• The Journal of the Korea Contents Association
• /
• v.13 no.10
• /
• pp.325-346
• /
• 2013

This study analyzed the differences of the religious activities, faith attitudes, depression and ego-integrity by the elderly's demographic characteristics. In addition, this study analyzed the effects of the elderly's religious activities and faith attitudes on depression and ego-integrity. The survey was conducted from May 4 to 25, 2013 among the aged 60 or older with Christian faith in the Seoul metropolitan areas. And 408 responses were used in the data analysis. As a summary of the results, first, there were partially differences in religious activities, faith attitudes, depression, and ego-integrity by the elderly's demographic characteristics. Second, the subjective religious activities and faith attitudes had a negative effect on depression factor, and all factors of the religious activities had a negative effect on anti-vitality factor of the elderly. Third, the subjective religious activities had a positive effect on the attitude about life and acceptance of death, and the organizational religious activities had a positive effect on the acceptance of aging. Also, all factors of the religious activities had a positive effect on the satisfaction of the present life.

• Journal of Chest Surgery
• /
• v.50 no.3
• /
• pp.153-162
• /
• 2017

Background: The mesenchymal-epithelial transition factor (MET) receptor can be overexpressed in solid tumors, including small cell lung cancer (SCLC). However, the molecular mechanism regulating MET stability and turnover in SCLC remains undefined. One potential mechanism of MET regulation involves the C-terminus of Hsp70-interacting protein (CHIP), which targets heat shock protein 90-interacting proteins for ubiquitination and proteasomal degradation. In the present study, we investigated the functional effects of CHIP expression on MET regulation and the control of SCLC cell apoptosis and invasion. Methods: To evaluate the expression of CHIP and c-Met, which is a protein that in humans is encoded by the MET gene (the MET proto-oncogene), we examined the expression pattern of c-Met and CHIP in SCLC cell lines by western blotting. To investigate whether CHIP overexpression reduced cell proliferation and invasive activity in SCLC cell lines, we transfected cells with CHIP and performed a cell viability assay and cellular apoptosis assays. Results: We found an inverse relationship between the expression of CHIP and MET in SCLC cell lines (n=5). CHIP destabilized the endogenous MET receptor in SCLC cell lines, indicating an essential role for CHIP in the regulation of MET degradation. In addition, CHIP inhibited MET-dependent pathways, and invasion, cell growth, and apoptosis were reduced by CHIP overexpression in SCLC cell lines. Conclusion: C HIP is capable of regulating SCLC cell apoptosis and invasion by inhibiting MET-mediated cytoskeletal and cell survival pathways in NCI-H69 cells. CHIP suppresses MET-dependent signaling, and regulates MET-mediated SCLC motility.

• Fisheries and Aquatic Sciences
• /
• v.23 no.2
• /
• pp.3.1-3.8
• /
• 2020

Background: The IGF system plays important roles in controlling growth, development, reproduction, and aging of organisms. Methods: To estimate maturation of the Pacific oyster Crassostrea gigas, we investigated the expression of insulin-like growth factor (IGF) system components and sex-specific genes. To determine the role of the IGF system in the growth and spawning period of female and male oysters, we examined mRNA expression levels of the C. gigas insulin receptor-related receptor (CIR), IGF binding protein complex acid labile subunit (IGFBP_ALS), and molluscan insulin-related peptide (MIP), as well as those of vitellogenin (Vg) and receptor-type guanylate cyclase (Gyc76C) in gonads of C. gigas collected between April and October, when sex can be determined visually in this species. Results: We found that MIP, IGFBP_ALS, and CIR mRNA expression levels were dependent on sex and month and were greater in males than in females. CIR and Vg mRNA expression levels were very similar among females, whereas IGF system components and Gyc76C were very similarly expressed among males. The highest expression values were observed in May, when oysters are mature; CIR and Vg mRNA expression levels were highest in females, and those of MIP, IGFBP_ALS, CIR, and Gyc76C were highest in males. Interestingly, we observed a 1:1 proportion of females to males during this period. Conclusion: Our results suggest that IGF system components, as well as Vg and Gyc76C, are associated with sexual maturation in C. gigas.

