• 대한한의학방제학회지
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• 제24권4호
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• pp.311-321
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• 2016

Chronic or acute alcohol abuse often leads to liver injury associated with alcoholic hepatitis, liver fibrosis, cirrhosis, and liver cancer. In addition to the liver, alcohol abuse also induces a variety of other tissue injuries including pancreatitis, cardiomyopathy, neurotoxicity and muscle loss. Chronic skeletal muscle myopathy, independent of peripheral neuropathy, is well recognised in alcoholic patients. Several mechanisms may be involved in the pathogenesis of alcoholic myopathy. Ethanol is a potent inhibitor of muscle protein synthesis. Gastrocnemius and plantaris muscles are Type II fiber-predominant and usually considered representative of the musculature as a whole. Whereas, soleus muscle is Type I fiber predominant. Shihosogan-san is a traditional Korean medicine that is widely employed to treat indigestion and liver diseases. Muscle diseases are often related to liver diseases and conditions. We therefore tested the hypothesis that treatment with Shihosogan-san could ameliorate the ethanol-induced changes in muscle protein synthesis. Young male Sprague-Dawley rats were orally given 25% ethanol (5ml/kg, body weight) daily with Ethanol for 28 days. Normal group was similarly administrated with saline. In Shihosogan-san treated group, rats were orally administrated Shihosogan-san extract, and rats of EtOH group were given with the vehicle only. After 4 week, the morphology of gastrocnemius and plantaris muscles were assessed by hematoxylin and eosin staining. For comparative purposes, liver function was also investigated. The muscles from rats of EtOH group displayed a significant reduction in average cross section area compared to Normal group. Shihosogan-san treated group had increased fiber compared to the EtOH group. Moreover, Shihosogan-san treated group compared with EtOH group showed significantly decreased pro-apoptotic BAX expression and increased anti-apoptotic Bcl-2 expression. In conclusion, Shihosogan-san extract showed ameliorating effects on chronic alcohol toxicity in skeletal muscle.

• 보건교육건강증진학회지
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• 제13권2호
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• pp.97-114
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• 1996

Recently, attention for health promotion is rising. Alcohol is widely consumed among adults. About 1/3 of people 15 years of older enjoy drinking alcohol. Some 80% of them drink a half or more bottle of soju each time. Regular excessive drinking of alcohol may cause various problems. WHO(1990) reported that social problems such as divorce, unemployment, and financial difficulties ; psychological problems such as melancholy, suicide, and drug abuse ; physical problems such as cirrhosis, lung cancer, high blood pressure, stroke, and sterilization. The patients with liver disease are estimated to be 628,000. Approximately, 12,000 persons are dying by chronic liver disease and cirrhosis each year. Among the people of 15 years or older, persons dependent on alcohol are estimated to be 1,480,000. This study suggests policies to reduce the consumption of alcohol for planning for health promotion. Limitations of sites and times of sales and designation of sellers, designation of sites prohibiting drinking, limitation of alcohol sales promotion, and restrictions on advertisement can be inaugurated. Increase of price through the raise of tax and taxation of promotion cost. Education of high risk groups such as soldiers, pregnant women, and the youth can be introduced. Provision of alternative socialization programs instead of drinking. Some approaches on target groups were suggested.

• Food Science and Biotechnology
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• 제14권6호
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• pp.832-835
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• 2005

Inhibitory activity of active compound isolated from Ruta chalepensis leaf was examined against alcohol dehydrogenase and, upon comparison to those of four commercially available compounds (quinoline, quinoline-3-carboxaldehyde, quinoline-3-carboxylic acid, and quinoline-4-carboxylic acid) and 1,10-phenanthroline as alcohol dehydrogenase inhibitor, was characterized as quinoline-4-caboxaldehyde by spectral analyses. Inhibitory effects ($IC_{50}$) of quinoline-4-caboxaldehyde and quinoline derivatives varied depending on chemicals and concentrations used. The $IC_{50}$ values of quinoline-4-carboxaldehyde, quinoline-3-carboxaldehyde, quinoline, quinoline-3-carboxylic acid, and quinoline-4-carboxylic acid were 0.04, 0.3, 0.8, >1, and >1 mg/mL, respectively. These results suggest inhibitory action of quinoline-4-carboxaldehyde against alcohol dehydrogenase as prospective therapeutics for treatment of alcoholic liver diseases such as alcohol hepatitis and cirrhosis resulting from chronic alcohol abuse.

