Journal of Pharmaceutical Investigation
- Volume 22 Issue 3
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- Pages.49-63
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- 1992
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Application of Bioisosterism in Development of Novel Cardiotonics Based on (2'-Aminoethyl)carbostyril and (2'-Aminoethyl)-1-hydroxy-2-pyridone Systems
Abstract
Two different types of chemical manipulations of dobutamine were investigated in order to develop novel, improved cardiotonic drugs. Three new analogues of carbostyril, in which the m-hydroxy group of dobutamine was isosterically modified with an amide type carbostyril system, were synthesized from,
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