The Effect of the Hot Water Extract from Taraxacum coreanum Nakai on Hepatocarcinogenesis Induced by N-nitrosodiethylamine in Rats
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Yoon, Jung-Sik
(Bio Control Center)
Song, Seon-Young (Department of Skin and Beauty, Gwangju Health University) Cheong, Min-Ju (Department of Biology, College of Natural Sciences, Chosun University) Kim, Da-Som (Department of Biology, College of Natural Sciences, Chosun University) Lee, Hyun-Hwa (Department of Biology, College of Natural Sciences, Chosun University) |
1 | Cho, S. Y., Oh, Y. J., Patk, J. Y., Jang, J. Y., Lee, M. K. and Kim, M. J. (2003) Effect of dandelion extracts (Taraxacum officinale) leaf extracts on hepatic antioxidative system in rats fed high cholesterol diet. J. Korean Soc. Food Sci. Nutr. 32: 458-463. DOI |
2 |
Koo, H. N., Hong, S. H., Song, B. K., Kim, C. H., Yoo, Y. H. and Kim, H. M. (2004) Taraxacum offcinale induces cytotoxicity throung TNF- |
3 | Sigstedt, S. C., Hooten, C. J., Callewaert, M. C., Jenkins, A. R., Romem, A. E., Pullin, M. J., Komienko, A., Lowrey, T. K., Slambrouck, S. V. and Steelant, W. F. (2008) Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostatw cancer cells. Int. J. Oncol. 32: 1085-1090. |
4 | Jeon, H. J., Kang, H. J., Jung, H. J., Kang, Y. S., Lim, C. J., Kim, Y. M. and Park, E. H. (2008) Anti-inflammatory activity of Taraxacum officinale. J. Ethnopharmacol. 115: 82-88. DOI ScienceOn |
5 | Mendizabal, M. and Reddy, K. R. (2009) Current management of hepatocellular carcinoma. Med. Clin. North Am. 93: 885-900. DOI ScienceOn |
6 | Maluccio, M. and Covey, A. (2012) Recent progredd in understanding, diagnosing, and treating hepatocellular carcinoma. CA Cancer J. Clin. 62: 394-399. DOI |
7 | Korea National Statistical Office (2013) Annual report on the cause of death statistics, each year. |
8 | Fenwick, S. W., Toogood, G. J., Lodge, J. P. A. and Hull, M. A. (2003) The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases Original Research Article. Gastroenterology 125: 716-729. DOI ScienceOn |
9 | Lee, K. W. and Suh, K. S. (2010) Review Articles: Liver transplantation for advanced hepatocellular carcinoma. J. Korean Soc. Transplant. 24: 4-12. DOI ScienceOn |
10 | Baud, L. and Ardalliou, R. (1986) Reactive oxygen species: production and role in the kidney. Ame. J. Physio. 251: 765-776. |
11 | Linza, A., Wills, P. J., Ansil, P. N., Prabha, S. P., Nitha, A., Latha, B., Sheeba, K. O. and Latha, M. S. (2013) Doseresponse effects of Elephantopus scaber methanolic extract on N-nitrosodiethylamine-induced hepatotoxicity in rats. Chinese J. Natural Medicines 11: 362-370. DOI ScienceOn |
12 | Park, H. S., Jang, Y. J., Choi, D. S., Namgung, M. A., Lee, Y. J. and Kang, S. A. (1995) Increased oxydative stress in sciatic nerves of streptozotocin-induced diabetic rats:lack of vitamin c effect. Diabetes Metabolism J. 19: 279-286. |
13 | Deng, H. L. and Zhang, J. T. (1991) Anti-lipid peroxilative effect of ginsenoside Rb1 and Rg1. Chin. Med. J. 104: 395-398. |
