• 재활치료과학
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• 제4권2호
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• pp.63-71
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• 2015

Objective : The purpose of this study was to investigate the effects of vibratory stimulation applied to the left forearm on unilateral neglect in patients with stroke. Methods : The subjects were 11 unilateral neglect patients with stroke. They were divided into 2 groups; 6 experimental subjects and 5 control subjects. Both groups received standardized rehabilitation program and occupational therapy for the intervention of unilateral neglect in a day. In random order, line bisection test (LBT), Albert test, and star cancellation test (SCT) were conducted at baseline, the next day. During the process of all assessments of the next day, vibration stimulation was provided for the 6 subjects in the experimental group (EG), while the 5 subjects in CG carried out all assessments without vibration stimulation. Result : No significant differences were found between groups on any demographic variable or baseline assessments scores. In the next day, there was significant improvement in the EG for the LBT(p<0.05), Albert's test(p<0.05), and SCT(p<0.05). However, there was no significant improvement in the CG for the LBT(p<0.05), Albert's test(p<0.05), and SCT(p<0.05). Conclusion : These result indicate that vibratory stimulation has a positive effect on the unilateral neglect, and may be considered as alternative choice in clinical occupational therapy for reducing unilateral neglect.

• 대한한방내과학회지
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• 제37권2호
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• pp.156-165
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• 2016

Objectives: This study reports on two cases of the clinical application of traditional Korean medicine on stroke patients with hemi-spatial neglect.Methods: We applied several traditional Korean medicine treatments and then evaluated the patients’ symptoms with Albert’s test, the clock-drawing test (CDT), the Catherine Bergego scale (CBS), and the numeric rating scale (NRS).Results: The scores of all of the scales showed improvement. In case 1, the Albert’s test score decreased from 2.5% to 0%, the CDT score increased from 6 to 10, and the CBS score decreased from 16 to 11. In case 2, the Albert’s test score decreased from 5% to 2.5%, the CDT score increased from 3 to 6, and the CBS score decreased from 23 to 16.Conclusion: We found that acupuncture, moxibustion, herbal medicine, and physical therapy appeared to be effective treatments for hemi-spatial neglect in these two stroke patients.

• 대한물리치료과학회지
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• 제10권1호
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• pp.18-29
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• 2003

The purpose of this study by examine the effect of visual neglect on hemiplegia motor recovery are showing trouble which can be raised by visual neglect and helping the patient's ADL and functional recovering. Among the patients who are being taken physical therapy in many other hospitals in Busan From February 1st 2002 to august 31st, we chose 20 patients as control group who did not have symptoms of visual neglect and 20 other patients who did have as case group. We used Albert's test and line bisection as visual neglect test, and MAS as motor recovery. The average age of the patient group is 51.55 and that of control is 44.9. The men's rate is higher than women' s in both groups. Although the rate of left hemiplegia is higher than right hemiplegia in case group, that of right hemiplegia is higher than left hemiplegia in control group. There is much lesion site of basal ganglia in case group. There is the most amount of transformation of MAS when visual neglect is shorter than 1.5centimeter. Each change of MAS point before and after therapy in case group and control group is revealed $6.5{\pm}4.37$ and $12.5{\pm}5.95$.

• 재활치료과학
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• 제2권1호
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• pp.48-56
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• 2013

목적 : 국내 작업치료사들에 의해 가장 많이 사용되는 지필검사인 직선이분 검사 와 알버트 검사를 관찰을 통해 행동적 무시를 평가하는 CBS와 비교하여 상관관계를 살펴보고 편측무시에 대한 민감도가 더 높은 검사 도구를 알아보고자 하는 것이다. 방법 : 기준에 따라 선정된 좌측 편마비 환자 44명을 대상으로 CBS, 직선이분검사, 알버트 검사, K-MBI를 시행하여 편측무시 정도를 비교 분석하였다. 결과 : 관찰을 통한 행동적 무시 검사인 CBS는 지필검사인 직선이분 검사, 알버트 검사와 유의한 상관관계를 보였다(p < .01). CBS가 지필검사보다 편측무시에 대한 민감도가 더 높았고, 일상생활활동과 더 높은 상관관계를 보였다(p< .01). 결론 : 본 연구의 결과를 살펴볼 때 CBS가 지필검사에 비해 편측무시를 판별하기 더 유용하며 질병부인검사도 가능한 검사도구이다. 따라서 편측무시 검사와 치료 시 CBS의 적용이 고려되어야 할 것이다.

