• BMB Reports
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• v.55 no.7
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• pp.323-335
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• 2022

Together with neuronal loss, the existence of insoluble inclusions of alpha-synuclein (α-syn) in the brain is widely accepted as a hallmark of synucleinopathies including Parkinson's disease (PD), multiple system atrophy, and dementia with Lewy body. Because the α-syn aggregates are deeply involved in the pathogenesis, there have been many attempts to demonstrate the mechanism of the aggregation and its potential causative factors including post-translational modifications (PTMs). Although no concrete conclusions have been made based on the previous study results, growing evidence suggests that modifications such as phosphorylation and ubiquitination can alter α-syn characteristics to have certain effects on the aggregation process in PD; either facilitating or inhibiting fibrillization. In the present work, we reviewed studies showing the significant impacts of PTMs on α-syn aggregation. Furthermore, the PTMs modulating α-syn aggregation-induced cell death have been discussed.

• Proceedings of the KIEE Conference
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• 2008.10a
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• pp.165-166
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• 2008

We investigate characteristics of J-aggregation as take advantage of LB technic. In order to confirm the applications possible for the molecular electronic device, the morphological properties of merocyanine dye were investigated by AFM. ${\pi}-A$ curves investigated the surface pressure of the LB film from a liquid to a solid state ranged between 90 and 100 mN/m. We observed aggregation and it's characteristics by using visible reflection spectroscopy. We have observed morphology of merocyanine dye on gold surface by STM. focuses on results obtained in mercocyanide dye of J-aggregation. When LB films of merocyanine dye are mixed with arachidic acid, J-aggregate formation is exhibited. J-aggregate formation has been serving as typical systems in revealing the physical and structural aspects of nano-sized molecular aggregates constructed as muiltilayers.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.50 no.1
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• pp.6-12
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• 2001

This paper deals with the development of dynamic equivalents of the Korea Electric Corporation (KEPCO) systems. The weak coupling method is chosen for the most suitable coherency identification to represent the characteristics of the KEPCO system by the dynamic characteristic comparison of several coherency identification methods. Also, this paper shows the detail aggregation of generator groups makes a better representation of the dynamic and static characteristics of the original system than the classical aggregation. The simulation results of the developed KEPCO equivalent system are presented in comparison with the original system to illustrate the validity of the equivalent system are presented in comparison with the original system to illustrate the validity of the equivalent system.

• Journal of Korean Institute of Industrial Engineers
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• v.40 no.1
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• pp.140-150
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• 2014

University ranking models, though they consider multiple indicators to evaluate universities, determine the overall score of each university based on their own normalization and aggregation methods. Thus, the rankings provided by such models primarily depend on actual scores of evaluation indicators, but they are also significantly affected by the normalization and aggregation methods. We examine the normalization methods of four university ranking models used in South Korea, China, and United Kingdom. We discuss a possible unintended consequence of these methods, i.e., some universities who want to improve their rankings may focus on unnecessary indicators, contrary to the evaluator's intension, due to the normalization methods. We suggest a new normalization method based on the statistical characteristics of the distribution of each evaluation indicator so that the new method can motivate the universities to move into the desirable directions intended by the evaluator.

• Journal of Korea Society of Industrial Information Systems
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• v.27 no.3
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• pp.127-144
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• 2022

This study attempted to analyze the influence of both internal and external business environment factors on the characteristics of the management accounting system (MAS). For this, external business environment factors were divided into environmental uncertainty and market competition while internal factors were classified into management strategy, organizational structure and advanced manufacturing technology. In addition, the characteristics of the MAS were categorized into information scope, timeliness, integration and aggregation. The study results found the followings: Among business environment factors, environmental uncertainty had a relatively significant effect on the scope, integration and aggregation of information while organizational structure revealed the largest influence on timeliness. However, market competition had no particular effect on the characteristics of the MAS.