14 | Yoon, J. S. and Kim J. S. (2009) The effect of the injinhotang extract on the hepatocarcinogenesis induced by N-nitrosodiethylamine and carbon tetrachloride in rats. J. Korean Soc. Food Sci. Nutr. 38: 436-441. DOI ScienceOn |
15 | Will, P. J., Surcesh, V., Arun, M. and Asha, V. V. (2006) Antiangiogenic effect of Lygodium flexuosum against N-nitrosodiethylamine- induced hepatotxicity in rats. Chemo- Biological Interactions 164: 25-38.25. DOI ScienceOn |
16 | Park, M. S., Park, J. H., Forghani, F. and Oh, D. H. (2011) Antioxidant activities and antimicrobial effects of extract and funcions from Taraxacum coreanum Nakai. Korean J. Food Preserv. 18: 946-953. |
17 | Cheong, M. J., Yoon, J. S., Huh, J., Roh, Y. B., Choi, Y. B., Kim, J. S. and Lee, H. H. (2008) Effects of dandelion (Taraxacum coreanum) extracts on the mouse liver with acute toxicated by mercury chloride. Korean J. Electron Microscopy 38: 1-10. |
18 | Im, D. Y. and Lee, K. I. (2011) Antitoxidative and antibacterial activity and tyrosinase inhibitory activity of the extract and fractions from Taraxacum coreanum Nakai. Korean J. Medicinal Sci. 19: 238-245. DOI |
19 | Gutteridge, J. M., Beard, A. P. and Quinlan, G. J. (1983) Suoercxide- dependent lipid peroxidation. Problems with the use of catalase as a specific probe for fenton-derived hydroxyl radicals. Biochem. Biophys. Res. Commun. 117: 901-907. DOI ScienceOn |
20 | Yoshikawa, T., Murakami, M., Yoshida, N., Seto, O. and Kondo, M. (1983) Effects od superoxide dismutase and catalase on disseminated intravascular coaulation in rats. Thromb Haemost 50: 869-872. |
21 | Baba, K., Abe, S. and Mizuno, D. (1981) Antitumor activity of hot water extract of dandelion, Taraxacum officinale corelation between antitumor activity and timing of administration. Yakugaku Zasshi 101: 538-543. |
22 | Lee, A. Y., Choi, J. M., Lee, S. L., Kim, H. Y., Lee, S. H. and Cho, E. J. (2013) The protective effects of the ethyl acetate fraction and flavonoids from Taraxacum coreanum against oxidative stress in neuronal cells induced by hydrogen peroxide and amyloid beta. Kor. J. Pharmacogn. 44: 263-268. |
23 | Kim, T. W. and Kim, T. H. (2011) Pancreatic lipase inhibitors in the roots of Taraxacum ohwlanum, a herb used in Korean traditional medicine. Kor. J. Food Preserve. 18: 53-58. DOI |
24 | Lee, M. H., Kang, H., Lee, K., Yang, G. S., Ham, I. H., Bu, Y. M., Kim, H. C. and Choi, H. Y. (2013) The aerial part of Taraxacum coreanum extract has an anti-inflammatory effect on peritoneal macrophages in vitro and increases survival in a mouse model of septic shock. J. Ethnopharm. 146: 1-8. DOI |
25 | Kim, D. H. (1995) Antitumor activity of fractions of Taraxaci Herba synergistic effect with anticancer drugs. M.S. thesis, Taejon University. |
26 | Aebi, H. E. (1983) Catalase: in methodes of enzymatic analyses. Verlag Chemie. Weinheim. 3: 273-282. |
27 | Chereroret, G., Dessor, D. and Lehr, P. R. (1994) In vitro effects of aluminum chloride on choline acethyltransferase activity of the rat brain during postnatal growth. Bull. Environ. Contam. Toxicol. 52: 487-490. |
28 | Oh, C. H., Sjin, N. S., Kwan. J., Lee, K. G., Lee, S. R. and Lee, C. H. (2012) antidiabetic effects of water extract from Taraxacum coreanum Nakai in type II diabetic mice. Kor. J. Oriiental Physiology & pathology 26:707-713. |
