• Journal of Life Science
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• v.19 no.4
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• pp.532-537
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• 2009

Previous studies reported that the N-methyl-D-aspartate (NMDA) receptor is related to alcohol dependence in terms of developing withdrawal or tolerance, however, it is controversial whether NMDA receptor antagonists are effective in preventing relapse in alcohol-dependent patients or not. The purpose of this study was to investigate the effect of memantine, an NMDA receptor antagonist, on alcohol intake in C57BL/6 mice, which prefer drinking hereditarily. Using limited access procedures in C57BL/6 mice in the state of alcohol dependence, vehicle, naltrexone 1.0 mg/kg or, memantine 5, 25, or 50 mg/kg i.p. was administered respectively for twelve days. Medication effects on 2-hours alcohol, 22-hour water, and 24-hour food intake and body weight were studied. Using repeated measure ANOVA, the naltrexone 1 mg/kg, memantine 5, 25, or 50 mg/kg, and vehicle groups showed significant medication by day interaction (naltrexone, df=4, F=11.827, p<0.01, memantine 5 mg/kg, df=4, F=7.999, p<0.01; memantine 25 mg/kg, df=4, F=6.199, p<0.05; memantine 50 mg/kg, df=4, F=10.522, p<0.01) in 2-hour alcohol intake. In 3 memantine groups, there was no significant medication by day interaction with the vehicle group in 22-hour water intake, 24-hour food intake, or body weight. The naltrexone and vehicle groups showed significant medication by day interaction in body weight, but not in 22-hour water or 24-hour food intake. From these results, it is suggested that memantine treatment can affect alcohol intake in mice. Therefore, it is possible that a pure NMDA receptor antagonist is effective in preventing relapse in alcohol-dependent patients.

• The Journal of Internal Korean Medicine
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• v.28 no.1
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• pp.34-46
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• 2007

Objectives: This study was to assess characteristics in acute stroke patients according to Sasangconstitution (SC). Methods : We assessed the type of SC of acute stroke patients in $2^{nd}$ Department of Internal Medicine at KyungHee University Oriental Hospital from October 2005 to September 2006. Each subject's SC type was confirmed when the result of QSCC II+ was in accordance with the opinion of the Sasangconstitutional medicine specialist. We investigated general characteristics, stroke type, blood test results, alcohol drinking, smoking and dietary preferences according to SC. Results: 108 subjects were included in the final analysis. This study showed that out of the total patients, the proportion of So-yang to Tae-eum to So-eum was equal to 5.5 to 3.5 to 1. Especially, men were higher proportion So-yang while women recorded a more significant ratio of Tae-eum. Also, the BMI, waist circumference, hip circumference, and WC/HC ratio recorded significantly high results. The result indicated that even though the Tae-eum let on the highest numerical value in the aspect of their past history and the final diagnosis, no significant difference was revealed according to SC. The ratio of cerebral infarction to cerebral hemorrhage was 9 to 1. SVO, LAA, SUE are the 3 types of cerebral infarction classified by TOAST; SVO ranked the highest while SUE ranked the lowest in all constitutions. The blood test result displayed that averages of both TL and the T-chol were the highest in Tae-eum while that of hematocrit in So-yangand that of HDL-chol in So-eum. However, there was no significant difference. There were no significant differences classified by gender or by SC in the aspect of the alcohol drinking and smoking history. The majority of So-yang and Tae-eum demonstrated a preference for meat while So-eum and So-yang displayed high preferences for sea food. Conclusions : With respect to these results. we could observe the general disposition of various characteristic distributions according to SC of acute stroke patients. For further research in this field. it seems necessary to construct fundamental databases for the prevention and treatment of stroke by increasing the number of patients observed and by analyzing delicate characteristics of each constitution type.

