• International Journal of Oral Biology
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• v.35 no.3
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• pp.75-81
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• 2010

The present study investigated the role of ERK in the onset of mechanical and cold allodynia in a rat model of compression of the trigeminal ganglion by examining changes in the air-puff thresholds and number of scratches following the intracisternal injection of PD98059, a MEK inhibitor. Male Sprague Dawley rats weighing between 250 and 260 g were used. Under anesthesia, the rats were mounted onto a stereotaxic frame and received 4% agar ($10\;{\mu}l$) solution to compress the trigeminal ganglion. In the control group, the animals were given a sham operation without the application of agar. Changes in behavior were examined at 3 days before and at 3, 7, 10, 14, 17, 21, 24, 30, and 40 days after surgery. Compression of the trigeminal ganglion significantly decreased the air-puff thresholds. Mechanical allodynia was established within 3 days and persisted over postoperative day 24. To evaluate cold allodynia, nociceptive scratching behavior was monitored after acetone application on the vibrissa pad of the rats. Compression of the trigeminal ganglion was found to produce significant cold allodynia, which persisted for more than 40 days after surgery. On postoperative day 14, the intracisternal administration of $1\;{\mu}g$ or $10\;{\mu}g$ of PD98059 in the rat model significantly decreased the air-puff thresholds on both the ipsilateral and contralateral side. The intracisternal administration of $10\;{\mu}g$ of PD98059 also significantly alleviated the cold allodynia, compared with the vehicle-treated group. These results suggest that central ERK plays an important role in the development of mechanical and cold allodynia in rats with compression of the trigeminal ganglion and that a targeted blockade of this pathway is a potential future treatment strategy for trigeminal neuralgia-like nociception.

• Journal of the Korean Society of Clothing and Textiles
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• v.17 no.4
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• pp.577-586
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• 1993

Pesticide protective clothing has not been frequently worn due to its lack of thermal comfort. It is important to develop fabrics which can allow the wearer to work in comfort. One of the possible way to achieve the goal is to produce fabrics with a water- and oil-repellent finish which would resist pesticide penetration but maintain some breathability. The purpose of this study were to evaluate the pesticide barrier properties of untreated and water- and oil-repellent finished nonwoven fabrics. Three types of nonwoven fabrics(Tyvek, Sontara and Kimlon) were used as test specimens. By pad-dry-cure method, each of the specimen was treated with fluorocarbon. The pesticide barrier properties (amount of pesticide penetration and residue) were measured by the gas chromatography. The performance properties of untreated and treated specimens were evaluated with respects to water pepellency(KS K 0590), oil repellency(AATCC 118), water resistance(KS K 0591, AATCC 42), water vapor transmission (KS A 1013) and air permeability(KS K 0570). The results of this study were as follows : 1) The untreated Sontara showed much more amount of pesticide penetration than untreated Tyvek and Kimlon, while the treated Sontara showed little amount of pesticide penetration. 2) After laundering, the amount of pesticide residue in the untreated and treated Sontara was less than that in Tyvek and in Kimlon. 3) Water- and oil-repellent finish improved water repellency, oil repellency, and water resistance of specimens. 4) The untreated Sontara and Kimlon showed higher water vapor transmission and air permeability than untreated Tyvek. Water vapor transmission and air permeability of treated specimen decreased compared to those of untreated.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.16 no.11
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• pp.1051-1059
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• 2004

Two phase thermosyphone loop for electronics cooling are designed and manufactured to test its performance under the partial load and low environment temperature conditions. The thermosyphone device has six evaporators connected parallel for the purpose of cooling six power amplifier units (PAU) independently. The heater modules for simulating PAUs are adhered with thermal pad to the evaporator plates to reduce the contact resistance. There are unbalanced distributions of liquid refrigerant in the differently heated evaporators due to the vapor pressure difference. To reduce the vapor pressure differences caused by partial heating, two evaporators are connected each other using the copper tube. The pressure regulation tube successfully reduces these unbalances and it is good candidates for a field distributed systems. Under the low environment temperature operating condition, such as $-30^{\circ}C$, there may be unexpected subcooling in condenser. It leads the very low saturation pressure, and under this condition there exists explosive boiling in evaporator. The abrupt pressure rise due to the explosive boiling inhibits the supplement of liquid refrigerant to the evaporator for continuous cooling. Finally the cooling cycle will be broken. For the normal circulation of refrigerant there may be an optimum cooling air flow rate in condenser to adjust the given heat load.

