• 한국농공학회지
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• 제34권4호
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• pp.69-79
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• 1992

To estimate soil behavior and structural characteristics under the conditions of cyclic loading, freezing & thawing and initial state, several testing was performed and obtained following results. 1.After repeated freezing and thawing processes, original soil structure was destroyed and changed to globular structure from honeycomb or tube in its structure types. Also above processes resulted increasing the soil compression strain while decreasing the failure stress in stress-strain relationship and reached the soil structure into the mode of brittle fracture. Under cyclic loading conditions, soil cluster which was originally dispersed structure colloided with each other, seperated, and finally the soil failed due to the effect of overcompaction. 2.Through the stabilization processes seperated by four steps, the structure of soil skeleton was changed to quite different globular type. The degree of compressibility of soil was decreased in the normally consolidated zone, while the strength against external load increased due to soil particle stabilization. 3.Soil stress-strain chracteristics were largely influenced by repeated up and down processes of temperature. The maximum deformation was obtained in the case of temperature between 0 10˚C by the reseon of particle cluster reformation. 4.Soil compressibility was largely influenced by the optimum moisture content. Under freezing process, swelling could be found and its magnitude was proportional to the density of soil. 5.Density of soil was decreased as increasing the number or repeated freezing and thawing processes and the largest decreasing rate was found at the first turning point from freezing to thawing cycle.

• 한국정보통신학회논문지
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• 제17권2호
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• pp.495-502
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• 2013

MANET(Mobile Ad-hoc Network)에서는 에너지 효율을 높이기 위한 다양한 클러스터링 기법과 라우팅 알고리즘이 연구되고 있다. 일반적으로 무선 Ad-hoc 네트워크에서는 LEACH와 같은 클러스터 기반의 동적 라우팅 알고리즘이 많이 사용된다. 본 논문에서는 클러스터내의 각 노드가 가지는 속성을 고려하여 클러스터를 생성하고 노드를 관리하는 ATICC(Adaptive Time Interval Clustering Control) 알고리즘 기법을 제안한다. 제안한 ATICC은 노드의 속성 중의 하나인 잔여에너지 값으로 노드의 에너지 레벨을 분류한다. 그리고 분류된 에너지 레벨에 대응하는 시간차 컨트롤 기법을 이용하여 클러스터링 과정을 수행하거나 노드들을 관리한다. 특히 제안한 ATICC 알고리즘은 MANET에서 클러스터의 생성, 재생성, 진입 노드 및 이탈 노드의 검출과 관리를 통해 노드의 에너지 관리 효율을 향상시키고 클러스터의 Lifetime을 증가시키는 결과를 보여주었다.

• 대한의생명과학회지
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• 제8권3호
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• pp.195-202
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• 2002

Osteoarthritis (OA), the most common form of arthritis, involves the destabilization of the normal balance between the degradation and the synthesis of articular cartilage and subchondral bone within a joint. As articular cartilage degrades over time, its smooth surface roughens and bone-against-bone contact ensues, producing the inflammation response symptomatic of this 'wear and tear' disease. Although a variety of genetic, developmental, metabolic, and traumatic factors may initiate the development of osteoarthritis, its symptoms (joint pain, stiffness, and curtailed function) typically evolve slowly, and patients experience periods of relative calm alternation with episodes of inflammation and pain. Rheumatoid arthritis (RA), an autoimmune disease of unknown etiology characterized by chronic synovitis and cartilage destruction, affect 1% of the total population. Cartilage is a specialized connective tissue in which the chondrocytes occupy only 5% of the volume. Cartilage is particularly rich in extracellular matrix, with matrix making up 90% of the dry weight of the tissue chondrocytes have cell processes that extend a short distance into the matrix, but do not touch other cells thus in cartilage, cell-matrix interactions are essential for the maintenance of the extracellular matrix. In this study, subtractive hybridization method was utilized to detect genes differentially expressed in chondrocytes treated with methylprednisolone. We have isolated 57 genes that expressed differentially in the chondreocytes by methylprednisolone. 13 clones of them were analyzed with sequencing and their homologies were searched. 8 cDNAS included KIAA 0368, upregulated during skeletal muscle growth 5 (usmg 5), ribosomal protein S 18 (RPS 18), skeletal muscle ryanodine receptor, radial spoke protein 3 (RSP 3), ribosomal protein QM, ribosomal protein L37a (RPL37A), cytochrome coxidase subunit VIII (COX8).

