• 대한화학회지
• /
• 제42권2호
• /
• pp.143-149
• /
• 1998

마취제를 purple membrane내 bacteriorhodopsin(bR)에 가했을 때 570nm 흡수 띠는 480nm로 이동한다. 마취제에 의해 유도된 분광학적 변화는 가역적이다. 이러한 평형의 겉보기 pKa(6.3)는 bR에 분산된 마취제의 성질에 의존한다. bR의 전기배향 측정은 비교적 작은 전기장에서도 쉽게 달성될 수 있었으며 이때의 배향각도는 60°이었다. 그러나 마취제로 처리한 bR은 이러한 변화를 관측할 수가 없다. 이들 결과들은 마취제에 의해 발색단과 발색단 주변의 단백질 구조의 민감한 변화가 단백질 매트릭스의 전하를 띈 잔기들의 공간적 배향에 영향을 준 것으로 보인다.

• 대한임상전기생리학회지
• /
• 제1권2호
• /
• pp.11-19
• /
• 2003

The purpose of this study investigated the anesthetic effects of lidocaine gel by phonophoretic transdermal delivery. The anesthetic effects were evaluated by two aspects as quantitative sensory testing and sensory nerve conduction study. Twelve healthy males(aged $23.25{\pm}2.09$ years) were studied. Exclusion criteria were ; pain, history of sensory disturbances and skin conditions in the areas to be examined. The subjects were divided into two groups; group I(lidocaine gel without ultrasound) and group II(lidocaine gel with ultrasound). The following results were obtained; 1. In changes of tactile threshold and electrical pain threshold, all groups were significantly increased(p<0.05). 2. In changes of electrical pain threshold, it was significantly differenced between the groups(p<0.05). We conclude that the transdermal delivery of lidocaine gel by phonophoresis has a possibility to use for surface anesthesia and the pain control of the superficial tissue.

• 한국임상수의학회지
• /
• 제10권2호
• /
• pp.215-220
• /
• 1993

The anesthetic effects by dosages of Tiletamlne-Zolazepam in the dogs were investigated and then the optimal dosages for the operation of patients were suggested. 1. In groups of T+Z 20, 10 and 5 mg/kg administration, anesthetic periods are 180~300, 33~47 and 40~50 minutes, respectively and complete recovery from anesthesia was shorted with taking 53~72 minutes in the group of 5 mg/kg administration. 2. Reflex responses to eyelids, cornea and pharyngolarynx were maintained but pedal reflexes became considerably sluggish 3. It showed tachycardias on ECG but there were no specific dysrhythmias. On EEG, it showed low voltage-fast waves before anesthesia, high voltage-fast waves in induction stage, low voltage-slow waves in anesthetic stage and high voltage-fast waves again in recovery stage. 4. Surgical procedures could be performed satisfactorily in 6 cases of the 10 mg/kg administration group, but in 3 of 5 cases of 5 mg/kg administration group it could be completed after additional administration. 5. In conclusion, it was considered desirable for anesthetizing dogs that for healthy cases T+Z at the level of 10 mg/kg B.W. was administered, and for poor risk patients, 5 mg/kg B.W., followed by an additional administration in unsatisfied cases.

• 한국임상수의학회지
• /
• 제18권1호
• /
• pp.22-28
• /
• 2001

A combined anesthesia in terms of balanced anesthesia has been widely used for enhancement of anesthetic potency, decrement of dosage, reduction of side effects and better muscle relaxation. Recently, tiletamine/zolazepam (T/Z) has been widely used for the general anesthesia in dogs, but there have been few studies on balanced anesthesia of this drug in combination with other drugs. In this experiment, the combinations of T/Z with acepromazine or fentanyl/xylazine/azaperone (F/X/A) have been compared for the anesthetic effects in dogs. Healthy 5 mongrel dogs were allocated into three treatment groups ; Group Z (atropine + T/Z), Group A + Z (atropine/acepromazine + T/Z) in runs of 10 replication. The rapid induction of anesthesia was shown in all three treatment groups. The maintenance time of anesthesia was significanty increased to 101.4$\pm$6.2 minutes (44 min. more than that of group Z) in Group A + Z and 127.4$\pm$4.7 minutes (70 min. more than that of group Z) in Group F + Z, respectively. The recovery from anesthesia was rapid in Group F + Z. In blood analysis, there was no significant variation in three groups but hyperglycemia in Group F + Z. These results indicate that the balanced anesthesia of T/Z with F/X/A was superior to other two methods for maintaining and recovering from the anesthesia, and could be applied for general anesthesia in dogs.

• 한국임상수의학회지
• /
• 제8권1호
• /
• pp.81-91
• /
• 1991

This study was carried out to investigate the effects of intravenous drip with ketamine hydrochloride and its application for control depth and maintenance of anesthesia in dogs. Changes of blood pressure, vital signs, blood gas and anesthetic state were observed in this study. The obtained were summerized as follows ; 1. Changes of blood pressure and heart rate after intravenous drip anesthesia with ketamine hydrochloride were observed with significant increase in all group ; group II (0.135m81k9/min), group III (0.269mg/kg/min) and group IV(0.538mg/kg/min). These conditions were maintained unchangeably until 160 minutes after administration in all group. This may be indicated that there were no side effects on account of ketamine accumulation. 2. There were irregular respiration, pain reflex, Jaw tone reflex and vomition probability in the anesthetic conditions of group II The anesthetic conditions of group III were rarely shown as mentioned above. Awakening time and recovery time of group H were more prolonged 21 minutes and 27 minutes respectively than those of group III. These experimental data suggested that the optimal dosage of intravenous drip anesthesia of ketamine Hcl was 0.269mg/kg/min.

