• Imaging Science in Dentistry
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• 제43권2호
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• pp.85-90
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• 2013

Purpose: This study was performed to determine the buccal alveolar bone thickness following rapid maxillary expansion (RME) using cone-beam computed tomography (CBCT). Materials and Methods: Twenty-four individuals (15 females, 9 males; 13.9 years) that underwent RME therapy were included. Each patient had CBCT images available before (T1), after (T2), and 2 to 3 years after (T3) maxillary expansion therapy. Coronal multiplanar reconstruction images were used to measure the linear transverse dimensions, inclinations of teeth, and thickness of the buccal alveolar bone. One-way ANOVA analysis was used to compare the changes between the three times of imaging. Pairwise comparisons were made with the Bonferroni method. The level of significance was established at p<0.05. Results: The mean changes between the points in time yielded significant differences for both molar and premolar transverse measurements between T1 and T2 (p<0.05) and between T1 and T3 (p<0.05). When evaluating the effect of maxillary expansion on the amount of buccal alveolar bone, a decrease between T1 and T2 and an increase between T2 and T3 were found in the buccal bone thickness of both the maxillary first premolars and maxillary first molars. However, these changes were not significant. Similar changes were observed for the angular measurements. Conclusion: RME resulted in non-significant reduction of buccal bone between T1 and T2. These changes were reversible in the long-term with no evident deleterious effects on the alveolar buccal bone.

• 대한치과의사협회지
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• 제50권3호
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• pp.126-139
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• 2012

Loss of dentition can lead to not only compromised esthetics and functions of the patient, but also alveolar bone resorption. Bone grafting with prosthetic reconstruction of the gingiva can be selected for the treatment, and it provides many benefits as prosthetic gingival reconstruction does not require a complicated surgical process and is available within a short period of time, with stable clinical results. However, conventional porcelain fused to metal prosthesis has certain limits due to its size, and deformation after several firing procedures. In this clinical report, the author would like to introduce a patient with severe alveolar resorption who was treated with gingiva-shaped zirconia/titanium CAD/CAM implant fixed prosthesis for esthetic and functional rehabilitation. Clinical reports Clinical report 1, 2 : A case of loss of anterior dentition with atrophied alveolar bone. Implant retained zirconia bridge applied with Procera implant bridge system to simulate the gingiva. Upper structure was fabricated with zirconia all ceramic crown. Clinical report 3, 4 : A case of atrophied maxillary alveolus was reconstructed with fixed implant prosthesis, a CAD/CAM designed titanium structure covered wi th resin on its surface. Anterior dentition was reconstructed with zirconia crown. Conclusion and clinical uses. All patients were satisfied with the outcome, and maintained good oral hygiene. Zirconia/titanium implant fixed prosthesis fabricated by CAD/CAM system was highly accurate and showed adequate histological response. No critical failure was seen on the implant fixture and abutment overall. Sites of severe alveolar bone loss can be rehabilitated by implant fixed prosthesis with CAD/CAM system. This type of prosthesis can offer artificial gingival structure and can give more satisfying esthetics and functions, and as a result the patients were able to accept the outcome more fondly, which makes us less than hard to think that it can be a more convenient treatment for the practitioners.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제33권4호
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• pp.314-318
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• 2011

Purpose: The purpose of this study is to evaluate the results of alveolar bone grafting in patients with various types of cleft lip and to compare the success rates according to the lateral incisors and canines. Methods: The postoperative radiographs of 20 patient with a cleft lip and alveolar process alone (CLAP), complete unilateral cleft lip and palate (UCLP) and complete bilateral cleft lip and palate (BCLP) were retrospectively analyzed. The alveolar bone height was classified according to ${\AA}$byholm (1981) and Bergland (1986) and we evaluated the dentition at the time of surgery and the existence of a lateral incisor and impacted canines. Results: 16 (80%) of the 20 patients were assigned to Type I & II and they were considered successful. In the UCLP group, the success rate was significantly better than that of the UCLP and BCLP groups. The success rate was significantly better than when the cleft was grafted with the existence of a lateral incisor and before the eruption of the canines. Conclusion: The severity of the deformity influenced the success rate. The timing of the operation was a critical variable that affected the outcome in patients with cleft lip and palate.