• 생약학회지
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• 제45권1호
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• pp.62-68
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• 2014

The present study was carried out to investigate the hepatoprotective effect of hot water extract of Korean white dandelion (Taraxacum coreanum Nakai) on liver cancer induced in rats by a single dose of N-nitrosodiethylamine (NDEA). The animals were divided into three groups. The animals in the normal (Nor) group were fed basal diet. Control (Con) group were administered with NDEA (200 mg/kg, i.p.). Hot water extract of Korean white dandelion (KDDA, KDDB) group treated with hot water extracts of Korean white dandelion (30, 60 mg/kg/day) for 8 weeks after NDEA. Serum AST and ALT were measured, enzyme activity of liver were examined by spectrophotometer and histological alternation of liver were examined by light microscopy. KDDA and KDDB group were decreased the increase of serum AST, ALT level induced by NDEA. The activities of SOD and CAT were significantly increased in KDDA, KDDB then in the Con. In the histological observation, KDDA and KDDB group were structure of liver lobula and nuclear shape was relatively cleared. In addition, the cytoplasm staining was similar to those of the Nor group. vacuolization of cytoplasm was not observed. These results suggest that administration of hot water extract of Korean white dandelion suppress or retard liver cancer induced by NDEA in rats.

• 대한암한의학회지
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• 제12권1호
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• pp.75-82
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• 2007

Drug eruption is a cutaneous reaction caused by various drugs. It is a very common drug induced adverse reaction. Contrast media induced drug eruption is rare. But approximately 10% of people injected with contrast media experience adverse reaction, and drug eruption accounts for more than 40% of all adverse reactions. We report a case of mild drug eruption and its treatment process based on korean traditional medicine. The patient is a 50 years old female diagnosed with functional dyspepsia. The patient had gastric discomfort and alternation between diarrhea and constipation. All symptoms showed nearly complete remission with continued korean traditional medical treatment. The patient had been injected with contrast media for Computed tomography(CT) evaluation of her breast cancer history. Rashes appeared on back and abdomen, and urticaria and pruritus appeared on the patient's finger 1 day after injection. We prescribed Goreisan(TSUMURA CO &, TJ-17) and acupuncture on Quchi(LI11), Zusanli(ST36), Yangxi(LI5), Yanggu(SI5). Consequently, the drug eruption showed remarkable improvement. So the author reports korean traditional medicine is effective complementary treatment for drug eruption.

• 대한한의학회지
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• 제29권2호
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• pp.71-80
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• 2008

Objective: There is increasing evidence that chronic non-bacterial prostatitis is recognized to be a local inflammatory disease, and there is substantiating evidence to support the role of the inflammatory responses in its pathogenesis, and clinical value in the evaluation of therapeutic efficacy. Prunella vulgaris has been traditionally used in treatment of inflammatory diseases, including of scrofula, goiter, and allergy diseases. In this study, we investigated the effects of Prunella vulgaris on inflammatory cytokines and cytopathological alternation in the rat model of non-bacterial prostatitis induced by castration and $17{\beta}-estradiol$ treatment. Methods: Two-month-old rats were treated with $17{\beta}-estradiol$ after castration for induction of experimental non-bacterial prostatitis, which is similar to human chronic prostatitis in histopathological profiles. Prunella vulgaris as an experimental specimen, and testosterone as a positive control, were administered orally. The prostates were evaluated by histopathological parameters including the epithelial score and epithelial-stromal ratio for glandular damage, and the expression of inflammatory cytokine genes including the interleukin $(IL)-1{\beta}$, IL-5, IL-12, and tumor necrosis factor $(TNF)-{\alpha}$. Results: While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with Prunella vulgaris showed a diminished range of tissue damage. Epithelial score was improved in Prunella vulgaris over that of the control (P<0.05). The epithelial-stromal ratio was lower with Prunella vulgaris when compared to that of the control (P<0.05). In the reverse transcription-polymerase chain reaction (RT-PCR) of inflammatory cytokine genes, Prunella vulgaris inhibited the expression of $IL-1{\beta}$ and $TNF-{\alpha}$ genes, while it modulated the expression of IL-5, which is an anti-inflammatory cytokine. Conclusions: These findings suggest that Prunella vulgaris may protect the glandular epithelial cells and also inhibit stromal proliferation in association with the immune modulation including the suppression of inflammatory cytokines and promotion of anti-inflammatory cytokine. From theses results, we suggest that Prunella vulgaris could be a useful remedy agent for treating chronic non-bacterial prostatitis.

• Journal of Microbiology and Biotechnology
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• 제25권9호
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• pp.1532-1536
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• 2015

To investigate the memory-enhancing effect of lactic acid bacteria, we selected the probiotic mixture KF, which consisted of Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (1 × 10¹¹ CFU/g of each strain), and investigated its antilipidemic and memoryenhancing effects in aged Fischer 344 rats. KF (1 × 10¹⁰ CFU/rat/day), which was administered orally once a day (6 days per week) for 8 weeks, significantly inhibited age-dependent increases of blood triglyceride and reductions of HDL cholesterol (p < 0.05). KF restored agereduced spontaneous alternation in the Y-maze task to 94.4% of that seen in young rats (p < 0.05). KF treatment slightly, but not significantly, shortened the escape latency daily for 4 days. Oral administration of KF restored age-suppressed doublecortin and brain-derived neurotrophic factor expression in aged rats. Orally administered KF suppressed the expression of p16, p53, and cyclooxygenase-2, the phosphorylation of Akt and mTOR, and the activation of NF-κB in the hippocampus of the brain. These findings suggest that KF may ameliorate age-dependent memory deficit and lipidemia by inhibiting NF-κB activation.