• Journal of Oral Medicine and Pain
• /
• 제35권4호
• /
• pp.275-281
• /
• 2010

가쪽날개근은 턱의 기능을 수행하는데 기본적인 저작근 중의 하나이다. 이 근육은 저작계의 심부에 위치하기 때문에 손가락을 이용한 촉진검사가 어려우며 그 결과도 신뢰할 만하지 못하다. 이러한 이유로 임상의에게 가쪽날개근에 이환된 근육통 질환을 진단하는 것은 쉽지 않은 문제이다. 근육내 국소마취 주사는 통증의 근원지를 감별하는 목적으로서 가쪽날개근을 검사하는 효과적인 방법이 될 수 있다. 또한 근육통을 즉각적으로 제거함으로써 근육을 전체 길이만큼 신장하는데 도움을 줄 수 있다. 저자들은 근육내 국소마취 주사를 이용하여 가쪽날개근의 근육통을 성공적으로 진단하고 치료한 두 증례를 보고하고자 한다.

• 대한치과마취과학회지
• /
• 제2권1호
• /
• pp.27-32
• /
• 2002

Hemophilia A is the most common congenital bleeding disorder, which is sex-linked disease, caused by a deficiency of clotting factor VIII. We experienced a case of alveolorrhaphy using iliac bone graft under general anesthesia for the correction of bilateral cleft alveolus in 10-year-old boy with hemophilia A. Factor VIII activity in this patient was 0.7%, on the severely deficient level, and aPTT was 100 seconds. Just before operation, he received 1,750 units of factor VIII intravenously for loading dose. After we confirmed his factor VIII activity improved to 95% and aPTT to 38.4 seconds, operation was begun. No more transfusion was needed during the operation. In his postoperative care, he received 50 units/kg a 12 hours for 3 days and 30 units/kg a 12 days for 2 days. His factor VIII activity was maintained at 57-139% during his hospitalization. He was discharged without any anesthetic complication. So we report this successful case of anesthetic management for the oral surgery in a child with hemophilia A.

• The Korean Journal of Pain
• /
• 제9권1호
• /
• pp.39-45
• /
• 1996

Tachyphylaxis to local anesthetics has shown to be promote longer interanalgesic intervals between injections. Previous study demonstrated thermal hyperalgesia accelerates development of tachyphylaxis to sciatic nerve blockade in rats, while MK-801 prevents development of tachyphylaxis. Dextromethorphan is one of NMDA receptor antagonist similar to MK-801. A hypothesis that dextromethorphan would prevent the development of tachyphylaxis was tested in this study. A catheter was surgically implanted along the sciatic nerve a in rat. After recovery from surgery, the animal received repeated injections of 3% 2-chloroprocaine followed by motor block testing with or without hot-plate testing at $56^{\circ}C$. In other experiments, dextromethorphan was administrered by intraperiotneal injection prior to an injection of local anesthetic therough the implanted catheter. Sensory and motor testing was then carried out. Rats injected with 2-chloroprocaine and subjected to hot-plate testing, developed tachyphylaxis to motor and sensory blockade. However, animals pretreated with dextromethorphan did not develop tachyphylaxis over series of three injections. Dextromethorphan seems to prevent development of tachyphylaxis to sciatic nerve blockade in this rat model. Dextromethorphan, one of N-Methyl-D-aspartate receptor antagonist, can be applied to prolong the effect of local anesthetic.

• The Korean Journal of Pain
• /
• 제8권1호
• /
• pp.60-64
• /
• 1995

Stellate ganglion block is a selective sympathetic blockade affecting the head and neck, and the upper extemity. It is an important method which has been used most frequently in neuro-pain clinic due to its wide range of indications. The authors attermpted to define the minimal volume of local anesthetic which need for successful stellate ganglion block by using 1% mepivacaine HCl mixed with dye. In 40 heathy volunteers, two different volumes, 3 ml in the group 1 (n=20) and 4 ml in the group 2 (n=20), were injected by an anterior paratracheal technique at the sixth cervical vertebral level. We compared the degree in sympathetic blockade by clinical sings and symptoms and also checked the spread range of dye by plain X-ray. With seven criteria for an effective block. mean score was 5.7 in group 2, while 3.4 in group 1. These results suggest that 4 ml of local anesthetic are adequate for a successful stellate ganglion block.

• 융합신호처리학회논문지
• /
• 제20권2호
• /
• pp.63-69
• /
• 2019

본 연구에서는 뇌파의 스펙트럼 분석에 의해 추출되는 마취심도 지표인 SEF(spectral edge freqency), MF(median frequency)의 가변성 감소를 위하여 뇌파의 비선형성에 근거하여 바이스펙트럼 분석기법을 도입하고자 한다. 수술환경에서 뇌파의 계측과 분석은 다양한 외부 아티팩트 요소를 감안하여야 한다. 바이스펙트럼 분석은 비선형적 신호의 특성을 추출하는 분석법으로 외부 유입 아티팩트의 유무를 확인 할 수 있어 뇌파에 인입되어 분석에 영향을 끼치는 아티팩트를 효과적으로 제거하는데 기여한다. 이러한 과정을 통해 SEF, MF와 같은 마취심도 파라미터의 실시간 가변성을 감소시킬 수 있었다. 이러한 가변성 감소는 수술현장에서 실시간 활용 가능한 임상 지표서 SEF, MF의 유용성을 제고시켜 줄 수 있을 것이다.