• 대한본초학회지
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• 제38권4호
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• pp.45-52
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• 2023

Objectives : Fine dust caused by environmental pollution cause oxidative damage and skin aging. In this study, The possibility of using the Codium fragile extract (CFE) as an anti-aging product for skin improvement was evaluated by confirming the protective effect of skin cells from PM10 (particulate matter 10) through inhibition of ROS and MMPs. Methods : In this study, elastase and collagenase inhibitory activities were evaluated. Cell viability was evaluated by treating keratinocytes (HaCaT cell line) with CFE at various concentrations. The cytoprotective effect from PM10 in keratinocyteswas evaluated using the 3-[4,5-dimethylthiazol]-2-yl]-2,5-diphenyl-tetrazoliumbromide (MTT) assay. ROS (reactive oxygen species) was measured in keratinocytes damaged by PM10 using DCF-DA (2′,7′-dichlorofluorescin diacetate) fluorescence staining. As an anti-aging effect of CFE, MMP-1 (matrix metalloproteinase-1) and MMP-1 (matrix metalloproteinase-9) inhibitory activities were evaluated. Results : As a result, CFE decreased the activity of elastase and collagenase. As a result of evaluating the toxicity of CFE, it is non-toxic at a concentration of 10 to 80 ㎍/㎖. Although cell viability of HaCaT cells treated with PM10 decreased, cell viability increased by 38% when treated with CFE 80 ㎍/㎖. Also, ROS decreased by 8.4%, and MMP-1 and MMP-9 decreased at CFE 80 ㎍/㎖. Conclusions : CFE showed excellent cell protection effect, and it is considered that it can be used in anti-aging products for skin improvement by effectively inhibiting ROS and MMPs from keratinocyte damage caused by fine dust.

• 한국노년학
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• 제36권4호
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• pp.1075-1088
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• 2016

본 연구는 고령자의 활동적 노화가 삶의 만족도에 미치는 영향요인을 분석하여, 고령자의 삶의 만족도를 향상시키기 위한 활동적 노화 증진방안을 모색하는데 목적을 두고 있다. 이를 위해 활동적 노화를 건강요인, 참여요인 및 보장요인으로 구분하고 국민노후보장패널 자료를 활용하여 55세 이상의 가구원 총 5,501명을 최종분석 대상으로 위계적 회귀분석을 실시하였다. 분석결과 고령자의 활동적 노화가 삶의 만족도에 미치는 영향에 대한 설명력은 34%로 나타났으며, 고령자의 활동적 노화 요인 중에서 건강요인인 주관적 건강상태와 심리적 건강상태, 참여요인인 노동시장의 참여 유무 및 보장요인인 소득수준과 주거보장이 삶의 만족도에 영향을 미치는 것으로 확인되었다. 활동적 노화 요인 중에서 삶의 만족도에 영향을 미치는 결정요인은 건강요인으로 확인되었으며, 이중에서도 주관적 건강상태가 삶의 만족도를 가장 많이 설명하는 결정요인으로 나타났다. 따라서 고령자의 활동적 노화를 촉진하고 삶의 만족도를 높이기 위해서는 고령자의 신체적 정신적 건강증진, 노동시장 참여 및 주거보장을 위한 국가적 지역적 차원의 다양한 정책 및 실천이 추진되어야 할 것이다.

• 한국식품과학회지
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• 제21권4호
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• pp.549-555
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• 1989