• The Journal of the Korea Contents Association
• /
• v.15 no.9
• /
• pp.257-272
• /
• 2015

This study is to verify how the economic, social and moderating effect factors of baby boomer generation workers' affect the subjective health evaluation. The subjective of this study was 1,202 workers of baby boomer generation by using the 4th data of Korea longitudinal study of aging(KLoSA) from Korea Labor Institute in 2012. Economic and social factors were selected as scales to analyze if there is meaningful difference in subjective health evaluation. Method of frequency analysis, t-test, ANOVA and correlation analysis was used, and multi regression analysis was also conducted to verify whether the private health insurance has control effect over the relation between the subjective health evaluation and the economic & social factor. As a result of the study, age, education, home ownership, peer group meeting, overall satisfaction, private health insurance were major factors affecting the subjective health evaluation of baby boomer generation. Moreover private health care were turned out to have a moderation effect in relation between economic, social factor and subjective health evaluation.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.45 no.2
• /
• pp.167-172
• /
• 2012

Minerals from marine materials such as deep ocean water and Dead Sea water have been used since ancient times. We made a mask pack sheet including deep ocean water and salt from the Dead Sea and evaluated the function of the mask pack sheet through animal study. Three full-thickness skin defects were made on the backs of Sprague-Dawley rats. The wounds were left untreated in group Con, and mask pack sheets including deep ocean water or deep ocean water and Dead Sea water were used as treatment for 20 min on the skin of animals in groups DP and DDP, respectively. We analyzed the gross, histological and biochemical findings. Groups DDP and DP showed decreases in wound size, as compared to group Con at 7 days after wound infliction. The histological findings revealed that wound healing had progressed further in groups DP and DDP than in group Con, with more rapid collagen deposition and regression of neutrophils. Also, the expression of vascular endothelial growth factor and transforming growth factor ${\beta}1$ were increased in groups DDP and DP compared with those in group Con at 3 days after wound infliction. Mask sheet packs including deep ocean water and Dead Sea salt affected wound healing by reducing the inflammatory phase and stimulated wound contracture by facilitating the deposition of collagen.

• Korean Journal of Social Welfare
• /
• v.67 no.2
• /
• pp.183-202
• /
• 2015

This study examined the relationships among fear of falling, ADL/IADL disability, and depressive symptoms among Korean community-dwelling middleaged and older adults based on the disablement process model. The panel data from the Korean Longitudinal Study of Aging(KLoSa) were used to test whether fear of falling affects disablement process as a risk factor and an exacerbator. The results of path analysis showed that middle-aged and older adults who reported fear of falling were more likely to experience ADL/IADL disability and depressive symptoms, and fear of falling influenced depressive symptoms through increasing the risk of ADL/IADL disability. In addition, fear of falling exacerbate the risk of ADL/IADL disability among middle-aged and older adults who had chronic illnesses. The results indicated that fear of falling is not only risk factor but also excerbator in predicting ADL/IADL disability and depressive symptoms prospectively.

• Land and Housing Review
• /
• v.7 no.3
• /
• pp.147-156
• /
• 2016

The government has been supplying public rental housing for stable life of low-income group since 1989. However, deteriorated public rental housing are likely to caused accident due to aging facilities. In this study, investigated the types of accidents that occur in the public rental housing and analyzed the hazard factors for each type. First, identified the type of accidents that occur in apartment through previous studies and interviews. Next determined the type of accidents that occur in public rental housing and analyzed the hazard factors through surveys. The results of this study would be basic information of planned and systematic management plan for safe and comfortable residental life in public rental housing. And it can be utilized on the basis information that can improve the design and management method to supply future public rental housing.

