• 대한수의학회지
• /
• 제26권1호
• /
• pp.117-124
• /
• 1986

The present study was undertaken to evaluate rosette formation and NK activity of splenic lymphocytes in 3-methylcholanthrene (MCA) treated mice. Mice were sensitized iv with 0.1ml of 1% sheep red blood cell (SRBC) suspension were treated with a single ip injection of olive oil alone or with different doses of MCA in oil at various time before or after sensitization, and were challenged at 4 days after SRBC. Rosette formation and NK activity of splenic lymphocytes were measured at 24 hours after challenge. Erythrocyte(E) rosette formation of splenic lymphocytes was significantly depressed in mouse treated with large dose of MCA (5~50mg) regardless of injecting time. But, there was no difference in the response between the treated with small dose of MCA (0.5mg). Whereas erythrocyte-antibody(EA) rosette or erythrocyte-antibody-complement(EAC) rosette forming cells were significantly depressed by MCA. Under small dose of MCA (0.5mg), any difference of NK activity was not observed in all course of injecting time. But, under large dose of MCA, the activity was markedly inhibited to about half the values seen in control and this suppression was transient, resulting that the normal level was reached again 19 days after MCA. These results, which conform with the predictions of immunosuppression hypothesis, suggest that MCA inhibits immunological responses including NK activity and thereby allows the outgrowth of antigenic neoplastic cells.

• The Journal of Advanced Prosthodontics
• /
• 제10권2호
• /
• pp.122-127
• /
• 2018

PURPOSE. This study evaluated the dimensional stability of a complete-arch prosthesis processed by conventional method in water bath or microwave energy and polymerized by two different curing cycles. MATERIALS AND METHODS. Forty maxillary complete-arch prostheses were randomly divided into four groups (n = 10): MW1 - acrylic resin cured by one microwave cycle; MW2 - acrylic resin cured by two microwave cycles: WB1 - conventional acrylic resin polymerized using one curing cycle in a water bath; WB2 - conventional acrylic resin polymerized using two curing cycles in a water bath. For evaluation of dimensional stability, occlusal vertical dimension (OVD) and area of contact points were measured in two different measurement times: before and after the polymerization method. A digital caliper was used for OVD measurement. Occlusal contact registration strips were used between maxillary and mandibular dentures to measure the contact points. The images were measured using the software IpWin32, and the differences before and after the polymerization methods were calculated. The data were statistically analyzed using the one-way ANOVA and Tukey test (${\alpha}=.05$). RESULTS. The results demonstrated significant statistical differences for OVD between different measurement times for all groups. MW1 presented the highest OVD values, while WB2 had the lowest OVD values (P<.05). No statistical differences were found for area of contact points among the groups (P=.7150). CONCLUSION. The conventional acrylic resin polymerized using two curing cycles in a water bath led to less difference in OVD of complete-arch prosthesis.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권8호
• /
• pp.4045-4050
• /
• 2012

Objective: The impact of ablative oral cancer surgery was studied, with particular reference to recurrence and nodal metastasis, to assess survival probability and prognostic indicators and to elucidate if ethnicity influences the survival of patients. Methods: Patients who underwent major ablative surgery of the head and neck region with neck dissection were identified and clinical records were assessed. Inclusion criteria were stage I-IV oral and oropharyngeal malignancies necessitating resection with or without radiotherapy from 2004 to 2009. All individuals had a pre-operative assessment prior to the surgery. The post operative assessment period ranged from 1 year to 5 years. Survival distributions were analyzed using Kaplan-Meier curves. Results: 87 patients (males:38%; females:62%) were included in this study, with an age range of 21-85 years. Some 78% underwent neck dissections while 63% had surgery and radiotherapy. Nodal recurrence was detected in 5.7% while 20.5% had primary site recurrence within the study period. Kaplan-Meier survival analysis revealed that the median survival time was 57 months. One year overall survival (OS) rate was 72.7% and three year overall survival rate dropped to 61.5%. On OS analysis, the log-rank test showed a significant difference of survival between Malay and Chinese patients (Bonferroni correction p=0.033). Recurrence-free survival (RFS) analysis revealed that 25% of the patients have reached the event of recurrence at 46 months. One year RFS rate was 85.2% and the three year survival rate was 76.1%. In the RFS analysis, the log-rank test showed a significant difference in the event of recurrence and nodal metastasis (p<0.001). Conclusion: Conservative neck is effective, in conjunction with postoperative radiotherapy, for control of neck metastases. Ethnicity appears to influence the survival of the patients, but a prospective trial is required to validate this.

