Browse > Article

Compression of The Trigeminal Ganglion Enhances Nociceptive Behavior Produced by Formalin in The Orofacial Area of Rats  

Yang, Gwi-Y. (Department of Oral Physiology, School of Dentistry, Kyungpook National University)
Park, Young-H. (Department of Oral Physiology, School of Dentistry, Kyungpook National University)
Lee, Min-K. (Department of Oral Physiology, School of Dentistry, Kyungpook National University)
Kim, Sung-K. (Department of Endodontics, School of Dentistry, Kyungpook National University)
Ahn, Dong K. (Department of Oral Physiology, School of Dentistry, Kyungpook National University)
Publication Information
International Journal of Oral Biology / v.33, no.4, 2008 , pp. 155-162 More about this Journal
Abstract
The present study investigated inflammatory hypersensitivity following compression of the trigeminal ganglion in rats. Experiments were carried out on male Sprague-Dawley rats weighing 250-260 g. Under anesthesia, rats were mounted on a stereotaxic frame and injected with $8{\mu}L$ of 4% agar solution through a stainless steel injector to compress the trigeminal ganglion. In the control group, rats underwent a sham operation without agar injection. Injection sites were examined with a light micrograph after compression of the trigeminal ganglion. Air-puff thresholds (mechanical allodynia) were evaluated 3 days before surgery and 3, 7, 10, 14, 17, 21, 24, 30, and 40 days after surgery. Air-puff thresholds significantly decreased after compression of the trigeminal ganglion. Mechanical allodynia was established within 3 days and remained strong over 24 days, returning to preoperative levels approximately 40 days following compression. After subcutaneous injection of 5% formalin ($50{\mu}L$) in the compression of the trigeminal ganglion-treated rats, nociceptive scratching behavior was recorded for 9 successive 5-min internals. Injection of formalin into the vibrissa pad significantly increased the number of scratches and duration of noxious behavioral responses in sham-treated rats. Noxious behavioral responses induced by subcutaneous formalin administration were significantly potentiated in rats with trigeminal ganglion compression. These findings suggest that compression of the trigeminal ganglion enhanced formalin-induced infla-mmatory pain in the orofacial area.
Keywords
Formalin; Inflammatory pain; Pain; Trigeminal ganglion; Trigeminal neuralgia;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Ahn DK, Kim KH, Jung CY, Choi HS, Lim EJ, Youn DH, Bae YC. Role of peripheral group I and II metabotropic glutamate receptors in IL-1$\beta$-induced mechanical allodynia in the orofacial area of conscious rats. Pain. 2005b;118:53-60   DOI   ScienceOn
2 Attal N, Kayser V, Jazat F, Guilbaud G. Behavioural evidence for a bidirectional effect of systemic naloxone in a model of experimental neuropathy in the rat. Brain Res. 1989;494:276-84   DOI   ScienceOn
3 Beaver DL, Moses HL, Ganote CE. Electron microscopy of the trigeminal ganglion III. Trigeminal neuralgia. Arch Pathol. 1965;79:571-82
4 Cairns BE, Sim Y, Bereiter DA, Sessle BJ, Hu JW. Influence of sex on reflex jaw muscle activity evoked from the rat temporomandibular joint. Brain Res. 2002;957:338-44   DOI   ScienceOn
5 Choi HS, Lee HJ, Jung CY, Ju JS, Park JS, Ahn DK. Central cyclooxygenase-2 participates in interleukin-1$\beta$-induced hyperalgesia in the orofacial formalin test of freely moving rats. Neurosci Lett. 2003c;352:187-90   DOI   ScienceOn
6 Dandy DW. Concerning the cause of trigeminal neuralgia. Am J Surg. 1934;24:447-55   DOI   ScienceOn
7 Devor M, Amir R, Rappaport ZH. Pathophysiology of trigeminal neuralgia: the ignition hypothesis. Clin J Pain. 2002a;18:4-13   DOI   ScienceOn
8 Hilton DA, Love S, Gradidge T, Coakham HB. Pathological findings associated with trigeminal neuralgia caused by vascular compression. Neurosurgery. 1994;35:299-303   DOI   ScienceOn
9 Jung CY, Choi HS, Ju JS, Park HS, Kwon TG, Bae YC, Ahn DK. Central metabotropic glutamate receptors differentially participate in IL-1$\beta$-induced mechanical allodynia in the orofacial area of conscious rats. J Pain. 2006;7:747-56   DOI   ScienceOn
