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Antimutagenicity and Cytotoxic Effects of Methanol Extract from Deep Sea Water Salt and Sea Tangle Added Soybean Paste (Doenjang) (해양심층수염 및 다시마분말을 첨가한 개량식 된장의 항돌연변이원성 및 암세포성장억제에 미치는 영향)

  • Ham, Seung-Shi;Kim, Soo-Hyun;Yoo, Su-Jong;Oh, Hyun-Taek;Choi, Hyun-Jin;Chung, Mi-Ja
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.37 no.4
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    • pp.416-421
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    • 2008
  • This study was performed to determine the antimutagenic and anticytotoxic effects of soybean paste (doenjang) added deep sea water salt and see tangle in Salmonella Typhimurium TA98, TA100 and human cancer cell lines. In the Ames test, methanol extract of doenjang did not exhibit any mutagenicity but showed substantial inhibitory effects against mutation induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 4-nitroquinoline-1-oxide (4NQO). The methanol extracts of doenjang ($200{\mu}g$/plate) added deep sea salt and see tangle (doenjang C) showed approximately 89.1% and 70% inhibitory effect on the mutagenesis induced by MNNG and 4NQO against TA100 strain, whereas 84.4% inhibitions were observed on the mutagenesis induced by 4NQO against TA98 strain. The cytotoxic effects of doenjang methanol extracts against the cell lines with human cervical adenocarcinoma (HeLa), human hepatocellular carcinoma (Hep3B), human gastric carcinoma (AGS), human lung carcinoma (A549) and human breast adenocarcinoma (MCF-7) were inhibited with the increase of the extract concentration. The treatment of 1.0 mg/mL doenjang C of methanol extracts showed strong cytotoxicities of 71%, 74.4%, 66.2%, 77.3%, and 71.2% against HeLa, Hep3B, AGS, A549, and MCF-7, respectively. In contrast 1 mg/mL treatment of doenjang C methanol extracts had only $10{\sim}40%$ cytotoxicity on normal human embryonal kidney cell (293). Doenjang methanol extract inhibited significantly the tumor growth in mice injected sarcoma-180 cells. Especially, doenjang C methanol extract showed an inhibition of tumor cell activity of 33% by the administration of 25 mg/kg methanol extracts.

Development and Validation of Korean Composit Burn Index(KCBI) (한국형 산불피해강도지수(KCBI)의 개발 및 검증)

  • Lee, Hyunjoo;Lee, Joo-Mee;Won, Myoung-Soo;Lee, Sang-Woo
    • Journal of Korean Society of Forest Science
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    • v.101 no.1
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    • pp.163-174
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    • 2012
  • CBI(Composite Burn Index) developed by USDA Forest Service is a index to measure burn severity based on remote sensing. In Korea, the CBI has been used to investigate the burn severity of fire sites for the last few years. However, it has been an argument on that CBI is not adequate to capture unique characteristics of Korean forests, and there has been a demand to develop KCBI(Korean Composite Burn Index). In this regard, this study aimed to develop KCBI by adjusting the CBI and to validate its applicability by using remote sensing technique. Uljin and Youngduk, two large fire sites burned in 2011, were selected as study areas, and forty-four sampling plots were assigned in each study area for field survey. Burn severity(BS) of the study areas were estimated by analyzing NDVI from SPOT images taken one month later of the fires. Applicability of KCBI was validated with correlation analysis between KCBI index values and NDVI values and their confusion matrix. The result showed that KCBI index values and NDVI values were closely correlated in both Uljin (r = -0.54 and p<0.01) and Youngduk (r = -0.61 and p<0.01). Thus this result supported that proposed KCBI is adequate index to measure burn severity of fire sites in Korea. There was a number of limitations, such as the low correlation coefficients between BS and KCBI and skewed distribution of KCBI sampling plots toward High and Extreme classes. Despite of these limitations, the proposed KCBI showed high potentials for estimating burn severity of fire sites in Korea, and could be improved by considering the limitations in further studies.

