• 공업화학
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• 제1권2호
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• pp.197-206
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• 1990

이미다졸린 핵에 유연성을 부여하기 위하여 소수성기로서 behenic acid를 선택하고 3종류의 polyalkylene polyamine 과 반응시켜 1, 2-이치환 이미다졸린 화합물인 1-behenoyl-aminoethyl-2-heneicosylimidazoline(BHI), 1-behenoylbis(aminoethyl)-2-heneicosylimidazoline(BBI) 및 1-behenoyltris(aminoethyl)-2-heneicosylimidazoline(BTI)을 합성하였다. 동 화합물들을 4급화 시켜 1, 2-이치환 이미다졸린 염화물인 1-behenoylaminoethyl-1-glycidyl-2-heneicosylimidazolinium chloride(BHIC), 1-behenoylbis(aminoethyl)-1-glycidyl-2-heneicosylimidazolinium chloride(BBIC) 및 1-behenoyltris(aminoethyl)-1-glycidyl-2-heneicosylimidazolinium chloride(BTIC)를 합성하였다. BHI, BBI 및 BTI 합성의 최적조건은 $210^{\circ}C$에서 8시간이었으며 BHIC, BBIC 및 BTIC 합성에서 BHIC는 BHI-epichlorohydrin의 mole ratio가 1:1.3, BBIC와 BTIC는 mole ratio가 1:1.5 이상일 때 완전 4급화가 이루어졌다. BHIC, BBIC 및 BTIC에서 유연제 BHICS, BBICS 및 BTICS를 제조한 후 아크릴 섬유에 유연처리를 하여 유연성을 측정한 결과 양호한 유연제임이 밝혀졌다.

• Archives of Pharmacal Research
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• 제18권6호
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• pp.449-453
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• 1995

The search for patinum (II)-based compounds with improved therapeutic properties was prompted to design and synthesize a new family of water-soluble, third generation cis-diamminedichlorplatinum (II) complexes linked to uracil and uridine. Six heretofore undescribed uracil and uridine-platinum (II) complexes are ; [N-(2-aminoethyl)uracil-5-carboxamide]dichloroplatinum (II)(3a), [N-2(2-aminoethyl)uracil-6-carboxmide]dichloroplatinum (II) (3b),[5-(2-aminorthyl)carbamoyl-2',3',5',-tri-O-acetyluridine] dichloroplatinum (II) (6b), [5-(2-aminoethyl)-carbamoyl]-2',3',5',-tri-O-acetyluridine] dichloroplatinum (II) (6b), [5-(2-aminoethyl)carbamoylu-ridine]dihloroplatinum (II) (7a), [6-(2-aminoethyl)carbamoyluridine]dichloroplatinum (II) (7b). These analogues were prepared from the key starting materials, 5-carboxyuracil (1a) and 6-carboxyuracil (1b) which were reacted with ethylenediamine to afford the respective N-(2-aminoethyl)uracil-5-carboxmide (2a) land N-(2-aminoethyl)uracil-6-carboxamide (2b). The cisplatin complexes 3a and 3b were obtained through the reaction of the respective 2a and 2b ficiently introduced on the .betha.-D-ribose ring via a Vorbruggen-type nucleoside coupling procedure with hexamethyldisilazane, trimethylchlorosilane and stannicchloride under anhydrous acetonitfile to yield the sterospecific .betha.-anomeric 5-carboxy-2',3',5'-tri-O-acetyluridine (4a) and 6-carboxy-2',3',5'-tri-O-acetyluridine (4b), respective 5-(2-aminoethyl)carbamoyl-2',3',5'-tri-O-acetyluridine (5a) and 6-(2-aminoethyl)carbamoyl-2',3',5'-tri-O-acetyluridine (5b). The diamino-uridines 5a and 5b were reacted with potassium tetrachloroplatinate (II) to give the novel nucleoside complexes, 6a and 6b respectively which were deacetylated into the free nucleosides, 7a and 7b by the treatment with CH/sub 3/ONa. The antitumor activities were evaluated against three cell lines (K-562, FM-3A and P-388).