• 대한치과마취과학회지
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• 제10권2호
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• pp.172-177
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• 2010

Background: Damages of trigeminal nerve, particularly inferior alveolar nerve and lingual nerve, could occur following dental procedures. In some cases, nerve damage may happen as a complication of the local anesthetic injection itself and not of the surgical procedure. Methods: From September 2006 to August 2010, 5 cases of inferior alveolar nerve and lingual nerve damages, which were assumed to happen solely due to local anesthesia, were reviewed. All cases were referred to Division of Oral and Maxillofacial Surgery, Department of Dentistry, Hanyang University Medical Center for legal authentication in the process of criminal procedure. Results: In all five cases, patients complained of altered sensation occurred in the distribution of the inferior alveolar or lingual nerve following block anesthesia. The local anesthetics were 2% lidocaine with 1 : 100,000 epinephrine and the amount of local anesthetics, which were used during injection, were varied. Most of patients experienced the electric stimulation during injection. Recovery was poor and professional supportive care was mostly absent. Conclusions: Dental practitioners should consider that the surgical procedure caused the trigeminal nerve damage, however, dental local anesthesia for inferior alveolar nerve and lingual nerve could be one of the causes for damages. The various mechanisms for nerve damages by local anesthesia are thoroughly discussed.

• 한방안이비인후피부과학회지
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• 제18권3호
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• pp.1-17
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• 2005

In many recent studies, molecular biological methods have been used to investigate the role of cytokines in pathogenesis of lung disease. This Experiment was conducted to investigate the effects of Sochungyong-tang on gene expressions in Mouse Alveolar Macrophage. Fer this purpose, we observed the cytokines ($IL-1{\beta}$, IL-6, IL-10, iNOS, $MIP-1{\alpha},\;MIP-1{\beta},\;MIP-1{\gamma},\;TGF-{\beta},\;TNF-{\alpha}$). We picked the alveolar macrophage out of mice and cultured it. We analyzed the cytokine gene expression by reverse transcription-PCR. The results obtained were as follows : 1 . Sochungyong-tang showed inhibitory effects on $IL-1{\beta}$ in time and concentration. 2. Sochungyong-tang showed inhibitory effects on IL-6 in time and concentration. 3. Sochungyong-tang showed inhibitory effects on IL-10 in concentration. 4. Sochungyong-tang showed inhibitory effects on iNOS. 5. Sochungyong-tang showed inhibitory effects on $TGF-{\beta}$ in time and concentration. 6. Sochungyong-tang showed on inhibitory effects on $MIP-1{\alpha},\;MIP-1{\beta},\;MIP-1{\gamma}$, $TCF-{\beta}$, $TNF-{\alpha}$. According to above results, it is supposed that Sochungyong-tang has the inhibitory effects on cytokine gene expression in mouse alveolar macrophage and can be usefully applied for curing inflammatory process of lung disease. Advanced studies are required to investigate the cure mechanism of Sochungyong-tang in the future.

• 대한치과교정학회지
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• 제30권4호
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• pp.413-421
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• 2000

