• The Journal of Internal Korean Medicine
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• v.31 no.3
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• pp.448-456
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• 2010

Objective : To summarize and make a reference number of antihyperlipidemic herbal plants worldwide. Method : We surveyed all papers of antihyperlipidemic studies using herbal plants in Pubmed database as "hyperlipidemia AND herb", "hyperlipidemia AND herbal", etc. of Default Tag "Title". The number of papers, the formation of experiments, frequency of herbal plants studies, and main studies were analyzed. Result : Total 178 studies were finally selected. The number of papers were rapidly was increased since 1998. RCT studies were most papers(39.9%). Most studies were about plant sterol or plant stanol studies(78%). 10 papers studied about Herbal plants. Crataegus pinnatifida Bunge, Salvia miltiorrhiza Bunge, Alisma orientale(Sam.) Juz. and so forth were relatively studied much. Conclusion : This study produced an overview of worldwide antihyperlipidemic plants. This result may provide a valuable information for development of Korean herbal medicine against hyperlipidemia in the future.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.4
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• pp.587-593
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• 1995

Lectin was purified by using $(NH_4)_2SO_4$, DEAE-cellulose ion-exchange chromatography and Sephadex G-150 column chromatography from Alismatis Rhizoma(AR). The specific activity of AR lectin was 50, 441units/mg, and purification folds were 114. The AR lectin agglutinated human erythrocytes of all types(A, B, O, AB). The molecular weight of AR lectin was estimated about 90, 500 daltons by gel filtration and each subunits were 42,000, 27,000 and 22,500 daltons on SDS-PAGE respectively. The hemagglutinating activity of the lectin was inhibited by sialic acid, glucose, ribose, galactose, sucrose, and lactose. It was also inhibited by cations such as $Hg^{++},\;Fe^{++},\;Cu^{++}\;and\;Pb^{++}$.

• YAKHAK HOEJI
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• v.60 no.1
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• pp.29-35
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• 2016

Traditional Korean medicines may be managed more scientifically, through the development of logical criterion to verify their cultivation region. It contributes to advance the industry of traditional herbal medicines. Volatile compounds were obtained from 14 samples of domestic Taeksa and 30 samples of Chinese Taeksa by steam distillation. The metabolites were identified by NIST mass spectral library in the obtained gas chromatography/mass spectrometer (GC/MS) data of 35 training samples. The multivariate statistical analysis, such as Principal Component Analysis (PCA), Partial Least Squares Discriminant Analysis (PLS-DA), and Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA), were performed based on the qualitative and quantitative data. Finally trans-(2,3-diphenylcyclopropyl)methyl phenyl sulfoxide (47.265 min), 1,2,3,4-tetrahydro-1-phenyl-naphthalene (47.781 min), spiro[4-oxatricyclo[5.3.0.0.(2,6)]decan-3-one-5,2'-cyclohexane] (54.62 min), 6-[7-nitrobenzofurazan-4-yl]amino-morphinan-4,5-epoxy (54.86 min), p-hydroxynorephedrine (55.14 min) were determined as marker metabolites to verify candidates for the origin of Taeksa. The statistical model was well established to determine the origin of Taeksa. The cultivation areas of test samples, each 3 domestic and 6 Chinese Taeksa were predicted by the established OPLS-DA model and it was confirmed that all 9 samples were precisely classified.

• Biomolecules & Therapeutics
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• v.31 no.6
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• pp.611-618
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• 2023

Rhizome of Alisma orientale has been used as a traditional medicine for treating kidney diseases in East Asian countries. Its inhibitory effects on hypersensitivity responses have been reported for methanol extracts, with alisol B 23-acetate (AB23Ac) being the most active constituent among six terpenes in inhibiting the direct passive Arthus reaction. However, whether AB23Ac has efficacy against allergic asthma has not been tested to date. The in vivo efficacy of AB23Ac in an ovalbumin (OVA)-induced allergic asthma mouse model was evaluated by administrating AB23Ac before OVA sensitization or OVA challenge in BALB/c mice. AB23Ac suppressed antigen-induced degranulation of RBL-2H3 mast cells in a concentration-dependent manner. The administration of AB23Ac both before OVA sensitization and OVA challenge greatly lowered pulmonary resistance and the increase in immune cell counts and inflammatory responses around the peribronchial and perivascular regions. In addition, the inflammatory cytokine levels of Th1/Th2/Th17 cells in the bronchoalveolar lavage fluid decreased in the AB23Ac-treated groups. AB23Ac reduced the number of PAS-stained cells in the lungs. Furthermore, a computer modeling study indicated that AB23Ac can bind tightly to spleen tyrosine kinase (Syk). These results suggest that AB23Ac may ameliorate allergic asthma by suppressing immune responses in dendritic cells during sensitization and in mast cells during challenge periods.