저급육인 한우숫소의 앞다리고기를 도살직후 $16{\pm}2^{\circ}C$에서 고온숙성하여 연도개선 효과를 검토하였다. 또한 24시간 고온숙성한 후, 재구성육을 조제하여 결착성 개선방법을 모색하였다. 시료의 처리는 소금(0, 0.5, 1.0%), pyrophosphate(0, 0.3, 0.5%)와 이들의 혼용효과를 검토하였고, 소금(0.5%)과 pyrophosphate(0.3%)를 혼용한 원료에 succinic anhydride(0, 0.1, 0.2, 0.3%)를 첨가하여 석시닐산의 첨가효과를 검토하였다. 얻어진 결과는 다음과 같다. 1. 고온숙성은 저온숙성에 비하여 전단력이 낮았고, 근원섬유소편화지수가 높았으며, 연도개선의 효과가 뛰어났다. 전자현미경에 의한 형태학적 변화의 결과도 이들 결과 일치하였다. 2. 재구성육의 파단응력은 소금과 인산염의 첨가수준이 증가할수록 높아졌고, 소금과 인산염을 혼용할 경우, 현저히 증가하였다. 3. 조리수율은 소금과 인산염의 첨가수준이 증가할수록 낮아졌고, 소금과 인산염을 혼용할 경우, 현저하게 감소하였다. 4. TBA가는 소금 첨가수준에 비례하여 증가하였으며, 인산염 및 인산염과 소금혼용의 경우는 약간 증가하는 경향이었다. 5. 석신산은 재구성육의 결착력과 품질개선에 전혀 도움이 되지 않았다.

• 혜화의학회지
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• 제13권2호
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• pp.327-335
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• 2004

Using aged Wistar rat living body change by aging Dokhwaljihwang was each orally administrated and achieved research about aging control. In Wistar rat 10, 30, 50 week and 40 week Dokhwaljihwang between 10 weeks form condition change of weight, change of intestine weight, hematology, blood chemistry, research result about serum content following conclusion get. 1. Observed gain in weight than control group form of Dokhwaljihwang to aged Wistar rat. 2. Is thought to promote activation of living body action gaining intestine weight along with gain in weight. 3. Displayed decrease of MDA's content of serum than control group form of Dokhwaljihwang to aged Wistar rat. 4. Change that is Wistar rat's hematological value by aging according to 10, 30, 50 week WBC, RBC, Hgb, monocytes, eosinophil etc. increase, and HCT, PLT etc. showed tendency that decrease according to old-week, and observed improvement that is hematological value than control group form of Dokhwaljihwang 5. Change that is Wistar rat's biochemical value by aging was measured highest in 50 week because ALT, AST, BUN, CRN, T-bili., T-chol, TG, TP, ALB, A/G, P etc. increase according to 10, 30, 50 week, and observed improvement that is biochemical value than control group form of Dokhwaljihwang. Is considered by being effect that Dokhwaljihwangimprove living body function decline by aging by this result.

• 대한안전경영과학회지
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• 제8권2호
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• pp.81-90
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• 2006

As aging society makes rapid progress, various social problems arise. The drop of productive labor and the increase of welfare cost can be taken as examples. From this point of view, a use of aged labor is a matter of great Important to national productivity improvement. But, the participation rate of the aged in economical activity amounts to 49.8 percent and their unemployment rate does 2.1 percent. The purpose of this paper is to analyze the deterioration of skill and the lowering of adaption to new working environments due to aging. Since the aging effect is closely related to worker's productivity, it should be properly measured and analyzed. The coordination tester is used to find out activity limitations. Experimental results show that the expert skill of the workers can be improved through the effective of their experience. Therefore we can say that some operation is not influenced by aging.

• 한국전문물리치료학회지
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• 제5권1호
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• pp.63-78
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• 1998

The decrease of muscle power and muscle size between twenties and seventies was about 30% and 40% respectively. The loss of muscle mass by aging resulted in the decrease of muscle power. The loss of muscle mass was due to the decrease of number of Type I fiber and Type II fiber and size of each muscle fiber. The aging skeletal muscle didn't show the loss of glycolysis capacity but showed 20% decrease of the oxidative enzymes and muscle vascularization. The vigorous endurance exercise training with graded intensity played a role in the vascular proliferation, increase of activity of oxidative enzymes and improvement of $VO_2$ max. The graded resistance exercise also played a role in the muscle hypertrophy and increase of muscle power, if it performed with adequate intensity and period. The exercise adaptation of aging skeletal muscle prevented it from sarcopenia, provided the activity of daily living with great effect and provided the aging related disease, that is Type II diabetes mellitus, arteriosclerosis, hypertension, osteoporosis and obesity, with great effect.