• 한국인터넷방송통신학회논문지
• /
• 제11권6호
• /
• pp.93-106
• /
• 2011

본 논문에서는 이더넷 환경에서 ARP 스푸핑(spoofing) 기능을 이용하여 특정 컴퓨터들의 인터넷 사용을 소프트웨어적으로 차단할 수 있는 인터넷 차단기를 설계하고 구현하였다. 구현된 차단기에서는 ARP 스푸핑을 작동시키고 모든 패킷들이 관리자 컴퓨터로 보내지는 상황에서 그 패킷들을 본래 라우터로 전달하지 않고 폐기하는 방식으로 인터넷 차단기를 구현하였다. 본 논문에서 구현한 차단기는 차단 대상 컴퓨터들에 에이젼트(Agent)와 같은 별도의 프로그램 설치 없이 관리자 컴퓨터 단독으로 차단 기능이 가능하다. 또한 차단 대상 컴퓨터들을 수동으로 정해주는 것 뿐만 아니라 네트워크에 접속되어있는 컴퓨터들을 자동으로 인식하는 기능을 갖는다. 다수의 컴퓨터를 대상으로 한 실험 결과 컴퓨터 수에 관계 없이 ARP 스푸핑 메시지 발송 주기를 4초 미만으로 유지하면 인터넷 차단이 가능하였으며 ARP 스푸핑을 위한 추가적인 네트워크 부담은 무시할 정도인 것으로 파악되었다. 구현된 인터넷 차단기는 물리적으로 같은 스위치에 연결되어 있다면 모든 서브넷의 노드들을 인식할 수 있으며 서로 다른 서브넷의 컴퓨터들에 대해서도 인터넷 차단이 가능하다. 구현된 인터넷 차단기는 대학교 실습실에서 강의 중 인터넷 차단을 위한 도구로 및 망 관리를 위한 효율적인 도구로도 활용되고 있다.

• 한국자원식물학회지
• /
• 제19권2호
• /
• pp.259-264
• /
• 2006

본 실험은 꼬리고사리과에 속하는 3종의 양치식물들(꼬리고사리, 거미고사리 및 변산일엽)에서 배지의 조성물질과 물리적 조건 및 생장조절물질이 전엽체 생장에 미치는 영향을 구명하기 위하여 수행하였다. 3종 모두에서 전엽체 배양에 적합한 배지는 MS배지로 확인되었다. 배지 내 $NH_4^+:NO_3^-$의 적정 농도비율은 꼬리고사리와 변산일엽의 경우 20:40mM(1:2 비율) 이었으며, 거미고사리는 30:30mM(1:1 비율) 이었다. 전엽체 생장에 적합한 당 농도는 $1{\sim}2%$였으며, pH는 $3.8{\sim}5.8$이었다. 배지에 첨가된 agar 농도는 전엽체 생장에 별다른 영향을 미치지 않는 것으로 나타났다. 6종의 생장조절물질(NAA, IA4, 2,4-D, BAP, kinetin 및 2ip)을 배지에 첨가하여 3종의 전엽재를 배양한 결과, 시토키닌류의 경우 생장촉진효과가 관찰되었으나 옥신류는 농도가 높아질수록 전엽체의 생장을 저해하는 것으로 확인되었다.