• The Korean Journal of Physiology and Pharmacology
• /
• v.22 no.4
• /
• pp.457-465
• /
• 2018

The expression of BCL-2 interacting cell death suppressor (BIS), an anti-stress or anti-apoptotic protein, has been shown to be regulated at the transcriptional level by heat shock factor 1 (HSF1) upon various stresses. Recently, HSF1 was also shown to bind to BIS, but the significance of these protein-protein interactions on HSF1 activity has not been fully defined. In the present study, we observed that complete depletion of BIS using a CRISPR/Cas9 system in A549 non-small cell lung cancer did not affect the induction of heat shock protein (HSP) 70 and HSP27 mRNAs under various stress conditions such as heat shock, proteotoxic stress, and oxidative stress. The lack of a functional association of BIS with HSF1 activity was also demonstrated by transient downregulation of BIS by siRNA in A549 and U87 glioblastoma cells. Endogenous BIS mRNA levels were significantly suppressed in BIS knockout (KO) A549 cells compared to BIS wild type (WT) A549 cells at the constitutive and inducible levels. The promoter activities of BIS and HSP70 as well as the degradation rate of BIS mRNA were not influenced by depletion of BIS. In addition, the expression levels of the mutant BIS construct, in which 14 bp were deleted as in BIS-KO A549 cells, were not different from those of the WT BIS construct, indicating that mRNA stability was not the mechanism for autoregulation of BIS. Our results suggested that BIS was not required for HSF1 activity, but was required for its own expression, which involved an HSF1-independent pathway.

• The Korean Journal of Applied Statistics
• /
• v.29 no.5
• /
• pp.987-998
• /
• 2016

Auto insurance is an insurance product that requires the proper application of pricing techniques due to intense market competition and the rate regulations of financial authorities. Especially, population change according to aging and rating faction segmentation mainly affect the pricing process. This study suggests a pricing optimization methodology through the proper estimation of age factors. To properly estimate the future distribution of age factor, age change, renewal and conversion of customers are considered as main effects for the optimization of estimation and application. The properness and effectiveness for the suggested method will be proved by a comparison of results applied (one for current distribution and the other for future distribution) at the off-balance process. This study suggests an appropriate risk estimation methodology based on optimization that uses the proper estimation of future distribution to protect from the over or under estimation of risk.

• Journal of the East Asian Society of Dietary Life
• /
• v.15 no.4
• /
• pp.475-482
• /
• 2005

As Korea has approached the aging society, older Koreans have become an important force in restaurant sales today. To succeed with this silver market, it is important for restaurant managers to know who they are and which factor influence the older Koreans' eating-out decision making process. The purpose of this study was to investigate the effect of the elderly consumers financial independency on restaurant selection process. Data were collected from 178 older consumers above 55 years old and analyzed using the descriptive statistic analysis, MANOVA, and one-way ANOVA. The results showed that the elderly consumers financial independency significantly influenced the decision making process in determining where they eat out Significant differences were found between high income group and low income group in the Problem Recognition Step(Wilks' Lambda=0.776, F=3.796), Information Search Step(Wilks' Lambda=0.779, F=2.959), Alternative Evaluation Step (I :Wilks' Lambda=0.835, F=1.748/ II :Wilks' Lambda=0.764, F=3.212), and Purchase Decision Step(Wilks' Lambda=0.849, F=2.412), except the Post-Purchase Behavior(Wilks' Lambda=0.933, F=1.179). The more financially independent older consumers were, the more directly they were involved in the eating out decision making process. Older consumers with higher income and more personal property were likely to 'propose to eat out by themselves'(F=10.986), to obtain restaurant information from the 'printed materials'(F=9.707), to consider 'convenient location' as most important factor when they eat out(F=5.594), and to go to 'family restaurant'(F=7.067), 'Japanese restaurant'(F=7.391) and 'fine dining restaurants'(F-=6.382). In conclusion, we found that the elderly consumers financial independency did influence the eating-out decision making process. Considering that older Korean will become a financially independent consumer and will be eating away from home more often, food service operations should actively position themselves for this market and develop the market-driven menus and services to meet their needs and expectations.