• 제목/요약/키워드: Anchorage

검색결과 843건 처리시간 0.028초

외부강선으로 긴장된 PSC 거더의 비선형 해석 (Nonlinear Analysis of PSC Girders with External Tendons)

  • 최규천;이재석
    • 한국전산구조공학회논문집
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    • 제23권3호
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    • pp.303-314
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    • 2010
  • 이 논문에서는 외부강선으로 긴장된 PSC 거더의 비선형 해석방법에 대한 연구를 수행하였다. 외부강선은 정착부와 편향부에서만 부재와 일체로 거동을 하고 정착부-편향부, 편향부-편향부 사이에서 독립적인 거동을 보이는 특성으로 인해 구조물의 처짐이 증가할 경우 부재와 외부강선의 편심량이 감소하여 모멘트가 변화하는 2차 효과(secondary effect)가 발생한다. 또한 편향부에서 외부강선의 인장력 차이로 인해 슬립(slip)이 발생할 경우 외부강선의 인장력이 재분배되어 복잡한 비선형 거동을 보이게 된다. 이 논문에서는 정착부-편향부, 편향부-편향부 사이의 외부강선을 여러 개의 곡선요소로 모사하고, 편향부에서의 마찰력과 driving force(미끄러지는 힘)의 평형관계를 이용하여 외부강선의 인장력을 재분배함으로써 편향부에서의 슬립효과를 고려하였다. 이 논문에서 제시한 외부강선의 유한요소모델과 해석방법을 저자들이 개발한 시공단계를 고려한 PSC 뼈대의 비선형 해석 프로그램에 통합하고, 외부강선으로 긴장된 PSC 보의 해석에 적용하여 외부강선에 대한 유한요소모델 및 해석방법의 정당성과 적용성을 확인하였다. 또한 편향부의 수와 편향부에서의 마찰계수에 따른 극한거동을 검토해본 결과, 편향부의 수가 증가할수록 PSC 보의 항복하중과 극한하중은 증가하였으며, 편향부에서의 마찰계수에 따른 극한거동은 외부강선과 편향부 사이의 마찰력으로 인해 부재에 전달되는 모멘트의 영향에 따라 마찰계수가 적정한 값일 경우에 극한내력이 최대치를 보이는 것을 확인하였다.

A Novel Pyruvate Kinase M2 Activator Compound that Suppresses Lung Cancer Cell Viability under Hypoxia

  • Kim, Dong Joon;Park, Young Soo;Kim, Nam Doo;Min, Sang Hyun;You, Yeon-Mi;Jung, Yuri;Koo, Han;Noh, Hanmi;Kim, Jung-Ae;Park, Kyung Chan;Yeom, Young Il
    • Molecules and Cells
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    • 제38권4호
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    • pp.373-379
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    • 2015
  • Pyruvate kinase M2 isoform (PKM2), a rate-limiting enzyme in the final step of glycolysis, is known to be associated with the metabolic rewiring of cancer cells, and considered an important cancer therapeutic target. Herein, we report a novel PKM2 activator, PA-12, which was identified via the molecular docking-based virtual screening. We demonstrate that PA-12 stimulates the pyruvate kinase activity of recombinant PKM2 in vitro, with a half-maximal activity concentration of $4.92{\mu}M$, and effectively suppresses both anchorage-dependent and -independent growth of lung cancer cells in non-essential amino acid-depleted medium. In addition, PA-12 blocked the nuclear translocalization of PKM2 in lung cancer cells, resulting in the inhibition of hypoxia response element (HRE)-mediated reporter activity as well as hypoxia-inducible factor 1 (HIF-1) target gene expression, eventually leading to the suppression of cell viability under hypoxia. We also verified that the effects of PA-12 were dependent on PKM2 expression in cancer cells, demonstrating the specificity of PA-12 for PKM2 protein. Taken together, our data suggest that PA-12 is a novel and potent PKM2 activator that has therapeutic implications for lung cancer.

Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma

  • Kim, Suyeon;Kim, Jaewon;Jung, Yeonjoo;Jun, Yukyung;Jung, Yeonhwa;Lee, Hee-Young;Keum, Juhee;Park, Byung Jo;Lee, Jinseon;Kim, Jhingook;Lee, Sanghyuk;Kim, Jaesang
    • Molecules and Cells
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    • 제43권7호
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    • pp.619-631
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    • 2020
  • In this study, we describe a novel function of TNNC1 (Troponin C1, Slow Skeletal and Cardiac Type), a component of actin-bound troponin, as a tumor suppressor of lung adenocarcinoma (LUAD). First, the expression of TNNC1 was strongly down-regulated in cancer tissues compared to matched normal lung tissues, and down-regulation of TNNC1 was shown to be strongly correlated with increased mortality among LUAD patients. Interestingly, TNNC1 expression was enhanced by suppression of KRAS, and ectopic expression of TNNC1 in turn inhibited KRASG12D-mediated anchorage independent growth of NIH3T3 cells. Consistently, activation of KRAS pathway in LUAD patients was shown to be strongly correlated with down-regulation of TNNC1. In addition, ectopic expression of TNNC1 inhibited colony formation of multiple LUAD cell lines and induced DNA damage, cell cycle arrest and ultimately apoptosis. We further examined potential correlations between expression levels of TNNC1 and various clinical parameters and found that low-level expression is significantly associated with invasiveness of the tumor. Indeed, RNA interference-mediated down-regulation of TNNC1 led to significant enhancement of invasiveness in vitro. Collectively, our data indicate that TNNC1 has a novel function as a tumor suppressor and is targeted for down-regulation by KRAS pathway during the carcinogenesis of LUAD.

팽창형 강관 록볼트의 암반 강성에 따른 정착 거동 특성 (Anchorage mechanism of inflatable steel pipe rockbolt depending on rock stiffness)

  • 김경철;김호종;정영훈;신종호
    • 한국터널지하공간학회 논문집
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    • 제19권2호
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    • pp.249-263
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    • 2017
  • 팽창형 강관 록볼트의 설치 전 단면 형상은 ${\Omega}$형이어서, 팽창 중 거동은 기하학적 비선형 특성을 보인다. 기존 팽창형 강관 록볼트의 정착 거동에 관한 연구는 주로 이론적 방법이었다. 하지만 이론적 방법은 팽창형 강관 록볼트의 등방 팽창을 가정하므로, 실제 거동을 지나치게 단순화하였다. 본 연구에서는 강관 팽창 거동의 비선형성과 다양한 영향 특성을 고려한 수치해석을 이용하여, 팽창형 강관 록볼트의 정착 거동을 모사하였다. 본 해석을 통해 강관의 팽창 과정, 접촉응력 분포, 평균 접촉 응력 및 접촉 면적의 변화를 분석하였다. 암반의 탄소성 조건에 따라 강관의 접촉응력이 다르게 나타났는데, 탄성 조건의 암반에 설치된 강관에 비해 탄소성 조건의 암반에 설치된 강관에서 작은 접촉응력이 발생했다. 또한 암반의 강성에 따라 팽창형 강관 록볼트의 정착 거동이 달라졌다. 주어진 해석 조건에서 암반 강성이 0.5 GPa 이하 일 때 강관은 완전히 펴지지만, 암반 강성이 0.5 GPa보다 클 때 완전히 펴지지 않았다. 강관이 완전히 펴진 경우 암반 강성이 증가함에 따라 접촉응력의 크기가 증가했지만, 강관이 완전히 펴지지 않은 경우 암반 강성이 증가함에 따라 접촉응력의 크기가 감소했다.

