• 대한임상전기생리학회지
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• 제3권1호
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• pp.31-47
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• 2005

Fatigue is a common experience in our daily life and in therapeutic exercises. Human muscle fatigue has been studied using a wide variety of exercise models, protocols and assessment methods. This study conducts quantitative evaluation of fatigue of knee extensor with surface electromyography and dynamometer and is to provide basic materials in physical therapy diagnosis and assessment of skeletal muscle. Measurement of two stages was conducted with 88 normal adults between their twenties and seventies, correlations and differences using collected data according to age was compared and correlations among measured items were analyzed and then the following conclusions were obtained. Analysis of sEMG and dynamometry of knee extensor showed that MDF, FI, MVIC, ET had the closest relations with age and MDF, FI, MVIC were significantly increase with aging. In addition, it was found that there were high correlation among items of analysis.

• IMMUNE NETWORK
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• 제15권4호
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• pp.177-185
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• 2015

Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in the clinical field to assess disease activity and severity. Recently, there has been increasing interest in the discovery of new diagnostic RA biomarkers that can assist in evaluating disease activity, severity, and treatment response. Proteomics, the large-scale study of the proteome, has emerged as a powerful technique for protein identification and characterization. For the past 10 years, proteomic techniques have been applied to different biological samples (synovial tissue/fluid, blood, and urine) from RA patients and experimental animal models. In this review, we summarize the current state of the application of proteomics in RA and its importance in identifying biomarkers and treatment targets.

• 한국병원경영학회지
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• 제14권4호
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• pp.52-70
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• 2009

This study is to analyse the reimbursement prices of drugs in Japan. Japan has the world's second-largest pharmaceutical market, and the world's largest price-controlled pharmaceutical market. The reimbursement prices of new drugs in Japan are determined by confidential negotiations between the manufacturer and the Japanese Ministry of Health, Labor, and Welfare. Pharmaceuticals account for a larger share of total healthcare expenditures in Japan than in most other major pharmaceutical markets such as France, Germany, United Kingdom and United States. Prescription drugs' share of total healthcare spending has slightly increased in recent years, from 20.2% in 2000 to 21.5% in 2004, the most recent year for which data are currently available. This trend is attributable to the effect of the Japanese rapidly aging population that stimulates demand for healthcare services. There are several method of price setting for drugs as below. First, on the initial pricing of branded drugs, is the similar-efficacy pricing method and cost calculation method. Second is postmarketing price changes which are biennial price revisions under the rule of National Health Insurance. Third is the rule of the generics price. Recently, the generics market is expanded because there are increasing numbers of hospitals by DPCs(Diagnosis-procedure Combinations).

• 한국임상보건과학회지
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• 제2권3호
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• pp.203-208
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• 2014

Purpose. To analysis the refractive error in 7-9 year-old Korea children. Methods. From July 2013 to June 2014, two hundred eighty two subjects were performed in refraction test using the Auto-Refractometry. Results. The refractive error by spherical equivalent among all subjects was myopia 47.58%, emmetropia 42.35%, astigmatism 32.33%, and hyperopia 8.76%. Myopia was more common in female than males although the difference was not statically significant. The axis of astigmatism was with the rule in 65%, against the rule in 31.5%, and oblique in 3.5% There was a statistical significance between 7 year and 9 year of male in the spherical equivalent power(p=0.010). Also there was a statistical significance between 7 years and 9 years of female in the spherical equivalent power(p=0.036). However, there was not a statistical significance between male and female in spherical equivalent power(p>0.5). Conclusions. In this study, myopia was the most common refractive error. On the other hand, The prevalence of the axis of astigmatism was the with- the- rule. The spherical equivalent of refractive error was similar results between male and female. However The refractive error was different style with aging. these data suggested that the analysis of the refractive error at young children can provide the information of useful diagnosis for the correction of visual acuity.

• 전기학회논문지
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• 제59권6호
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• pp.1087-1094
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• 2010

We have developed a cylindrical multi-terminal capacitive-conductive sensor that could be attached to the internal surface of cooling system pipe to evaluate capacitance and conductivity of heat transfer fluid. It was used as measuring system to diagnose insulating condition, by which was kept a insulating resistance of inner stack and at the same time was cooled electrochemical heat of reaction of FCEV(fuel cell electric vehicle) stack that used a compressed hydrogen gas reacting with oxygen in accordance with variation on thermal degradation of nonconductive heat transfer fluid. Also to assess diagnosis characteristics of heat transfer fluid, i.e. coolant, we have performed accelerated aging test using developed sensor attached to cooling system. Consequently, it was measured dielectric and electric resistance of coolant to estimate and analyse for dielectric properties by degradation condition.