• 보건행정학회지
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• 제29권1호
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• pp.58-67
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• 2019

Background: In this study, we aimed to investigate the drinking behaviors and drinking-related problems of college students in South Korea to produce national alcohol statistics. Methods: We carefully examined the questionnaires and previous research developed in the previous research project and selected questions that reflect the special environment and culture of college students. In order to stratify a nationally representative sample of college students, the distribution of students around the country were found through the educational statistics database of the Korea Educational Development Institute. Based on this information, we conducted a survey in collaboration with Gallup (Korea) to survey and analyze the drinking behaviors of 5,024 Korean students. Results: A nationwide cross-sectional survey was conducted in 2017, for Korean college students. A total of 5,024 students were recruited and analyzed. The monthly drinking rate was 78.0% for male students and 72.9% for female students. The high-risk drinking rate was 23.3% for male students and 17.2% for female students. The most popular category for number of drinks per drinking session was 'more than 10 glasses' per drinking session for both male (44.1%) and female (32.8%). On the alcohol use disorders identification test, the greatest proportion of male students were in the high-risk drinking category (score 8 to 15) 43.8%, followed by the 'low-risk drinking' (score 0 to 7) in 43.6%, 'alcohol abuse' (score 16 to 19) 7.2%, and 'alcohol dependence' (greater than 20) 5.4% categories, respectively. For female students, the greatest proportion of female students were in the 'low-risk drinking' in 49.6%, followed by 'high-risk drinking' 37.1%, 'alcohol abuse' 8.4%, and 'alcohol dependence' 4.9% categories, respectively. Conclusion: The results of the study showed that the drinking behavior of Korean college students was excessive. Overall, it was found that the college population has a greater high-risk drinking behaviors than general adult population. Furthermore, these problem drinking behaviors were prominent among female college students. Results from the present study suggest that it is necessary to monitor the drinking behavior of college students with constant interest and to prepare policies and strategies suitable for these circumstances.

• 한국사회복지학
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• 제56권3호
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• pp.303-325
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• 2004

본 연구는 사법부의 보호처분을 받은 전국의 217명 가정폭력 가해남성들을 대상으로 행위자의 유형을 구분하고 각 유형별 특성을 살펴보았다. 유형화 과정에서 본 연구는 특히 Holtzworth-Munroe와 Stuart가 제안한 세 하위유형이 타당한지 확인하였다. 군집분석을 사용해서 밝혀진 결과에 따르면, Holtzworth-Munroe와 Stuart의 세 유형분류는 타당성이 있으며 그에 따라 한국 행위자들에 대한 적용 가능성도 어느 정도 확인되었다. 첫 번째 유형은 신체 및 심리적 폭력 수준이 가장 낮고, 아동기 학대경험이 적으며, 알코올에 덜 의존하는 생활패턴을 보인다. 성격기질 측면에서도 특징이 없는 편이며, 모든 MCMI 변인들에서 가장 낮은 점수를 기록하고 있다. 유형1은 아내에게만 폭력을 행사하며, 비교적 양호한 성평등적 태도를 갖고 있고 부부관계 만족도가 높다. 두 번째 유형은 중간 수준의 폭력성을 보이며 이러한 폭력은 아내에게만 행해지고 있었다. 유형2는 가장 높은 수준의 의존성, 경계선성, 회피성, 수동공격성을 기록하고 있다. 알코올 의존도는 유형1과 비슷하나 질투심, 자존감, 태도 변인들은 유형3과 근사한 수치를 보인다. 이들은 특히 주장기술이 부족하고, 부부관계에서의 불만족을 표출하고 있었다. 세 번째 유형은 신체적, 심리적 폭력의 정도가 가장 높고 아내에 대해서뿐만 아니라 일반적인 상황에서도 폭력을 행사한다. 이들은 가장 높은 반사회성과 공격성을 나타내고 있다. 아동기 학대경험이 가장 많고, 알코올 남용이 심하며, 통제력이 낮다. 또한 여성의 성역할에 대해 보수적이면서 폭력 사용에 대한 허용도가 매우 높았다. 이러한 결과들을 기초로 행위자 유형별로 상담 효과를 높이기 위한 개입방안들이 제시되었다.

• 한국농촌간호학회지
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• 제10권2호
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• pp.43-58
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• 2015

Purpose: The aim of this study was to analyze the cause of alcoholism based on a systematic review of previous studies published from 2009 to 2014. Methods: The study design was a systematic review of the literature in which factors constituting causes of alcoholism were analyzed. Search words used to retrieve foreign studies were "alcoholism" or a combination of "alcohol dependency" and "etiology" or "predictor. Research Information Sharing Service (RISS) of the Korea Education and Research Information Service and Dbpia, a database for domestic academic studies, were used as search engines for retrieving domestic papers. Results: The systematic literature review found that for emotional and psychological factors as etiology of alcoholism, abuse-related factors had the largest proportion with a total of 63%. Conclusions: In this study factors related to alcoholism were examined in terms of emotions, psychology, environments, families and others. As a result, it was found that alcohol consumption at an early age and experience of abuse were major causes for alcoholism.

