• 한국학교ㆍ지역보건교육학회지
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• 제17권3호
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• pp.11-25
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• 2016

Background & Objectives: There were increasing evidence about the relationship between allergy related disease such as asthma, atopic dermatitis and allergic rhinitis and suicide ideation. However little was known about the concrete relatedness between severity and comorbidity of allergy related disease with suicide ideation. The objective of this study was to investigate the cases of the prevalence of suicide ideation among adolescents with allergy related disease such as asthma, atopic dermatitis and allergic rhinitis, and examine the association between allergy related disease and suicidal ideation among adolescents in South Korea. Methods: Data was based on Korean Youth Risk Behavior Web-based Survey(2014) which was a cross-sectional study containing 34,874 Korean middle and high school students who diagnosed with allergy related disease. We used the weights, strata and primary sampling unit information provided by the public use dataset to compute descriptive statistics and logistic regressions. Computations were done with SPSS version 20.0. Results: 19.9%, 15.6%, 13.8% of adolescents who suffered from one, two and three of allergy related diseases respectively reported having been thought of suicide ideation. Socio-demographic factors were adjusted as control variables. Students with greater severity of disease were more likely to have suicide ideation. Odds ratio for students who were absent one to three days from school because of allergies was 1.96(95% CI 1.51-2.46), and odds ratio for those who were absent more than four days from school was 3.60(95% CI 2.46-5.28). Conclusions: Given that adolescents' severity and comorbidity of allergy related disease were clearly associated with suicide ideation, suicide prevention programs for adolescents with allergy related disease should be improved by strategic approaches towards the severity and comorbidity of disease.

• 동의생리병리학회지
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• 제16권5호
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• pp.831-839
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• 2002

Allergy has a born predominant cause of atopy in body and react oversenstively several meterial. The cause of allergy are tick, house dust, egg, milk, bean, cosmetics, virus, bacteria, flesh and meat in Western medicine. While, Oriental medicine did not have an application on the allergy, but recognized that allergy is connected with fetal toxicosis, heat-syndrome in new born, syndrome characterized by dyspnea, sneezing, stuffy nose, nasal discharge and phlegm. Therefor, We knowed method of medical treatment following cause of disease and pathogenesis against allergy. Allergic disease(atopic dermatitis, bronchial asthma, rhinitis) were related with lung, spleen, kidney. To prevent allergic disease in born, Oriental medicine taked a serious view of fetal education. In Western medicine, The cause of allergy applied to exopathogen of Oriental medicine. In Oriental medicine, Treatment of allergy used generally strengthening the body resistance to eliminate pathogenic factors.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제4권2호
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• pp.238-242
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• 2001

저자들은 우유 단백질에 대한 FPIES의 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 동의생리병리학회지
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• 제21권6호
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• pp.1646-1654
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• 2007

The aim of this study was to investigate the effects of several herbal prescriptions in patients with allergy or atopic disease, such as atopic dermatitis, asthma and allergy rhinitis and others, on the blood immunological parameters and to verify the safety of long-term use of herbal medicine. Eighty one patients with allergy or atopy disease who taken herbal medicine at least for 2 months were compared with patients who taken same medicine with no allergy & atopy disease (n=14) and normal healthy subjects (n=22). According to the comparison of immunological parameters change, the data showed that herbal medicine decreased IgE (P=0.003), Eosinophil ratio (P<0.001) and count (P<0.001) of White Blood Cell (WBC) and did not affect to the liver cell enzymes in blood. This results indicated that herbal medicine decreased immune hypersensitivity and improved chronic inflammation related to blood immunological parameters of allergy or atopy diseases. In addition, herbal medicine seemed to be safe to the liver function for long-term use.

• 한국융합학회논문지
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• 제10권6호
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• pp.347-353
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• 2019

본 연구는 제6기 국민건강영양조사(2015년)의 원시자료를 이용하여 한국청소년의 알레르기질환에 영향을 미치는 비만, 흡연, 음주를 파악하기 위한 서술적조사연구이다. 연구대상은 만 12세에서 18세 청소년 535명이었고, Rao-Scott $x^2$. 복합표본 로지스틱 회귀분석을 실시하였다. 연구결과는 청소년의 천식 진단율 5.4%, 아토피피부염 진단율 15.5%, 알레르기비염 진단율 22.8%순으로, 비만, 흡연, 음주 여부에 따른 천식, 아토피피부염, 알레르기비염 진단율의 차이는 나타나지 않았다. 반면에. 알레르기 진단의 위험을 높이는 변수로 천식은 비만, 아토피피부염은 음주가 유의하게 나타났다. 본 연구결과를 바탕으로, 알레르기 질환을 진단받은 청소년에게 질 높은 삶을 중재하기 위한 차별화된 간호를 제공하기 위하여 비만, 흡연, 음주와 관련된 건강증진 프로그램 개발의 기초자료를 제공하고자 한다.

