• The Korean journal of internal medicine
• /
• v.33 no.6
• /
• pp.1210-1223
• /
• 2018

Background/Aims: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin can potentially be used to treat asthma in obese patients by inhibiting interleukin 17 (IL-17) expression. This study investigated the combined effects of pravastatin and anti-IL-17 antibody treatment on allergic inflammation in a mouse model of obesity-related asthma. Methods: High-fat diet (HFD)-induced obesity was induced in C57BL/6 mice with or without ovalbumin (OVA) sensitization and challenge. Mice were administered the anti-IL-17 antibody, pravastatin, or both, and pathophysiological and immunological responses were analyzed. Results: HFD exacerbated allergic airway inflammation in the bronchoalveolar lavage fluid of HFD-OVA mice as compared to OVA mice. Blockading of the IL-17 in the HFD-OVA mice decreased airway hyper-responsiveness (AHR) and airway inflammation compared to the HFD-OVA mice. Moreover, the administration of the anti-IL-17 antibody decreased the leptin/adiponectin ratio in the HFD-OVA but not the OVA mice. Co-administration of pravastatin and anti-IL-17 inhibited airway inflammation and AHR, decreased goblet cell numbers, and increased adipokine levels in obese asthmatic mice. Conclusions: These results suggest that the IL-17-leptin/adiponectin axis plays a key role in airway inflammation in obesity-related asthma. Our findings suggest a potential new treatment for IL-17 as a target that may benefit obesity-related asthma patients who respond poorly to typical asthma medications.

• Clinical and Experimental Pediatrics
• /
• v.50 no.5
• /
• pp.409-415
• /
• 2007

Allergy skin prick test and intradermal test represent one of the major tools in the diagnosis of IgE-mediated diseases like as atopic asthma, allergic rhinitis, atopic dermatitis, food and drug allergy, and insect bite when properly performed. Skin tests are of particular importance in fields such as allergen standardization, pharmacology, and epidemiology. Even if skin tests seem easy to perform, adequate and proper interpretation requires well-trained physicians who can recognize the numerous factors that may modify the results of skin tests.

• Natural Product Sciences
• /
• v.15 no.3
• /
• pp.139-143
• /
• 2009

The anaphylactic allergic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. In this report, I investigated the effect of ripe fruits of Rubus coreanus Miq. (Rosaceae) (RFRC) on the anaphylactic allergic reaction and studied its possible mechanisms of action. RFRC inhibited compound 48/80-induced systemic anaphylactic reaction in mice. RFRC dose-dependently decreased the IgE-mediated passive cutaneous anaphylaxis. In addition, RFRC decreased the gene expression and production of tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated human mast cells. These findings provide evidence that RFRC could be a candidate as an anti-allergic agent.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.8
• /
• pp.494-502
• /
• 2019

Various international reports have shown strong proof that socioeconomic and sociodemographic variables are correlated with allergic diseases, yet little is known about how these variables affect Korean adolescents. This study was conducted to identify the socioeconomic and sociodemographic risk factors for allergic diseases of Korean adolescents, and to provide information for preventing and managing such conditions. Data from the 2018 Korean Youth Risk Behavior Survey (KYRBS) of 60,040 adolescents was used for this study. An anonymously administered online survey was conducted to collect information on the dependent variables. The independent variables were asthma, allergic rhinitis and atopic dermatitis. Multivariate logistic regression analysis was performed to analyze the correlations between the dependent variables and the independent variables. Low economic status, living with mother, high education level of parents, high school record, obesity, drinking and smoking were the risk factors for asthma. Low economic status, the place of residence, living with mother, high education level of the parents, gender, high school record, obesity, drinking and smoking were the risk factors for allergic rhinitis. Low economic status, living with mother, high education level of parents, genderhigh school record, obesity and drinking were the risk factors for atopic dermatitis. We found that low socioeconomic status and unhealthy behavior were the risk factor for allergic diseases of Korean adolescents. Balanced economic growth in the community and controlling unhealthy behavior can help reduce the prevalence of allergic diseases.

