• 생약학회지
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• 제29권2호
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• pp.86-92
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• 1998

Chang-Back-San and Chil-Mi-Chang-Back-San have been used for the treatment of neuralgia and arthritis in traditional medicine. The anti-inflammatory activities of Chang-Back-San and Chil-Mi-Chang-Back-San water extract (CBSE and CCBSE) on the carrageenin induced edema, Corton oil induced granuloma pouch, and adjuvant arthritis in rats were examined. The analgesic effects of the CBSE and CCBSE were also investigated utilizing acetic acid induced writhing syndrome in mice. The oral administration of CBSE and CCBSE showed to have the anti-inflammatory activities in 1% carrageenin induced edema in rats. They also showed significant inhibitory effects on granuloma and exudate formation in rats. In the method of adjuvant arthritis, they orally administered for 19 days, inhibited the hind paw edema in rats from 3rd day to 19th day, especially CCBSE has the efficacy more than CBSE. They significantly decreased the number of writhing syndromes induced by acetic acid in mice. In the present study, CBSE and CCBSE were indicated to have the anti-inflammatory and analgesic activities.

• 대한한방소아과학회지
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• 제9권1호
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• pp.257-278
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• 1995

Experimental studies were done to research the clinical effect of Bojeosodokeum on the Analgesic, Antipyretic, Anti-inflammatory, Antimicrobial and Anti-convulsive effects in mice and rats. The results obtained as follows : 1. The solid extract powders of Bojeosodokeum was revealed significant action on analgesic effect. 2. the solid extract powders of Bojeosodokeum was revealed significant action on Anti-inflammatory effect. 3. The solid extract powders of Bojeosodokeum was revealed significant action on antipyretic effect. 4. Antimicrobial effects of solid extract powders of Bojeosodokeum against Escherichia coli and staphylococcus aureus was observed. 5. The solid extract powders of Bojeosodokeum was revealed significant action on anticonvulsive effect. According to the above results, it is confirmed that analgestic, anti-inflammatory, antipyretic, antimicrobial and anticonvulsive effect were recognized in solid extract powders of Bojeosodokeum.

• 대한한방소아과학회지
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• 제4권1호
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• pp.1-17
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• 1990

?In order to investigate effects of Zanthoxyli Fructus (Sample-A) and Fagarae mandshuricae Fructus (Sample-B), experimental study was performed through observation on isolated - ileum analgesic, hypothermal, anti-pyretic, anti-inflammatory, capillary permeability, blood flow rate, blood pressure and respiratory works. The results were as follows; 1. In spontaneous movement of mice isolated-ileum, both samples were noted to have strong inhibitory action after temporary contraction, and to show antagonism against acetylcholine chloride and barium chloride. 2. Both samples were showed to have antihistamin work on guinea pig isolated-ileum 3. In analgesic work by the acetic acid method, only Fagarae mandshuricae Fructus was proved to have significant analgesic effect in mice. 4. Both sample groups indicated anti-pyretic and anti-inflammatory effect. 5. Both samples were noted to have inhibitory effect against capillary permeability ?rise in mice. ?6. Both samples were noted to have dose-dependent falling effect on blood pressure in rabbits.

• 한방안이비인후피부과학회지
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• 제6권1호
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• pp.1-13
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• 1993

Experimental studies were done to research the clinical effects of Sopoongyangjetang on the Anti-allergic effect, Analgesic action and Anti-inflammatory action. The results obtained as follows ; 1. In effect of Sopoongyangjetang on vascular permeability responses to intradermal serotonin, it had tendency to decrease, but was none significant effect. 2. In effect of Sopoongyangjetang on vascular permeability responses to intradermal histamine, it revealed significant effect. 3. In the homologous PCA provoked by the IgE-like antibody against white egg albumin, Sopoonyangjetang showed significant effect. 4. In the delayed type hypersensitivity responses to picryl chloride, Sopoongyangjetang was proved significant effect. 5. In the delayed type hypersensitivity responses to SRBC, Sopoongyangjetang revealed significant effect. 6. In analgesic action by acetic acid method, Sopoongyangjetang was recognized significantly. 7. In Anti-inflammatory action by carrageenine method, Sopoongyangjetang showed significant effect.

• 대한의생명과학회지
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• 제29권3호
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• pp.152-158
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• 2023

The aim of this study is to investigate the analgesic effects of Syneilesis aconitifolia Maxim. extract (SAM). We evaluated analgesic effects of SAM on animal pain model. Male SD rats were administered intra-orally with SAM according to prescribed dosage. During 7 days. After 7 days later, serum TNF-α, IL-1β, and IL-6 levels were measured by ELISA. In our experiment, administration of SAM decreased IL-1β, IL-6, TNF-α and PGE2 level in serum. Furthermore, it was confirmed that allodynia was relieved in evaluation of pain behavior. It was confirmed that administration of SAM reduces nociceptive pain by reducing nociceptive stimuli by acting as an anti-inflammatory drug.

