• 제목/요약/키워드: Analgesic action

검색결과 230건 처리시간 0.026초

Studies on the Anti-inflammatory and Analgesic Activities of Ohyaksungisan (오약순기산(烏藥順氣散)의 소염 진통작용에 관한 연구)

  • Lee, Don-Il;Lee, Seong-Yim;Moon, Young-Hee
    • Korean Journal of Pharmacognosy
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    • 제27권3호
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    • pp.184-189
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    • 1996
  • Ohyaksungisan, combined preparation of crude drugs, has been used for hemiplegia, arthralgia and paralysis in traditional Korean medicine. The anti-inflammatory activity of the aqueous extract from Ohyaksungisan(OSSE) was investigated on acetic acid-induced edema and adjuvant arthritis in rats. Acute toxicity and analgesic action in mice were also examined. Its anti-inflammatory activity on 5% acetic acid-induced edema and adjuvant arthritis was observed with oral administration. The acute toxicity showed 10% mortality at 2400 mg/kg (p.o), but was not showed at 1200 mg/kg (i.p). OSSE was showed to have significant analgesic action (P<0.05) at 150 mg/kg and this action was strengthened at 300, 600 mg/kg. The anti-inflammatory effect was showed significant preventive effect on the hind paw edema from 90 min. and the adjuvant arthritis, when orally administered for 19 days. showed significant inhibitory effect on the hind paw edema from the 5th day.

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Analgesic Action Mechanism of DA-5018, a New Capsaicin Derivative : Relationship to Opiate :Receptors and Prostanoids (새로운 캅사이신 유도체 DA-5018의 진통활성 기전연구: Opiate 수용체 및 :Prostanoid와의 상관성)

  • 손미원;손문호;배은주;김순희;김원배;양중의
    • Biomolecules & Therapeutics
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    • 제5권1호
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    • pp.87-93
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    • 1997
  • DA-5018, a new capsaicin derivative, showed potent analgesic effect comparable to that of morphine in various experimental acute pain models. in this study, whether the analgesic mechanism of DA-5018 is related to opiate receptors or prostanoids was investigated. The affinity of DA-5018 for opiate receptor was determined by receptor binding assay. The Ki values of DA-5018 for nonspecific and specific $\mu$, $textsc{k}$, $\delta$-opiate receptor was 299$\pm$8.88, 735$\pm$215, 2930$\pm$ 163, 1550$\pm$813 nM, respectively and DA-5018 exhibited lower affinity than morphine. DA-5018 (10-"~3$\times$10-′M) inhibited electrically-evoked contractions of the guinea ply ileum and rat vas deferens, and these inhibition was not antagonized by naloxone(10 nM), an opiate receptor antagonist. Antagonism of analgesic effect of 7A-5018 by naloxone was examined by tail pinch test. Analgesic action of DA-5018(0.1 ~2 mg/kg, 5.c.) was not antagonized by naloxone(1 mg/rg, i.p.). These results indicate that pharmacological action of DA-5018 is not related with opiate receptor. Cyclooxygenase and 5-lipoxygenase activities in rat peritoneal neutrophil treated with A23187 and arachidonic acid were measured by radioimmunoassay. DA-5018 stimulated the cyclooxygenase activity and the concentration show-ing the two fold increase of activity was 124$\mu$M. DA-5018 slightly inhibited 5-lipoxygenase activity and these results together indicate that analgesic action of 3A-5018 is not mediated through inhibition of cyclooxy genase or lipoxygenase. These results suggest that the analgesic effect of DA-5018 is not due to blocking opiate receptor or to inhibiting the synthesis of prostanoids in the arachidonic acid metabolism pathway.

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Pharmacological Studies on Root Bark Extract of Aralia elata -General Pharmac \logical Action on the Butanol Fraction- (두릅나무 근피 추출물의 약물학적 연구 - 두릅나무 추출물의 Butanol분획의 일반약리작용 -)

  • 정춘식;이은방
    • YAKHAK HOEJI
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    • 제37권6호
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    • pp.631-637
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    • 1993
  • In the previous report, it was described that the butanol fraction of the root bark extract of Aralia elata had potent antigastritic and antiulcerative effects in rats, In this pharmacological profile, the fraction revealed low acute toxicities in mice and rats, no central nervous system activities, moderate analgesic action, weak inhibitory action in carrageenin edema of rats and no direct effects on isolated smooth muscles of rats and guinea-pigs. Slight lowering of blood pressure as given i.v. in rabbit was observed.