29 | Sivalokanathan, S., Ilayaraja, M. and Balasubramanian, M. P. (2004) Anticancer potency of Terminalia arjuna bark on Nnitrosodiethylamine- induced hepatocellular carcinoma in rats. Natural Product Sciences 10: 190-195. |
30 | Lee, S. H., Park, H. J., Cho, G. J., Cho, S. M. and Rhie, S. G. (2004) A study of the nutritional composition of the dandelion extracts by part (Taraxacum officinale). Korean J. Comm. Living Sci. 15: 57-61. |
31 | Im, D. Y. and Lee, K. I. (2011) Nitric oxide production inhibitory and scaveinging activity and tyrosinase inhibitory activity of extracts from Taraxacum officinale and Taraxacum coreanum. Kor. J. Medicinal Crop Sci. 19: 362-367. DOI |
32 | Han, S. H., Hwang, J. K., Park, S. N., Lee, K. H., Ko, K. U., Kim, K. S. and Kim, K. H. (2005) Potential effect of solvent fractions of Taraxacum mongolicum H. on protection of gastric mucosa. Korean J. Food Sci. Technol. 37: 84-89. |
33 | Kang, M. J., Seo, Y. H., Lim, J. B., Shin, S. R. and Kim, K. S. (2000) The chemical composition of Taraxacum officinale consumed in korea. Korean J. Soc. Food Sci. 16: 182-187. |
34 | Oh, S. L., Yang, J. M., Cha, W. S., Cho, Y. J., Kand, W. W., Kand, M. J. and Kim, K. S. (2000) Changes on properties of dandelion extracts tea induced by roasting conditions. J. East Asian Soc. Dietary life 10: 129-135. |
35 | Yang K. S. and Jeon C. M. (1996) Effect of Taraxacum coreanum Nakai on low density lipoprotein oxidation. Kor. J. Pharmacogn. 27: 267-273. |
36 | Kartin, S., Carles, R.. and Schieber, A. (2006) Taraxacum- Areview on its phytochemical and pharmacological profile. J. Ethnopharm. 107: 313-323. DOI ScienceOn |
37 | Yoon, T. J. (2008) Effect of water extracts from root of Taraxacum officinale in innate and adaptive immune reponses in mice. Kor. J. Food Nutr. 21: 275-282. |
38 | Lee, H. H. and Lee, S. Y. (2008) Cytotoxic and antioxidant effects of Taraxacum coreanum Nakai and T. officinale WEB. extracts. Kor. J. Med. Crop Sci. 16: 79-85. |
39 | Heo, S. I. and Wang, M. H. (2008) Antioxidant activity and cytotoxicity effect of extracts from Taraxacum mongolicum H. Kor. J. Pharm. 39: 255-259. |
40 | Park, J. Y., Park, C. M., Kim, J. J. and Song, Y. S. (2008) Hepatoprotective activity of dandelion (Taraxacum officinale) water extract against D-galactosamine-induced Hepatitis in rats. J. Kor. Soc. Food Sci. Nutr. 37: 177-183. DOI |
41 | Gedaly, R., Galuppo, R., Musgrave, Y., Angulo, P., Hundley, J., Shah, M., Daily, M. F., Chen, C., Cohen, D. A., Spear, T. and Evers, B. M. (2013) PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation. J. Surgical Research 185: 225-230. DOI |
42 | Sahgal, A., Roberge, D., Schellenberg, D., Purdie, T. G., Swaminath, A., Pantarotto, J., Filion, E., Gabos, Z., Butler, J., Letourneau, D., Masucci, G.L., Mulroy, L., Bezjak, A., Dawson, L. A. and Parliament, M. (2012) The canadian association of radiation oncology scope of practice guidelines for lung, liver and spine stereotactic body radiotherapy. Clin. Oncology 24: 629-639. DOI |
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