인조골에서 식립 방법이 교정용 미니 임플란트의 기계적 안정성에 미치는 영향에 대한 예비연구 (The effects of different pilot-drilling methods on the mechanical stability of a mini-implant system at placement and removal: a preliminary study)

  • 조일식;추혜란;김성균;신윤섭;김덕수;김성훈;정규림;존황
    • 대한치과교정학회지
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    • 제41권5호
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    • pp.354-360
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    • 2011
  • Objective: To investigate the effects of different pilot-drilling methods on the biomechanical stability of self-tapping mini-implant systems at the time of placement in and removal from artificial bone blocks. Methods: Two types of artificial bone blocks (2-mm and 4-mm, 102-pounds per cubic foot [102-PCF] polyurethane foam layered over 100-mm, 40-PCF polyurethane foam) were custom-fabricated. Eight mini-implants were placed using the conventional motor-driven pilot-drilling method and another 8 mini-implants were placed using a novel manual pilot-drilling method (using a manual drill) within each of the 2-mm and 4-mm layered blocks. The maximum torque values at insertion and removal of the mini-implants were measured, and the total energy was calculated. The data were statistically analyzed using linear regression analysis. Results: The maximum insertion torque was similar regardless of block thickness or pilot-drilling method. Regardless of the pilot-drilling method, the maximum removal torque for the 4-mm block was statistically higher than that for the 2-mm block. For a given block, the total energy at both insertion and removal of the mini-implant for the manual pilot-drilling method were statistically higher than those for the motor-driven pilot-drilling method. Further, the total energies at removal for the 2-mm block was higher than that for the 4-mm block, but the energies at insertion were not influenced by the type of bone blocks. Conclusions: During the insertion and removal of mini-implants in artificial bone blocks, the effect of the manual pilot-drilling method on energy usage was similar to that of the conventional, motor-driven pilot-drilling method.

3차원 배근설계 및 배근시공도 작성 자동화 시스템 개발 (Development of 3-Dimensional Rebar Detail Design and Placing Drawing System)

  • 최현철;이윤재;이시은;김치경
    • 한국전산구조공학회논문집
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    • 제27권4호
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    • pp.289-296
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    • 2014
  • 철근 공사에는 원청 건설사, 골조 전문건설사, 배근시공도 작성자, 철근 가공장, 감독/감리사, 구조설계자 등 다수의 업무 주체가 참여하고 있으나 이들간의 합리적인 협업이 이루어질 수 있는 업무 프로세스가 구축되어 있지 않아 비효율을 초래할 가능성이 높다. 특히 철근공사는 RC골조 품질에 결정적 영향을 주는 업무이지만 참여 주체간 원활한 협업 부재로 인하여 골조의 품질 저하, 생산성 감소, 공기 지연 등 많은 문제를 야기하고 있다. 그러므로 RC골조공사는 혁신이 매우 시급한 분야라 하겠다. 최근 BIM은 건설산업의 기술 환경 패러다임을 전환시키는 기술로 인식되고 확산되고 있다. 그런데 3차원 모델 상에서 방대한 양의 철근상세정보를 모델링하기 위해서는 많은 시간과 노력이 소요되고, 모델링 후에도 데이터량의 방대함으로 인하여 프로그램 성능이 원활하게 발현되지 않기에 BIM 기술의 확산에도 불구하고 배근 설계와 시공과 관련하여 BIM 기술이 활용되고 있지 않은 상황이다. 본 기술은 3차원 BIM 환경 하에서 골조상세정보 모델링과 배근상세설계, 정밀물량산출 및 공사관리까지를 지원하는 Rebar HUB를 개발하여 RC 골조 설계 및 공사 프로세스를 합리화할 수 있는 실용적 기술 개발을 목표로 하였다.