A Study on Operation Strategy by Multi-variate Regression of Deagu Arboretum Visitor's Satisfaction (대구수목원 이용객 만족모델을 통한 운영 방안 연구)

  • Kang, Kee-Rae
    • Journal of Korean Society of Forest Science
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    • v.101 no.1
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    • pp.36-45
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    • 2012
  • Education on the environment and plants offered by arboretum for today's people not only contribute to foster a better natural environment in urban region but also provide visitors with decent refreshment environment and beyond. In the study, the author undertook the observation on usage behavior and satisfaction model of arboretum visitors expect and investigated the facilities and programs to be offered by arboretum in order to propose the opinion regarding the service. For observation size of variables in a multiple regression analysis of variables is influencing satisfaction rankings walks the line of flow, the educational effect on the environment, cleanliness of the facility, visits pay, natural beauty, diversity of trees, accessibility and friendliness of staff, expansion of facilities in the arboretum and appeared as a complement. In case of visitor attribute, the residents living near the facility showed the highest visit frequency of more than 5 times, especially as part of taking a walk. This proves that the visit to arboretum is considered as part of everyday life, and thus a new program and walk path as well as movement route are needed to be developed for the visitors. In the question relating to the facilities and operation programs in Daegu Arboretum, particularly the requests by visitors, they responded that the establishment of cultural event, beautiful natural scenery, refreshment and convenience facilities is the most critical issue. In addition, the management on withered trees and bare lands is an urgent issue as well. In this sense, the Operation and Management Strategies based upon the visitor behaviors and model of satisfaction are needed to deal with the adoption of diverse events and festivals joined by local residents, ombudsman program, environmental program development for students and teachers within the region, negligent bare lands and withered tree replacement, and cafeteria facility improvement and supplement as well as the bench marking of other facilities than arboretums located in other regions. These items are thought to be sufficiently dealt with by Daegu Arboretum having no more external resources. It is recognized that the visitor satisfaction begins from a minor thing, and a small difference determines a great satisfaction, and thus the software approach rather than hardware one is in need.

Effectiveness Analysis for Traffic and Pedestrian Volumes of Pedestrian Pushbutton Signal (차량 및 보행자 교통량에 따른 보행자 작동신호기의 효과 분석)

  • Cho, Han-Seon;Park, Ji-Hyung;Noh, Jung-Hyun
    • International Journal of Highway Engineering
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    • v.9 no.4
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    • pp.33-43
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    • 2007
  • Because usually signal controllers on the crosswalks of mid-block provide pedestrian signals every cycle based on the fixed signal plan, pedestrian signals are provided even when there is no pedestrian demand. Consequently, signal is operated inefficiently and this may cause drivels to experience useless delay or violate the signal. Even though recently pushbuttons have been installed to improve the efficiency of pedestrian signal control in the crosswalks of mid-block and the pedestrian safety. they are not spread out national-wide in Korea because of the cost of the pushbutton equipments and the lack of an acknowledgement of the efficiency of the pushbutton. In this study, the effectiveness of the pushbutton on saving the vehicle delay was verified through before and after study in 4 study sites using a traffic micro-simulation model, VISSIM. To evaluate the viability of the pushbutton, a benefit/cost analysis was also performed for 4 study sites. It was found that B/C ratio of all of 4 study sites was greater than 1. The sensitivity analysis for the traffic volume and pedestrian volume were performed to identify the impact of the both volume on the operation of pushbutton. And, a benefit/cost analysis was performed for all scenarios. It was found that when the pedestrian volume is greater than 90ped/h, the pedestrian signal was operated same as the fixed signal plan. That is, there is no benefit of pushbutton at all once the pedestrian volume is greater than 90ped/h. When the pedestrian volume is equal to or less than 90ped/h and the traffic volume is greater than 2,500veh/h, B/C ratio is greater than 1. Also it was found that as traffic volume increases and pedestrian volume decreases, the benefit increases. In this study, the criteria for installation of pushbutton on the crosswalks of mid-block are developed through the sensitivity analysis and benefit/cost analysis. The results of this study may be used as a criteria for expansion of pushbutton system.