• Journal of East-West Nursing Research
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• v.23 no.2
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• pp.180-189
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• 2017

Purpose: This study was conducted to identify the perception of and attitude toward dementia and depression among residents in a community. Methods: Data were collected using the questionnaire from 226 residents in Incheon city from February to May, 2017. The data were analyzed using t-test, ANOVA and Scheffe's test to identify differences in perception of and attitude toward dementia and depression. Pearson correlation coefficients were used to identify the correlation between the study variables, and multiple regression was used to identify factors affecting depression. Results: There were significant differences in perception of dementia according to age, education, marital status, and exercise. Also, significant differences in attitude toward dementia were found in occupation, family history of dementia and education about dementia. Depression was significantly different depending on the type of health insurance coverage and alcohol drinking. The scores of perception of dementia and depression were 11.09, 2.37, respectively on a 2-point scale and for attitude toward dementia was 85.94 on a 7-point Likert scale. The perception of dementia was positively correlated with the attitude toward dementia and there were negative correlations between perception of dementia and age and between depression and attitude toward dementia. Conclusion: The results of this study suggest that we should improve perception of and attitude toward dementia and reduce depression to prevent and manage dementia effectively.

• Research in Community and Public Health Nursing
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• v.23 no.1
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• pp.31-39
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• 2012

Purpose: The purpose of this paper was to compare community health status by region and to investigate related factors using community health and social indicators. Methods: Data were collected from statistics of local districts that were provided by KNSO and KCDC. ANOVA and correlation were analyzed using PASW 18.0. Results: The standardized cancer mortality rate was higher in metropolitan areas than in other areas. On the contrary, the mortality of respiratory disease, traffic accident, and suicide were higher in rural areas. Small cities and county districts showed higher prevalence in obesity prevalence than metropolitan areas. Metropolitan areas presented higher prevalence in alcohol drinking during the previous month, perceived stress, and seat belt use. The age-adjusted standardized mortality rate was correlated with higher prevalence of smoking, obesity, percentage of the elderly, number of beds, number of social welfare facilities, number of registered cars, lower percentage of financial independence, number of doctors, and percentage of water supply service & sewage. Conclusion: Since significant differences in mortality rate and prevalence of health risk behaviors exist between regional areas and the mortality rate was correlated with other social indicators and health indicators, health policies and social policies considering these differences should be develop and implemented to the communities.

• The Korean Journal of Health Service Management
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• v.7 no.1
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• pp.155-165
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• 2013

This study aims to identify the significance of adolescent suicidal ideation in a multicultural family, propose suicidal prevention strategies, and provide considerable foundations supporting their secured future. The research results are in the follow. For the results of main factors of relative influence on the suicidal ideation, the relative dangerousness levels were 5.5 times more likely to experience with drugs, 4.5 times more likely to have depressive symptoms, 3.2 times more likely to experience violence at school, and 2.8 times more likely to experience drinking alcohol, 1.4 times more likely to feel unhappiness and 1.3 times more likely to be bad off in economic status, all of which contribute to suicidal ideation. All results turned out to be statistically significant. Therefore, the findings and results of this study indicate that appropriate and practical prevention strategies to address the suicidal behavior of adolescents in a multicultural family need to be carefully considered and designed in a most urgent manner.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.14 no.1
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• pp.72-82
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• 2007

Purpose: The purpose of this study was to identify relationships among trait anger, life styles and physical symptoms in elderly people. Method: The participants were 348 elderly persons over 65 years of age who lived in Seoul, Geonggi Province, South Chungcheong Province and South Jeolla Province. The data were analyzed using descriptive $X^2-test$, t-test, one-way ANOVA and Pearson's correlation coefficient with SPSS win 12.0. Results: Physical symptoms of the participants correlated with trait anger and life style. Trait anger in the elderly people had a significant positive correlation to cardiovascular symptoms. Smoking showed a significantly positive correlation to alcohol drinking and cardiovascular symptoms. Regular diet showed a significantly negative correlation to general symptoms, cardiovascular symptoms and gastrointestinal symptoms. Caffeine intake significantly negative correlation to general symptom and cardiovascular symptom. Conclusion: These results suggested that elderly people with a high degree of trait anger are likely to be high in perceived physical symptoms. Therefore nursing interventions to reduce levels of trait anger and change life style should be provided for elderly people.

