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http://dx.doi.org/10.7732/kjpr.2012.25.6.670

Screening for Anti-diabetic Effects of Prescribed Korean Traditional Medicines  

Shin, Seon Mi (Department of Oriental Internal Medicine, Semyung University)
Jeong, Yong Joon (Department of Life Science, Gachon University)
Park, Dae Won (Department of Life Science, Gachon University)
Ko, Heung (Department of Oriental Internal Medicine, Semyung University)
Kim, Gi Tae (Department of Oriental Internal Medicine, Semyung University)
Kim, Ee-Hwa (Department of Meridian & Acupoint, Semyung University)
Kim, Taeseong (Department of Herbal Medicine Resource, Kangwon National University)
Sohn, Eun-Hwa (Department of Herbal Medicine Resource, Kangwon National University)
Kwon, Jung-Eun (Department of Life Science, Gachon University)
Koo, Hyun Jung (Department of Life Science, Gachon University)
Kang, Se Chan (Department of Life Science, Gachon University)
Publication Information
Korean Journal of Plant Resources / v.25, no.6, 2012 , pp. 670-681 More about this Journal
Abstract
Herb extracts commercially used in Korea were screened for PPAR-${\gamma}$ agonist test and ${\alpha}$-glucosidase inhibition assay. Total 16 herb plants had a PPAR-${\gamma}$ agonist activity. Specially, Alisma orientale Juz (108.41%), Ephedra sinica (98.22%), Sasa japonica Makino var. purpurascens Nakai (140.68%), Astragalus membranaceus Bunge (106.79%) and Cnidium officinale Makino (113.00%) showed high PPAR-${\gamma}$ agonist activity rate compared with rosiglitazone's (167.46%). And Cornus officinalis S. et Z. (90.3%), Cinnamomum cassia Blume (89.2%), Psoralea corylifolia L. (89.8%), Paeonia japonica (Makino) Miyabe (92.4%) and Paeonia suffruticosa Andr (93.2%), showed high ${\alpha}$-glucosidase inhibition rates. These results support previous reports of the efficacy of Oriental medicinal plants used for diabetes mellitus.
Keywords
Korean traditional medicine; Screening; PPAR-${\gamma}$ agonist; ${\alpha}$-Glucosidase inhibition; Diabetes mellitus;
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