• 제목/요약/키워드: Alisma orientale

검색결과 35건 처리시간 0.031초

택사의 Alisol B, Alisol B acetate 함량과 안정성 (Content and Stability of Alisol B, Alisol B acetate in Alismatis Rhizoma)

  • 백미은;이영종;원재희
    • 생약학회지
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    • 제48권4호
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    • pp.343-349
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    • 2017
  • The current definition of Arismatis Rhizoma is the tuberous root of Alisma orientale Juzepzuk in the Korean Pharmacopoeia, but there is still no marker compound. So it has difficulties in quality control. Therefore, in this study, we have established a method to analyze alisol B and alisol B acetate using HPLC as a marker compounds of Arismatis Rhizoma. As the result of the analysis, alisol B content was ranged from 0.02% to 0.50% and alisol B acetate content was ranged from 0.12% to 0.25% in 40 samples. The stability of alisol B and alisol B acetate was investigated during 24 months. As a result, alisol B acetate was significantly decreased. The marker compound of Arismatis Rhizoma is alisol B acetate and the content of 0.05% or more is suitable by applying the stability results.

Caco-2 세포에서 Interleukin-6로 유도한 밀착연접 기능 장애에 대한 황금, 택사, 백출 혼합 추출물의 예방 효과 (Preventive effects of Scutellaria baicalensis, Alisma orientale and Atractylodes japonica mixtures extract on Interleukin-6-induced intestinal tight junction dysfunction in Caco-2 cells)

  • 김광연;김태인;김연지;강윤미;김경호
    • 대한한의학방제학회지
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    • 제32권2호
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    • pp.121-128
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    • 2024
  • Objectives : This study aimed to investigate the protective effects of mixed extracts from Scutellaria baicalensis Georgi, Alisma orientale Juzepzuk, and Atractylodes japonica Koidzumi on interleukin (IL)-6-induced damage to tight junction (TJ) integrity in a Caco-2 cell model. Methods : We assessed the TJ integrity of Caco-2 monolayers by measuring the flux of FITC-labeled dextran and transepithelial electrical resistance (TEER). Additionally, we evaluated the expression of TJ proteins, such as ZO-1 and Occludin. Results : Treatment with IL-6 (50 ng/ml) increased TJ permeability and decreased TEER values of Caco-2 monolayers. Pretreatment with HTB (50-200 ㎍/ml) for 1 h significantly alleviated IL-6-induced TJ disruption, as evidenced by reduced TJ permeability and increased TEER values. Furthermore, HTB reversed the IL-6-induced inhibition of TJ protein expression, including ZO-1 and Occludin. Conclusions : These findings indicate that HTB protects barrier function by reversing the IL-6-induced decrease in TJ integrity and the suppression of TJ protein expression.

이뇨성(利尿性) 생약(生藥)의 약리학적(藥理學的) 연구(硏究) (A pharmacological Study of Diuretic Medicinal Plants)

  • 안영란;김학성;박정섭
    • 생약학회지
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    • 제9권2호
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    • pp.99-102
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    • 1978
  • Several kinds of medicinal plants are used as diuretics in folk medicines and oriental drugs. The diuretic action of water extracts of the ten kinds of crude drugs, such as Pachyma hoelen $R_{UMPHIUS}$ Zea mays L., Akebia quinata $D_{ECAISNE}$, Alisma orientale Juzepezuk, Atractylodes koreana $N_{AKAI}$, phytolacca americana L., Achyranthes japo-nica $N_{AKAI}$, Juncus decipiens $N_{AKAI}$, Prunella asiatica $N_{AKAI}$ and Artemisia capillaris $T_{HUNBERG}$ was examined in mouse and compared with aminophylline as a control the following results were obtained. The urine volume was found to be remarkably increased by the Pachyma hoelen RUMPHIUS, Phytolacca americana L., Prunella asiatica $N_{AKAI}$ and Artemisia capillaris $T_{HUNBERG}$, moderately increased by the Akebia quinata $D_{ECAISNE}$, Achyranthes japonica $N_{AKAI}$ and Juncus decipiens $N_{AKAI}$, and slightly increased by Zea mays $L_{ENNE}$, Alisma orientale $J_{UZFPEZUK}$ and Atractylodes koreana $N_{AKAI}$.