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Ultrasonography findings on thyroid nodule with no clinical symptom (임상적 증상이 없는 갑상선 결절에 대한 초음파영상 소견)

  • Kim, Wha-Sun
    • Journal of radiological science and technology
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    • v.28 no.3
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    • pp.211-217
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    • 2005
  • This study obtained the following conclusions by analyzing whether or not thyroid nodule, the number of nodules depending on age and gender, and the developed site of nodule, targeting 838 persons in their 30s-70s who were conducted the thyroid ultrasonography, without clinical symptoms, at the Health Promotion Center. 1. As for the general characteristics of 838 research subjects, men were 368 persons(44%), and women were 470 persons (56%), and the mean age was 51. 2. Among 838 whole subjects, a case, which was diagnosed to be normal, was 590 persons(70%), and persons with nodules findings were 248 persons (30%), thus it was indicated 30% on an average in having the thyroid nodules findings. 3. As for the frequency by age level in thyroid nodule, it was represented men with 10%-14% and women with $20{\sim}29%$ in their $30{\sim}40s$, and men with $27{\sim}33%$ and women with 37-52% in their 50-60s, and men with 46% and women with 50% in their 70s. 4. As a result of obtaining 248 persons, who have thyroid nodules findings, with the solitary nodule and the multiple nodule, it was indicated the solitary nodule of 50.5% with 125 persons and the multiple nodule of 49.5%, thereby representing the almost same ratio. 5. As for the size of thyroid nodule, the majority in all the age levels had the nodule in small size, and the size of $1{\sim}10\;mm$ was largest with 187 persons (75%) among 248 persons with abnormal findings, and it was 45 persons (18%) in $11{\sim}20\;mm$, 14 persons (5.6%) in $21{\sim}30\;mm$, and 2 persons in more than 31 mm. 6. As for the anatomically developed site in nodule, it was indicated the right lobe with 93 persons (38%), the left lobe with 67 persons (27%), both lobes with 75 persons (30%), and isthmus with 13 persons (5.3%), thereby representing the largest frequency in the right lobe, and it was discovered less in isthmus.

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Analyze for the Quality Control of General X-ray Systems in Capital region (수도권지역 일반촬영 장비의 정도관리 분석)

  • Kang, Byung-Sam;Lee, Kang-Min;Shim, Woo-Yong;Park, Soon-Chul;Choi, Hak-Dong;Cho, Yong-Kwon
    • Journal of radiological science and technology
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    • v.35 no.2
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    • pp.93-102
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    • 2012
  • Thanks to the rapid increase of the interest in the quality control of the General X-ray systems, this research proposes the direction of the quality control through comparing and inspecting the actual condition of the respective quality control in the Clinic, the educational institution and the hospital. The subjects of the investigation are diagnostic radiation equipment's in the clinic, the educational institution and the hospital around the capital. A test of kVp, mR/mAs out put test and reproducibility of the exposure dose, half value layer, an accordance between the light field and the beam alignment test, and lastly reproducibility of the exposure time. Then the mean difference of the percentage, the CV (Coefficient of Variation, CV) and the attenuated curve which are respectively resulted from the above tests are computed. After that we have evaluated the values according to the regulations on the Diagnostic Radiation Equipment Safety Administration regulations. In the case of the clinic and the educational institution, there were 22 general X-ray devices. And 18.2% of the kVp test, 13.6% of the reproducibility of exposure dose test, 9.1% of the mR/mAs out put test, and 13.6% of the HVL (Half Value Layer) test appeared to be improper. In the case of the hospital, however, there were 28 devices. And 7.1% of the reproducibility of exposure dose, 7.1% of the difference in the light field/ beam alignment, and 7.1% of the reproducibility of the exposure time appeared to be improper. According to the investigation, the hospital's quality control condition is better than the condition in the clinic and the educational institution. The quality control condition of the general X-ray devices in the clinic is unsatisfactory compared to the hospital. Thus, it is considered that realizing the importance of the quality control is necessary.