임신중 전신의 호르몬 변화는 골대사과정에 영향을 주고 임신 중에는 골교체가 증가하며, 교정력에 의한 치아이동에는 치조골 교체가 수반된다고 알려져 있다. 이 연구는 임신으로 인한 전신의 호르몬 변화가 치아이동 중 치조골 교체에 주는 영향을 알아보기 위하여 시행되었다. 생후 10주령의 암컷 백서 60마리를 대상으로 정상군과 정상-치아이동군, 임신-치아이동군의 3군으로 나누고 치아이동일수에 따라 1,3,7,14일군으로 세분한 후 상악 제1대구치 에 40g의 교정력을 가하여 근심측으로 치아이동을 시행하였다. 치아이동 전후에 촬영한 X-ray사진을 계측하여 치아이동 거리를 비교하고 치조골에서의 alkaline phosphatase, tartrate-resistant acid phosphatase 농도를 측정하여 치아이동에 따른 골형성과 흡수 활성을 비교하여 다음과 같은 결과를 얻었다. 1. 치아이동량은 임신-치아이동군이 정상-치아이동군에 비하여 더 크게 나타났다(p<0.01). 2. 정상-치아이동군의 치아이동에 따른 골형성은 대조군과 차이가 없었지만 골흡수 경향은 증가되었고(p<0.01), 정상-치아이동군에서는 대조군에 비하여 치조골의 형성과 흡수 활성이 모두 치아이동 7일에 가장 크게 증가하였고 (p<0.01) 이후 골형성 활성은 감소하였지만(p<0.05) 골흡수 활성은 대조군보다 높게 유지되었다(p<0.01). 3. 임신군과 정상군의 치아이동에 따른 골형성과 흡수 경향에는 차이가 없었지만, 임신-치아이동군의 치조골 형성 (p<0.01)과 흡수(p<0.05) 활성의 증가는 3일경에 가장 높게 나타났으며, 이후 골형성 활성은 감소하였으나 골흡수 활성은 높게 유지되었고, 정상-치아이동군은 7일경에 치조골 형성과 흡수 활성의 증가가 나타났다. 임신중의 치아이동량이 정상 치아이동에 비하여 크게 나타났으며, 치조골 흡수와 형성 활성의 증가가 빠르게 나타났고 치조골 흡수가 더 오랬동안 지속되어 빠른 치조골 교체를 보이므로 임신상태에서 치 아이동은 정상상태보다 촉진될 가능성이 있음을 시사한다.

• 구강회복응용과학지
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• 제34권3호
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• pp.167-174
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• 2018

목적: 발치와에 치조제 보존술을 시행한 부위에 식립한 임플란트의 일정 기간의 생존율을 초기고정 값과 방사선학적 계측을 통해 분석해보고자 하였다. 연구 재료 및 방법: 19명의 환자에 sandblasted, large-grit, acid-etched (SLA) 표면을 갖는 단일 제품의 21개의 임플란트를 조사하였다. 임플란트는 치조제 보존술(Alveolar ridge preservation technique: ARP) 시행 후 2 - 3개월의 치유 기간 후 식립 되었으며, 식립 시 및 보철 시행 전 Periotest value (PTV)와 식립 시 및 최종 점검시의 방사선 사진을 통한 Marginal bone level (MBL)의 변화를 측정하였다. 결과: 전체 임플란트의 생존율은 100%로 나타났고 식립 시의 PTV는 평균 $-0.06{\pm}8.33$이었으며 보철 시행 전 PTV는 평균 $-5.75{\pm}1.72$이었다. 근 원심 평균 MBL의 변화는 -0.55 mm에서 1.6 mm의 범위로 평균 $0.19{\pm}0.58mm$를 나타내었다. 결론: 발치와 보존술을 시행한 부위에 식립한 임플란트는 높은 생존율을 나타내며 안정적인 변연골 유지를 보이는 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제48권4호
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• pp.478-486
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• 2000