• Journal of Korean Academy of Nursing
• /
• v.48 no.1
• /
• pp.96-108
• /
• 2018

Purpose: This study aimed to construct and test a hypothetical model of the quality of life of school-age children with asthma based on the health-related quality of life model by Wilson and Cleary. Methods: Data were collected from 205 pairs of pediatric outpatients diagnosed with asthma and their parents in Seoul and Gyeonggi-do from July 2016 to April 2017. The exogenous variables were asthma knowledge, number of accompanying allergic diseases, and social support. The endogenous variables were asthma self-efficacy, asthma symptom control, perceived health status, parental quality of life, and children's quality of life. For data analysis, descriptive statistics, factor analysis, and structural equation modeling were performed. Results: Eighteen of the twenty-four hypotheses selected for the hypothetical model were attentive and supported statistically. Quality of life was explained by asthma self-efficacy, asthma symptom control, perceived health, parental quality of life, and asthma knowledge with 83.5%. Conclusion: Strategies for promoting self-efficacy and enforcing asthma knowledge will be helpful for the improvement of health-related quality of life with school-aged asthmatic children.

• Journal of Korean Biological Nursing Science
• /
• v.10 no.1
• /
• pp.53-61
• /
• 2008

Purpose: This study was conducted to estimate the prevalence of asthma and its risk factors in childhood asthma. Method: Random samples of 10,236 were selected from 43 kindergarten (1,418) and 57 elementary (8,718) in K city between september and November (2007). 1,079 (kindergarten children) and 7,271 (elementary children) were in the final analysis. The Korean-translated modified version of the questionnaire for the International Study of Asthma and Allergies in Childhood was used in this cross-sectional survey. Parents were surveyed to answer for the questionnaire. Result: The lifetime and 12-month prevalence of wheezing were 11.50%; 11.06% in kindergarten children and 19.24%; 4.80% in elementary children. The lifetime prevalence of asthma diagnosis and the 12-month prevalence of asthma treatment were 11.59%; 4.43% in kindergarten children and 4.43%; 10.78% in elementary children. The 12-month prevalence of night cough and exercise-induced wheezing were 12.90%; 3.33% in kindergarten children and 20.72%; 4.74% in elementary children. Risk factors analysis showed that age, paternal and maternal asthma, allergic disease, carpet use, monthly income, indoor environment were associated with a higher risk of asthma. Conclusion: The study suggests that prevalence of asthma has increased among the community children. These data have been used to manage a possible role of risk factors as predictors of childhood asthma.

• Journal of Food Hygiene and Safety
• /
• v.30 no.4
• /
• pp.376-382
• /
• 2015

Allergic diseases have rapidly increased in recent years. Mast cells play a critical role in IgE-mediated allergy responses and, therefore, closely associated with rhinitis, asthma, and atopic dermatitis. We studied anti-allergic effect of Penthorum chinense extract (PCE) in vitro and in vivo. PCE inhibited the degranulation of mast cells by antigen stimulation and its effect was dose-dependent and reversible in mast cells. PCE also suppressed the production of inflammatory cytokines such as TNF-${\alpha}$ and IL-4 by antigen in mast cells. Mechanistically, PCE inhibited the activation of Syk/LAT pathway which is a key signaling pathway for the activation of mast cells by antigen. Notably, PCE suppressed IgE-mediated allergic responses by antigen in mice. These results strongly suggest that PCE is a potential candidate for anti-allergic treatment.