10 Love S, Coakham HB. Trigeminal neuralgia: pathology and pathogenesis. Brain. 2001;124:2347-60   DOI   ScienceOn
11 Lovely TJ, Jannetta PJ. Microvascular decompression for trigeminal neuralgia. Surgical technique and long-term results. Neurosurg Clin N Am. 1997;8:11-29
12 Kerr FW, Miller RH. The pathology of trigeminal neuralgia. Electron microscopic studies. Arch Neurol. 1966;15:308-19   DOI   ScienceOn
13 Koltzenburg M, Wall PD, McMahon SB. Does the right side know what the left is doing? Trends Neurosci. 1999;22:122-7   DOI   ScienceOn
14 Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 1992;50:355-63   DOI   ScienceOn
15 Sindrup SH, Jensen TS. Pharmacotherapy of trigeminal neuralgia. Clin J Pain. 2002;18:22-7   DOI   ScienceOn
16 Vos BP, Strassman AM, Maciewicz RJ. Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve. J Neurosci. 1994;14:2708-23   DOI
17 Beaver DL. Electron microscopy of the gasserian ganglion in trigeminal neuralgia. J Neurosurg. 1967;26:138-50   DOI
18 Choi HS, Ju JS, Lee HJ, Kim BC, Park JS, Ahn DK. Effects of intracisternal injection of interleukin-6 on nociceptive jaw opening reflex and orofacial formalin test in freely moving rats. Brain Res Bull. 2003b;59:365-70   DOI   ScienceOn
19 Choi HS, Ju JS, Lee HJ, Jung CY, Kim BC, Park JS, Ahn DK. Effects of TNF-alpha injected intracisternally on the nociceptive jaw opening reflex and orofacial formalin test in freely moving rats. Prog Neuropsychopharmacol Biol Psychiatry. 2003a;27:613-8   DOI   ScienceOn
20 Adams CBT. Microvascular compression: an alternative view and hypothesis. J Neurosurg. 1989;57:1-12
21 Rappaport ZH, Devor M. Trigeminal neuralgia: the role of self-sustaining discharge in the trigeminal ganglion. Pain. 1994;56:127-38   DOI   ScienceOn
22 Gardner WJ. Concerning the mechanism of trigeminal neuralgia and hemifacial spasm. J Neurosurg. 1965;19:947-58
23 Iwata K, Tashiro A, Tsuboi Y, Imai T, Sumino R, Morimoto T, Dubner R, Ren K. Medullary dorsal horn neuronal activity in rats with persistent temporomandibular joint and perioral inflammation. J Neurophysiol. 1999;82:1244-53   DOI
24 Jensen TS, Gottrup H, Sindrup SH, Bach FW. The clinical picture of neuropathic pain. Eur J Pharmacol. 2001;429:1-11   DOI   ScienceOn
25 Vickers ER, Cousins MJ. Neuropathic orofacial pain part 1--prevalence and pathophysiology. Aust Endod J. 2000a;26:19-26   DOI   ScienceOn
26 Vos BP, Strassman AM. Fos expression in the medullary dorsal horn of the rat after chronic constriction injury to the infraorbital nerve. J Comp Neurol. 1995;357:362-75   DOI   ScienceOn
27 Zhou Q, Imbe H, Dubner R, Ren K. Persistent Fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: implications for persistent orofacial pain. J Comp Neurol. 1999;412:276-91   DOI   ScienceOn
28 Jacquin MF, Chiaia NL, Rhoades RW. Trigeminal projections to contralateral dorsal horn: central extent, peripheral origins, and plasticity. Somatosens Mot Res. 1990;7:153-83   DOI   ScienceOn
29 Clavelou P, Pajot J, Dallel R, Raboisson P. Application of the formalin test to the study of orofacial pain in the rat. Neurosci Lett. 1989;103:349-53   DOI   ScienceOn
30 Okamoto K, Martin DP, Schmelzer JD, Mitsui Y, Low PA. Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain. Exp Neurol. 2001;169:386-91   DOI   ScienceOn
31 Lim EJ, Jeon HJ, Yang GY, Lee MK, Ju JS, Han SR, Ahn DK. Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1322-9   DOI   ScienceOn
32 Anderson LC, Rao RD. Interleukin-6 and nerve growth factor levels in peripheral nerve and brainstem after trigeminal nerve injury in the rat. Arch Oral Biol. 2001;46:633-40   DOI   ScienceOn
33 Dickenson AH, Sullivan AF. Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin. Pain. 1987;30:349-60   DOI   ScienceOn
34 Anderson LC, Vakoula A, Veinote R. Inflammatory hypersensitivity in a rat model of trigeminal neuropathic pain. Arch Oral Biol. 2003;48:161-9   DOI   ScienceOn
35 Benoist JM, Gautron M, Guilbaud G. Experimental model of trigeminal pain in the rat by constriction of one infraorbital nerve: changes in neuronal activities in the somatosensory cortices corresponding to the infraorbital nerve. Exp Brain Res. 1999;126:383-98   DOI