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남한강 비내늪의 공사전후 관속식물상과 생태적 특성 (Flora and Ecological Characteristics Before and After Construction of the Binae Marsh, Namhan River)

  • 유주한;안영섭;이철희
    • 한국환경복원기술학회지
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    • 제15권4호
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    • pp.61-80
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    • 2012
  • This study is to offer the basic data for restoration and conservation of wetland ecosystem by surveying and analysing the flora distributed in the Binae marsh, Namhan River, Chungju-si. The flora in the Binae marsh were verified 204 taxa including 48 families, 152 genera, 179 species, 23 varieties and 2 forms. In flora, pteridophyta were 2 taxa including 1 family, 1 genus and 2 species, among angiospermae, dicotyledonae were 153 taxa including 37 families, 110 genera, 138 species, 13 varieties and 2 forms and monocotyledonae were 49 taxa including 10 families, 41 genera, 39 species and 10 varieties. In the result of classifying the life form of flora, megaphanerophytes (M), nanophanerophytes (N) and chamaiphytes (Ch) were each 9 taxa (4.4%), 37 taxa (18.1%) of hemicryptophytes (H), 19 taxa (9.3%) of geophytes (G), 97 taxa (47.6%) of therophytes (Th) and 24 taxa (11.8%) of hydrophytes (HH). The rare plant designated by Korea Forest Service was 1 taxa (Aristolochia contorta), and the endemic plant was 1 taxa (Salix koriyanagi) too. The specific plants by floristic region were 6 taxa. From among these, the species of degree I were 5 taxa including Salix chaenomeloides, Aristolochia contorta, Artemisia selengensis, Cirsium pendulum and Vallisneria natans, and degree III was 1 taxa including Alisma orientale. The naturalized plants were 45 taxa and the invasive alien plants were 3 taxa including Sicyos angulatus, Ambrosia artemisiifolia and Ambrosia trifida. The naturalized index (NI) was about 22.1%, 16.1% of urbanized index (UI) and 27.3% of disturbed index (DI). The extinct species by construction were 17 taxa including Persicaria sagittata, Typha orientalis, Zizania latifolia and so forth. The new-occured species were 14 taxa including Brassica juncea, Thlaspi arvense, Carduus crispus and so forth. The important species among the extinct species were Aristolochia contorta, Alisma orientale and Vallisneria natans.

시비양(施肥量)에 따른 택사(澤瀉)의 수양(收量) 및 Alisoi-B monoacetate 함양(含量) 변화(變化) (Effect of Fertilizer Levels on Yield and Alisol-B monoacetate Content of Alisma plantago-aquatica var. orientale Samuelsson)

  • 김정곤;류길림;황인목;맹봉길;윤경하;이상갑;강상재
    • 한국약용작물학회지
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    • 제4권4호
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    • pp.340-344
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    • 1996
  • 고품질(高品質) 택사(澤瀉)의 다수확(多收穫)을 위하여 시비양(施肥量)에 따른 택사(澤瀉)의 생육(生育) 및 유효성분(有效成分)인 alisol-B monoacetate의 함양변북(含量變北)를 조사(調査)한 결과(結果)는 다음과 같다. 시비양(施肥量)의 증가(增加)는 지상부(地上部)의 생육증진(生育增進)에 효과적(效果的)이었으며 수양(收量)은 20-10-20 구(區)에서 가장 높은 287kg/10a 정도로 관행(慣行) 시비구(施肥區)보다 약 25% 증수(增收)되어 가장 높았으나30-15-30 구(區)는 20% 증수(增收) 되었다. 시비양(施肥量)에 따른 식물체중(中) 질소(窒素)와 린산(燐酸)함량은 증비(增肥) 할수록 줄기보다 잎의 함량이 높았으나 기타 무기성분(無機成分)은 대차없었다. 유효성분(有效成分)인 근경(根莖)내의 alisol-B monoacetate의 함양(含量)은 증비(增肥)할수록 함량이 증가되는 경향으로 30-5-30 시비구(施肥區)에서 4737.6ppm 으로 관행시비구(慣行施肥區)보다 66% 증가(增加)되었다.