• Journal of Aerospace System Engineering
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• v.16 no.4
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• pp.77-87
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• 2022

The Precision Aerial Delivery System is an instrument designed to improve the poor landing accuracy of aerial delivery system with conventional circular parachutes, and is equipped with an Airborne Guidance Unit to safely transport supplies to the desired destination. Currently, the landing accuracy of the PADS product is reported as CEP₅₀ 100m and also differs significantly, depending on the actual topography and weather environment. In this study, HILS was constructed based on the 6DOF nonlinear modeling of PADS to analyze the maneuver characteristics of Ram Air Parachute under wind environments. By using the new algorithm a precision soft landing algorithm including Energy Management and Final Approach is designed. HILS results show that it is possible to achieve a precise soft landing within CEP₅₀ 40m, and it can be exploited to develop an actual PADS drop test.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.3
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• pp.160-168
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• 2021

This study was undertaken to determine the effect of different cooling systems on the performance and hair cortisol of sows under heat stress. During a 21-day experiment, a total of 40 multiparous sows (Landrace×Yorkshire; 242.84±2.89 kg) were allotted to 4 treatments, each with 10 replicates (1 sow per pen). The experimental treatments were CP (Cooling pad), AC (Air conditioner), SC (Snout cooling), and MS (Mist spray). We observed an increase in the average daily feed intake during lactation (p<0.05) in the CP and AC treatment groups. AC treatment had the highest (p<0.05) and SC treatment had the lowest (p<0.05) piglet weight at weaning. During lactation, sows administered SC and MS treatments had higher (p<0.05) hair cortisol accumulation, as compared with the AC and CP treatments. Hair cortisol accumulation in piglets during lactation was highest with MS treatment (p<0.05), and lowest after CP treatment (p<0.05). MS treatment had the highest (p<0.05), and AC treatment had the lowest (p<0.05) respiratory rate and rectal temperature during lactation. In conclusion, our results indicate that a cooling pad and air conditioning cooling system increases the productivity of a sow, as compared to snout cooling and mist spray cooling systems.

• Journal of Aerospace System Engineering
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• v.14 no.1
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• pp.68-73
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• 2020

This purpose of this paper was to review the development trend of the VTOL MAVs with a ducted propellant that can fly like the VTOL at intermediate and high speeds, hovering, landing, and lifting off vertically over urban areas, warships, bridges, and mountainous terrains. The MAV differs in flight characteristics from helicopters and fixed wings in many respects. In addition to enhancing thrust, the duct protects personnel from accidental contact with the spinning rotor. The purpose of the U.S. Army FCS and DARPA's OAV program is spurring development of a the VTOL ducted MAV. Today's MAVs are equipped with video/infrared cameras to hover-and-stare at enemies hidden behind forests and hills for approximately one hour surveillance and reconnaissance. Class-I is a VTOL ducted MAV developed in size and weight that individual soldiers can store in their backpacks. Class-II is the development of an organic VTOL ducted fan MAV with twice the operating time and a wider range of flight than Class-I. MAVs will need to develop to perch-and-stare technology for lengthy operation on the current hover-and-stare. The near future OAV's concept is to expand its mission capability and efficiency with a joint operation that automatically lifts-off, lands, refuels, and recharges on the vehicle's landing pad while the manned-unmanned ground vehicle is in operation. A ducted MAV needs the development of highly accurate relative position technology using low cost and small GPS for automatic lift-off and landing on the landing pad. There is also a need to develop a common command and control architecture that enables the cooperative operation of organisms between a VTOL ducted MAV and a manned-unmanned ground vehicle.

• International Journal of Oral Biology
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• v.34 no.1
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• pp.1-6
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• 2009

