• Title/Summary/Keyword: AnCE

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Protein structure analysis : Pharmacophore study for new insecticide target AnCE using the substrate of ACE, HHL molecule (단백질의 구조연구 : ACE의 기질 HHL을 이용한 신규 살충제 표적 AnCE에 대한 약리단 연구)

  • Lee, Jung-Kyung;Kim, Kyeong-Yee
    • The Korean Journal of Pesticide Science
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    • v.9 no.3
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    • pp.191-198
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    • 2005
  • Hippuryl-L-histidyl-L-leucine (Hip-L-His-L-Leu, HHL) is the known substrate of ACE, which used often in inhibition kinetic study to design new inhibitor. Here we use HHL molecule as a template to predict pharmacophore which can interact with residues in active site of AnCE, new potential insecticide target protein. To explain physicochemical properties related to molecular geometry and conformational change in reaction field as well as electron density of atoms associated to pharmacophores, geometry optimization, NMR chemical shifts and natural population analysis were performed by ab initio and DFT method. Calculated NMR chemical shifts showed good agreement with the experimental ones and obtained electron densities were used for analyzing pharmacophores of corresponding atoms. Finally, we could extract aye pharmacophores related to hydrophobic aliphatic and aromatic site, hydrogen bonding donor and acceptor site and Zn binding site from the HHL molecule.

Standardized Total Tract Digestibility of Phosphorus in Copra Expellers, Palm Kernel Expellers, and Cassava Root Fed to Growing Pigs

  • So, A.R.;Shin, S.Y.;Kim, B.G.
    • Asian-Australasian Journal of Animal Sciences
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    • v.26 no.11
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    • pp.1609-1613
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    • 2013
  • An experiment was conducted to determine the apparent total tract digestibility (ATTD) and standardized total tract digestibility (STTD) of phosphorus (P) in copra expellers (CE), palm kernel expellers (PKE), and cassava root (CR). Eight barrows (initial BW of 40.0 kg, SD = 4.5) were individually housed in metabolism crates. A replicated $4{\times}3$ incomplete Latin square design was employed involving 4 dietary treatments, 3 periods, and 8 animals. Three experimental diets contained 40% CE, PKE or CR as the only source of P. A P-free diet mainly based on corn starch, sucrose, and gelatin was also prepared to estimate the basal endogenous loss of P. The marker-to-marker method was used for fecal collection. Values for the ATTD of P in the CE and PKE were greater than in the CR (46.0 and 39.7 vs -14.0%; p<0.05). However, the STTD of P did not differ greatly among the test ingredients (56.5, 49.0, and 43.2% in the CE, PKE, and CR, respectively). In conclusion, the ATTD of P values in CE and PKE were greater than that in CR, but the STTD of P did not differ greatly among CE, PKE, and CR.

Removal of S $O_{2}$ and NO by Dry Sorbent(II) - Efficiency of Cu-Ce and Cu-7Al - (건식법에 의한 이산화황과 산화질소의 제거(II) - Cu-Ce 및 Cu-7Al의 효율 -)

  • 신창섭
    • Journal of Korean Society for Atmospheric Environment
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    • v.9 no.4
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    • pp.288-294
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    • 1993
  • Flue gas control systems for small-scale combustors must be designed to provide highly effective removal of three criteria pollutants (S $O_{2}$, N $O_{x}$ and particulate matter), and must be safe, reliable and small. These requirements make dry, regenerative clean-up process particularly attractive and this paper describes a new concept for integrated pollutant control : a filter comprised of layered, gas permeable membranes that act as an S $O_{2}$ sorbant, a N $O_{x}$ reduction catalyst and a particulate filter. A mixed metal oxide sorbent, Cu-Ce was used as a sorbent/catalyst and the activity was compared with Cu-7Al. The S $O_{2}$ removal eficiency of Cu-Ce was increased with temperature increase up to 500$^{\circ}$C and the catalytic activity for NO was higher than that of Cu-7Al. By the sulfation of Cu-Ce, the reduction activity was increased at the temperature higher than 350$^{\circ}$C. The regeneration of Cu-Ce was very fast and some amount of elemental sulfar was found.

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Chiral Purity Test of Bevantolol by Capillaryelectrophoresis and High Performance Liquid Chromatography

  • Long, Pham Hai;Trung, Tran Quoc;Oh, Joung-Won;Kim, Kyeong-Ho
    • Archives of Pharmacal Research
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    • v.29 no.9
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    • pp.808-813
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    • 2006
  • Two methods for the chiral purity determination of bevantolol were developed, namely capillary electrophoresis (CE) using carboxymethyl-${\beta}$-cyclodextrin (CM-${\beta}$-CD) as a chiral selector and high-perfomance liquid chromatography (HPLC) using a chiral stationary phase. In the HPLC method, the separation of bevantolol enantiomers was performed on a Chiralpak AD-H column by isocratic elution with n-hexane-ethanol-diethylamine (10:90:0.1, v/v/v) as mobile phase. In the CE method, bevantolol enantiomers were separated on an uncoated fused silica capillary with 50 mM amonium phosphate dibasic adjusted to a pH 6.5 with phosphoric acid containing 15 mM CM-${\beta}$-CD as running buffer. Validation data such as linearity, recovery, detection limit, and precision of the two methods are presented. The detection limits of S-(-)-bevantolol were 0.1% and 0.05% for CE and HPLC method, respectively and R-(+)-bevantolol were 0.15% and 0.05% for CE and HPLC method, respectively. There was generally good agreement between the HPLC and CE results.

