• 생물정신의학
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• 제5권2호
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• pp.235-242
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• 1998

Objectives : Alcohol-induced oxidative stress has been known to injure various tissues or organs. This stress is related with free radicals which are produced as the result of long-term alcohol consumption. Malonyldialdehyde(MDA) is produced by the interaction of free radicals and cell membrane lipids, and indicates the degree of lipid peroxidation indirectly. The purpose of this study was to investigate the relationship between red blood cell(RBC) membrane lipid peroxidation by free radicals, and associated hepatic injuries and hematologic changes. Methods : Thirty-three subjects diagnosed as alcohol dependence according to DSM-IV diagnostic criteria were evaluated within 72 hours after discontinuing alcohol drinking. Clinical characteristics were evaluated by CAGE questionnaire and Korean Michigan Alcoholism Screening Test(MAST). RBC membrane MDA level was measured as the marker of RBC membrane lipid peroxidation. Aspartate aminotransferase(AST), alanine aminotransferase(ALT) and gamma-glutamyltransferase(GGT) were used as the biochemical markers of liver damage due to alcohol ingestion. The alcohol-induced hematologic change was assessed by mean corpuscular volume(MCV). Results : The results were as follows. Clinical characteristics were not different between two groups having normal and abnormal levels of AST, ALT, GGT or MCV. The levels of MDA were not correlated with the clinical characteristics and serum levels of AST, ALT and GGT. However, there was a significant correlation between the levels of MDA and the value of MCV(p=0.017). Conclusions : These findings suggest that oxidative stress in alcohol dependence may not be reflected in liver enzyme markers such as AST, ALT and GGT, but may be reflected in MCV.

• 한국콘텐츠학회논문지
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• 제17권11호
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• pp.632-640
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• 2017

목적: 본 연구는 부모의 음주문제정도에 따른 간호대학생의 알코올중독자 돌봄에 대한 태도의 차이를 파악하기 위한 서술적 조사연구이다. 방법: 연구대상자는 G시에 위치한 4개 대학 간호학과에 재학 중인 2학년 및 4학년 학생으로 총 281명을 조사하였다. 수집된 자료는 SPSS 22.0프로그램을 활용하여, 평균과 표준편차, t-test와 ANOVA로 분석하였다. 결과: 연구대상자가 지각한 부모의 문제음주정도는 평균 $3.70({\pm}5.85)$점이며, 사회적음주군(225명)은 평균 $1.25({\pm}1.71)$점, 알코올남용군(29명)은 평균 $8.59({\pm}2.07)$점, 알코올의존군(27명)은 $18.85({\pm}5.17)$점이었다. 연구대상자의 알코올중독자에 대한 돌봄의 태도 평균은 $45.25({\pm}6.49)$점이었다. 알코올중독자의 간호실무에 참여 희망 유무에 따라 알코올중독자 돌봄에 대한 태도는 통계적으로 유의한 차이를 보여주었다. 부모의 문제음주가 심각할수록 간호대학생의 알코올중독자 돌봄에 대한 태도는 부정적인 것으로 나타났다. 결론: 본 연구결과를 통하여 향후 부모의 문제음주가 심각한 수준에 있는 간호대학생은 환자간호에 부정적 영향을 미칠 수 있으므로 간호대학생의 자기인식 증진 프로그램 개발을 위한 기초자료로 활용될 수 있을 것으로 기대된다.

• 여성건강간호학회지
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• 제9권3호
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• pp.270-276
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• 2003

Purpose: The purpose of this study was to investigate the self-care and the physical symptom and to analyse the correlation between self-care and physical symptom in type2 diabetic patients. Method: 201 Participants were recruited from the endocrinology outpatient department of a tertiary care hospital in an urban city. The data were collected by self report self-care and physical symptom questionnaire. Results: The alcohol drinking frequency was lower in female than in male patients. The frequency of nausea or vomiting, morning headaches, lightheadedness, weakness, pain in the heart, pain in the back, stiffness in any join or muscle, and getting very tired in a short time were higher in female than in male diabetic patients. The exercise frequency was negatively correlated with physical symptom in female patients. Conclusion: The alcohol drinking frequency was lower in female than in male patients. The female patients had more physical symptoms than the male patients. The exercise frequency was negatively correlated with physical symptom in female patients.

