• Archives of Pharmacal Research
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• v.25 no.1
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• pp.49-52
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• 2002

Syntheses of ($\pm$)-homoepibatidine analogues (2), which contain the 8-azabicyclo [3.2.1 ]octane ring system, were achieved by using palladium-catalyzed reductive-coupling reaction from 3 and the analgesic activity was tested by Mouse writhing antinociceptive assay

• Archives of Pharmacal Research
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• v.26 no.1
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• pp.21-23
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• 2003

Indolyl alkaloids, $N_b-acetyltryptamine$ (1) and the known oxaline (2) have been isolated from the organic extract of the broth of an unidentified fungus collected from the surface of the marine red alga Gracilaria verrucosa. The structure of $N_{b}$-acetyltryptamine (1) was assigned on the basis of comprehensive spectroscopic analyses.s.

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.146.2-147
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• 2002

• Journal of Korea Foresty Energy
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• v.21 no.1
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• pp.16-24
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• 2002

Three alkaloids and two steroids were isolated from the sclerotia of Grifola umbellata. Structures of the isolated compounds were determined as 9-$\beta$-D-ribofuranosyladenine (adenosine), 1-$\beta$-D-ribofuranosyluracil (uridine), 2,4-pyrimidinedione (uracil), ergosta-4, 6, 8 (14), 22-tetraen-3-one and ergosta-5, 7, 22-tritene-$3\beta$-ol (ergosterol) respectively on the basis of spectroscopic data and chemical correlations.

• Advances in Traditional Medicine
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• v.4 no.2
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• pp.70-76
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• 2004

Petroleum ether, benzene and alcohol extracts of the seeds of C. juncea were tested for antiimplantation and pregnancy interruption activities in female albino rats. Of these three extracts, the alcohol extract was found to be the most effective in causing antiimplantation and pregnancy interruption activities. These adverse effects on fertility are reversible upon withdrawal of the extract treatments. The alcohol extract was found to possess estrogenic activity. After subjecting to preliminary phytochemical screening, the alcohol extract showed positive tests for alkaloids, steroids, glycosides, saponins, flavonoides, fixed oils, phenols and tannins.

• Advances in Traditional Medicine
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• v.3 no.3
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• pp.123-128
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• 2003

Stephania hernandifolia belonging to the family Menispermaceae is the biggest storehouse of diphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the bulb of S. hernandifolia by the application of modern separation techniques yielded a DBBI alkaloid which was identified as cycleanine using spectroscopic methods (UV, IR, $^1HNMR$. $^{13}CNMR$, Mass). Cycleanine showed significant anti-inflammatory activity against carrageenin induced paw oedema, comparable to that produced by diclofenac sodium, used as standard drug. It exhibited potent analgesic effects against chemical and thermal noxious stimuli. It was also found to possess anticonvulsive activity in the strychnine induced convulsion model.

• Korean Journal of Plant Resources
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• v.5 no.2
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• pp.73-84
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• 1992

Many types of compounds have been isolated from higher plants till now, that is, alkaloids, terpenes, lignans, steroids and so on. One of them, named as RA series Cyclic hexapeptides isolated from Rubia akane and R. cordijofia also have strong antineoplastic activity against various types of tumors. Till now 10 kinds ofRA series compounds were isolated and named as RA - I, II, III, IV, V, VI, VII, VIII, IX and X. Moreover,monogl-ucoside of RA - V newly Isolated from same plant. Many kinds of derivatives including natural RAcompounds were tested for QSAR, and one of them, RA - VII was screened up as a most suitable substance asan antitumor agent. RA - VII(=RA-700) has strong cytotoxic activity against KB cells, P388 Iymphocyticleukemia and MM2 mammary carcinoma cells. RA - VII has been under investigation for Phase I clinical trials.

• YAKHAK HOEJI
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• v.30 no.1
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• pp.1-7
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• 1986

The alkaloid components in the root of Codonopsis lanceolata were studied. From the ether soluble alkaloid fraction, four $\beta$-carboline alkaloids were isolated in crystalline state by chromatographic purification process; comp. I mp $178^{\circ}$, isolated yield 4.5$\times$$10^{-5}%$, comp. II mp $166^{\circ}$, 6.0$\times$$10^{-5}%$, comp. III mp $164^{\circ}$, 1.8$\times$$10^{-4}%$ and comp. IV mp $197^{\circ}$, 3.5$\times$$10^{-5}%$. They were identified by spectral analysis and by total synthesis as being a new component $N_9$-formylharman, and already known components in other plant 1-carbomethoxy-$\beta$-carboline, perlolyrine and norharman.

• Archives of Pharmacal Research
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• v.8 no.4
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• pp.243-247
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• 1985

A new $\beta$-carboline alkaloid, 1-carbobutoxy-$\beta$-carboline as well as $N_{9}$ -formylharman, 1-carboethoxy-$\beta$-carboline, 1-carbomethoxy-$\beta$- carboline, perloyrine, harman and norharman were isolated from the rhizoma of Polygala tenuifolia Willdenow. The structures were elucidated on the basis of spectroscopic studies and chemical evidence.

• Archives of Pharmacal Research
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• v.19 no.3
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• pp.240-242
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• 1996

We have reported the convenient biomimetic methodology for the synthesis of all kinds of substituent pattern benzo[c]phenanthridine alkaloids (Hanaoka et al., 1990; Hanaoka et al., 1991). Regioselective demethylation of C-8 position on oxyfagaridine (5), an intermediate for the synthesis of Fagaridine (4), would afford the precursor for the synthesis of Isofagaridine because the strong hydrogen bonding between amide and hydroxyl group of C-7 position probably resists to be reacted with week base and electrophiles. Thus, a selective alkylation of dihydroxy compound supposed to be possible and be lead to the target compound, Isofagaridine.