• The Korean Journal of Physiology and Pharmacology
• /
• v.25 no.6
• /
• pp.555-564
• /
• 2021

We investigated the effects of naringenin and morin on IL-5 and ROS production in PMA+ionomycin-treated EL-4 cells with the corroboration of their antioxidant and anti-inflammatory properties using an asthma-induced mouse model. The EL-4 cell line was used to study the outcomes of naringenin or morin, followed by cell viability studies. Western blot analysis and ELISA test were used to determine Th2 mediated cytokines. In vivo studies were carried out on BALB/c mice to induce allergic asthma using ovalbumin administered intraperitoneally. Intracellular ROS was determined using 2',7'-dichlorodihydrofluorescein diacetate, followed by serum enzymatic (AST and ALT) estimations and inflammatory cell count in the bronchoalveolar lavage fluid (BALF) and lung tissues. Histopathological studies were conducted to examine lung tissue-stained architecture. Our findings suggested that naringenin and morin significantly suppressed IL-5 and ROS production via various pathways. Interestingly, by reducing NFAT activity, naringenin and morin stimulated HO-1 expression, thereby suppressing IL-5 secretion due to regulating the transcription factor Nrf2 via P13/Akt or ERK/JNK signalling pathways in EL-4 cells, demonstrating the involvement of HO-1 expression in inhibiting asthmatic inflammation. The increased inflammatory cells in the BALF were substantially decreased by both naringenin and morin, followed by inhibition in the elevated Th-2 cytokines levels. The TNF-α protein levels in an allergic asthma mouse model were significantly reduced by suppressing Akt phosphorylation and eosinophil formation. Recent findings confirmed that naringenin and morin possess the potential to control asthma-related immune responses through antioxidant and anti-inflammatory properties, indicating potential therapeutic agents or functional foods.

• The Journal of Pediatrics of Korean Medicine
• /
• v.29 no.2
• /
• pp.49-58
• /
• 2015

Objectives Asthma is an allergic disease that frequently occurs in children. This study aims to research acupuncture and acupoint-application treatment of pediatric asthma. Methods We got 53,653 search results with searching word 'child' 'children' 'pediatric' 'juvenile' 'adolescence' 'baby' 'infant' 'asthma' in Pubmed and got 147 results among them with searching word 'acupuncture' 'acupoint application'. We selected 13 articles among them which were seem to be related to this study. We classified these studies according to the type of study, the treatment methods and treatment outcomes. Results There were few studies about acupuncture and acupoint application on pediatric asthma. According to current research, conducting acupuncture and acupoint application treatment on pediatric asthma patient is recommended. Especially, acupoint application and laser acupuncture treatment were important to consider as treatment options on pediatric asthma patients for non-invasive way and less painful to children. Conclusions For the study on acupuncture and acupoint application treatment in pediatric asthma, it is necessary that we conduct research on various merit of acupuncture. More clinical data would be needed to prove the effects of acupuncture and acupoint application treatment in pediatric asthma.

• Korean Journal of Bronchoesophagology
• /
• v.4 no.1
• /
• pp.85-90
• /
• 1998

The role of the ECP(Eosinophilic cationic protein) is still unknown in the allergic rhinitis. In bronchial asthma, ECP can induce the exposure of the neuropeptidergic nerve to environments destroying the bronchial mucosa, aggravating the bronchial hypersensitivity and delay the mucociliary clearance. In the clinical aspect, we can (md that patients with perennial allergic rhinitis sometimes have sinusitis. The purpose of this article is to evaluate whether mucosal damage by ECP can play a role to develop the sinusitis by delaying the mucociliary clearance, and relationship between long symptom duration of allergic rhinitis and mucociliary clearance. In 32 perennial allergic rhinitis patients, we elucidated there is correlation among ECP presence, mucociliary clearance, sinusitis, and symptom durations. The obtained results were as follows : 1. ECP appeared in all mucosa of each specimen. 2. Mean mucociliary clearance time is 6 mins. 12 sec. in allergic patients with sinusitis, 6 mins. 36 sec in allergic patients without sinusitis. 3. n out of 32 cases have mucosal destruction. 4. Symptom duration is not correlated with the development of sinusitis. This study suggests that ECP may destroy the mucosa in allergic rhinitis and the mucociliary clearance of allergic rhinitis is not related to sinusitis and symptom dotation. Therefore development of sinusitis in allergic rhinitis seems not to be caused by delaying of mucociliary clearance due to mucosal destruction, but by some other factors.