. https://doi.org/10.4040/jkan.2006.36.3.523
  20. Na YK, Hong HS. The effect of ulmus dressing on burn wound in rats. Journal of Korean Biological Nursing Science. 2005;7(1):89-98.
  21. Na YK. The effect of ulmus root-bark dressing in fibroblast growth factor and vascular endothelial growth factor of induced pressure ulcer in rats. Journal of Korean Biological Nursing Sicence. 2013;15(4):257-263. http://dx.doi.org/10.7586/jkbns.2013.15.4.257
  22. Hong HS, Na YK. The effect of capsaicin on the peripheral nerve damage of intervibrissal fur in rats. Journal of Korean Biological Nursing Science. 2006;8(1):39-48.
  23. Tkacs NC, Thompson HJ. From bedside to bench and back again: Research issues in animal models of human disease. Biological Research for Nursing. 2006;8(1):78-88. http://dx.doi.org/10.1177/1099800406289717
  24. Chaperon C. Sleep deprivation impairs I2-Hr urine volume excretion in old rats. Biological Research for Nursing. 2010;11(3):236-244. http://dx.doi.org/10.1177/1099800409336868
  25. Franco NH. Animal experiments in biomedical research: A historical perspective. Animals. 2013;3(1):238-273. http://dx.doi.org/10.3390/ani3010238
  26. Choe MA, An GJ. Effects of nitric oxide synthase inhibitor on hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury. Journal of Korean Academy of Nursing. 2011;41(4):520-527. http://dx.doi.org/10.4040/jkan.2011.41.4.520
  27. Kim JI, Choe MA. Effects of antioxidant on reduction of hindlimb muscle atrophy induced by cisplatin in rats. Journal of Korean Academy of Nursing. 2014;44(4):371-380. http://dx.doi.org/10.4040/jkan.2014.44.4.371
  28. Kang KA, Seong H, Jin HB, Park J, Lee J, Jeon JY, et al. The effect of treadmill exercise on ischemic neuronal injury in the stroke animal model: Potentiation cerebral vascular integrity. Journal of Korean Academy of Nursing. 2011;41(2):197-203. http://dx.doi.org/10.4040/jkan.2011.41.2.197
  29. Choe MA, An GJ. Effects of exercise on affected and unaffected hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury. Journal of Korean Academy of Nursing. 2010;40(5):611-619. http://dx.doi.org/10.4040/jkan.2010.40.5.611