The purpose of the present study was to examine the role of peripheral nitric oxide (NO) pathways in the onset of interleukin (IL)-1$\beta$-induced mechanical allodynia in the orofacial area. Experiments were carried out on male Sprague-Dawley rats weighing 230-280 gm and surgical procedures were performed under pentobarbital sodium (40 mg/kg, i.p.). Under anesthesia, a polyethylene tube (PE10) was implanted into the subcutaneous area of one vibrissa pad, which enabled the injection of IL-1$\beta$ or other chemicals. We subcutaneously injected 50 ${\mu}L$ of IL-1$\beta$ into a vibrissa pad through the implanted polyethylene tube with a 100 ${\mu}L$ Hamilton syringe. After the administration of 0.01, 0.1, 1, or 10 pg of IL-1$\beta$, withdrawal behavioral responses were examined. The subcutaneous injection of saline had no effects on the air-puff thresholds. Following the subcutaneous injection of 0.01, 0.1, 1, or 10 pg of IL-1$\beta$, the threshold of air puffs decreased significantly to 12 $\pm$ 3, 7 $\pm$ 2, 5 $\pm$ 1, or 5 $\pm$ 1 psi, respectively, in a dose dependent manner. Pretreatment with L-NAME, a nitric oxide synthase (NOS) inhibitor, blocked IL-1$\beta$-induced mechanical allodynia. However, neither D-NAME, an inactive isomer of L-NAME, nor vehicle affected the IL-1$\beta$-induced mechanical allodynia. Subcutaneous injection of IL-1$\beta$ increased the number of c-fos-like immunoreactive neurons, whereas pretreatment with L-NAME decreased this number, in the trigeminal caudal nucleus. These results suggest that pro-inflammatory cytokines and NO are important contributors to the pathogenesis of persistent and exaggerated IL-1$\beta$-induced pain states. Based on these observations, peripheral application of NOS inhibitors may be of therapeutic value in treating pain disorders in the clinic.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.22 no.1
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• pp.22-28
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• 2012

While a dash panel component, close to passengers, plays a very important role to protect heat and noise from a power train, it is also a main path that transfers vibration energy and eventually radiates acoustic noise into the cavity. Therefore, it is important to provide optimal design schemes incorporating sound packages such as a dash isolation pad and a floor carpet, as well as structures. The present study is the extension of the previous investigation how design variables affect sound radiation, which was carried out using the simple plate and framed system. A novel FE-SEA hybrid simulation model is used for this study. The system taken into account is a dash panel component of a sedan vehicle, which includes front pillars, front side members, a dash panel and corresponding sound packages. Design variables such as panel thicknesses and sound packages are investigated how they are related to two main NVH indexes, sound radiation power(i.e. structure-borne) and sound transmission loss(i.e. air borne). In the viewpoint of obtaining better NVH performance, it is shown that these two indexes do not always result in same tendencies of improvement, which suggests that they should be dealt with independently and are also dependent on frequency regions.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.05a
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• pp.618-622
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• 2004

The vibration test system of SITC(Satellite Integration and Test Center) at KARI(Korea Aerospace Research Institute) has been used successfully for the environmental tests of a majority of korean space programs, such as KOMPSAT, Koreasat KITSAT, STSAT and KSR program since 1996. To meet the recent needs of large size test facility available for the vibrational tests of the huge launch vehicles and tole-communication satellites which will be developed in the near future, KARI undertook to construct the large size multi-electromagnetic shaking system with 3 $\times$ 3m head expander system. The new system will consist of three electromagnetic shakers which has 160 kN thrust force individually, and be able te sustain up to 8 tons test load and 300 kNm overturing moment. And to avoid the tremendous cost and effort to furnish the seismic block with large size and weight, it will adopt a Lin-E-Air type configuration with which the seismic block is less severe than a Solid-Truninon type. In addition, to fulfill the strong requirement of high overturning moment the additional guidance system including a central bearing system on a central support and several pad bearings around the head expander body is now considered. This paper describes the configuration and the design parameters of the multi-shaking system which is under development by KARI's engineers.

• International Journal of Oral Biology
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• v.33 no.4
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• pp.155-162
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• 2008

The present study investigated inflammatory hypersensitivity following compression of the trigeminal ganglion in rats. Experiments were carried out on male Sprague-Dawley rats weighing 250-260 g. Under anesthesia, rats were mounted on a stereotaxic frame and injected with $8{\mu}L$ of 4% agar solution through a stainless steel injector to compress the trigeminal ganglion. In the control group, rats underwent a sham operation without agar injection. Injection sites were examined with a light micrograph after compression of the trigeminal ganglion. Air-puff thresholds (mechanical allodynia) were evaluated 3 days before surgery and 3, 7, 10, 14, 17, 21, 24, 30, and 40 days after surgery. Air-puff thresholds significantly decreased after compression of the trigeminal ganglion. Mechanical allodynia was established within 3 days and remained strong over 24 days, returning to preoperative levels approximately 40 days following compression. After subcutaneous injection of 5% formalin ($50{\mu}L$) in the compression of the trigeminal ganglion-treated rats, nociceptive scratching behavior was recorded for 9 successive 5-min internals. Injection of formalin into the vibrissa pad significantly increased the number of scratches and duration of noxious behavioral responses in sham-treated rats. Noxious behavioral responses induced by subcutaneous formalin administration were significantly potentiated in rats with trigeminal ganglion compression. These findings suggest that compression of the trigeminal ganglion enhanced formalin-induced infla-mmatory pain in the orofacial area.