• Korean Journal of Plant Resources
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• v.25 no.6
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• pp.670-681
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• 2012

Herb extracts commercially used in Korea were screened for PPAR-${\gamma}$ agonist test and ${\alpha}$-glucosidase inhibition assay. Total 16 herb plants had a PPAR-${\gamma}$ agonist activity. Specially, Alisma orientale Juz (108.41%), Ephedra sinica (98.22%), Sasa japonica Makino var. purpurascens Nakai (140.68%), Astragalus membranaceus Bunge (106.79%) and Cnidium officinale Makino (113.00%) showed high PPAR-${\gamma}$ agonist activity rate compared with rosiglitazone's (167.46%). And Cornus officinalis S. et Z. (90.3%), Cinnamomum cassia Blume (89.2%), Psoralea corylifolia L. (89.8%), Paeonia japonica (Makino) Miyabe (92.4%) and Paeonia suffruticosa Andr (93.2%), showed high ${\alpha}$-glucosidase inhibition rates. These results support previous reports of the efficacy of Oriental medicinal plants used for diabetes mellitus.

• Journal of Wetlands Research
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• v.15 no.2
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• pp.203-214
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• 2013

Knowing how many species live in a ecosystem is a major work because of the distributions of species are determined by the environmental condition. This study was carried out to investigate the distribution of vascular plants of Gonggeom-ji, located in Sangju-si, Gyeongsangbuk-do, from April to October on 2012. The vascular plants were summarized as 240 taxa including 69 families, 176 genus, 204 species, 2 subspecies, 29 varieties, and 5 forma. Among the investigated taxa, 3 taxa of Korean endemic plants were included. Based on the list of specially designated plants by Ministry of Environment, 11 taxa including Alisma orientale, Monochoria korsakowii and Nymphoides peltata were recorded. The naturalized plants were identified as 26 taxa and the ratio of naturalized index (NI) was 10.8% of vascular plants recorded. 31 taxa of hydrophytes showed 17.8% of Korea. To conservation of wetlands, we suggest that it is required to minimize for unnecessary disturbance of human and to make a strategy for effective management by continuous monitoring for ecosystem alteration.

• The Journal of Internal Korean Medicine
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• v.38 no.6
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• pp.891-901
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• 2017

Objectives: The aim of the study was to evaluate the anti-asthmatic effect of alismatis rhizoma and alisol acetate B combination therapy in a murine asthma model. Methods: C57BL/6 mice were sensitized to and challenged with a mixture of ragweed, dust mite, and aspergillus to induce an asthma animal model. Alismatis rhizoma extract and alisol acetate B combination therapy was co-administered only in the experimental group. To evaluate the anti-asthmatic effect of the combination therapy, inflammatory cell counts in bronchoalveolar lavage (BAL) fluid were determined, and tissue was examined histologically with hematoxylin and eosin (H & E) and periodic acid-Schiff (PAS) stains, by enzyme-linked immunosorbent assay (ELISA) of IgE, IL-4, and IL-5, and with reverse transcription polymerase chain reaction (RT-PCR) of IL-5, IL-33, MUC5AC. Results: Alismatis rhizoma and alisol acetate B combination therapy reduced the number of inflammatory cells, alleviated histologic features, and down-regulated all the investigated asthma mediators, IgE, IL-4, IL-5, IL-33, and MUC5AC. Conclusions: According to the above results, alismatis rhizoma and alisol acetate B combination therapy may have therapeutic potential for asthma.

• Journal of the East Asian Society of Dietary Life
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• v.2 no.1
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• pp.35-56
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• 1992