• Toxicological Research
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• 제35권4호
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• pp.353-359
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• 2019

The purpose of this study was to investigate the effect of $7-MEGA^{TM}$ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, $7-MEGA^{TM}$ 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with $7-MEGA^{TM}$ 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by $7-MEGA^{TM}$ 500. Therefore, the intake of $7-MEGA^{TM}$ 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed.

• Elastomers and Composites
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• 제22권2호
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• pp.109-120
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• 1987

In this study, as one of the developing ways of the functional elastomer, improvement of the functionality of CB-BR was attemped through stabilization. At first the stabilization effect of CB-BR and the concentration dependancy in CB-BR were determined. Then, triazine thiol derivative(BPTT) was synthesized by reacting p-aminodiphenylamine with cyanuric chloride. Further the functional mechanism and the effects of the antioxidants were investigated using BPTT together with other various antioxidants in liquid and solid states. The results obtained are as follows: 1) The aging of CB-BR depended on the concentration and temperature. Thus, at a low temperature of $50^{\circ}C$, the aging proceeded with gel formation; at high temperature above $100^{\circ}C$ and in above 4wt% concentration, the aging occured by the formation of gel. And in concentrations below that, the aging proceeds with a decomposition caused by oxygen attacked to elastomer molecules. 2) The effect of antioxidation of CB-BR in the liquid state was at it's best when the MBIZ and BPTT were used at $110^{\circ}C$, 4hrs after the oxidation. 3) The effect of antioxidation of CB-BR in the solid state was the best choice the simultaneous use of NDBC and BPTT at $50^{\circ}C$, 30days after the oxidation.

• 한국건설순환자원학회논문집
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• 제10권1호
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• pp.30-39
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• 2022

본 연구에서는 비탈면 보강을 위해 순환자원을 재활용하여 개발된 시멘트 대체재료를 사용하여 노후 저수지의 사면 개량 재료로 활용하기 위해 실내시험 및 수치해석, 현장에서의 시험시공을 실시하고, 결과를 분석하였다. 실내시험 결과, 점착력과 내부마찰각의 변화를 고려할 때 시멘트 대체재료의 혼합비는 9 %가 적절하며, 투수계수는 약 10,000배 감소하여 국내에서 적용되고 있는 차수재료에 근접한 수준을 나타내는 것으로 분석되었다. 또한 수치해석과 시험시공 결과, 시멘트 대체재료를 사용하여 보강한 부분에서는 침투가 발생하지 않고, 국내 기준 대비 높은 안전율을 확보할 수 있어 충분한 차수 및 보강효과를 보이는 것으로 나타났다. 따라서 노후 저수지를 보강하기 위해 사용되고 있는 기존의 시멘트를 사용한 보수 및 보강방법을 충분히 대체할 수 있을 것으로 판단된다.

• 한국안전학회지
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• 제15권4호
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• pp.78-87
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• 2000

The $\gamma$-ray irradiation and aging effects on electrical characteristics of $^{60}Co$ $\gamma$-ray irradiated ethylene-propylene-diene-terpolymer(EPDM) contained with 1 to 3phr phenolic and quinolinic antioxidants as antirads were investigated. The marked effects of type and amounts of the antioxidant on the volume resistivity and AC breakdown strength of the $\gamma$-ray irradiated EPDM are different. A phenolic antioxidant(IR 1010) contribute to improving the electrical insulation properties on the EPDM better than quinolinic antioxidant(Kumanox RD) during irradiation. In aging the irradiated EPDM specimens contained antioxidants at room temperature in air, it was shown a improvement of insulation properties due to radical scavenging and crosslinking of EPDM aged until 360 days.