• The Journal of the Korea Contents Association
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• v.11 no.11
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• pp.329-337
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• 2011

This paper reports about relationships between stress and dietary life of the college students. From the survey results, 35.6% of the male students and 9.8% of the female students were overweight. Specially, the male students is in a critical situation than the females. Moreover, 66% of the students were very stressed out and it seemed to be continued for about 3days. The female students showed increase in the size of their meal when they were stressed, however the male students did not show difference on their meal. Most of the male students preferred to have alcohol & beverage when they are under lots of stress, and many females had sweets. The students in age 19~21 choose sweets, in 22~24 choose alcohol & beverage, and ages over 25 preferred spicy soup & stew. The students drunk alcohol & beverage for stress releasing never considering their monthly spending money. Many of the students said they worry about body weight after eating to get rid of stress, but they thought it is good for free from stress. The stress comes from worrying about their the past and the future life, or job & work. They release themselves from the stress listening to the music, sleeping or drinking alcohols. As a result, we need to provide them a nutrition education program that guide the students to improve their dietary life style.

• Research in Community and Public Health Nursing
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• v.21 no.2
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• pp.156-168
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• 2010

Purpose: The purpose of this study was to construct a questionnaire to assess male workers' sobriety behavior based on Ajzen's Theory of Planned Behavior (TPB). Methods: A primary questionnaire with 56 questions was constructed based on literature review and structured interview with male workers. The Content Validity Index (CVI) was evaluated by a group of experts, construct validity was tested by principle component analysis, and reliability was evaluated by Cronbach's ${\alpha}$ and the test-retest reliability test. Results: Fifty two questions showed higher than .8 of CVI. Four factors explained 78.71% of the total variance among items for sobriety intention and direct measure, and six factors explained 67.99% of the total variance among indirect measure items and those factors coincided with the variables of TPB in factor analysis. Cronbach's ${\alpha}$ of this questionnaire was .873 and the result of test-retest reliabilty test was relatively reliable. A total of 41 items with 7-point scale were constructed in the final version. Conclusion: This questionnaire was valid and reliable to measure sobriety behavior based on TPB in male workers. It can be useful to evaluate the result of a sobriety program for male workers.

• Journal of Korean Public Health Nursing
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• v.17 no.2
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• pp.299-316
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• 2003

A phenomenological methodology was used to identify the life of children living with alcoholic parents. Nine adolescents participated in the in-depth interviews, done between October and December 2001. The Colaizzi's method was used for data analysis. The results of this study are as follows. One theme and thirteen meanings were identified, The one theme is Paradoxical Coping in Life. The meanings are obsessive behavior as a way to control father's behavior, always on the defensive due to anxiety and tension, being afraid of life alone due to paranoid thoughts, contradictory expectations about father's drinking behavior due to life with chronic tension, stress becoming familiar and life being boring and tendious without stimulation, life that is fake and filled with misinterpretations about reality, affection sought from others due to loneliness, compensatory life within peer group, negative expectation about the future due to negative experiences, controling others to protect ego, denial of real emotion to protect self from hurt, life of regretting self, and strong need for approval from others. The results of this study can provide a foundation for the development of programs for children of alcohol dependent parents.

• Korean Journal of Occupational Health Nursing
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• v.17 no.2
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• pp.117-125
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• 2008

Purpose: The purpose of the study was to find the ways to prevent the fatigue of the office of railroad employees. Method: The data were collected from the male employees of Korea Railroad Corporation. Results: The mean score of the degree of fatigue was 4.33. The factors that affected the level of fatigue were support from senior officials, exercise, age, work stress, number of work hours per week, alcohol intake and working area. To be more specific, the level of fatigue was lower when the support from senior officials was higher. The employees who did no exercise, who are in the age between 31 and 40, with high working stress, who worked 61 hours per week of higher, non-drinkers were found to have higher level of fatigue. The employees with the age of 51 years or older with unspecified work area had relatively lower level of fatigue. Conclusion: In conclusion, to decrease the level of fatigue of the office of railroad employees, the development of health improvement programs are required such as increase of the support from senior officials, change in exercise and drinking habit, decrease of the work stress and adjustment of the working hours.