• Toxicological Research
• /
• 제24권4호
• /
• pp.281-287
• /
• 2008

Impairment of hepatic metabolism of sulfur-containing amino acids has been known to be linked with induction of liver injury. We determined the early changes in the transsulfuration reactions in liver of rats challenged with a toxic dose of $CCl_4$ (2 mmol/kg, ip). Both hepatic methionine concentration and methionine adenosyltransferase activity were increased, but S-adenosylmethionine level did not change. Hepatic cysteine was increased significantly from 4 h after $CCl_4$ treatment. Glutathione (GSH) concentration in liver was elevated in $4{\sim}8$ h and then returned to normal in accordance with the changes in glutamate cysteine ligase activity. Cysteine dioxygenase activity and hypotaurine concentration were also elevated from 4 h after the treatment. However, plasma GSH concentration was increased progressively, reaching a level at least several fold greater than normal in 24 h. ${\gamma}$-Glutamyltransferase activity in kidney or liver was not altered by $CCl_4$, suggesting that the increase in plasma GSH could not be attributed to a failure of GSH cycling. The results indicate that acute liver injury induced by $CCl_4$ is accompanied with extensive alterations in the metabolomics of sulfurcontaining amino acids and related substances. The major metabolites and products of the transsulfuration pathway, including methionine, cysteine, hypotaurine, and GSH, are all increased in liver and plasma. The physiological significance of the change in the metabolomics of sulfur-containing substances and its role in the induction of liver injury need to be explored in future studies.

• 천문학회보
• /
• 제35권2호
• /
• pp.51.2-51.2
• /
• 2010

We have investigated 63 intense geomagnetic storms (Dst $\leq$ -100 nT) that occurred from 1998 to 2006. Using these events, we compared Dst forecast models: Burton et al. (1975), Fenrich and Luhmann (1998), O'Brien and McPherron (2000a), Wang et al. (2003), and Temerin and Li (2002, 2006) models. For comparison, we examined a linear correlation coefficient, RMS error, the difference of Dst minimum value (${\Delta}$peak), and the difference of Dst minimum time (${\Delta}$peak_time) between the observed and the predicted during geomagnetic storm period. As a result, we found that Temerin and Li model is mostly much better than other models. The model produces a linear correlation coefficient of 0.94, a RMS (Root Mean Square) error of 14.89 nT, a MAD (Mean Absolute Deviation) of ${\Delta}$peak of 12.54 nT, and a MAD of ${\Delta}$peak_time of 1.44 hour. Also, we classified storm events as five groups according to their interplanetary origin structures: 17 sMC events (IP shock and MC), 18 SH events (sheath field), 10 SH+MC events (Sheath field and MC), 8 CIR events, and 10 nonMC events (non-MC type ICME). We found that Temerin and Li model is also best for all structures. The RMS error and MAD of ${\Delta}$peak of their model depend on their associated interplanetary structures like; 19.1 nT and 16.7 nT for sMC, 12.5 nT and 7.8 nT for SH, 17.6 nT and 15.8 nT for SH+MC, 11.8 nT and 8.6 nT for CIR, and 11.9 nT and 10.5 nT for nonMC. One interesting thing is that MC-associated storms produce larger errors than the other-associated ones. Especially, the values of RMS error and MAD of ${\Delta}$peak of SH structure of Temerin and Li model are very lower than those of other models.