• Journal of Pharmaceutical Investigation
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• 제22권3호spc1호
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• pp.49-63
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• 1992

Two different types of chemical manipulations of dobutamine were investigated in order to develop novel, improved cardiotonic drugs. Three new analogues of carbostyril, in which the m-hydroxy group of dobutamine was isosterically modified with an amide type carbostyril system, were synthesized from, ${\rho}-methoxyphenethylamine$ via multi-steps. Two analogues of (2'-aminoethyl)-1-hydroxy-2-pyridone system which has isosteric structural similarity with dopamine without having the COMT vulnerable m-hydroxy group were synthesized via 12 synthetic steps. Their biological stabilities in various media and inotropic activities were evaluated.

• 한국환경과학회지
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• 제17권12호
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• pp.1373-1380
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• 2008

Anthracene appended new host compounds have been synthesized by imine reaction. Fluorescent open chain host compounds Trisanthryl-tris(2-aminoethyl)imine 1 was synthesized from the reaction of tris(2-aminoethyl)amine and anthracene-9-carboxaldehyde in EtOH. Tris-10-chloroanthryl-tris(2-aminoethyl)imine 2 was synthesized from tris(2-aminoethyl)amine and 10-chloro-9-anthraldehyde in EtOH. The structures of all reaction product were identified by $^1H$ NMR, $^{13}C$ NMR, GC/MS, FAB Mass, IR spectrum and DSC. Cation complexation behavior was investigated by fluorescence spectroscopy measurements. The capability of transition metals cation recognition between fluorescent open chain host compound 1, 2 were investigated with $Co^{2+},\;Ni^{2+}\;and\;Cu^{2+}$. The fluorescence intensity was increased by host compounds corresponding guest cations. The relative order of fluorescence intensity changes were $Co^{2+}>Cu^{2+}>Ni^{2+}$. Compound 2 is very sensitive fluorescent sensor of $Co^{2+}$ ion.

• 한국식품과학회지
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• 제11권4호
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• pp.283-290
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• 1979

Kluyveonyces fragilis로부터 정제한 ${\beta}-fructosidase$ (inulase)를 Tygon 관과 aminoethyl-cellulose에 고정화 시킨후 효소의 일반적 성질을 알아 보았다, Tygon곤에 효소를 고정화 시키는데 있어서는 크로로포름 용액에서 65^{\circ}C의 조건으로 실란화(silanization) 시킨 다음 10 % 글루타르알데히드로 처리하는 것이 매우 중요한 처리 조건인 반면 2 % 글루타르알데히드 처리가 aminoethyl-cellulose에 inulase를 고정화 시키는데 매우 효과적이 었다. Tygon관에 고정화 시킨 inulase는 g matrix당 11.5 units의 inulase 역가로 보여 주었고 효소 역가의 회수율은 22.5 %인 반면 aminoethyl-cellulose에 고정화 시킨 제품은 g matrix 당 39.3 units, 53.4 % 효소 역가 회수율을 보여 주었다. 두 고정화 제품을 사용하여 invertase(기질이 sucrose) inulase (기질이 inulin) 역가에 대한 효소 안정성, pH 효과, 온도 효과 및 기질 효과를 살펴 보았다.

• 약학회지
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• 제37권1호
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• pp.36-40
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• 1993

The 4-(2'-(N-(l-methyl-3'-carbamylphenyl)-n-propyl))aminoethyl)-l- hydroxy-2-pyridone which has isoelectronic and isosteric structural similarity with dobutamine without having the Catechol-O- Methyltransferase(COMT) vulnerable m-hydroxy group was synthesized via 12 synthetic steps.