The Development of Education Model for CA-RP(Cognitive Apprenticeship-Based Research Paper) to Improve the Research Capabilities for Majors Students of Radiological Technology (방사선 전공학생의 연구역량 증진을 위한 인지적 도제기반 논문작성 교육 모형 개발)

  • Park, Hoon-Hee;Chung, Hyun-Suk;Lee, Yun-Hee;Kim, Hyun-Soo;Kang, Byung-Sam;Son, Jin-Hyun;Min, Jung-Hwan;Lyu, Kwang-Yeul
    • Journal of radiological science and technology
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    • v.36 no.2
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    • pp.99-110
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    • 2013
  • In the medical field, the necessity of education growth for the professional Radiation Technologists has been emphasized to become experts on radiation and the radiation field is important of the society. Also, in hospitals and companies, important on thesis is getting higher in order to active and cope with rapidly changing internal and external environment and a more in-depth expert training, the necessity of new teaching and learning model that can cope with changes in a more proactive has become. Thesis writing classes brought limits to the in-depth learning as to start a semester and rely on only specific programs besides, inevitable on passive participation. In addition, it does not have a variety opportunity to present, an actual opportunity that can be written and discussed does not provide much caused by instructor-led classes. As well as, it has had a direct impact on the quality of the thesis, furthermore, having the opportunity to participate in various conferences showed the limitations. In order to solve these problems, in this study, writing thesis has organized training operations as a consistent gradual deepening of learning, at the same time, the operational idea was proposed based on the connectivity integrated operating and effective training program & instructional tool for improving the ability to perform the written actual thesis. The development of teaching and learning model consisted of 4 system modeling, scaffolding, articulation, exploration. Depending on the nature of the course, consisting team following the personal interest and the topic allow for connection subject, based on this, promote research capacity through a step-by-step evaluation and feedback and, fundamentally strengthen problem-solving skills through the journal studies, help not only solving the real-time problem by taking wiki-space but also efficient use of time, increase the quality of the thesis by activating cooperation through mentoring, as a result, it was to promote a positive partnership with the academic. Support system in three stages planning subject, progress & writing, writing thesis & presentation and based on cognitive apprenticeship. The ongoing Coaching and Reflection of professor and expert was applied in order to maintain these activities smoothly. The results of this study will introduce actively, voluntarily and substantially join to learners, by doing so, culture the enhancement of creativity, originality and the ability to co-work and by enhance the expertise of based-knowledge, it is considered to be help to improve the comprehensive ability.

Comparison of Noise Power Spectrum Methodologies in Measurements by Using Various Electronic Portal Imaging Devices in Radiation Therapy (방사선치료시 전자포털영상장치를 이용한 잡음전력스펙트럼 방법론 측정비교)

  • Son, Soon-Yong;Choi, Kwan-Woo;Jeong, Hoi-Woun;Kwon, Kyung-Tae;Kim, Ki-Won;Lee, Young-Ah;Son, Jin-Hyun;Min, Jung-Whan
    • Journal of radiological science and technology
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    • v.39 no.1
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    • pp.99-105
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    • 2016
  • The noise power spectrum (NPS) is one of the most general methods for measuring the noise amplitude and the quality of an image acquired from a uniform radiation field. The purpose of this study was to compare different NPS methodologies by using megavoltage X-ray energies. The NPS evaluation methods in diagnostic radiation were applied to therapy using the International Electro-technical Commission standard (IEC 62220-1). Various radiation therapy (RT) devices such as TrueBeam$^{TM}$(Varian), BEAMVIEW$^{PLUS}$(Siemens), iViewGT(Elekta) and Clinac$^R$ iX (Varian) were used. In order to measure the region of interest (ROI) of the NPS, we used the following four factors: the overlapping impact, the non-overlapping impact, the flatness and penumbra. As for NPS results, iViewGT(Elekta) had the higher amplitude of noise, compared to BEAMVIEW$^{PLUS}$ (Siemens), TrueBeam$^{TM}$(Varian) flattening filter, Clinac$^{R}$iXaS1000(Varian) and TrueBeam$^{TM}$(Varian) flattening filter free. The present study revealed that various factors could be employed to produce megavoltage imaging (MVI) of the NPS and as a baseline standard for NPS methodologies control in MVI.