• 대한한방내과학회지
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• 제29권3호
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• pp.535-542
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• 2008

Objectives : Ryodoraku, which is a physiological function test using electric current, is closely related to skin sympathetic tone. Pulse analysis is known to reflect cardiovascular reactivity. Refer to the previous researches Ryodoraku and pulse analysis have value as tools for diagnosing respiratory diseases. In this study we examined the diagnostic values of Ryodoraku and pulse analysis for respiratory disease patients. Methods : For this study. we conducted Ryodoraku and pulse analysis on 114 people, including 83 respiratory disease outpatients and 31 volunteers who did not have any respiratory symptoms or disease history. The respiratory patients were divided into three subgroups according to their symptoms: rhinorrhea group, cough-sputum group and wheezing-dyspnea group. Then we compared the disease groups with the control group. Results : When all experimental groups were compared with the control group, mean Ryodoraku was significantly lower. Mean H2, mean H3 and mean H6 were significantly lower in the rhinorrhea group (P<0.05), all the test results of Ryodoraku were evidently lower in the cough-sputum group (P<0.01), and most results of Ryodoraku were evidently lower in the wheezing-dyspnea group except H1 (P<0.01). Compared with the control group on pulse analysis, mean YP+/YP- was significantly lower in the wheezing-dyspnea group (P<0.05). Conclusion : Ryodoraku and pulse analysis were found to have a high value as quantitative diagnosis tools reflecting individuals' weakness and firmness. Nevertheless, more research is needed to find the further values.

• 사상체질의학회지
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• 제13권3호
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• pp.75-88
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• 2001

The purpose of this research was to investigate the effects of Kwakhyangjeonggisan (KJS) on the anti-allergic action. In the present study, we examined the effect of KJS on type I and type IV allergic reaction. KJS inhibited the systemic anaphylaxis induced by compound 48/80 and platelet activating factor (PAF), and inhibited the passive cutaneous anaphylaxis (PCA) induced by anti-dinitrophenyl (DNP)-IgE and DNP-human serum albumin (HSA) in vivo. In addition, KJS dose-dependently inhibited the release of histamine from peritoneal mast cells in rat. Also, KJS inhibited the delayed type hypersensitivity (DTH) induced by SRBC and the contact dermatitis induced by dinitrofluorobenzene (DNFB). KJS inhibited the proliferation of splenocytes, the subpopulation of B220+ cells and CD4+CD8-(Th) cells in splenocytes and the production of γ-interferon in serum and splenocytes. These findings suggest that KJS prevented the type I allergy by the inhibition of histamine release from mast cells and the type IV allergy by the inhibition of γ-interferon production and B lymphocytes subpopulation. These results indicate that KJS may be useful for the prevention and treatment of type I and type IV allergy related disease.

• 생명과학회지
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• 제14권5호
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• pp.847-854
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• 2004