• BMB Reports
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• 제29권2호
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• pp.146-150
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• 1996

A 2.1 kb cDNA clone for rat transketolase was isolated from rat liver ${\lambda}gt11$ cDNA library and its sequence was determined. The predicted rat transketolase (655 amino acids with $M_r$ 71,186) is highly similar (92%) to that of the human enzyme except that it contains an extra 32 amino acids at its N-terminus. Although it is less similar (<27%) to transketolases from non-mammalian species, the functional motifs such as the catalytic sites and thiamine binding domain are well conserved in the rat enzyme. Southern blot analysis of genomic DNA verified that transketolase appears to be derived from a single gene. Immunoblot and Northern blot analyses suggested that hepatic transketolase was activated pretranslationally by a 2.1-fold while little change was observed in brain enzyme, indicating a tissue-specific pretranslational activation during postnatal development.

• 한국보건간호학회지
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• 제27권3호
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• pp.592-607
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• 2013

Purpose: The purpose of this study was to examine the personal, family, and community factors that affect addictive behavior of adolescents. Methods: This study was conducted using a descriptive survey design. Subjects included 398 adolescents in three middle schools and four high schools located in three cities. Data were obtained from these subjects between July 11 and July 19, 2013 using self-report questionnaires. Analysis of the data was performed using the SPSS 19.0 program. Results: Of the participants, 62.0% were included in the non-addictive group, and 38.0% in the risk for addictive behavior group. Significant factors related to addictive behavior includes eight personal factors: alcohol consumption, sexual experience, suicidal ideation, experience of being a runaway, time spent using the smartphone, and time management skills; five family factors: physical abuse by parents, parental alcohol abuse, parental rearing attitudes [the type of rearing attitude among emotional warmth, rejection, and overprotection]; and two community factors: number of peers who practice risk behavior and relationship with peers. Conclusion: Based on the outcomes of this study, it is suggested that a school health program to decrease adolescent addictive behavior should consider personal, family, and community factors.

• Investigative Magnetic Resonance Imaging
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• 제19권2호
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• pp.122-126
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• 2015

Madelung's disease, or benign symmetric lipomatosis, is an uncommon disorder that is characterized by massive symmetrical deposits of adipose tissue in the upper trunk, neck and head, and is usually associated with alcohol abuse; as such, patients usually complain of cosmetic issues. Historically, Madelung's disease is usually encountered in men between 30 and 60 years of age, and is more prevalent in the Mediterranean population. In this case study, we describe a rare case of Madelung's disease, in an Asian patient who presented with symmetrically located bilateral masses in the anterior neck, which grew progressively larger over a period of seven years.

• Journal of Preventive Medicine and Public Health
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• 제37권3호
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• pp.232-237
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• 2004

Objectives : The study was designed to test if alcohol use and alcohol-related problems among adolescent females are related to their parents' level of alcohol problems. Methods : In 2001, a stratified sample of 2077 adolescent females, grades 10-11, from twelve female-only high schools located in a large metropolitan city in the Republic of Korea completed a questionnaire about alcohol use, parental attention, and parental alcohol consumption, and other risk and protective factors. Data were analyzed with chi-square and regression analyses. Results : Nearly 63% of the student drinkers had experienced at least one to two alcohol-related problems in their lives. Two-thirds of all 2077 students indicated that at least one of their parents had an alcohol-related problem and that approximately 29% had experienced several problems. Results of random effects ordinal logistic regression analyses suggest a dose-response relationship between parental and youth alcohol-related problems. Youth who report having parents with some and many alcohol problems were 30% (Odds Ratios [OR] = 1.30; 95% Confidence Interval [CI] = 1.10 - 1.53) and 55% (OR = 1.55; 95%CI = 1.23 - 1.95) more likely to experience alcohol-related problems than youth whose parents do not have alcohol problems, respectively, after statistically adjusting for important covariates. Conclusions : This study presents evidence that alcohol-related problems among adolescent female students is highly prevalent. Also, the study findings reveal a high percentage of parents with alcohol problems, as reported by students. This study presents evidence of what might be a hidden problem among adults and youths in the Republic of Korea that merits serious attention.