• International Journal of Vascular Biomedical Engineering
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• v.1 no.2
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• pp.4-12
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• 2003

The present study investigated the effect of transverse vibration on the hemorheological characteristics of blood using a newly designed pressure-scanning capillary viscometer. As vibration was applied, aggregated blood cells (rouleaux) were disaggregated. The range of vibration frequency and amplitude are $0{\sim}100\;Hz$ and $0{\sim}0.8\;mm$, respectively for a capillary diameter 0.84 mm. As vibration increased, blood viscosity initially increased and tended to decrease. In order to delineate the unexpected results, the present study proposed two counteracting mechanisms of vibration related with red blood cell (RBC) aggregation affecting hemo-rheological properties. One is the reduction of RBC aggregation due to vibration causing an increase of blood viscosity. The other is forced cell migration due to the transverse vibration, which in turn forms a cell-free layer near the tube wall and causes a decrease of flow resistance.

• Korea-Australia Rheology Journal
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• v.16 no.3
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• pp.129-134
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• 2004

The aggregation characteristics of red blood cells (RBCs) were measured using a newly developed light-transmission slit rheometer. Conventional methods of RBC disaggregation such as the rotational Couette system were replaced with a pressure-driven slit flow system with a vibrational mechanism. Using a vibration generator, one can disaggregate the RBC aggregates stored in the slit. While shear stress decreases exponentially, instantaneous pressure and the transmitted light intensity were measured over time. Applying an abrupt shearing flow after disaggregation caused a rapid elongation of the RBCs followed by loss of elongation with the decreasing shear stress. While the shear stress is further decreasing, the RBCs start to re-aggregate and the corresponding transmitted intensity increases with time, from which the aggregation indices can be obtained using a curve-fitting program.

• The Journal of the Korea institute of electronic communication sciences
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• v.8 no.1
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• pp.71-76
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• 2013

In this paper, end-to-end performances for some VoIP traffics are measured and analyzed over MANET(Mobile Ad-hoc Networks) with packet aggregation transmission under blackhole attacks. A VoIP simulator based on NS-2 is used for performance measure. In the simulation, MOS, call connection ratio, network delay and packet loss rate are measured for end-to-end transmission performance. With analysis of measured data, characteristics of each traffics for performance parameters of packet aggregation transmission is showed on MANET under blackhole attack, As a results of this paper, some considerations be required for packet aggregation transmission are suggested to implement VoIP services on MANET under blackhole attacks.

• Journal of KIISE
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• v.42 no.6
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• pp.781-790
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• 2015

In recent times, microblogs have become popular owing to the development of the Internet and mobile environments. Among the various types of microblog data, those containing location data are referred to as spatial social Web objects. General aggregations of such microblog data include data aggregation per user for a single piece of information. This study proposes a spatial aggregation algorithm that combines a general aggregation with spatial data and uses the Geohash and MapReduce operations to perform spatial social analysis, by using microblog data with the characteristics of a spatial social Web object. The proposed algorithm provides the foundation for a meaningful spatial social analysis.

• Journal of Microbiology and Biotechnology
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• v.13 no.5
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• pp.809-814
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• 2003

${\beta}-amyloid$ ($A{\beta}$) peptides from the proteolytic processing of ${\beta}-amyloid$ precursor protein (${\beta}-APP$) aggregates in the brain to form senile plaques, and their aggregation plays a key role in pathogenesis of Alzheimer's disease (AD). To isolate an active compound that has an $A{\beta}$ aggregation-inhibitory activity, 2,000 microbial metabolite libraries were screened based on their ability to inhibit $A{\beta}$ aggregation by using both Congo red and thioflavin T assays. As a result, a water-soluble fraction of a soil microorganism, KK565, showed a potent $A{\beta}$ aggregation-inhibitory activity. The strain was identified as Streptomyces species, based on the cultural and morphological characteristics, the presence of diaminopimelic acid in the cell wall, and the sugar patterns for the whole-cell extract. In addition, the purification of active principle resulted in identifying a heat-unstable protein responsible for the $A{\beta}$ aggregation-inhibitory activity.