알러지는 복합적인 유전적, 환경적 요인에 의해 발병하는 질환이다. 선진국에서 알러지 질환의 수가 증가함에 따라 알러지에 대한 관심이 증가하고 있으며 이에 대한 유전적인 원인에 대한 관심도 증가하고 있다. 알러지에는 천식, 아토피, 비염을 포함한 알러지에 관련된 유전자와 염색체 부위가 밝혀지고 있다. 하지만 이들에 대한 평가 및 확인이 제대로 진행되지 않는 상황이다. 본 연구팀은 알러지를 일으키는 유전적인 요인을 찾고자 하였다. 과학영재학교 138명을 대상으로 하였고 이들 중 약 30%가 천식, 아토피, 비염과 같은 알러지 질환을 앓고 있었다. 본 연구팀은 지금까지 보고된 연구 결과들을 토대로 알러지에 관련된 유전자를 찾았으며 그중 알러지를 일으키는데 관여하는 IL-4와 IL-4Ra를 후보 유전자로 선정하였다. 지금까지 발표된 보고들은 SNP의 발견과 그리고 하나 혹은 두개의 SNP에 초점을 맞추어 발표한 반면, 본 연구팀은 알러지와 관련하여 발표된 IL-4와 IL-4Ra의 SNP를 종합적으로 분석하고자 하였다 과학영재학교 학생들 96명을 머리카락 샘플을 확보하고 이 것으로 9개 의 SNP를 선정 하여 염기서열 분석 및 MALDI-TOF을 이용한 유전자 분석을 진행하였다. 각각의 SNP에 대해 알러지를 가지고 있는 그룹과 정상 그룹간의 약간의 차이들은 있었지만 이것이 알러지를 가지고 있는 사람과 정상인과의 구분을 시켜줄 수 있을 정도는 아니었다. 이러한 결과는 현재 한국에서 널리 행하여지고 있는 유전자 검사에 대한 재고가 필요함을 시사한다.

• 한국콘텐츠학회논문지
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• 제16권3호
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• pp.596-606
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• 2016

본 연구의 목적은 우리나라 청소년에서 천식, 알레르기 비염 및 아토피 피부염을 포함하는 알레르기 질환의 유병 영향요인을 파악하고자 하는 것이다. 본 연구는 제10차(2014년)청소년건강행태 온라인조사의 원시자료를 이용하였으며, 만 12-18세 청소년 총 72,060명을 연구대상자로 선정하였다. 알레르기 질환 유병 영향요인을 파악하기 위해 로지스틱 회귀분석 결과 모든 변수가 보정된 상태에서 천식은 성별, 연령, 체질량지수, 주관적 경제상태, 흡연 및 주관적 스트레스 인지가 알레르기 비염은 연령, 도시규모, 주관적 경제상태, 음주 및 주관적 스트레스 인지가 아토피 피부염은 성별, 연령, 주관적 경제상태, 음주 및 주관적 스트레스 인지가 알레르기 질환 유병 영향요인으로 나타났다. 따라서 앞으로 청소년의 알레르기 질환에 악영향을 미치는 흡연과 음주와 같은 생활습관들의 규제정책 강화, 포괄적인 예방교육 및 스트레스 관리가 국가적 측면에서 시행될 필요가 있다.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.614-627
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• 2018

Purpose: Asthma is a heterogeneous disease that responds to medications to varying degrees. Cluster analyses have identified several phenotypes and variables related to fixed airway obstruction; however, few longitudinal studies of lung function have been performed on adult asthmatics. We investigated clinical, demographic, and inflammatory factors related to persistent airflow limitation based on lung function trajectories over 1 year. Methods: Serial post-bronchodilator forced expiratory volume (FEV) 1% values were obtained from 1,679 asthmatics who were followed up every 3 months for 1 year. First, a hierarchical cluster analysis was performed using Ward's method to generate a dendrogram for the optimum number of clusters using the complete post-FEV1 sets from 448 subjects. Then, a trajectory cluster analysis of serial post-FEV1 sets was performed using the k-means clustering for the longitudinal data trajectory method. Next, trajectory clustering for the serial post-FEV1 sets of a total of 1,679 asthmatics was performed after imputation of missing post-FEV1 values using regression methods. Results: Trajectories 1 and 2 were associated with normal lung function during the study period, and trajectory 3 was associated with a reversal to normal of the moderately decreased baseline FEV1 within 3 months. Trajectories 4 and 5 were associated with severe asthma with a marked reduction in baseline FEV1. However, the FEV1 associated with trajectory 4 was increased at 3 months, whereas the FEV1 associated with trajectory 5 was persistently disturbed over 1 year. Compared with trajectory 4, trajectory 5 was associated with older asthmatics with less atopy, a lower immunoglobulin E (IgE) level, sputum neutrophilia and higher dosages of oral steroids. In contrast, trajectory 4 was associated with higher sputum and blood eosinophil counts and more frequent exacerbations. Conclusions: Trajectory clustering analysis of FEV1 identified 5 distinct types, representing well-preserved to severely decreased FEV1. Persistent airflow obstruction may be related to non-atopy, a low IgE level, and older age accompanied by neutrophilic inflammation and low baseline FEV1 levels.