• Bulletin of the Korean Chemical Society
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• 제32권9호
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• pp.3377-3381
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• 2011

In this work, the amine grafting treated activated carbons were studied for carbon dioxide adsorbent. The surfaces of activated carbon were functionalized by 3-chloropropyltrimethoxysilane, which was subsequently grafted with amine compounds tris-(2-aminoethyl)amine and tri-ethylenetetramine and subjected to comparison. The surface functional groups of the amine grafted activated carbons were characterized using XPS. The textural properties of the amine grafted activated carbons were analyzed by $N_2$/77 K isotherms. Carbon dioxide adsorption behaviors of the amine grafted activated carbons were examined via the amounts of carbon dioxide adsorption at 298 K and 1.0 atm. From the results, tris-(2-aminoethyl)amine grafted activated carbons showed 43.8 $cm^3$/g of carbon dioxide adsorption while non-treated activated carbons and triethylenetetramine grafted activated carbons showed less carbon dioxide adsorption. These results were thought to be due to the presence of isolated amine groups in the amine compounds. Tris-(2-aminoethyl)amine grafted activated carbons have basic features that result in the enhancement of adsorption capacity of the carbon dioxide molecules, which have an acidic feature.

• Bulletin of the Korean Chemical Society
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• 제15권9호
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• pp.795-799
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• 1994

Kinetic studies of the deacylation reactions of p-and m-nitrophenyl esters of (R or S)-${\alpha}$ -methoxyphenylacetic acid were performed in ${\beta}$ -CD, mono-6-deoxy-6-[N-(2-aminoethyl)]amino-${\beta}$-CD (${\beta}$-CDen) and mono-6-deoxy-6-[N-(2-aminoethyl)-2-aminoethyl] amino-${\beta}$-CD (${\beta}$-CDdien) media. The binding constants (K) of the substrates to the hosts and the rate constants ($k_{\varphi}^{CD}$) for the complexed substrates were determined. $k_{\varphi}^{CD}$ values are highly dependent on the hosts and the substrates, whereas differences in K values among them are modest. The p-nitrophenyl esters show larger acceleration by -${\beta}$-CDen and -${\beta}$-CDdien than the corresponding m-isomers, while the m-isomers are more reactive than the p-isomers in -${\beta}$-CD media. This is taken as an indication that the amino groups attached to the primary side of -${\beta}$-CD participate in the deacylation reaction.

• Archives of Pharmacal Research
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• 제13권3호
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• pp.240-245
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• 1990

Asymmetric 2, 6-dimethyl-4-aryl-1, 4-dihydropyridine-3, 5-dicarboxylate with [N-(3, 4-methylenedioxybenzyl)-N-methyl] aminoethyl group as the ester moiety and related 1, 4-dihydropyridine derivatives were prepared and tested for the effects on vascular smooth muscles. 2-6-dimethyl-4-(3'-nitrophenyl)1-4-dihydropyridine-3, 5-dicarboxylic acid 3-[N-(3', 4-methylenedioxybenzyl-N-methyl] aminoethyl ester 5-methyl ester (11) and 2, 6-dimethyl-4-(3'-nitrophenyl)-1, 4-dihydropyridine-3, 5-icarboxylic acid 3-[N-2', 3'-methylenedioxybenzyl)-N-methyl] aminoethyl ester 5-ethyl ester (150 showed potent vasodilating activities $IC_{50}$($10_{-8}M$) was 2, 6 and 2.7 for 11 and 15, compared with 3.5 for nicardipine.

• 약학회지
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• 제39권5호
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• pp.506-510
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• 1995

The 5-(2'-(N-(1-methyl-3'-carbamylphenyl)-n-propyl))aminoethyl)-8- hydroxy-4-methyl-carbostyril derivatives which have isoelectronic and isosteric structural similarity with dobutamine without having the Catechol-O-Methyltransferase (COMT) vulnerable m-hydroxy group were synthesized via 7 synthetic steps, and their stabilities in phosphate buffer solution(pH=7.4), human blood. 80% human plasma and 20% rat liver homogenate were determined in vitro condition.