• YAKHAK HOEJI
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• v.56 no.6
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• pp.401-406
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• 2012

Previously, we identified that Cirsium japonicum (CJ) extract posses antidepressant properties. In order to look for the optimal hebal preparation, CJ extracts collected from Koheung, Yesan, Cheju, Pyungchang and Pocheon were compared. The psychopharmacological activities of each extract were investigated using the open field test, the rota-rod test and the forced swimming test. Effect of each extract on $Cl^-$ influx in neuroblastoma cells were also identified. All of the extracts were orally administered at dosages of 50, 100, 200, 400 mg/kg of body weight. Supplementation of CJ did not significantly alter psychomotor behaviors such as movement, rearing frequency and total turn angle on the open field. Supplementation of CJ's extract from Pyungchang (100 mg/kg, p.o.), Cheju (200 and 400 mg/kg p.o.) and Yesan (100 and 200 mg/kg, p.o.) significantly decreased immobile duration and increased mobile duration in the forced swimming test. All of extracts have no influence on NE uptake in HEK-293 cells, but increased $Cl^-$ influx in neuroblastoma cell. The extract from Yesan demonstrated the most potent effect on $Cl^-$ influx. These results indicate that CJ's extracts from Pyungchang, Cheju and Yesan may alleviate depression, and the extract from Yesan may be the most effective preparation.

• Journal of the Korean Society of School Health
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• v.33 no.2
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• pp.89-96
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• 2020

Purpose: The aim of the research was to define the effects of lifestyle habits, smartphone addiction, and mental health on irritable bowel syndrome in college students Methods: The data was collected through convenience sampling of 185 college students. To draw conclusions from the data, we used statistical analysis of independent t-test, χ² test, Fisher's exact test, and multiple logistic regression using SPSS/WIN 24.0. Results: There were significant differences in gender, grade, major, mental health, and smartphone addiction according to the presence of irritable bowel syndrome. Variables identified as influencing factors were gender (OR=4.03, CI: 1.42~11.49) and mental health (OR=1.05, CI: 1.01~1.08). Conclusion: In order to alleviate and improve the symptoms of irritable bowel syndrome, it is necessary to assess and continuously manage mental health, such as stress, anxiety and depression of college students, which are the factors that could be intervened.

• Health Policy and Management
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• v.28 no.2
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• pp.162-167
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• 2018

Background: In this research, we conducted an analysis to grasp the relationship between hearing and quality of life and to prepare effective troubleshooting. Methods: In this study, we analyzed using the data of the 6th term of the National Health and Nutrition Survey of the Disease Management Headquarters. And, out of 7,380 people, 3,598 adults over the age of 40 years who participated in the hearing test were selected as final research subjects and analyzed. Results: It was confirmed that the result of the analysis affects the quality of life based on hearing. The quality of life associated with hearing loss was unpleasant, motor ability, anxiety/depression, and everyday life affected in order of self management. And factors having an effect on the quality of life of the study subjects were found to be gender, elderly, unmarried, low hearing, low household income, absence of economic activity, and low teaching standards. Conclusion: The conclusion is that strengthening education for realistic management and prevention rather than treatment for unconditional hearing impairment will overcome low self esteem and loneliness and alleviate any uncomfortable life that people with hearing loss give. It is expected to be possible.

• Perspectives in Nursing Science
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• v.3 no.1
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• pp.73-89
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• 2006

Complementary and alternative medicine has gained popularity and respectability in recent years in the United States. Since aging is often associated with chronic health conditions that commonly lead to physical and psychosocial disabilities (e.g., depression, functional and/or cognitive disabilities, and decreased quality of life), older adults often seek options to maintain health and treat chronic conditions as an adjunct to conventional medical care. Herbal products, the most commonly used among various complementary and alternative medicines (CAM), should be used with caution due to potential herbal-drug interactions (related to polypharmacy) and herbal-disease interactions (related to comorbidities). Five of the most common chronic conditions in older adults are chronic pain, cardiovascular problems, hypertension, diabetes, and chronic lung problems. A high rate of falls or risk of falling is also a problem unique to this older population. For these conditions, only a few types of CAM (e.g., acupuncture, qi gong, tai chi) were tested, with promising results. However, in spite of evidence supporting the use of certain types of CAM to alleviate some common chronic conditions, findings are limited in terms of other types of CAM tested and both short and long-term effects. More rigorous clinical trials of various CAM types are thus warranted to advance scientific knowledge and establish evidence-based practices to care for the growing number of older adults who deserve to have a better quality of life.

• Journal of Agricultural Extension & Community Development
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• v.23 no.3
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• pp.271-283
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• 2016

The purpose of this study is to verify the effect of urban agricultural practice on the factors of adolescent problem behavior. The main findings of this study are as follows. First, as a result of measuring quantitative research, urban agricultural practice improves 16.7% of self-worth, reduces 28.1% of depression, and improves 19.4% of sociality, the factors of adolescent problem behavior, and statistical significance is confirmed in all lower measures. Second, as a result of measuring qualitative research, there are overwhelmingly many cases that most items change positively or are maintained in sentence completion test. Third, a positive change of mind in adolescent communication, cognitive and problem- solving abilities, and participation is confirmed through observation of program participation behavior. It is significant for this study to confirm that urban agricultural experiential activity has a positive impact on the factors of adolescent problem behavior, and to verify educational effects and social values of urban agricultural practice including the necessity of development and operation of urban agricultural program to solve youth problems.