• 재활치료과학
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• 제7권1호
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• pp.27-35
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• 2018

목적 : 본 연구는 편측 공간무시 환자의 평가도구 중 KF-NAP (Kessler Foundation - Neglect Assessment Process)과 지필검사 (직선이분검사, 글자소거검사, 알버트 검사) 사이의 상관관계와 편측 공간무시에 대한 민감도가 높은 평가도구를 알아보고자 한다. 연구방법 : 2014년 9월부터 2015년 9월까지 서울 소재의 병원 재활의학과에 입원한 32명의 뇌졸중 환자를 대상으로 하였다 (남성 19명, 여성 13명, 평균연령 61.8세). KF-NAP과 지필평가는 입원 7일 이내에 시행하였으며, 각 평가도구의 결과 값으로 편측 공간무시 정도를 비교하였다. 결과 : 편측 공간무시 정도는 KF-NAP 93.8%, 직선이분검사 53.1%, 글자지우기 53.1%, 알버트 검사 37.5%로 편측 공간무시에 대한 민감도가 가장 높은 평가도구는 KF-NAP이었다. KF-NAP은 직선이분검사(r=.430), 글자 지우기(r=.641), 알버트 검사(r=.398) 모두에서 유의한 상관관계가 있었다 (p<0.05). 결론 : KF-NAP은 환자의 일상생활 동안 편측 공간무시를 평가하는 도구로써 지필검사에 비해 편측 공간무시의 진단에 더 민감할 뿐 아니라 편측 공간무시의 중증도에 대한 평가가 가능하다. 따라서 편측 공간무시의 평가에 KF-NAP이 유용하게 사용되어져야 한다.

• 대한한방내과학회지
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• 제44권2호
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• pp.87-96
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• 2023

Objective: This study reports the effectiveness of the Korean medicine treatment of patients with intracerebral and intraventricular hemorrhages suffering unilateral neglect symptoms. Case presentation: The patient was treated using Korean medicine, including acupuncture, herbal medicine, moxibustion, and a limb activation exercise. We measured Unilateral Neglect Symptom progress with a numeric rating scale, Albert's test, Line bisection test, Clock drawing test, and Catherine Bergego Scale. After eight days of combined Korean medicine and rehabilitation exercise, the Unilateral Neglect Symptom intensity reduced from NRS 8 to 6. In addition, Albert's test score decreased from 2.5% to 0%. The Line bisection test score decreased from 19 mm to 12 mm, and the Clock drawing test score improved from 8 to 10. Last, the Catherine Bergego Scale decreased from 12 to 9. No adverse events were observed during treatment. Conclusion: This study suggested that a complex treatment including Jaeumkunbi-tang, acupuncture, moxibustion, and limb activation exercise can be effective for an intracerebral hemorrhage with intraventricular hemorrhage patient suffering from Unilateral Neglect Symptoms. Consequently, more research is needed in the future.

• 한국임상보건과학회지
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• 제1권1호
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• pp.75-82
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• 2013

Purpose : The aim of this study was to identify the relation of cognition and visuospatial perception in stoke patients. Methods : A total of 16 stroke patients recruited from two hospital located in Donghae, Kang-won participated in this study(Right hemiplegia : twelve, Left hemiplegia : four). All participants scored higher than 20 point on the MMSE-K. To assess the cognitive function, we performed the Korean version of Mini Mental State Examination(MMSE-K), spatial perception domain of Lowenstein Occupational Therapy Cognition Assessment(LOTCA), Figure Color Copy(FCC), Linebisection Test(LBT) and Albert's test in stoke patients. Results: The Korean version of Mini Mental State Examination and spatial perception domain of Lowenstein Occupational Therapy Cognition Assessment were the highest points in sixty ages, Figure Color Copy is difference between Right hemiplegia and Left hemiplegia. Linebisection Test(LBT) and Albert's test had much relation, visuospatial perception had not relationship. Conclusion: Aging was cognition function and visuospatial perception had an interrelationship. visuospatial perception according to affected side in brain had an interrelationship but cognition function and visuospatial perception had not any interrelationship.