보철학적 교합 재구성을 위한 교합진단과 치료계획 (The Occlusal Evaluation and Treatment Planning for Prosthodontic Full Mouth Rehabilitation)

  • 이승규;이성복;최대균
    • 구강회복응용과학지
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    • 제16권2호
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    • pp.149-159
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    • 2000
  • Occlusal disease is comparable to periodontitis in that it is generally not reversible. Occlusal disease, however, like periodontitis, often maintainable. It does itself to treatment and when restorative dentistry is utilized it becomes, in that sense, reversible. Moreover, a systematized and integrated approach will lead to a prognosis that is favorable and predictable. This approach facilitates development of optimum oral function, comfort, and esthetics, resulting in a satisfied patient. Such a systematized approach consists of four logical phase : (1) patient evaluation, (2) comprehensive analysis and treatment planning, (3) integrated and systematic reconstruction, and (4) postoperative maintenance. An integrated treatment plan is first developed on one set of diagnostic casts, properly mounted on a semiadjustable articulator using jaw relationship records. This is accomplished by using wax to make reconstructive modifications to the casts. These modified casts become the blueprint for planned occlusal changes and the fabrication of provisional restorations. The treatment goals are : (1) comfortably functioning temporomandibular joints and stomatognathic musculature, (2) adherence to the basic principle of occlusion advocated by Schuyler, (3) anterior guidance that is in harmony with the envelope of function, (4) restorations that will not violate the patient's neutral zone. This report shows the treatment procedures for a patient whose mandibular position has been altered due to posterior bite collapse. Migration of the maxillary anterior teeth had occurred, and the posterior occlusal contacts showed pathologic interference. Precise diagnosis using mounted casts was executed and prosthodontic reconstruction by the aid of an unconventional orthodontic correction on maxillary flaring was planned. An unconventional orthodontic correction can be accomplished by using preexisting natural teeth, which can be modified for use in active tooth movement or splinted together for orthodontic anchorage. This technique has an advantage over conventional fixed appliance orthodontic therapy because it can accomplish tooth movement concurrently with restorative and periodontal therapy. On occasion, minor tooth movement can be necessary to achieve the optimum occlusal scheme, crown form, and tooth position for the forces of occlusion to be displaced down the long axis of the periodontally compromised teeth. Once the occlusion, periodontal health, and crown contours for the provisional splinted restoration are acceptable, the final splinted restoration can be similarly fabricated, and it becomes an excellent orthodontic retainer.

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마우스세포주 Balb/c 3T3 A31-1-1에서 Epigallocatechin gallate(EGCG)의 세포암화 억제효과에 대한 유전자발현 해석 (Genome-based Gene Expression Analysis of EGCG-mediated Cell Transformation Suppression Effect in Mouse Cell line Balb/c 3T3 A31-1-1)

  • 정기경;서수경;김태균;박문숙;이우선;박순희;김승희;정해관
    • 한국환경성돌연변이발암원학회지
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    • 제26권4호
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    • pp.125-132
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    • 2006
  • Previous studies showed that epigallocatechin gallate(EGCG) have substantial effects of suppressing the N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)-initiated cell transformation process on the bases of foci formation frequency and loss of anchorage dependency. In this study we tried to clarify the molecular mechanism of suppressing the cell transformation process. Mouse cell line balb/c 3T3 A31-1-1 was exposed 2 days to MNNG followed by 15 days 12-O-tetradecanoylphorbol-13-acetate(TPA) treatment for our transformation process. EGCG was added after the time point of 24 hours exposure to TPA and incubated for 19 days. 2029 genes were selected in our transformation process that showed fold change value of 1.5 or more in the microarray gene expression analysis covering the mouse full genome. These genes were found to be involved mainly in the cell cycle pathway, focal adhesion, adherens junction, TGE-$\beta$ signaling, apoptosis, lysine degradation, insulin signaling, ECM-receptor interaction. Among the genes, we focused on the 631 genes(FC>0.5) reciprocally affected by EGCG treatment. Our study suggest that EGCG down-regulate the gene expressions of up stream signaling factors such as nemo like kinase with MAPK activity and PI3-Kinase, Ras GTPase and down stream factors such as cyclin D1, D2, H, T2, cdk6.