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Prostane-type Triterpenes from Alismatis Rhizoma and Their Anti-complement Activity

  • Lee, Sang-Myung;Kim, Jung-Hee;An, Ren-Bo;Na, Min-Kyun;Min, Byung-Sun;Bae, Ki-Hwan;Lee, Hyeong-Kyu
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.373.3-374
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    • 2002
  • Alismatis Rhizoma is originated from the rhizome of Alisma plantago-aquatica L. var. orientale Samuelson or A. canaliculatum A. Br. et Bouche (Alismataceae). Prostane-type triterpenes, guaiane-type sesquiterpenes, and kaurane-type diterpenes have been reported as the main canstituents from these plants. Four prostane-type triterpenes. alisol B 23-acetate (1). alisol C 23-acetate (2), alisol B (3). and alisol A 24-actate (4). were isolated from the EtOAc-soluble fraction of this dried rhizome. (omitted)

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Screening of Hepatoprotective Activity of Medicinal Plant Extracts on Carbon Tetrachloride-induced Hepatotoxicity in Rats

  • Jeong, Choon-Sik;Suh, In-Ok;Hyun, Jin-Ee;Lee, Eun-Bang
    • Natural Product Sciences
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    • 제9권2호
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    • pp.87-90
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    • 2003
  • The purpose of this study was to find the effect of 36 traditional medicinal plant species on hepatoprotective activity screening. For this study, carbon tetrachloride $(CCl_{4})$ intoxificated rats were used. Test extracts were made with the traditional medicinal plants refluxed in 95% MeOH and orally administered to the rats. Sixteen species, such as Mentha arvensis, Sophora japonica, Benincasa hispida, Lonicera japonica (Lonicerae Flos), Agaricus blazei, Epimedium koreanum, Aralia continentalis, Lithospermum erythrorhizon, Cimicifuga foetida, Gastrodia elata, Sanguisorba officinalis, Cephalonoplos segetum, Bupleurum falcatum, Alisma plantago-aquatica var. orientale, Lonicera japonica (Lonicerae Folium) and Sinomenium acutum showed protective effect against increased serum alanine aminotransferase (ALT) and/or serum asparteate aminotransferase (AST) activities.

Phosphodiesterase 4와 7에 대한 억제 기전을 갖는 아토피 억제 물질의 탐색 (Screening of Anti-atopic Herbs Having Phosphodiesterase 4 and 7 Inhibition)

  • 윤원호;이경호
    • 생약학회지
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    • 제45권3호
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    • pp.268-274
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    • 2014
  • The aim of this study is to explore the potent phosphodiesterase 4 and 7 inhibitor from various herbal medicines for atopy treatment. In this study, 51 kinds of each herbal medicine, which were extracted with ethanol, was carried out the screening of PDE 4 and 7 inhibition using enzyme inhibitory assay. Of these, 8 species of herbal medicines, Rubus coreanus, Duchesnea chrysantha, Alisma orientale, Rehmannia glutinosa, Angelica dahurica, Thuja orientalis, Astragalus membranaceus and Perilla frutescens were screened as potential inhibitor against PDE 4 and 7. Among 8 species, Duchesnea chrysantha showed poteinial anti-atopic effect on DNCB-induced atopic model. Duchesnea chrysantha extract decreased serum IgE and histamine release significantly.

