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http://dx.doi.org/10.5487/TR.2019.35.4.353

Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin  

Park, Kyo-Hyun (Department of Public Health, Keimyung University)
Kim, JiYeon (Department of Public Health, Keimyung University)
Jung, Suryun (Department of Public Health, Keimyung University)
Sung, Kyung-hwa (Environmental Health Services Center, Daegu Catholic University)
Son, Yeon-Kyoung (R&D Team, Food & Supplement Health Claims)
Bae, Jung Min (Department of Technical Assistance, Agency for Korea National Food Cluster (AnFC))
Kim, Bae-Hwan (Department of Public Health, Keimyung University)
Publication Information
Toxicological Research / v.35, no.4, 2019 , pp. 353-359 More about this Journal
Abstract
The purpose of this study was to investigate the effect of $7-MEGA^{TM}$ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, $7-MEGA^{TM}$ 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with $7-MEGA^{TM}$ 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by $7-MEGA^{TM}$ 500. Therefore, the intake of $7-MEGA^{TM}$ 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed.
Keywords
$7-MEGA^{TM}$ 500; Photoaging; Hairless mice; c-Jun; MMP-3;
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