• 대한통합의학회지
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• 제6권4호
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• pp.29-38
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• 2018

Purpose: The purpose of this study was to investigate the psychological symptoms of insomnia, impulsiveness, and memory impairment according to the drinking frequency of college students. Methods: From May 4 to May 17, 2018, a questionnaire survey was conducted for men and women enrolled in J city S university in the Department of Occupational Therapy, Architecture, Social Welfare, and Digital Content. After visiting the department to explain the purpose of the study, 400 questionnaires were distributed to those who agreed to participate in the study. The SPSS 22.0 program was used to analyze the data collected. All statistical analyses were performed at the significance level of 5 %. Results: There is a correlation between alcohol consumption and psychological symptoms, such as insomnia, impulsivity, and memory impairment. As a result of analyzing all departments, insomnia, impulsivity, and memory impairment were the highest in the addiction level. In post-analysis of psychological symptoms, insomnia and impulsiveness had no significant difference, but there was a significant difference in memory impairment (p=.04). Conclusion: Our hope is that this study will help activate programs like preventative education and counseling on alcohol-related psychological symptoms for college students.

• 한국식생활문화학회지
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• 제30권5호
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• pp.596-610
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• 2015

This study is on the alcohol beverage utensils represented on the Chinese tomb mural paintings of Song, Liao, Jin, and Yuan those countries had foreign exchange with Koryo Dynasty. These mural paintings are distributed in the areas such as Hebei, Henan, Inner mongolia, Shanxi, Shaanxi, Peijing. etc. The Alcohol beverage vessels were classified mainly into storage vessel, pouring vessel, drinking vessel and ladles according to the purpose. The storage vessels of Song, Liao and Jin were called Jiuping, Jingping, Jiuzun as well as Meiping. Pouring vessels are basically one set of Zhuzi, Wenwan and Jiuzhu, or Zhuhu and Zhuwan. On the mural paintings of Yuan Dynasty, Meiping as storage vessels disappear, and a variety of shapes of pouring vessels such as Mayu and Yuhuchunping appear. This trend indirectly indicates the new arrival of distilled liquor, which seems to have affected transition of the alcohol beverage utensils.

• 정신신체의학
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• 제29권2호
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• pp.111-120
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• 2021

연구목적 이전 연구에 따르면 교대근무는 인간의 자연적인 일주기 리듬에 적응하기 어렵게 만들어 각종 건강문제를 일으킨다. 특히 교대근무자는 근무 일정과 연관된 수면의 어려움을 호소하는 경향이 있으며, 알코올을 수면유도를 위한 자가약으로 사용하는 경우가 있다. 현재까지 교대근무와 수면 및 음주와의 관련성에 관한 명확한 기전이 밝혀지지 않고 있는 상태이다. 따라서 이 연구에서는 교대근무와 수면과의 관련성을 확인하고, 교대근무로 인한 수면의 변화가 음주를 유발하는지에 대해 분석하고자 한다. 방 법 이 연구는 국민건강영양조사 제6기, 제7기 자료 중 2014, 2016, 2018년도를 분석대상으로 하였으며 총 11360명(남성 5704명, 여성 5656명)을 연구대상인원으로 포함시켰다. 6 am-6 pm사이의 근무형태를 주간근무, 이외의 근무형태를 교대근무로 정의하였으며 로지스틱 회귀분석을 통하여 교대근무와 수면의 질, 교대근무와 고위험 음주, 음주량 및 음주 횟수의 관계를 분석하였다. 또한 매개분석을 통하여 수면이 교대근무와 음주의 관계를 매개하는지 여부를 분석하였다. 결 과 교대근무는 남성과 여성에서 수면 질과 유의한 음의 관계를 보였다(남성 OR=1.37, 95% CI=1.11-1.70, 여성 OR=1.26, 95% CI=1.05-1.50). 교대근무와 음주와의 관계에서는 남성의 경우 유의한 관계가 나타나지 않았으나, 여성의 경우 교대근무와 음주횟수에서 유의한 양의 관계를 보였다(OR=1.34, 95% CI=1.04-1.72). 매개분석 시행 시 여성의 수면 질은 교대근무와 음주횟수의 관계를 부분매개하는 것으로 나타났다. 결 론 이 연구의 결과는 교대근무가 수면의 어려움을 유발하며, 여성의 경우에서는 수면의 부분매개효과를 통해 음주를 유발할 수 있음을 시사한다. 여성이 수면장애에 대한 대처방안으로 음주를 선택할 가능성이 높은 점을 고려할 때, 여성 교대근무자에 대한 보다 적극적인 중재방안이 마련된 필요가 있다.