Template-free Synthesis and Characterization of Spherical Y3Al5O12:Ce3+ (YAG:Ce) Nanoparticles

  • Kim, Taekeun;Lee, Jin-Kyu
    • Bulletin of the Korean Chemical Society
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    • v.35 no.10
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    • pp.2917-2921
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    • 2014
  • Cerium-activated yttrium aluminate ($Y_3Al_5O_{12}:Ce^{3+}$) exhibiting a garnet structure has been widely utilized in the production of light emitting diodes (LEDs) as a yellow emitting phosphor. The commercialized yttrium aluminum garnet (YAG) phosphor is typically synthesized by a solid-state reaction, which produces irregular shape particles with a size of several tens of micrometers by using the top-down method. To control the shape and size of particles, which had been the primary disadvantage of top-down synthetic methods, we synthesized YAG:Ce nanoparticles with a diameter of 500 nm using a coprecipitation method under the atmospheric pressure without the use of template or special equipment. The precursor particles were formed by refluxing an aqueous solution of the nitrate salts of Y, Al, and Ce, urea, and polyvinylpyrrolidone (55 K) at $100^{\circ}C$ for 12 h. YAG:Ce nanoparticles were formed by the calcination of precursor particles at $1100^{\circ}C$ for 10 h under atmospheric conditions. The phase identification, microstructure, and photoluminescent properties of the products were evaluated by X-ray powder diffraction, scanning electron microscopy, absorption spectrum and photoluminescence analyses.

The Effects of Carnitine and/or Gamma-Aminobutyric Acid (GABA) Supplementation on the Recovery of Chronic Ethanol Administered Rats

  • Soh, Ju-Ryoun;Tokuo T. Yamamoto;Cha, Youn-Soo
    • Preventive Nutrition and Food Science
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    • v.8 no.2
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    • pp.119-123
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    • 2003
  • To investigate the effects of the supplementation of carnitine and/or ${\gamma}$ -aminobutric acid (GABA), Sprague-Dawley male rats were orally treated with either an AIN-76 diet (control), a control diet plus ethanol (CE, 4 g ethanol/kg bw), CE plus L-carnitine (CEC, 0.5 g/kg bw), CE plus GABA (CEG, 0.5 g/kg bw), or CE plus L-carnitine plus GABA (CECG, 0.25 g/kg bw each) for 6 weeks. Serum triglyceride levels were increased in the CE group and were decreased significantly in the CEC, CEG and CECG groups. HDL-cholesterol was increased and LDL-cholesterol was decreased in the CEG and CECG groups compared with the CE group. Serum GOT and GPT levels increased by the chronic ethanol administration were decreased in the CEC group. In addition, we have evaluated the mRNA levels of carnitine palmitoyltransferase-I in those groups. Supplementation of carnitine/GABA had some recovery effects on the liver CPT-I mRNA levels which decreased by chronic ethanol administration. These results may suggest that supplementations of either L-carnitine or GABA aye effective on the recovery of chronic ethanol-related symptoms, but no combined effects were shown.

Effect of La3+ and Ce3+ Ions on Photoluminescence Behavior of YBO3: Tb Phosphors (YBO3: Tb 형광체의 광특성에 대한 La3+ 및 Ce3+ 이온의 영향)

  • On, Ji-Won;Lee, Jeong-Baek;Kim, You-hyuk
    • Korean Journal of Materials Research
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    • v.13 no.8
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    • pp.509-513
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    • 2003
  • In the present investigation, $La^{3+}$ and $Ce^{V}$ ions were substituted for $Y^{3+}$ in the $YBO_3$: Tb in various concentrations. It has been found that these phosphors form solid solutions within limited concentration ranges Excitation and emission spectra under 254 nm and 147 nm were investigated for these phosphors to evaluate influences of $La^{3+}$ and $Ce^{3+}$ ions on brightness and CIE color coordinates. It has been observed that brightness of $(Y, La)BO_3$: Tb under 254 nm and 147 nm when $La^{3+}$ ions are added show an increase of 2.7 times and 1.25 times, respectively. On the other hand, emission intensities of peaks in $Y_{0.8-x}$ $BO_3$: $Tb_{0.2}$ , $Ce_{x}$ show continuos decrease as $Ce^{3+}$ / content is increased from 0 to 0.4. CIE color coordinates of prepared phosphors show yellowish green which is needed to be improved to be used for display applications.