36 LaBuda CJ, Donahue R, Fuchs PN. Enhanced formalin nociceptive responses following L5 nerve ligation in the rat reveals neuropathy-induced inflammatory hyperalgesia. Pain. 2001;94:59-63   DOI   ScienceOn
37 Panneton WM, Klein BG, Jacquin MF. Trigeminal projections to contralateral dorsal horn originate in midline hairy skin. Somatosens Mot Res. 1991;8:165-73   DOI   ScienceOn
38 Wagner R, Myers RR. Endoneurial injection of TNF-alpha produces neuropathic pain behaviors. Neuroreport. 1996;7:2897-901   DOI   ScienceOn
39 Zakrzewska JM, Lopez BC, Kim SE, Coakham HB. Patient reports of satisfaction after microvascular decompression and partial sensory rhizotomy for trigeminal neuralgia. Neurosurgery. 2005;56:1304-11   DOI
40 McLaughlin MR, Jannetta PJ, Clyde BL, Subach BR, Comey CH, Resnick DK. Microvascular decompression of cranial nerves: lessons learned after 4400 operations. J Neurosurg. 1999;90:1-8   DOI   ScienceOn
41 Kitt CA, Gruber K, Davis M, Woolf CJ, Levine JD. Trigeminal neuralgia: opportunities for research and treatment. Pain. 2000;85:3-7   DOI   ScienceOn
42 Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain. 1992;51:5-17   DOI   ScienceOn
43 Bennett GJ. An animal model of neuropathic pain: a review. Muscle Nerve. 1993;16:1040-8   DOI   ScienceOn
44 Cairns BE, Sessle BJ, Hu JW. Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles. J Neurosci. 1998;18:8056-64   DOI
45 Yang CS, Jung CY, Ju JS, Lee MK, Ahn DK. Intracisternal administration of mitogen-activated protein kinase inhibitors reduced IL-1beta-induced mirror-image mechanical allodynia in the orofacial area of rats. Neurosci Lett. 2005;387:32-7   DOI   ScienceOn
46 Ahn DK, Jung CY, Lee HJ, Choi HS, Ju JS, Bae YC. Peripheral glutamate receptors participate in interleukin-1beta-induced mechanical allodynia in the orofacial area of rats. Neurosci Lett. 2004;357:203-6   DOI   ScienceOn
47 Stender A. Gangliolysis for the surgical treatment of trigeminal neuralgia. J Neurosurg. 1954;11:333-6   DOI
48 Ahn DK, Chae JM, Choi HS, Kyung HM, Kwon OW, Park HS, Youn DH, Bae YC. Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats. Pain. 2005a;117:204-13   DOI   ScienceOn
49 Kerr FW. Pathology of trigeminal neuralgia: light and electron microscopic observations. J Neurosurg. 1967;26:151-6   DOI
50 Benoliel R, Eliav E, Iadarola MJ. Neuropeptide Y in trigeminal ganglion following chronic constriction injury of the rat infraorbital nerve: is there correlation to somatosensory parameters? Pain. 2001;91:111-21   DOI   ScienceOn
51 Vickers ER, Cousins MJ. Neuropathic orofacial pain. Part 2-Diagnostic procedures, treatment guidelines and case reports. Aust Endod J. 2000b;26:53-63   DOI   ScienceOn
52 Vos BP, Benoist JM, Gautron M, Guilbaud G. Changes in neuronal activities in the two ventral posterior medial thalamic nuclei in an experimental model of trigeminal pain in the rat by constriction of one infraorbital nerve. Somatosens Mot Res. 2000;17:109-22   DOI
53 Jannetta PJ. Arterial compression of the trigeminal nerve at the pons in patients with trigeminal neuralgia. J Neurosurg. 1967;26:159-62   DOI
54 Yang GY, Lee JH, Ahn DK. Participation of NMDA and non-NMDA glutamate receptors in the formalin-induced inflammatory temporomandibular joint nociception. International Journal of Oral Biology. 2007;32:59-65   과학기술학회마을
55 Devor M, Govrin-Lippmann R, Rappaport ZH. Mechanism of trigeminal neuralgia: an ultrastructural analysis of trigeminal root specimens obtained during microvascular decompression surgery. J Neurosurg. 2002b;96:532-43   DOI   ScienceOn
56 Imamura Y, Kawamoto H, Nakanishi O. Characterization of heat-hyperalgesia in an experimental trigeminal neuropathy in rats. Exp Brain Res. 1997;116:97-103   DOI
57 Milligan ED, Twining C, Chacur M, Biedenkapp J, O'Connor K, Poole S, Tracey K, Martin D, Maier SF, Watkins LR. Spinal glia and proinflammatory cytokines mediate mirrorimage neuropathic pain in rats. J Neurosci. 2003;23:1026-40   DOI
58 Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain. 1990;43:205-18   DOI   ScienceOn
59 Kim KJ, Yoon YW, Chung JM. Comparison of three rodent neuropathic pain models. Exp Brain Res. 1997;113:200-6   DOI