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Analgesic Action of p-Methoxycinnamic acid. (p-Methoxycinnamic Acid의 진통작용)

  • 우원식
    • YAKHAK HOEJI
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    • 제9권3_4호
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    • pp.31-33
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    • 1965
  • In the previous papers, it was reported that p-methoxycinnamate showed good antipyretic action when tested on the typhoid-vaccinated rabbits and decreased the ascorbic acid content of the adrenals of rats like other wellknown antipyretics. In the present work, it was shown that p-methoxycinnamic acid exhibited marked analgesic properties. The method employed for testing analgesic effect was modification of that described by Woolfe and Macdonald. Of mice which had been trained and jumped out within 5 seconds on the hot plate of $59{\deg}$, the reaction time was prolonged by subcutaneous injection of its sodium salt aqueous solution. Mean responses were proved to increase linearly with the log doses (from doses 160 mg to 500 mg/kg).

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Anti-inflammatory, Analgesic and Ulcerogenic Activities of Fentiazac (Fentiazac의 항염증. 진통 및 소화기궤양 형성작용에 관한 연구)

  • 김충규;김원배;양중익;민신홍
    • YAKHAK HOEJI
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    • 제25권1호
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    • pp.9-14
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    • 1981
  • Anti-infammatory, analgesic and ulcerogenic activities of fentiazac were investigated in comparison with those of acetylsalicylic acid, fenbufen, naproxen and phenylbutazone. On the anti-inflammatory activity in carrageenin-induced rat paw edema and the analgesic activity on writhing syndrome induced with acetic acid in mice, fentiazac displayed more potent effect than acetylsalicylic acid, fenbufen and pbenylbutazone. But the ulcerogenic action of fentiazac on gastrointestinal tract in fasting rats was less than that of reference drugs. From these investigation, fentiazac seemed to indicate a poor correlation between the extent of anti-inflammatory activity and ulcerogenic action.

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Effect of Bojeosodokeum on the Analgesic, Antipyretic, Anti-inflammatory, Antimicrobial and Anti-convulsive Actions (보제소독음(普濟消毒飮)의 진통(鎭痛), 해열(解熱), 소염(消炎), 항균(抗菌) 및 항경련(抗痙攣)에 대한 실험적(實驗的) 연구(硏究))

  • Hong Hyun-Jung;Lee Han-Cheul
    • The Journal of Pediatrics of Korean Medicine
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    • 제9권1호
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    • pp.257-278
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    • 1995
  • Experimental studies were done to research the clinical effect of Bojeosodokeum on the Analgesic, Antipyretic, Anti-inflammatory, Antimicrobial and Anti-convulsive effects in mice and rats. The results obtained as follows : 1. The solid extract powders of Bojeosodokeum was revealed significant action on analgesic effect. 2. the solid extract powders of Bojeosodokeum was revealed significant action on Anti-inflammatory effect. 3. The solid extract powders of Bojeosodokeum was revealed significant action on antipyretic effect. 4. Antimicrobial effects of solid extract powders of Bojeosodokeum against Escherichia coli and staphylococcus aureus was observed. 5. The solid extract powders of Bojeosodokeum was revealed significant action on anticonvulsive effect. According to the above results, it is confirmed that analgestic, anti-inflammatory, antipyretic, antimicrobial and anticonvulsive effect were recognized in solid extract powders of Bojeosodokeum.

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An Experimental Studies on the Anti-allergic Reaction, the Antipyretic Action, the Anti-inflammatory and the Analgesic Action of Yenhwagamchotang and Gamiyenhwagamchotang (銀花甘草湯과 加味方이 抗 알레르기, 解熱, 消炎, 鎭痛效果에 미치는 影響)

  • Choe, Gyu-Dong;Kim, Jung-Ho;Chae, Byeong-Yun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • 제6권1호
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    • pp.15-29
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    • 1993
  • Yenhwagamchotang has been widely used in treatment of inflammatory disease which is based on Oriental Medical literatures. These studies were attempted experimental effects of Yenhwagamchotang(sample A), Yenhwagamchotang plus Forsythia koreana NAKAI.(sample B), and Yenhwa-gamchotang plus Taraxacum mongolicum HAND- MAZZ(sample C),on the Anti-allergic reaction, the antipyretic action,the anti-inflammatory and the analgesic action,in rats. THe results of the studies were as follow: 1. Vascular permeability responses to intradermal serotonin in rats were showed significant effect at all sample groups. 2. The homologous passive cutaneous anaphylaxis in rats provoked by the IgE-like antibody aganist egg white albumin showed the decreasing effect. 3. The delayed type hypersensitivity responses to picryl chloride in mice were showed significant effect at all sample groups. 4. The delayed type hypersensitivity response to sheep red blood cell in mice were showed significant effect at all sample groups. 5. In anti-pyretic effect by yeast method were showed significant effect at all sample groups. 6. The anti-inflammatory effect by carrageenin method were showed significant effect at all sample groups. 7. The analgesic action by acetic acid method in mice were showed significant effect at all sample groups. According to the above result, Yenhwagamchotang(sample A), Yenhwagamchotang plus Forsythia koreana NAKAI(sample B), AND yenhwagamchotang plus Taraxacum mongolicum HNAN- MAZZ.(sample C ) were concluded to have the anti-allergic reaction, the antipyretic action, the anti-inflammatory, the analgesic action.