• 한국임상수의학회지
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• 제22권1호
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• pp.6-15
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• 2005

본 연구는 개에서 장문합술 후 비침습적인 행동관찰을 통해 통증을 평가하기 위하여 수행되었으며, 또한 이를 토대로 butorphanol의 진통효과에 대해 연구하였다. 본 실험에서 대조군은 마취를 실시하였으나 장문합술은 시행되지 않았다. 진통제 투여군의 5마리 개들에게는 장문합술을 실시하였고 butorphanol을 투여하였다. 진통제 비투여군의 5마리 개들에게는 진통제 투여 없이 장문합술을 실시하였다. 진통제 투여군의 개들은 수술 전 그리고 수술직후 butorphanol(0.4mg/kg, IM)이 투여되었고, 반면에 대조군과 진통제를 투여하지 않은 군에서는 동일한 양의 멸균 생리식염수가 투여되었다. 개의 행동은 마취 후 400분 동안 비디오테이프로 기록되었고, 그 시간에 실험자는 매 80분마다 개와 상호작용을 하였다. 각각의 상호작용에서, 실험자는 관찰된 행동을 바탕으로 멜버른 대학의 통증 측정방법을 이용하여 통증 점수를 기록하였다. 한 사람의 관찰자에 의해 정량화 된 상호작용과 비 상호작용의 행동을 측정하기 위하여 한 개체에 집중하는 연속적 표본 추출 방법이 적용되었다. 발성은 마취 후 400분 동안 녹음하였고 소리 길이, 소리 강도, 소리 pitch와 1-4 포먼트를 분석하였다. 외과수술은 통증측정 점수를 증가시켰다. 실험자와의 상호작용 중에서 수술 후 인사하는 행동이 감소되었다. 진통제를 투여한 수술군과 위약을 투여한 군사이의 차이점은 정량화된 행동측정과 발성을 통하여 구별할 수 있었다. Butorphanol을 투여한 수술군과 위약을 투여한 군 사이에는 유의적인 차이를 관찰할 수 있었다 (p< 0.05).

• 한국식품영양과학회지
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• 제23권4호
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• pp.671-674
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• 1994

The anti-inflammatory and analgesic action of the components isolated from some edible plants carried out. We isolated the quercitrin, compound 3 and o-counmaric acid from Cedrela sinensis, Oenanthe javanica and Artemisia princeps var. Orientalis respectively. O-coumaric acid showed the inhibitory effect on carrageenin-induced edema as well as vascular permeability in mice. And we also found the analgesic activity in all compounds isolated from these plants.

• 생약학회지
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• 제38권4호
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• pp.334-338
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• 2007

Roots of Rumex crispus (Rc) (Polygonaceae) has been used as therapeutic agents of acute and chronic cutaneous diseases, cathartics, fever and jaundice in folk medicines. Recently, Seeds of Rc has known as a digestive, an anticancer agent and a remedy of acute hepatitis, among many traditional folk medicines. So far it isn't reported about pharmacological effects of Rumecis Semen. The present study describes the preliminary evaluations of biological activities, anti-inflammatory activity (AA, Carrageenan) analgesic activity (writhing test), and hepatoprotective activities ($CCl_4$), of its methanol extract, ethyl acetate fraction and butanol fraction. Among them butanol fraction showed the highest activity in analgesic acivity.

• 생약학회지
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• 제31권2호
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• pp.216-223
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• 2000

The anti-inflammatory activity of SEO-KYONG-TANG extract(SKTWE) was examined by using carrageenin- and acetic acid-induced edema, croton oil-induced granuloma pouch, and adjuvant arthritis in rats. In addition, the acute toxicity, analgesic and antipyretic effects of SKTWE were investigated by using general experimental methods in mice. SKTWE did not show acute toxicity at 2400 mg/kg(p.o.) nor 1200 mg/kg(i.p.). After oral administration of the SKTWE to rats, significant anti-inflammatory activity was observed on 1% carrageenin- and 5% acetic acid-induced edema. Also, it significantly inhibited granuloma and exudation in these. In the adjuvant arthritis experiment, the SKTWE decreased the hind paw edema after 3 days of oral administration. In addition, it inhibited the writhing syndromes induced by 0.7% acetic acid in mice. The antipyretic activity of SKTWE was also observed through the typhoid vaccine experiment. These results suggest that SKTWE has analgesic, anti-inflammatory and antipyretic action.

• 약학회지
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• 제38권3호
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• pp.345-350
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• 1994

Fourteen melandrin derivatives(I-XIV) were investigated on analgesic, anti-inflammatory and antiviral activities . Compound I [N-(p-hydroxybenzoyl)-5-hydroxyanthranilic acid methvl ester], Xll [N-(2-phenoxypropionyl)-5-hydroxy anthranilic acid propyl ester and XIV [N-(2-phenoxypropionyl)-5-hydroxyanthranilic acid exhibited analgesic activity in tail pressure and Randall-Selitto method. But no anti-inflammatory activity was shown. Compound I exhibited weak antiviral activity on Herpes simplex virus type I F strain by virus-induced cytopathic effect(CPE) assay and it's selectivity index(Sl) was 8.17.