• 고령자･치매작업치료학회지
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• 제12권2호
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• pp.87-95
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• 2018

목적 진동자극기는 타 치료도구에 비하여 임상환경에서 손쉽게 구할 수 있으며, 팔 활성화훈련을 수동적으로 할 수 있다는 것이 장점이다. 다음과 같은 장점에도 불구하고 최근 진동감각에 관련한 연구는 활성화 되지 않고 있는 실정이다. 본 연구는 환측 상지의 손에 제공된 진동감각이 뇌졸중 환자의 편측무시 감소에 미치는 영향을 알아보는 것이다. 연구방법 뇌졸중으로 인한 편측무시 증상을 가진 환자를 대상으로 2018년 10월 19일부터 동년 11월 7일가지 약 3주간 실시하였다. 연구 설계는 개별실험 연구방법(single-subject experimental research design) 중 ABA설계를 사용하였으며, 평일 하루에 한 번 총 18회로 (기초선 과정 4회, 중재 과정 6회, 기초선 회귀 과정 3회)를 실시하였다. 대상자 선정을 위하여 MMES-K를 사용하였으며 편측무시 검사도구로는 선 나누기 검사(Line Bisection test; LBT), 알버트 검사(Albert's test), 별 지우기 검사(Star Cancellation Test: SCT)를 사용하였다. 분석을 위해서 기초선과 중재기의 회기 별 측정값은 그래프를 이용하여 시각적으로 분석하였고, 평균값을 사용하였다. 연구결과 세 가지 평가결과 모두 기초선 기간보다 훈련 기간에 놓친 오류의 개수가 감소하였고, 훈련 후에도이 감소는 유지되었다. 선 나누기 검사에서 평균 $4.5{\pm}1$개 누락에서 평균 $2{\pm}1.2$개 누락 그리고 평균 $0.6{\pm}0.5$개 누락으로 오차가 감소하였다. 알버트 검사 결과, 평균 $22.5{\pm}1.9$개 누락에서 평균 $8{\pm}7.3$개 누락 그리고 평균 $0.3{\pm}0.5$개 누락으로 오차가 감소하였다. 별 지우기 검사에서는 평균 $26{\pm}4.6$개 누락에서 평균 $21.8{\pm}1.7$개 누락 그리고 평균 $20{\pm}0$개 누락으로 오차가 감소하였다. 결론 본 연구에서는 진동감각 자극치료가 편측무시 증상 개선에 지속적인 효과가 있다는 결과를 보였다. 이러한 연구 결과를 바탕으로 추후의 연구에서는 객관성을 높이기 위한 보다 체계적인 연구가 진행되어야 할 것이며 중재효과를 더욱 극대화 시킬 수 있는 다양한 중재법에 대한 추가적인 연구가 필요할 것으로 사료된다.

• Journal of Multimedia Information System
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• 제8권3호
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• pp.197-202
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• 2021

Bitcoin and blockchain are often making headlines not only on TV or media but also among the public in today's society. These technologies have been developed after the risk of the centralized financial system came to the fore during the 2007 global financial crisis. Since then, an anonymous inventor called Satoshi Nakamoto penned the bitcoin white paper where a blockchain-based reference implementation was introduced. Bitcoin was able to achieve unprecedented growth by positioning itself as one of the top global currencies in terms of market capitalization after five years since its development. The pace of Vietnam's economic development is notably fast among Asian nations, while the nation was expected to be a Southeast Asian blockchain hub but they have banned virtual currency trading recently. However, they've also designated the State Bank of Vietnam (SBV) as a responsible agency for the research of blockchain-based cryptocurrencies, the construction of a service ecosystem, and their test operations. The fast-growing economy, increasing number of smartphone users, and the Vietnam government's support policies for startups substantiate these efforts. Therefore, this paper attempts to study the current status of Vietnam's blockchain technology that has been considered to be the center of blockchain systems right behind Singapore, and its implications for Korean companies.

• Archives of Pharmacal Research
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• 제27권6호
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• pp.633-639
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• 2004

The expression of therapeutic transgenes in recombinant adenoviral vectors is a major cause of toxicity in dividing cancer cells as well as non dividing normal cells. To solve the problem of toxicity to normal cells, we have reported on a recombinant adenoviral vector system （AdLP-） in which the expression of the transgene is directed by the tumor-specific L-plastin promoter （LP） （Chung et al., 1999）. The object of this study was to generate a recombinant adenoviral vector system which would generate tumor cell specific expression of cytosine deaminase （CD） gene. We report the construction of a replication-incompetent adenoviral vector in which CD is driven by the L-plastin promoter （AdLPCD）. Infection of 293 cells by AdLPCD generated the functional CD protein as measured by HPLC analysis for the conversion of 5-Fluorocy-tosine （5-FC） to 5-Fluorouracil （5-FU）. HPLC analysis in conjunction with counting radioactivity for ［6-$^3$H］-5FC and ［6-$^3$H］-5FU demonstrated vector dose-dependent conversion of 5-FC to 5-FU in AdLPCD infected ovarian cancer cells. The results from present and previous studies（Peng et al., 2001； Akbulut et al., 2003） suggest that the use of the AdLPCD／5-FC system may be of value in the treatment of cancer including microscopic ovarian cancer in the peritoneal cavity.