• The Korean Journal of Pain
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• v.26 no.1
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• pp.89-93
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• 2013

Compensatory hyperhidrosis or reflex hyperhidrosis is the increase in sweating in the postoperative stage of thoracic sympathectomy or lumbar sympathectomy. It shares several features with anxiety disorders and has a negative impact on a patient's quality of life. Oralglycopyrrolate is one of the treatment options available. This study reviewed case notes in a series of 19 patients with compensatory hyperhidrosis. We made a comparison between the Milanez de Campos score of a pre-glycopyrrolate medication group and the Milanez de Campos score of a post-glycopyrrolate medication group. The Beck Depression Inventory (BDI) score, Beck Anxiety Inventory (BAI) score, and autonomic nervous system (ANS) scale score were also compared between the pre-medication and post-medication groups. In the post-glycopyrrolate medication group, there was decrease in the Milanez de Campos score, BAI score, and BDI score (P < 0.05). But no meaningful change was seen in the ANS score in the post-glycopyrrolate medication group (P > 0.05). Glycopyrrolate is an effective medication in the treatment of compensatory hyperhidrosis that, can alleviate anxiety and improve patients' quality of life.

• CELLMED
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• v.13 no.10
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• pp.9.1-9.6
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• 2023

This study aims to explore the potential of Korean language learning as a means of psychological healing and improving the quality of life for Japanese middle-aged and older learners. Results showed that Korean language learning could help alleviate various psychological issues experienced by middle-aged learners and contribute to enhancing their quality of life. Learning a foreign language is not just about acquiring information but also about meeting people who use the language and understanding and experiencing their culture. In particular, for Japanese middle-aged learners, Korean language learning can be advantageous as it can lead to the discovery or development of new hobbies or interests. Results also showed that Korean language learning increased learners' opportunities for interaction with others and enjoyment of learning new cultural customs. These positive outcomes suggest the need for discussion of teaching strategies that focus on psychological healing in foreign language education. Further clinical trials with participants who learn foreign languages for healing purposes may provide more conclusive evidence on the diverse effects of language learning on stress, anxiety, depression, self-development, social connections, and cognitive ability.

• Nutrition Research and Practice
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• v.17 no.5
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• pp.1007-1018
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• 2023

BACKGROUND/OBJECTIVES: This study aimed to examine whether the tailored home-delivered meal (HDM) services included nutrition counseling impacts alleviating self-rated frailty among low-income older adults in Korea. SUBJECTS/METHODS: Pre- and post-test were implemented on May 27 and on November 25 in 2019 during 3 weeks, respectively, before and after the 6 months intervention program. Participants completed a questionnaire measuring frailty, malnutrition, food security, depression, and underlying diseases. Initially, 136 older adults were selected as participants for this study, they were recipients of a free meal program from 2 senior welfare centers in Seoul, the final sample size of those who completed the intervention program was 117 (female 70.9%, male 29.1%). Statistical analyses were conducted with IBM SPSS package program, paired t-test and χ² test to validate the test. RESULTS: There were statistically significant differences in the score of the Tilburg Frailty Indicator (TFI) before and after receiving the tailored HDM services (pre-test 9.46, post-test 2.8, P < 0.01). The differences in the score of TFI by 3 risk groups at the pre-test decreased as a result of receiving these services. CONCLUSIONS: The tailored HDM services alleviated the self-rated frailty of low-income older adults with limited mobility in a community setting. Based on the positive outcomes this study could be applied to developing social services for aging in place.

• Clinical Nutrition Research
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• v.12 no.2
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• pp.154-167
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• 2023

Hepatic encephalopathy (HE) associated with liver failure is accompanied by hyperammonemia, severe inflammation, depression, anxiety, and memory deficits as well as liver injury. Recent studies have focused on the liver-brain-inflammation axis to identify a therapeutic solution for patients with HE. Lipocalin-2 is an inflammation-related glycoprotein that is secreted by various organs and is involved in cellular mechanisms including iron homeostasis, glucose metabolism, cell death, neurite outgrowth, and neurogenesis. In this study, we investigated that the roles of lipocalin-2 both in the brain cortex of mice with HE and in Neuro-2a (N2A) cells. We detected elevated levels of lipocalin-2 both in the plasma and liver in a bile duct ligation mouse model of HE. We confirmed changes in cytokine expression, such as interleukin-1β, cyclooxygenase 2 expression, and iron metabolism related to gene expression through AKT-mediated signaling both in the brain cortex of mice with HE and N2A cells. Our data showed negative effects of hepatic lipocalin-2 on cell survival, iron homeostasis, and neurite outgrowth in N2A cells. Thus, we suggest that regulation of lipocalin-2 in the brain in HE may be a critical therapeutic approach to alleviate neuropathological problems focused on the liver-brain axis.

• 한국노년학
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• v.36 no.3
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• pp.693-709
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• 2016

This study was to investigate depressive symptoms of caregiving grandmothers in South Korea and related factors focusing on caregiving characteristics. The data were drawn from the fourth wave of Korean Longitudinal Study on Ageing (KLoSA). The study participants were 3,291 grandmothers who had at least one grandchild, and we limited our analysis to 127 grandmothers who had provided care for their grandchild(ren) during the past one year. As for the depressive symptoms, Center for Epidemiological Survey-Depression 10(CES-D 10) short version were applied. Caregiving characteristics including caregiving duration by weeks per year, caregiving hours per week and the number of grandchildren who received grandmother care were examined. A multiple logistic regression was performed to detect association between caregiving characteristics and depressive symptoms while adjusting for general socioeconomic characteristics and health status of caregiving grandmothers. The longer duration of caregiving lowered the depressive symptoms and in contrast, those who spent more hours for providing care to their grandchildren were more exposed to the depressive symptoms. Physical pain significantly increased their depressive symptoms and low income level were more likely to induce depressive symptoms. More detailed studies on grandchild caregiving patterns among grandmothers were needed. Also, tailored support policy and services should be considered to alleviate their burden and depression in the future.