Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Cigarette Smoking, Alcohol Consumption, Tuberculosis and Risk of Lung Cancer: The Korean Multi-center Cancer Cohort Study

흡연, 음주, 폐결핵과 폐암 발생 위험에 관한 코호트 연구

  • Bae, Ji-Suk (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Gwack, Jin (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Park, Sue-Kyung (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Shin, Hai-Rim (National Cancer Center) ;
  • Chang, Soung-Hoon (Department of Preventive Medicine, Konkuk University College of Medicine) ;
  • Yoo, Keun-Young (Department of Preventive Medicine, Seoul National University College of Medicine)
  • 배지숙 (서울대학교 의과대학 예방의학교실) ;
  • 곽진 (서울대학교 의과대학 예방의학교실) ;
  • 박수경 (서울대학교 의과대학 예방의학교실) ;
  • 신해림 (국립암센터) ;
  • 장성훈 (건국대학교 의과대학 예방의학교실) ;
  • 유근영 (서울대학교 의과대학 예방의학교실)
  • Published : 2007.07.31
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Abstract

Objectives : The aim of this study was to evaluate the roles of cigarette smoking, alcohol consumption, tuberculosis, and their interactions in the risk of lung cancer in a Korean cohort. Methods : The study subjects comprised 13,150 males and females aged above 20 years old. During the follow up period from 1993 to 2002, 79 lung cancer cases were identified by the central cancer registry and the national death certificate database. Information on cigarette smoking, alcohol consumption and the history of physician-diagnosed tuberculosis was obtained by interview. Indirect chest X-ray findings were also evaluated to ascertain tuberculosis cases. Cox proportional hazard models were used to estimate relative risks (RR) and 95% confidence intervals (CI) after adjusting for age and gender. Results : Cigarette smoking was statistically significantly associated with an increased risk of lung cancer [for current smokers, RR = 2.33 (95% CI = 1.23 - 4.42) compared to non-smokers]. After further adjustment for cigarette smoking, both alcohol consumption and tuberculosis showed no statistically significant association with the risk of lung cancer [for current drinkers, RR = 0.80 (95% CI = 0.48 - 1.33) compared to non-drinkers] [for tuberculosis cases, RR = 1.17 (95% CI = 0.58 - 2.36) compared to non-cases]. There was no statistically significant interaction between cigarette smoking and alcohol consumption (p-interaction = 0.38), or cigarette smoking and tuberculosis (p-interaction = 0.74). Conclusions : Although cigarette smoking was confirmed as a risk factor of lung cancer in this cohort study, this study suggests that alcohol consumption and tuberculosis may not be associated with the risk of lung cancer.

Keywords

References

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