• 대한기계학회논문집A
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• 제41권7호
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• pp.621-627
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• 2017

다양한 신경성 퇴행 질병을 유발하는 아밀로이드 섬유의 기계적 특징에 대한 이해는 아밀로이드 성장 메커니즘에 직접 관련되어 있기 때문에 질병 역학적 관점에서 많은 연구 진행 되어 왔다. 최근 아밀로이드 섬유의 높은 물성 값과 자가 결합능력을 통해 새로운 재료로 이용 하려는 시도가 진행되고 있다. 본 연구에서는 심혈관 질환을 유발하는 transthyretin($TTR_{105-115}$)의 핵심 영역의 기계적 특성을 분자 동역학 전산 역학을 통해 평가했다. 특히 end-terminal capping의 효과가 $TTR_{105-115}$의 구조적 안정성에 미치는 영향을 평가했다. 인장모사 분자 동역학을 통해(steered molecular dynamics, SMD) 기계적 거동과 물성을 측정하였다. 재료의 기계적 특성에 영향을 주는 인자를 밝히고 자연 모사 재료로써의 활용 가능성에 대한 제시를 하였다.

• 대한의생명과학회지
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• 제24권4호
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• pp.418-425
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• 2018

Amyloid brain positron emission tomography (PET) images are visually and subjectively analyzed by the physician with a lot of time and effort to determine the ${\beta}$-Amyloid ($A{\beta}$) deposition. We designed a convolutional neural network (CNN) model that predicts the $A{\beta}$-positive and $A{\beta}$-negative status. We performed 18F-florbetaben (FBB) brain PET on controls and patients (n=176) with mild cognitive impairment and Alzheimer's Disease (AD). We classified brain PET images visually as per the on the brain amyloid plaque load score. We designed the visual geometry group (VGG16) model for the visual assessment of slice-based samples. To evaluate only the gray matter and not the white matter, gray matter masking (GMM) was applied to the slice-based standard samples. All the performance metrics were higher with GMM than without GMM (accuracy 92.39 vs. 89.60, sensitivity 87.93 vs. 85.76, and specificity 98.94 vs. 95.32). For the patient-based standard, all the performance metrics were almost the same (accuracy 89.78 vs. 89.21), lower (sensitivity 93.97 vs. 99.14), and higher (specificity 81.67 vs. 70.00). The area under curve with the VGG16 model that observed the gray matter region only was slightly higher than the model that observed the whole brain for both slice-based and patient-based decision processes. Amyloid brain PET images can be appropriately analyzed using the CNN model for predicting the $A{\beta}$-positive and $A{\beta}$-negative status.

• The Journal of Korean Physical Therapy
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• 제33권3호
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• pp.136-141
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• 2021

Purpose: Dementia is a disease in which cognitive function declines, leading to deterioration of body functions and activities of daily living. The purpose of this study is to explore the effects of dual-task training, including cognitive tasks, on cognitive and body function and β-amyloid levels in Alzheimer's dementia patients. Methods: 34 inpatients diagnosed with Alzheimer's dementia at a nursing hospital located in South Korea. The patients were randomly divided into a dual-task group (n=16) and a single-task group (n=18). Each group was trained for 30 minutes three times a week for eight weeks. The MMSE-K was used to measure the patients' cognitive function. To assess the patients' static balance ability, their LOS was measured using BioRescue. while dynamic balance was measured using the BBS. The 10MWT were conducted to evaluate the patients' walking ability. Blood analysis was performed to measure levels of β-amyloid. Results: Both groups exhibited statistically significant improvements in gait function after the training (p<0.05). The dual-task group exhibited statistically significant differences in cognitive function, static and dynamic balance function, and β-amyloid levels after training (p<0.05). A significant difference was observed between the two groups (p<0.05). Conclusion: Dual-task training were found to be effective in improving cognitive and bodily functioning and reducing β-amyloid levels in Alzheimer's dementia patients. Thus, this may be suggested as an effective exercise method for the treatment and early prevention of Alzheimer's dementia.

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.191-191
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• 2002

• Bulletin of the Korean Chemical Society
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• 제35권11호
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• pp.3369-3372
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• 2014

• Bulletin of the Korean Chemical Society
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• 제30권6호
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• pp.1237-1238
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• 2009

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2002년도 Current Trends in Toxicological Sciences
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• pp.94-94
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• 2002

• Bulletin of the Korean Chemical Society
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• 제29권12호
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• pp.2331-2336
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• 2008

• 한국응용과학기술학회지
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• 제37권3호
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• pp.409-417
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• 2020

본 연구는 서로 다른 운동유형이 당뇨처치 그룹의 베타 아밀로이드, BDNF 및 인지기능에 미치는 영향을 알아보기 위하여 24마리의 C57BL/6 쥐를 당뇨처치를 하지 않은 그룹 6마리(통제그룹: 6)와 당뇨처치 그룹 18마리로 무작위 할당하여, 이를 다시 당뇨처치 그룹의 경우 통제그룹 6마리, 유산소 운동그룹 6마리, 저항운동 그룹 6마리로 나누었고 운동그룹은 8주간 주 5회 저강도로 각각 트레드밀 운동과 사다리 운동을 실시하였다. 그 결과 베타아밀로이드는 8주 후 당뇨처치 그룹의 통제그룹(DM.G.)이 나머지 세 그룹에 비하여 높은 수준을 나타내었으나 통계적으로 유의한 차이는 나타나지 않았다. BDNF의 경우는 당뇨통제그룹이 나머지 세 그룹에 비하여 낮은 수준을 나타냈으며 통계적으로 유의한 차이를 나타냈다(p<.05). 인지기능을 알아보기 위한 Y-미로 검사에서도 당뇨통제 그룹이 나머지 세그룹에 비하여 낮은 수준을 보였으며 통계적으로도 유의한 차이를 나타냈다(p<.05).

• BMB Reports
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• 제42권9호
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• pp.541-551
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• 2009

Amyloidogenesis defines a condition in which a soluble and innocuous protein turns to insoluble protein aggregates known as amyloid fibrils. This protein suprastructure derived via chemically specific molecular self-assembly process has been commonly observed in various neurodegenerative disorders such as Alzheimer's, Parkinson's, and Prion diseases. Although the major culprit for the cellular degeneration in the diseases remains unsettled, amyloidogenesis is considered to be etiologically involved. Recent recognition of fibrillar polymorphism observed mostly from in vitro amyloidogeneses may indicate that multiple mechanisms for the amyloid fibril formation would be operated. Nucleation-dependent fibrillation is the prevalent model for assessing the self-assembly process. Following thermodynamically unfavorable seed formation, monomeric polypeptides bind to the seeds by exerting structural adjustments to the template, which leads to accelerated amyloid fibril formation. In this review, we propose another in vitro model of amyloidogenesis named double-concerted fibrillation. Here, two consecutive assembly processes of monomers and subsequent oligomeric species are responsible for the amyloid fibril formation of $\alpha$-synuclein, a pathological component of Parkinson's disease, following structural rearrangement within the oligomers which then act as a growing unit for the fibrillation.