• 정보관리학회지
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• 제23권2호
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• pp.61-79
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• 2006

본 연구는 특허 및 상표 검색 개선을 위한 방법을 제안하고자 하는 목적에서 출발하였다. 이를 위해 193일간 한국 특허정보원의 특허기술정보서비스를 이용한 17,559명의 이용자가 작성한 100,016개의 질의문에 대한 로그 데이터를 분석하였다. 개별적인 질의로그 분석 이외에, 2,202개의 복수 질의문을 이용한 탐색세션을 분석함으로써 검색 개선을 위한 추가적인 단서를 발견하였다. 분석결과에 의하면, 특허 및 상표검색은 일반적인 웹 검색의 유형과 유사한데, 특히 질의문의 길이가 짧다는 측면에서 매우 흡사하다. 그러나 특히 및 상표검색의 경우, 일반 웹 검색보다 불리언 연산자를 많이 사용하고 있었다. 복수 질의문 분석을 통해 이용자들이 질의문을 재작성하는데 도움이 될 수 있는 탐색기능을 제안할 수 있었다. 복수의 질의문으로 구성된 탐색세션을 분석한 결과, 이용자들은 질의문을 재작성하기 위하여 부연하기, 특정화하기, 일반화하기, 교체하기, 중단하기와 같은 방법을 사용하고 있음을 알 수 있었다.

• 한국콘텐츠학회논문지
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• 제9권2호
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• pp.181-192
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• 2009

현대미술에 있어서 프린트는 시각이미지 분야에서도 판화가 지닌 특성을 유지하면서도 동시에 대중의 욕구를 충족하고 소통하는 데에 있어서 전위성을 띠고 있다. 그것은 판화의 형식이 르네상스 시기의 라인컷(Line Cut)에서부터 칼라 프린트의 프로세스, 사진, 20세기의 카툰의 시작, 그리고 광고와 예술, 그래픽 포스터로 이어지는 다양한 표현과 매개체의 변화에서 보듯이 고정적이기 보다는 유동적인 매체로서 복잡하고 다양한 문화 지형 속에서 말-언어보다는 개인들의 욕구와 특성을 원활히 소통할 수 있는 시각 언어 행위로써의 그 역할을 훌륭히 수행해왔음을 알 수 있다. 이 연구는 대중문화의 전위언어로서 프린트들, 즉 판화가 정치와 경제 분야에서 첫 번째, 언어와 그림언어간의 특성의 차이들과 그것들이 우리의 감각적인식이나 행동에 어떻게 작용하는 가를, 그래픽 포스터의 구체적인 특성에 초점을 맞추었으며, 두 번째로는 판화예술이 순수 예술로서 그 언어적인 행위를 어떻게 수행해 왔는가를 연구하는 데에 있다.

• 대한한의학원전학회지
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• 제26권4호
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• pp.267-280
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• 2013

Objective : One of the unique syndromes in Asian traditional medicine named 'heat entering the blood chamber(熱入血室, HEBC)' first appeared in Shanghanlun(傷寒論) and Jinguiyaolue(金匱要略) written by Zhangzhongjing(張仲景) who is the most famous doctor in ancient China. Method : Through comparison between Huangdineijing(黃帝內經), Shanghanlun(傷寒論), Jinguiyaolue(金匱要略) and other medical texts, the correct meaning, causes and mechanisms of HEBC can be analysed and organized to suggest new view of HEBC in modern society. Result : This syndrome is usually occurred in women during catching cold and menstruation, accompanying alternation of chillness and fever, pseudo-malaria, delirium, raveled chest(結胸), uterine hemorrhage, etc. The main sign of this syndrome, delirium belongs to the category of liver disease and fever in Huangdineijing(黃帝內經) which is a document more early published than Shanghanlun. Although there are still many other comprehensions about what blood chamber is, it could be the same as uterus according to Huangdineijing, it is relevant to the control of menstruation and emotions, and the function of liver and thoroughfare vessel(衝脈). Conclusion : HEBC is a syndrome exclusive to women, caused by their unique physical and psychological characteristics. It's beginning can be found in Huangdineijing, and by Shanghanlun and Jinguiyaolue, its concept as a single disease pattern becomes established. In other words, HEBC is a complex disease related to menstruation and its related hormonal dysfunctions, closely related to PMS, menopausal syndrome of today. Physical symptoms accompanied by psychological anxiety and fear is characteristic of this condition. Therefore gynecological approaches as well as socio-cultural issues related to women in modern society must be adopted when dealing with HEBC.