This paper has made a close examination of Shingan Goohwang Chowalyo(1660), Cheesaeng yoram(1691), Sallim Gyungjae(1715) and Imwon simyook Jee(1827), to grasp what kinds of famine relief foods have been analyzed in terms of nutrition elements and cooking methods. And also this paper has surveyed the changes of these famine relief foods according to the times. Three hundred forty one famine relief foods are recorded in the above mentioned books, Among them, ten foods are recorded in common in these four books: pine needles, elm tree skin, soybeans, wax, jujubes, black beans, glutinous millet, turnip seeds white pine-mushroons and Chool-Atractylodes japonica. The methods of cooking and processing are most varied in the order of pine needles, black beans and elm tree skin, Pine needles are rich in protein and fat, and so may be regarded as the first of famine relief foods. Elm tree skin is of more than 50% carbohydrate and may be used in plate of cereals. I addition to these, Hwangui-milk vetch, Choonsu-cedrela Sinensis, Tacksa-Alisma Orientale Juzep and some other foods contain starch, glucose, fatty acids, and amino acids. So they may be used for replacing cereals and relieving famine. Before these famine relief foods are cooked or processed, according to their ingredients they should be soaked in water for a time in some cases the water should be changed several times. In Shingan Goohwang Chowalyo and Cheesaeng Yoram, measuring units are rarely recorded, while in sallim Gyungjae, they are explicitly shown. Imwon Simyook Jee clearly shows the use of oriental medicine materials. And the fur above mentioned books show no record of famine relief animal foods. To these days, vegetables have been boiled, squeezed and seasoned with salt and oil, but the better the economic conditions become, the less other famine relief foods are used. Nevertheless it is expected that these natural foods can be made favorite dishes with the best use of their good flavors and tastes.

• Journal of dental hygiene science
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• v.7 no.3
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• pp.197-200
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• 2007

This study was carried out to assess anticariogenic activity from natural products. The hexane extracts of 11 medicinal plants were tested for the antimicrobial activities against a cariogenic bacterium, S. sobrinus B13. The hexane extracts of 11 medicinal plants such as Alisma orientale, Cyperus rotundus, Saussurea lappa, Atractylodes japonica, Kalopanax pictus, Angelica gigas, Salvia miltorrhiza, Lonicera japonica, Gardenia jasmoides, Aurantii nobilis percarpium and Bupleurum lorgiradiatum were used for this study, and S. sobrinus B13 was cultured with 0.5% extracts of the medicinal plants, in trypticase soy broth medium under 5% $CO_2$ for 0, 6, 12, 24 hours at $37^{\circ}C$. The obtained results were as follows. Immediately after culturing for inoculation, Kalopanax pictus and Cyperus rotundus showed better antimicrobial activities than those of others. After culturing for 6 hours, the order of effective antimicrobial activity was Salvia miltorrhiza, Angelica gigas. After incubation for 12 hours, Salvia miltorrhiza showed the best antimicrobial activity. After incubation for 24 hours Salvia miltorrhiza, Cyperus rotundus, Saussurea lappa, Atractylodes japonica had better antimicrobial activity than others. In conclusion, among Hexane extracts of 11 medicinal plants, Cyperus rotundus, Saussurea lappa, Atractylodes japonica showed effective antimicrobial activity.

• Korean Journal of Plant Resources
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• v.25 no.2
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• pp.209-224
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• 2012

This study was carried out to survey the vascular plants of Namhan River located in Chungju-si, and the period of survey was from June, 2010 to June, 2011. The results are as follows. The vascular plants distributed in Neungam, Mokgye and Jangcheon around Namhan river were summarized as 225 taxa including 52 families, 164 genera, 200 species, 23 varieties and 2 forms. The rare plant designated by Korea Forest Service was $Aristolochia$ $contorta$ Bunge, and the endemic plant was identified as $Salix$ $koriyanagi$ Kimura. The specific plants by floristic region were 7 taxa including $Salix$ $chaenomeloides$ Kimura, $Aristolochia$ $contorta$ Bunge, $Actinostemma$ $lobatum$ Maxim., $Artemisia$ $selengensis$ Turcz., $Cirsium$ $pendulum$ Fisch., $Alisma$ $plantago-aquatic$ var. $orientale$ Samuels. and $Carex$ $versicaria$ L.. The naturalized plants were 47 taxa including $Fallopia$ $dumetorum$ (L.) Holub., $Chenopoidum$ $album$ L., $Silene$ $armeria$ L., $Brassica$ $juncea$ (L.) Czern., $Melilotus$ $alba$ Medicus, $Trifolium$ $pratense$ L., $Oenothera$ $erythrosepala$ Borb$\acute{a}$s, $Ipomoea$ $hederacea$ var. $integriuscula$ A.Gray, $Bidens$ $frondosa$ L., $Matricaria$ $inodora$ L., $Xanthium$ $canadense$ Mill., $Panicum$ $dichotomiflorum$ Michx. and so forth. In life forms, megaphanerophytes (M) were 13 taxa, 13 taxa in nanophanerophytes (N), 14 taxa inchamaiphytes (Ch), 40 taxa in hemicryptophytes (H), 20 taxa in geophytes (G), 103 taxa in therophytes (Th) and 22 taxa in hydrophytes (HH). The ratios of the naturalized index (NI), the urbanized index (UI) and the disturbed index (DI) were 20.9%, 14.6% and 18.2% in all sites.