• 지역사회간호학회지
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• 제18권3호
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• pp.391-399
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• 2007

Purpose: The purpose of this study was to investigate stress, depression and health risk behaviors in elderly people. Methods: The subjects were 238 Korean elders who had visited the convalescent center. The level of stress was measured by the Korean version of BEPSI, which was developed by Bae, Jeung & Yoo (1992) and modified by Yim et al.(1996). CES-D was used to measure the level of depression. For health risk behaviors, we measured cigarette consumption and alcohol drinking during the last one month. Results: Of the subjects, 17.4% were excessive drinkers and 18.9% were currently smokers. The level of stress was between moderate and high, and 62.7% of the subjects were depressed. There were significant differences in stress and depression according to economic status and self-reported health. In addition, depression had positive correlations with stress and QF score. Conclusion: Stress and depression management programs for the elderly are needed. These findings indicate that nurses must consider stress and alcohol drinking when they take care of depressed elderly people.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.204-204
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• 2002

Alcohol drinking during pregnancy can result in abnormal fetal development including fetal alcohol syndrome (FAS). The molecular mechanisms of FAS, however, is not completely elucidated. In the present study, we evaluated the developmental toxicity of ethanol and its metabolite, acetaldehyde using post implantation whole embryo culture and determined changes of gene expression by ethanol treatment by cDNA microarray.(omitted)

• Journal of Preventive Medicine and Public Health
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• 제40권4호
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• pp.321-328
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• 2007

Objectives : The aim of this study was to evaluate the roles of cigarette smoking, alcohol consumption, tuberculosis, and their interactions in the risk of lung cancer in a Korean cohort. Methods : The study subjects comprised 13,150 males and females aged above 20 years old. During the follow up period from 1993 to 2002, 79 lung cancer cases were identified by the central cancer registry and the national death certificate database. Information on cigarette smoking, alcohol consumption and the history of physician-diagnosed tuberculosis was obtained by interview. Indirect chest X-ray findings were also evaluated to ascertain tuberculosis cases. Cox proportional hazard models were used to estimate relative risks (RR) and 95% confidence intervals (CI) after adjusting for age and gender. Results : Cigarette smoking was statistically significantly associated with an increased risk of lung cancer [for current smokers, RR = 2.33 (95% CI = 1.23 - 4.42) compared to non-smokers]. After further adjustment for cigarette smoking, both alcohol consumption and tuberculosis showed no statistically significant association with the risk of lung cancer [for current drinkers, RR = 0.80 (95% CI = 0.48 - 1.33) compared to non-drinkers] [for tuberculosis cases, RR = 1.17 (95% CI = 0.58 - 2.36) compared to non-cases]. There was no statistically significant interaction between cigarette smoking and alcohol consumption (p-interaction = 0.38), or cigarette smoking and tuberculosis (p-interaction = 0.74). Conclusions : Although cigarette smoking was confirmed as a risk factor of lung cancer in this cohort study, this study suggests that alcohol consumption and tuberculosis may not be associated with the risk of lung cancer.

• 한국산학기술학회논문지
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• 제13권4호
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• pp.1690-1698
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• 2012

음주는 손상의 가장 위험 요인으로 정확한 평가를 위하여 세계보건기구에서 개발한 Alcohol Use Disorders Identification Test (만성음주행태측정 이하 AUDIT)와 같은 도구를 이용하여 성인에서의 음주행태와 손상 발생률 및 손상 세부 특성과의 연관성을 평가하고자 실시 하였다. 본 연구는 2009년도 국민건강영양조사를 이용하였으며 성인 만 19세 이상 성인 중 7,893명이 참여하여 손상에 응답한 7,511명, 그 중 음주행태조사 참여는 6,6362명 설문에 무응답 104명을 제외 최종 6,258명 연구 대상으로 분석하였다. AUDIT범주에 따른 손상 발생률 및 세부특성 즉 신체부위, 유형, 기전별 손상 발생율의 비교위험도를 T-test, ANOVA, Logistic regression 이용하여 산출하였다. 통계분석은 SPSS 19.0 통계프로그램을 사용하였다. 분석결과 체전손상에서 남자가 손상의 발생이 유의하게 높았다. 음주 관련 손상의 경우에서 남자가 여자에 비해 손상의 발생 위험이 8.3배 높았다. 교육은 고등학교 졸업자가 AUDIT이 가장 높은 비율을 보여 유의하였으며, 결혼한 사람과 월소득이 201-300만원인 사람들이 AUDIT가 가장 높게 나타났으며 유의하였다. 문제음주자와 알코올의존자에서 의미있게 증가된 신체부위의 손상은 두 경부에서 0.0371로 유의하게 나타났고 AUDIT와 손상외인 기전에서는 운수사고, 미끄러짐, 기타, 부딪힘, 추락의 순으로 나타났으며, 손상의 유형 분류상 기타(열상, 좌상, 중독, 관통상 등)에서 유의하였다. 음주로 인한 손상 및 손상외인의 기전은 매우 중요하며, 상담자를 통한 동기유발 조정이 이루어 지게 되면 음주횟수를 줄여 음주로 인한 손상을 완화시킬 수 있는 장치가 필요하다.