• 대한전자공학회논문지SD
• /
• 제45권2호
• /
• pp.34-43
• /
• 2008

평판 디스플레이 인터페이스를 위한 OpenLDI 수신기 IP를 설계하고, $0.18-{\mu}m$ high-voltage CMOS 공정을 사용하여 프로토타입 칩을 제작하였다. 수신기 회로는 크게 DLL과 parallelizer로 구성된다. DLL은 클록을 재생하고, Parallelizer는 데이터를 병렬화하여 재생된 클록에 정렬한다. 회로의 입력은 한 개의 클록 채널과 네 개의 데이터 채널로 구성된다. 측정을 통해 $10Mhz{\sim}65Mhz$ 범위의 입력주파수에서 클록을 재생하는 것을 확인하였으며, 이는 한 개 채널당 $70Mbps{\sim}455Mbps$의 속도에, 네 개의 데이터 채널을 모두 사용할 시 $280Mbps{\sim}1.82Gbps$의 속도에 해당한다. 상용 LCD 모니터를 개조하여 제작된 칩을 사용한 영상데이터 전송을 실험하였다. 이때의 클록 주파수는 49Mhz, 소모되는 전력은 코어가 19mW, 출력버퍼가 82.5mW로 측정되었다.

• 한국통신학회논문지
• /
• 제34권6B호
• /
• pp.630-640
• /
• 2009

본 논문에서는 고성능 모바일 TFT LCD/OLED 모듈(이하, 모듈)을 위한 헨드헬드 검사장비를 제안한다. 기존 모듈 검사장비는 명멸현상을 구분하기 위해선 동영상 데이터를 모듈에 출력시켜 구분할 수 있으나, 저속 시스템으로는 불가능하다. 또한 기존 검사장치는 저속의 CPU와 FPGA 시스템에서 필요한 몇 가지의 기능을 IP로 설계하고 사용하기 때문에 시스템의 한계를 지니고 있다. 이에 제안한 시스템은 고성능 모바일 모듈을 위한 검사장비로 다양한 크기의 모듈을 H/W나 FPGA의 설계 변경 없이 검사 장비를 휴대하여 여러 가지 부가기능들을 동시에 확인할 수 있다. 시스템은 크게 헨드헬드 검사장비와 내장된 테스터 소프트웨어, 정밀 분석을 위한 PC기반의 소프트웨어로 구성되며, USB 인터페이스 하여 헨드헬드 검사장비의 모든 모듈 테스트 내용을 확인, 저장, 출력 할 수 있도록 설계되어 있다. 제안된 시스템의 유효성 검증은 현장에서 사용하는 9가지의 대표 항목으로 설정하여, 고성능 모바일 TFT LCD/OLED에서 중요한 명멸현상에 대한 풀 프레임 동영상 구동시 별도의 모듈 없이 확인이 가능하였고, 기타 스캔타임 설정, 감마설정, 레지스터 변경, 인터페이스 지원, 다 인치 모듈지원 등이 가능하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제2권1호
• /
• pp.23-35
• /
• 2008

Mobile IP (MIP) is the solution supporting the mobility of Mobile Nodes (MNs), however, it is known to lack the support for NEtwork MObility (NEMO). NEMO manages situations when an entire network, composed of one or more subnets, dynamically changes its point of attachment to the Internet. NEMO Basic Support (NBS) protocol ensures session continuity for all the nodes in a mobile network, however, there exists a serious pinball routing problem. To overcome this weakness, there are many Route Optimization (RO) solutions such as Bi-directional Tunneling (BT) mechanism, Aggregation and Surrogate (A&S) mechanism, Recursive Approach, etc. The A&S RO mechanism is known to outperform the other RO mechanisms, except for the Binding Update (BU) cost. Although Improved Prefix Delegation (IPD) reduces the cost problem of Prefix Delegation (PD), a well-known A&S protocol, the BU cost problem still presents, especially when a large number of Mobile Routers (MRs) and MNs exist in the environment such as train, bus, ship, or aircraft. In this paper, a solution to reduce the cost of delivering the BU messages is proposed using a multicast mechanism instead of unicasting such as the traditional BU of the RO. The performance of the proposed multicast-based BU scheme is examined with an analytical model which shows that the BU cost enhancement is up to 32.9% over IPDbased, hence, it is feasible to predict that the proposed scheme could benefit in other NEMO RO protocols.