CE-OLSR: a Cartography and Stability Enhanced OLSR for Dynamic MANETs with Obstacles

  • Belghith, Abdelfettah;Belhassen, Mohamed
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.6 no.1
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    • pp.270-286
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    • 2012
  • In this paper, we propose a novel routing protocol called the Cartography Enhanced OLSR (CE-OLSR) for multi hop mobile ad hoc networks (multi hop MANETs). CE-OLSR is based on an efficient cartography gathering scheme and a stability routing approach. The cartography gathering scheme is non intrusive and uses the exact OLSR reduced signaling traffic, but in a more elegant and efficient way to improve responsiveness to the network dynamics. This cartography is a much richer and accurate view than the mere network topology gathered and used by OLSR. The stability routing approach uses a reduced view of the collected cartography that only includes links not exceeding a certain distance threshold and do not cross obstacles. In urban environments, IEEE 802.11 radio signals undergo severe radio shadowing and fading effects and may be completely obstructed by obstacles such as buildings. Extensive simulations are conducted to study the performances of CE-OLSR and compare them with those of OLSR. We show that CE-OLSR greatly outperforms OLSR in delivering a high percentage of route validity, a much higher throughput and a much lower average delay. In particular the extremely low average delay exacerbated by CE-OLSR makes it a viable candidate for the transport of real time data traffic in multi hop MANETs.

Differences in Perception and Needs for Continuing Education according to the Career of Physiotherapists

  • Kim, Kijong;Kim, Jinyoung
    • Journal of The Korean Society of Integrative Medicine
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    • v.7 no.4
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    • pp.81-88
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    • 2019
  • Purpose : The purpose of this paper is to review the continuing education (CE) for physiotherapists and especially to draw attention to the perception and need of the education so that the present study aimed to provide information for improving the education program. Methods : The study obtained information from CE of the Korea Physical Therapy Association held in Gwangju on April 12 and July 19, 2015 to understand the perception and needs of CE. Present study showed that 431 out of 563 people who answered to the survey, with a 76.5 % response rate. Among them, 350 people were selected for the final analysis, except for questionnaires whose responses were insufficient. Among them, the level of perception of CE was 238, excluding 112 people who did not receive an education in 2014. Results : The perception of CE according to experience showed a weak positive correlation in questions 1 (r=.244), 5 (r=.244) and 10 (r=1.129) (p<.05). There was no significant correlation in questions 2, 3, 4, 6, 7, 8, and 11 (p>.05). The needs of CE according to experience showed weak negative correlations in musculoskeletal system (r=-.141), nervous system (r=-.136), geriatric (r=-.117), oriental physical therapy (r=-.130), and other new technologies (r=-.232) (p<.05). Basic education, pediatric, cardiopulmonary system, sports, physical agents, and women's fields were not significantly correlated (p>.05). Conclusion : There was little or no significant correlation between perception and needs for the CE based on physical therapists' experiences. Current research suggests that for a CE for physical therapists, the perception of education should first be renovated, and then the quality of education should also be improved based on the need of them.

The Formation Behavior of Non-metallic Inclusion in the Ce-added Hyper Duplex STS (Hyper Duplex STS 중 Ce 첨가 시 비금속개재물 생성거동)

  • Hong, S.H.;Jang, P.Y.;Park, Y.M.;Byun, S.M.;Kim, K.T.;You, B.D.
    • Transactions of Materials Processing
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    • v.19 no.5
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    • pp.311-319
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    • 2010
  • Rare earth metal Ce has a relatively low melting point and high specific gravity. Because of its significantly high affinity to oxygen, nitrogen and sulfur, it is highly usable as a steel refining agent. However, because Ce compound has relatively high specific gravity, it is difficult to be separated from molten steel through floatation, and it degrades the purity of molten steel, or may clog the nozzle in continuous casting. Such problem may be solved by using an appropriate deoxidation agent together with Ce and settling molten steel sufficiently after refining. Thus a fundamental study in the formation behavior of non-metallic inclusion in Ce added Hyper Duplex STS melts was investigated. The addition amount of Ce, melt temperature were considered as experimental variables. A main non-metallic inclusion in mother alloy is 51(wt%MnO) - 27.6(wt%SiO$_2$)- 10.9(wt%$Cr_2O_3$). Non-metallic inclusion was dramatically decreased and the particle size was fined as the amount of Ce increased. Moreover (%MnO) and (%SiO$_2$) of non-metallic inclusion were decreased. But (%$Al_2O_3$)were relatively increased. The number of non-metallic inclusion were decreased and the large particle size were increased by increasing the temperature of molten steel.