• Journal of Microbiology and Biotechnology
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• v.30 no.8
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• pp.1222-1226
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• 2020

Lactobacillus reuteri NK33 (NK33) and Bifidobacterium adolescentis NK98 (NK98) alleviate immobilization stress-induced depression. To understand the gut microbiota-mediated mechanisms of NK33 and NK98 against depression, we examined their effects on Escherichia coli K1 (K1)-induced depression and gut dysbiosis in mice. NK33, NK98, and their mixtures (1:1, 4:1, and 9:1) mitigated K1-induced depression and colitis. NK33 and NK98 additively or synergistically increased BDNF⁺/NeuN⁺ cell population and suppressed NF-κB action in the hippocampus. They alleviated gut dysbiosis by reducing the Proteobacteria population and increasing the Clostridia population. These results suggest that NK33 and NK98 may alleviate depression and colitis by ameliorating gut dysbiosis.

• Journal of Microbiology and Biotechnology
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• v.29 no.9
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• pp.1369-1374
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• 2019

We isolated Lactobacillus mucosae NK41 and Bifidobacterium longum NK46 from human feces, which induced BDNF expression in corticosterone-stimulated SH-SY5Y cells, and examined their anti-depressive effects in mice. NK41, NK46, and their (1:1) mixture significantly mitigated immobilization stress (IS)-induced anxiety-like/depressive behaviors, hippocampal $NF-{\kappa}B$ activation, BDNF expression, $Iba1^+$ cell population, and blood corticosterone, $TNF-{\alpha}$, IL-6, and lipopolysaccharide levels. Furthermore, they inhibited colitis marker $NF-{\kappa}B$ activation, and $TNF-{\alpha}$ expression in mice with IS-induced anxiety/depression. They additionally suppressed gut Proteobacteria and Bacteroidetes populations and bacterial lipopolysaccharide production. These findings suggest that NK41 and NK46 may alleviate anxiety/depression and colitis by suppressing gut dysbiosis.

• Women's Health Nursing
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• v.25 no.3
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• pp.273-284
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• 2019

Purpose: As the number of infertile couples has grown, many infertile women have experienced depression during the diagnosis and treatment of their infertility. This study aimed to identify the factors related to depression in infertile women who underwent reproductive treatments. Methods: The study subjects were 149 infertile women who underwent reproductive treatments. The data were collected by self-administered questionnaires from August 1 to December 24, 2018. The questionnaire consisted of questions about fatigue, health-promoting behavior, and depression. Analyses of the descriptive statistics, t-tests, one-way analysis of variance, correlation, and multiple regression were conducted using the SPSS 25.0 Windows program. Results: Thirty-six of the women in the study (24.2%) were in the probably depressed group and 113 (75.8%) were in the definitely depressed group and 100% of the subjects experienced symptoms of depression. Depression was positively correlated with fatigue and negatively correlated with health-promoting behavior. Multiple regression analysis revealed that fatigue and interpersonal relationships were factors significantly related to depression in the model (p<.001), with an explanatory power of 42.6%. Conclusion: The results confirmed that fatigue and interpersonal relationships, which is a subfactor of health-promoting behavior, were factors related to depression. To alleviate depression in infertile women, efforts should be made to identify and reduce psychological and physical fatigue. In addition, minimizing relational difficulties that they experience during an infertility diagnosis and treatment and strengthening positive interpersonal relationships can be positive strategies to alleviate depression.

• Korean Journal of Adult Nursing
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• v.27 no.3
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• pp.262-272
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• 2015

Purpose: This study was conducted to examine the mutual reciprocal relationship between elders' ego integrity and depression including physical and psycho-social predictors of both variables. The study also investigated the significant predictors of elders' ego integrity and depression. Methods: Data were collected using a structured questionnaire from 137 elders. Results: Perceived health status, self-esteem, family interaction, and depression were significant predictors of ego integrity, whereas pain, self-esteem, and ego integrity were significant factors of depression. The results also showed that ego integrity and depression had reciprocal relationship with each other. Conclusion: Psycho-social factors might be more important to improve ego integrity and to alleviate depression in elderly subjects than physical factors.

• International Journal of Contents
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• v.14 no.1
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• pp.12-17
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• 2018

This study explored potential therapeutic mechanisms of playing preferred online games as predictors of therapeutic interventions for players' psychosocial factors (i.e., aggression, depression, and loneliness). Based on theories of catharsis, the generic model of psychotherapy, we took a therapeutic approach to integrate these perspectives. We created a path model describing how therapeutic catharsis-seeking, online game self-efficacy, and life self-efficacy were associated with psychosocial factors of aggression, depression, and loneliness, including generalized sub-constructs of each factor as multi-dimensional sources. We analyzed the path model using data of 1,227 online game players in Korea. Our results indicated that therapeutic catharsis-seeking could alleviate aggression via favorite game playing. Life self-efficacy was a primary predictor for alleviating depression and loneliness. However, online game self-efficacy was positively associated with depression and loneliness. Implications of these findings are discussed.