• 대한물리치료과학회지
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• 제8권2호
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• pp.1015-1021
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• 2001

Objectives: The objective of this study was to investigate analysis of women with low back pain and osteoporosis were measured for 40 normal in the women from July 20, 2000 to October 20, 2000. Methods: Bone mineral density(BMD) of lumbar spine was measured using energy absorptiometry and were correlated with age, calcium. alkaline phosphatase. bone mineral density standard T scores(p<0.05). Results: The bone mineral density of the lumbar spine decreased with aging, The bone mineral density of the lumbar spine decreased with the serum calcium and phosphate increased. The mean bone mineral density of the lumbar spine of healthy women in age($50\sim59$) was $0.83g/cm^2$, the lumbar spine of women low back pain in age($50\sim59$) was 0.75 glad. Conclusion: In the multiple regression of risk factors to bone mineral density(BMD) of lumbar spine were correlated with age, of abortion, calcium, bone mineral density standard T scores(p<0,05). In the prevention and early diagnosis and treatment of osteoporosis, the physician should consider the risk factors.

• 센서학회지
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• 제15권5호
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• pp.362-370
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• 2006

The wireless sensor network (WSN) based ECG and body temperature measuring system for ubiquitous health-care were designed and developed. The system was composed of a wireless sensor network node, base station and server computer for the continuous monitoring of ECG signals and body temperatures of patients at home or hospital. ECG signal and body temperature data, important vital signals which are commonly used in clinical and trauma care, were displayed on a graphical user interface (GUI). The data transfer from sensor nodes on patients' body to server computer was accomplished through a base-station connected to a server computer using Zigbee compatible IEEE802.15.4 standard wireless communication. Real-time as well as historical, ECG data of elderly persons or patients, can also be retrieved and played back to assist the diagnosis. The ubiquitous health care system presented in this study can effectively reduce social medical expenses, which will be increased greatly in the coming aging society.

• 한국임상약학회지
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• 제27권3호
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• pp.136-142
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• 2017

Background: Dementia is one of important social and economic healthcare issues in the aging age. Therefore, it signifies to analyze the relationship between chronic disease or cardiovascular drug use and the incidence of dementia to establish a basis for increasing or preventing the risk of dementia. The purpose of this study was to investigate the correlation between the prevalence of chronic diseases and the use of cardiovascular drugs in patients diagnosed with dementia. Methods: In this study, we used data from sample of elderly patients from the Health Insurance Review and Assessment Service. We analyzed by logistic regression analysis with age, gender, and medication as covariates. KCD-7 was used to diagnosis of the disease, and drugs were analyzed using ATC codes and Korean standardized drug classification codes. Results: A total of 1,276,331 patients were analyzed in the sample of the elderly population, of which 532,075 (41.7%) were male and 744,256 (58.3%) were female. The patients have the higher risk of dementia in the older, women, and lower socioeconomically status. Cerebral infarction and ischemic heart disease increases risk of dementia. Patients taking statins, angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptor antagonists (ARB) showed low incidence of dementia. Conclusion: This study has been shown that ACEI, ARB, and statin drugs may associate with lower incidence of Alzheimer's and other dementia except vascular dementia.

• 한국철도학회논문집
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• 제9권4호
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• pp.357-361
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• 2006

This paper dealt with the performance evaluation and the diagnostic techniques of lightning arresters for DC electric traction vehicle. Field Measurements on the protective operation of lightning arresters against surge currents were carried out on running vehicles to acquire the data necessary for the diagnosis. The frequency and the magnitude of surge events were analyzed. Surge currents of $1\sim3$ times were recorded in one running service route and their magnitudes were ranges of $150A\sim2kA$. Also, an acceleration experiment on a lightning arrester by the standard lightning impulse current of 8/20 us and 5 kA was performed to know the aging characteristics. After the surge current application of 3,000 times, the reference voltage decreased by 4.5 %, and the leakage current was below 10 uA at the continuous operating voltage and about 50 uA at the rated voltage. From the experimental results, we propose a decision level of leakage current for the arrester used in this paper and designed an arrester tester which analyzes arrester condition by the magnitude of leakage current.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2006년도 Spring Conference
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• pp.123-135
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• 2006

Alzheimer's disease (AD) is the most common form of dementia in the aging population and is clinically characterized by a progressive loss of cognitive abilities. Pathologically, it is defined by the appearance of senile plaques - extracellular insoluble, congophilic protein aggregates composed of amyloid $\beta$ (A$\beta$) and neurofibrillary tangles (NFTs) - inyracellular lesions consisting of paired helical filaments from hyperphosphorylated cytoskeletal tau protein as described by Alois Alzheimer a century ago. These hallmarks still serve as the major criteria for a definite diagnosis of the disease. Consequently, one of the key strategy for drug development in this disease area focuses on reducing the concentration of cerebral A$\beta$ plaque by using substances that inhibit A$\beta$ fibril formation. We focused on developing inhibitors by synthesizing several kinds of aromatic molecules. The synthetic compounds were initially screened to evaluate the effective compound by tioflavin T fluorescence assay. The selected effective compounds were tested cytotoxicity and protective effect from A$\beta$-induced neuronal toxicity by cell based MTT assay with HT22 hippocampal neurons. The BBB permeability on effectors was also tested in in vitro co-culture model(HUVEC/C6 cell line). The behavior test wea carried out in mutant APP/PS1 transgenic mouse model of Alzheimer's disease. And inhibition of A$\beta$ fibril formation by the effective compound was monitored with transmitted electron microscopic images.