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골든타임 확보를 위한 선박 대피항로 선정 시 고려사항에 관한 연구 - 선박운항자 관점에서 - (A Study on Considerations of Ship Evacuation Route for Goldentime - Based on Ship Operators Perspective -)

  • 박상원;박영수;이명기
    • 해양환경안전학회지
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    • 제23권6호
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    • pp.620-627
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    • 2017
  • 사고에서 인명을 구조할 수 있는 시간인 골든타임의 중요성은 날로 커져가고 있다. 특히 해양사고의 경우 발생 위치에 따라 구조세력이 도착하는 데는 수시간이 걸릴 수 있으므로 이에 대한 대비가 필요하다. 본 논문은 해상에서 긴급상황이 발생하여 대피항로를 선정 시, 선박운항자 관점의 우선 고려사항을 도출하는 것을 목적으로 한다. 이를 위해서 선행연구와 해양사고 재결서 및 국내선사의 비상대응 매뉴얼 분석을 통하여 선박 대피시의 고려사항을 식별하고 선박운항자를 대상으로 AHP 분석(의사결정계층 분석)을 실시하였다. AHP 분석 결과 선박운항자는 인명의 안전을 선박의 안전보다 약 6배 중요하게 생각하며, 대피항로를 선정하기 위해서는 주변의 해경함정에 도움요청, 피난항 위치, 비상투묘, 주변선박 도움요청, 표류, 임의좌주 순으로 고려하는 것으로 나타났다. 우선순위를 이용해서 긴급상황 발생 시 공황 상태의 선교에 선박운항자의 의사결정을 도울 수 있는 기초 정보자료로 제공할 수 있다.

Ancient Seaports on the Western Coast of India: The Hub of the Maritime Silk Route Network

  • DAYALAN, DURAISWAMY
    • Acta Via Serica
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    • 제3권2호
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    • pp.49-72
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    • 2018
  • The extensive maritime trade network between the Harappan and Mesopotamian civilizations as early as the $3^{rd}$ millennium BCE is a testimony to the long maritime trade history of India. From the dawn of the historical epoch, the maritime trade network of India expanded extensively. The findings of a large number of coins, pottery, amphorae and other materials from Italy and various other European countries, west Asia, China, Korea, Africa, the Arabian Peninsula, Sri Lanka, Southeast Asia and Far-East countries in India, particularly in the coastal regions, are a testimony to the dynamic maritime trade of India with other countries in the early period. Similarly, pottery, sculptures, inscriptions and other materials of Indian origin are also found in those countries. The depiction of different types of ships on the coins, paintings, sculptures, seals and sealing, exhibit the variety of vessels used for navigation and other purposes in the early period. The over 7500 km-long coastline of India is well known for its seaports located at river mouths or outlets to the sea. The Periplus Maris Erythraei, Ptolemy, and Indian literary sources mention many seaports on the western coast of India. Interestingly, archaeological investigations in many of these port towns have yielded material evidence exhibiting their dominant role in transoceanic trade and commerce with many countries in the early period. This paper discusses in detail all the major ancient seaports on the western coast of India and their maritime trade activities. At the outset, the paper briefly deals with the Harappan's maritime network, their seaports and the type of ships of that period. Following this, the maritime trade network of India during the historical period with various countries in the east and west, the traces of Indian influence and materials abroad and foreign materials found in India, the products exported from India, the trade winds and navigational devices and the depiction of ships on the coins, paintings, and sculptures of the period are discussed in detail. After briefly highlighting the coastline of India and its favourable nature for safe anchorage of ships and the strategic position of the seaports of western India, an extensive account of the major ancient seaports of western India like Barygaza, Ashtacampra, Gundigar, Kammoni, Khambhat, Bardaxema, Suparaka, Calliena, Semylla, Sanjan, Naura, Tyndis, Muziris, Nelcynda and other seaports, and their maritime trade activities are given based on archaeological excavations and explorations, literature, epigraphy, foreign accounts, and numismatic evidence.