The Degree of Requirements for Retirement Preparation and the Effect of Retirement Preparation on Quality of Life: The Moderated Mediating Effect of the Degree of Participation in Retirement Education (은퇴준비필요도와 은퇴준비가 삶의 질에 미치는 영향 : 은퇴교육참여도의 조절된 매개효과)

  • Park, Hae-Ri;Min, Hyun-Jung
    • Journal of radiological science and technology
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    • v.40 no.4
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    • pp.647-655
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    • 2017
  • This study was conducted to review the mediating effects of retirement preparation in how the degree of requirements for retirement education and the degree of preparation for retirement education affects quality of life, and how the degree of participation in retirement education which is a moderating variable is moderated. The study findings show that first, in terms of the difference in quality of life across different general characteristics, those who live in a city rather than a Gun, those who had received education of graduate school or higher rather than those with an education of undergraduate university programs or lower, those who were public officers or employees of corporations rather than those who were self-employed had a higher quality of life. The group satisfied with their economic status and health status were found to be more satisfied with their quality of life. Second, a correlation analysis showed that there was a positive correlation between retirement preparation, quality of life, and degree of requirements for retirement preparation. Moreover, there was also a positive correlation between quality of life, retirement education and the degree of requirements for retirement education. There was a positive correlation between retirement education and the degree of requirements for retirement preparation. Third, participation in retirement education moderated the indirect effect that the degree of preparation for retirement education affected quality of life through the degree of retirement preparation. In other words, the degree of requirements for retirement education affects retirement preparation and affects quality of life through the indirect effects of retirement education. As such, the moderated mediating effects of retirement education on retirement preparation was found to be greater. This indicates that quality of life may also vary in accordance with the requirements for retirement education.

Application of Machine Learning Algorithm and Remote-sensed Data to Estimate Forest Gross Primary Production at Multi-sites Level (산림 총일차생산량 예측의 공간적 확장을 위한 인공위성 자료와 기계학습 알고리즘의 활용)

  • Lee, Bora;Kim, Eunsook;Lim, Jong-Hwan;Kang, Minseok;Kim, Joon
    • Korean Journal of Remote Sensing
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    • v.35 no.6_2
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    • pp.1117-1132
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    • 2019
  • Forest covers 30% of the Earth's land area and plays an important role in global carbon flux through its ability to store much greater amounts of carbon than other terrestrial ecosystems. The Gross Primary Production (GPP) represents the productivity of forest ecosystems according to climate change and its effect on the phenology, health, and carbon cycle. In this study, we estimated the daily GPP for a forest ecosystem using remote-sensed data from Moderate Resolution Imaging Spectroradiometer (MODIS) and machine learning algorithms Support Vector Machine (SVM). MODIS products were employed to train the SVM model from 75% to 80% data of the total study period and validated using eddy covariance measurement (EC) data at the six flux tower sites. We also compare the GPP derived from EC and MODIS (MYD17). The MODIS products made use of two data sets: one for Processed MODIS that included calculated by combined products (e.g., Vapor Pressure Deficit), another one for Unprocessed MODIS that used MODIS products without any combined calculation. Statistical analyses, including Pearson correlation coefficient (R), mean squared error (MSE), and root mean square error (RMSE) were used to evaluate the outcomes of the model. In general, the SVM model trained by the Unprocessed MODIS (R = 0.77 - 0.94, p < 0.001) derived from the multi-sites outperformed those trained at a single-site (R = 0.75 - 0.95, p < 0.001). These results show better performance trained by the data including various events and suggest the possibility of using remote-sensed data without complex processes to estimate GPP such as non-stationary ecological processes.