• Journal of the Korean Society of School Health
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• v.36 no.1
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• pp.1-8
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• 2023

Purpose: The purpose of the study was to identify the sequential mediating effects of grit and depression on the relationship between negative parenting style and functional somatic symptoms. Methods: This was a secondary analysis of data from the 2018 Korean Children and Youth Panel Survey (KCYPS). Mediation analysis was conducted using the PROCESS macro model 6. Results: The mediating effects of grit and depression between negative parenting style and functional somatic symptoms were significant. A negative parenting style was found to significantly affect functional somatic symptoms going through sequential mediating effects of grit and depression. Conclusion: To alleviate functional somatic symptoms in adolescents, it is necessary to provide interventions for developing grit that could reduce depression.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.24 no.2
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• pp.138-145
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• 2017

Purpose: This study was conducted to determine factors affecting depression in women patients with osteoarthritis. Methods: Raw data from the 6th Korea National Health and Nutrition Examination Survey in 2014 was used. Data for 480 women were included. Variables related to general, physical and psychological characteristics were selected. After a sampling plan compound file was created using IBM SPSS 23.0 program, data were analyzed by giving weights. Results: The results of the study are as follows. 1) Depression was significantly different according to economic status, marital status, knee pain, stress and subjective health status (p<.05). 2) Factors affecting the women included marital status, knee pain, stress, and subjective health status. The explanatory power was 41.0%. Conclusion: Results indicate that there is a need to give comprehensive consideration to the factors identified in this study when designing preventive interventions and management plans to alleviate depression in women with osteoarthritis.

• CELLMED
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• v.13 no.11
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• pp.42.1-42.5
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• 2023

Objective: Case report of improvement in muscle pain, insomnia, and depression in a breast cancer patient using Ortho-Cellular Nutrition Therapy. Methods: A Korean woman in her 50s was diagnosed with breast cancer. After being diagnosed with stage 1 breast cancer, her quality of life has greatly deteriorated due to the side effects of the drugs administered. Results: Symptoms of insomnia and muscle pain improved after nutritional therapy. Conclusion: Applying nutritional therapy to patients with the aforementioned condition can help alleviate symptoms.

• Journal of Korean Public Health Nursing
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• v.32 no.1
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• pp.96-108
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• 2018

Purpose: This study the mediating effects of marital intimacy the relationship between depression and marital satisfaction of infertile women. Methods: 165 infertile women visiting a hospital in Gyeonggi-do and Busan, Korea from January 2016 to April 2016. The data was analyzed the SPSS WIN 22.0 program. Results: Depression, marital satisfaction, and marital intimacy averaged $1.51{\pm}.32$ (range of scale 0~3), $3.50{\pm}.56$ (range of scale 1~5), and $3.74{\pm}.65$ (range of scale 1~5), respectively. Depression had a negative correlation with marital satisfaction (r=-.361, p<.001) and marital intimacy(r=-.183, p<.001). Marital intimacy also had a positive correlation with marital satisfaction (r=.637, p<.001). Marital intimacy partial mediating effects between depression and marital satisfaction (${\beta}=.591$, p<.001). Conclusion: the intimacy of couple can alleviate the causal consequences that lead to a decrease in the marital satisfaction due to depression. Therefore, healthcare providers for infertile women should screen depressed women and help support infertile women from negative values for marriage depression. In addition, it is necessary to include interventions for maintaining and enhancing the intimacy of couples during infertility treatment.

• The Journal of Korean Physical Therapy
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• v.32 no.6
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• pp.329-334
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• 2020

Purpose: The purpose of this study is to provide basic evidence on the need to approach osteoarthritis patients through a psychological factors-considering rehabilitation program by understanding how activity restrictions in osteoarthritis affect health-related quality of life and depression. Methods: This study assessed 3,761 osteoarthritis patients from the Korea National Health and Nutrition Examination Survey. The subjects were divided into two categories: with and without activity restriction. Results: The prevalence of osteoarthritis in women was higher than that of men (men: 19.7%; women: 80.3%), and high BMI increased the prevalence of osteoarthritis. The EQ-5D index of subjects with activity restriction was 0.84±0.18 (points), while in those without activity restriction was 0.93±0.12, and the diagnosis of depression was 15.8%, 8.2%. There was a statistically significant difference in the odds ratio for each item in the EQ-5D. Moreover, the odds ratio for depression with activity restriction was 2.098 compared with no activity restriction. Conclusion: Activity restriction of osteoarthritis patients significantly decreases the health-related quality of life and increase the probability of depression. Therefore, early diagnosis of depression symptoms to prevent deterioration of symptoms in patients with osteoarthritis and to increase compliance with rehabilitation treatment, and to provide arbitration, including treatment that can alleviate depression.