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Effects of Glucosamine Hydrochloride, Taurine and Their Combined Administration on Anti-inflammatory and Analgesic Action in Rats (흰쥐의 항염증 및 진통작용에 대한 Glucosamine Hydrochloride와 Taurine 및 그 혼합 투여시의 효과)

  • 김옥경
    • Journal of the Korean Society of Food Science and Nutrition
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    • 제28권5호
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    • pp.1113-1123
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    • 1999
  • The purpose of this study was to see the effect of anti inflammatory and analgesic action of the glucosamine hydrochloride(GA HCl) or taurine. Male Sprague Dawley rats(100~250g) and ICR mice(20 ~30g) were used. Experimental groups were divided into seven groups, one control group given as saline and six groups given as oral administration of GA HCl or taurine; GA HCl 250mg/kg, b.w group, taurine 250mg/kg, b.w group, GA HCl 250mg/kg, b.w+taurine 250mg/kg, b.w group, GA HCl 500mg/kg, b.w group, taurine 500mg/kg, b.w group, GA HCl 500mg/kg, b.w+taurine 500mg/kg, b.w group. Carrageenan induced edema test were shown to be significantly inhibited in the GA HCl 250mg/kg group and taurine 250mg/kg group compared to the control group, but the GA HCl 500mg/kg+taurine 500mg/kg group were significantly inhibited than the control group. Capillary permeability test were shown to be sig nificantly inhibited in the taurine 500mg/kg group, but the GA HCl 500mg/kg+taurine 500mg/kg group were significantly inhibited than the control group. Leucocyte emigration test were shown to be significantly inhibited in the GA HCl 250mg/kg+ taurine 250mg/kg group and GA HCl 500mg/kg+taurine 500mg/kg group compared to the control group. Acetic acid, Phenyl p benzoquinone writhing syndrome were shown to be significantly inhibited in the GA HCl 500mg/kg+taurine 500mg/kg group compared to the control group. Inhibitory action against COX 1 and COX 2 were not significantly inhibited in the experimental group. These results suggest that the combined administration of the GA HCl and taurine have potential action in anti inflammatory and analgesic action.

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Anti-Inflammatory and Analgesic Effects of the Components from Some Edible Plants (식용식물에서 분리한 화합물의 항염증 및 진통효과)

  • Park, Jong Cheol;Yu, Yeong Beop;Lee, Jong Ho;Kim, Nam Jae
    • Journal of the Korean Society of Food Science and Nutrition
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    • 제23권4호
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    • pp.671-674
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    • 1994
  • The anti-inflammatory and analgesic action of the components isolated from some edible plants carried out. We isolated the quercitrin, compound 3 and o-counmaric acid from Cedrela sinensis, Oenanthe javanica and Artemisia princeps var. Orientalis respectively. O-coumaric acid showed the inhibitory effect on carrageenin-induced edema as well as vascular permeability in mice. And we also found the analgesic activity in all compounds isolated from these plants.

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Pharmacological Studies on the Sopunghwalhul-Tang -On Analgesic, Antiinflammation and Hypotension- (소풍활혈탕(疎風活血湯)의 약효에 관한 연구(硏究) -진통(鎭痛), 항염증(抗炎症) 및 혈압(血壓)에 미치는 효과에 대하여-)

  • Moon, Young-Hee;Kim, Gyung-Wan;Um, Kie-Jin
    • Korean Journal of Pharmacognosy
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    • 제22권4호
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    • pp.240-245
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    • 1991
  • This study was attempted to examine the acute toxicity and the effect of Sopunghwalhul-Tang water extract(SHTE) on analgesic action in mice, anti- inflammatory action in rats and blood pressure in rabbits. The results were as follows; SHTE showed 10% mortality at 2,000mg/kg(p.o.), had significant analgesic activity in the pain caused by 0.7% acetic acid and was shown to have significant anti-inflammatory activity in the edema-induced by 5% acetic acid at 450mg/kg. SHTE given into a ear vein of rabbits produced a dose-related vasodepressur responses. SHTE-induced hypotension was significantly inhibited by pretreatment with atropine, but was not affected by chlorisondamine, phentolamine, propranolol, and dephenhydramine.

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