연구배경 : 급성폐손상에서 폐포대식세포는 초기에 일어나는 염증반응 뿐 아니라, 후기의 복구 및 섬유화 과정에 관여하는 중요한 세포로 형태, 기능면에서 특성이 다른 여러 세포군으로 구성되어져 있는 것으로 알려져 있다. 95% 이상의 고농도산소로 폐손상을 일으킨 쥐를 12시간군, 24시간군, 48시간군으로 나누어서 고농도 산소 투여시기에 따른 폐포대식세포의 숫적인 변화 및 아형군의 분포변화를 관찰하고, 이들 아형군세포의 형태학적인 차이를 통해서 고농도 산소에 의한 폐손상시에 관련되는 특정 아형세포군이 있는지를 알아보고 이러한 분포의 차이와 조직병리적인 변화를 비교 관찰하였다. 방 법 : Sprague-Dawley계 흰쥐를 대상으로 고농도 산소 투여 후 12시간, 24시간, 48시간 경과시의 폐포대식세포를 추출하여 아형세포군의 분포 및 형태 변화와 조직의 변화를 비교 관찰하였다. 결 과 : 1) 총 폐포대식세포는 정상군 $171.6{\pm}24.1({\times}10^5)$, 12시간군 $194.8{\pm}17.9$, 24시간군 $207.6{\pm}27.1$, 48시간군 $200.0{\pm}77.8$개로 초기 장시간까지는 증가하나 이후에는 유의한 차이를 보이지 않았다. 2) 광학현미경 관찰로 측정한 폐포간질의 두께는 정상군 $0.7{\pm}0.2{\mu}m$, 12시간군 $1.5{\pm}0.4{\mu}m$, 24시간군 $2.3{\pm}0.4{\mu}m$, 48시간군 $2.5{\pm}0.4{\mu}m$로 24시간까지는 시간에 따라서 증가하나 24시간 이후로 유의한 차이는 없었다. 3) 폐포대식세포 분포의 시간 경과에 따른 변화는 fraction 1과 fraction 2는 의미 있게 증가되었으며 fraction 3는 의미 있게 감소하였다. fraction 4는 감소되어지는 양상을 보이나 통계적인 의의는 없었다. 4) 고밀도군에서 주로 관찰되는 세포는 세포 및 핵의 모양이 불규칙적이며 크기가 작고 한쪽으로 치우쳐 있으며, pseudopod, electron dense inclusion의 수가 현저히 많이 관찰됐다. 반면 저밀도군에서 주로 관찰되는 세포는 크기가 크고 세포 및 핵이 둥근형태를 보였다. heterogenous, empty inclusion이 보다 많이 관찰되었고 전반적인 inclusion의 수도 증가했다. 결 론 : 이상의 결과로 고농도산소에 의한 폐손상에서 특정한 폐포대식세포아형군이 폐손상에 중요한 역할을 할 것으로 보여지며 추후 이들 세포군이 증가한 이유 및 기전과 이들 세포군의 기능 및 표현형등에 관한 연구가 계속되어야 할 것이다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제44권3호
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• pp.93-102
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• 2018

Angiogenesis is one of the essential processes that occur during wound healing. It is responsible for providing immunity as well as the regenerative cells, nutrition, and oxygen needed for the healing of the alveolar socket following tooth extraction. The inappropriate removal of formed blood clots causes the undesirable phenomenon of alveolar osteitis (AO) or dry socket. In this review, we aimed to investigate whether enhanced angiogenesis contributes to a more effective prevention of AO. The potential pro- or anti-angiogenic activity of different materials used for the treatment of AO were evaluated. An electronic search was performed in the PubMed, MEDLINE, and EMBASE databases via OVID from January 2000 to September 2016 using the keywords mentioned in the PubMed and MeSH (Medical Subject Headings) terms regarding the role of angiogenesis in the prevention of AO. Our initial search identified 408 articles using the keywords indicated above, with 38 of them meeting the inclusion criteria set for this review. Due to the undeniable role of angiogenesis in the socket healing process, it is beneficial if strategies for preventing AO are directed toward more proangiogenic materials and modalities.

• 대한방사선치료학회지
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• 제7권1호
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• pp.92-96
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• 1995

All patients who will Undergo irraidiation of the oral cavity cancer will need dental before and during Radiotherapy. The extent of the region and the presence of numerous critical normal tissues(mucosa, gingiva, teeth and the alveolar ridge, alveolar bony structure, etc) in the oral cavity area, injury to which could result in serious functional impairment. Therefore I evaluate the Usefulness of custom-made intraoral shielding device before and during Radiotherapy in oral cavity cancer. Materials and Methods(1) : Manufacture process of Custom-made intraoral shielding device Containing Cerroband. A. Acquisition of impression B. Matrix Constitution C. Separation by Separator D. Sprincle on method E. Trimming F. Spacing G. Fill with Cerroband Materials and Methods (2) A. Preannealing B. TLD Set up C. Annealing D. TLD Reading = Results = Therefore dosimetric characteristics in oral cavity by TLD Compared to isodose curve dose distribution Ipsilateral oral mucosa, Contralateral oral mucosa, alveolar ridge, tongue, dose was reduced by intraoral shielding device containning Cerroband technique Compard to isodose plan = Conclusions = The custom-made intra-oral shielding device containing Cerroband was useful in reducing the Contralateral oral mucosa dose and Volume irradiated.