택사(澤瀉)의 재배조건(栽培條件)이 수량(收量) 및 유효성분(有效成分)의 함량(含量)에 미치는 영향(影響) (Effects of Cultural Condition on the Yield and Contents of Effective Components in Alisma orientale(Samuels.) Juzepcz.)

  • 김금숙;김정곤;성재덕;박창기;서형수;곽용호
    • 한국약용작물학회지
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    • 제4권2호
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    • pp.139-144
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    • 1996
  • 택사(澤瀉)의 품질평가(品質評價) 기준의 하나로서 혈중콜레스테롤 강하작용(降下作用)을 하는 Alisol B-monoacetate의 적절한 추출조건(抽出條件)과 재배방법상(栽培方法相)의 정식깊이를 $0{\sim}1$, $2{\sim}4$, $5{\sim}7$, $8{\sim}10cm$ 등(等) 4수준(水準)으로 달리할 때의 수량(收量) 및 품질(品質)의 변이(變移)를 구명하고 적절한 수확시기(收穫時期) 및 구경(球莖) 크기별 일반성분(一般成分) 및 유효성분(有效成分) 함량변이(含量變移)를 구명 하였던 바 결과를 요약(要約)하면 다음과 같다. 1. Alisol B-monoacetate의 HPLC 분석(分析) 조건(條件)으로는 Nova-Pak C18 column를 $35^{\circ}C$ 일정한 온도로 유지해 줌으로써 UV 208nm에서 약(約) 20분대(分代)의 양호(良好)한 HPLC 크로마토그람 분리(分離) peak를 구하였다. 2. Alisol B-monoacetate는 $25^{\circ}C$ 진탕 추출시 0. 402%, $40^{\circ}C$, $60^{\circ}C$ 가온 환류추출시 각각(各各) 0. 425%, 0. 431% 용출(溶出)되었으며 이때 추출회수(抽出回數)는 매회(每回) 30분(分)씩 추출(抽出)하여$25^{\circ}C$ 진탕 추출시는 2회(回), $40^{\circ}C$, $60^{\circ}C$ 가온 환류추출시 는 3회(回) 추출(抽出)이 적합(適合)하였다. 3. Alisol B-monoacetate는 11월(月) 30일(日) 수확한 택사구경(澤瀉球莖)이 10월(月) 30일(日) 수확(收穫)한 것보다 함량(含量)이 0. 25% 즉 1.5배(培) 가량 크게 증가(增加)하였으나 다른 일반성분(一般成分)의 경우 조단백질(組蛋白質) 함량(含量)은 10월(月), 11월(月) 수확시 각각 평균(平均) 24. 8%, 27. 3%였고 개분함량(漑粉含量)은 10월(月), 11월(月) 각각 30. 8%, 27, 7%로서 수확시기별(收穫時期別) 함량(含量)에는 변이폭(變移幅)이 크지 않았다. 이를 종합하면 유효성분(有效成分)의 함량(含量)이 높은 11월(月) 30일(日) 수확(收穫)이 10월(月) 30일(日) 수확(收穫)보다 유리(有利)할 것으로 판단된다. 4. 구경(球莖) 크기별 약효성분(藥效成分)의 함량변이도 커서 10월(月), 30일(日) 경우 S가 0. 53%로 가장 높고 M, L 순(順)으로 구경(球莖)이 커지면서 함량(含量)이 감소(感少)하였다. 5. 정식(定植)깊이 $0{\sim}1cm$가 다른 정식(定植)깊이에 비교하여 수량(收量)이 206kg/10a로 가장 많았으며 유효성분(有效成分) 변이(變移)는 $0. 33{\sim}0. 39%$로서 정식(定植)깊이에 따라 크지않은 것을 고려하면 택사(澤瀉) 재배시(栽培時) 정식(定植)깊이는 $0{\sim}1cm$가 가장 유리(有利)할 것으로 판단된다.

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