• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.2
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• pp.485-500
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• 2018

The behavior of cement-based permeation grouting is divided into three different groups depending on the grain size distribution of the soils: (1) zone of cement-based permeation grouting not feasible; (2) zone of cement-based permeation grouting feasible; and (3) zone in which an accelerating agent should be added to limit the penetration depth. In the cement-based permeation grouting feasible zone, the concept of a representative pore radius was proposed. The ratios of the representative pore radius to the mean pore radius were obtained by performing laboratory test and comparing with clogging theory; these values were in the range of 1.07 and 1.35 depending on the grain size distribution of the soils. In addition, a functional relationship between the lumped parameter (${\theta}$), the representative pore radius and the w/c ratio were derived by comparing and matching experimental results with predictions from theory. In the zone in which the accelerating agent should be added, the controlling process of gel time to limit the penetration depth was experimentally verified. The test results matched well with those obtained from theory utilizing the developed grout penetration program on condition that the viscosity increasing tendency of grout suspension with time is properly taken into account.

• Journal of KIISE:Computing Practices and Letters
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• v.7 no.1
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• pp.63-76
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• 2001

As reusability becomes recognized more importantly, with the introduction of ObjectOriented Programming Languages, developers not only want to reduce development duration, but also to develop a proper system robustly and safely by renovating the Hot Spot in order to reuse the existing framework. When we perform these works, we need the development environment which is the Rapid Application Development tool, and the RAD tools provide us with the convenient development environment. The need of RAD tools is recognized by every Object-Oriented programmer, and many business enterprises are developing them. In this paper, we will present a design and implementation of module-based modeler as a method for developing technique to constmct user-driven Intranet environment for the generation of the program based on the framework. The framework modeler used Java language that is independent on platform, and applied the technique of OMT editor that provides the UML notation partially. Additionally, The modeler also includes the notations that are not supported in OMT editor. In addition to this characteristic, it is structured to develop system consistently with applying the Agent pattern, which is a design pattern suggested by ourselves, to send messages occurred between various Views. The existing MVC(Model-View-Controller) architecture does not have this function. Thus, this tool has a flexibility when user's requirements are changed, or functions are extended.

• The Korean Journal of Pharmacology
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• v.32 no.1
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• pp.93-102
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• 1996

Platinum coordination complexes are currently one of the most compounds used in the treatment of solid tumors. However, its use is limited by severe side effects such as nephrotoxicity. Our platinum-based drug discovery program is aimed at developing drugs capable of diminishing toxicity and broadening the clinical spectrum of activity of cisplatin. We synthesized new Pt(II) complex analogue containing 1,2-diaminocyclohexane (dach) as carrier ligand and 1,3-bis(diphenyl phosphino)propane (DPPP) as a leaving group. Furthermore, nitrate was added to improve the solubility. A new series of PC-1 [Pt(cis-dach) (DPPP)]. $2NO_3_2$ was synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (IR), $^{13}carbon$ nuclear magnetic resonance (NMR)]. PC-1 was demonstrated acceptable antitumor activity aganist SKOV -3, OVCAR-3 human ovarian adenocarcinomacells and significant activity as compared with that of cisplatin. The toxicity of PC-1 was found quite less than that of cisplatin using MTT, $[^3H]thymidine$ uptake and glucose consumption tests in rabbit proximal tubule cells, human kidney cortical cells and human renal cortical tissues. Based on these results, this novel platinum compound represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low toxicity.

• Journal of KIISE:Software and Applications
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• v.32 no.12
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• pp.1271-1282
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• 2005

Recently, PC-based control is incredibly developed in the industrial control field, but it is difficult for PLC programming in PC. Therefore, I need to develop the softeware PLC, which support the international PLC programming standard(IECl131-3) and can be applied to diverse control system by using C language. In this paper, I have developed the ISPLC(Intelligent Agent System based Software Programmable Logic Controller). In ISPLC system, LD programmed by a user which is used over $90\%$ among the 5 PLC languages, is converted to IL, which is one of intermediate codes, and IL is converted to the standard C rode which can be used in a commercial editor such as Visual C++. In ISPLC, the detection of logical error in high level programming(C) is more eaier than PLC programming itself The study of code conversion of LD->IL->C is firstly tried in the world as well as KOREA. I developed an execution engine with a good practical application. To show the effectiveness of the developed system, 1 applied it to a practical case, a real time traffic control(RT-TC) system. ISPLC is minimized the error debugging and programming time owing to be supported by windows application program.

• Membrane Journal
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• v.24 no.6
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• pp.484-490
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• 2014

To find out the feasibility of the separating/enriching esters from aqueous solution using FASs (Fluoloalkyl-silanes-coupling agent)-surface modified hydrophobic membrane, the solubility parameter of FASs was obtained and compared with those of esters and water. The value of the solubility parameter of FASs (${\delta}_t=16.9$) was almost same with those of esters (ethyl acetate ${\delta}_t=18.1$, propyl acetate ${\delta}_t=18.0$, ethyl propionate ${\delta}_t=17.9$, butyl acetate ${\delta}_t=17.4$, ethyl butyrate ${\delta}_t=17.0$). However, the calculated value of the solubility parameter of water was ${\delta}_t=47.8$, which was far from the value of the solubility parameter of FASs (${\delta}_t=16.9$). This means that the FASs-modified membrane has a much higher affinity to esters than water. The experimental results of permeation flux of esters used in this study showed that the order of permeation flux predicted by the solubility parameter was almost coincide with experimental results. It might be concluded that the solubility parameter may be applicable for a separating/enriching flavors from aqueous natural-flavor solution, in which esters are main components of natural flavors.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.5 no.4
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• pp.1-9
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• 2002

This study is carried out to make the environmentally affinitive porous planting block for revegetation and to make a effective program for greening plans. The summary is shown below. 1. In order to get stronger intensity and distribute proper porosity in the block for planting, the cements mixed with fine soil were used and the finer in soil grains gives the stronger in intensity of the cements. Use of the furnace slag cements instead of the portland cements showed relatively stronger in intensity of the block. The intensity of the block became stronger when the mixed ratio of the cements to soil is 5 : 1, but the pore space ratio was lower. The percolate pH of the portland cements after one month of treatment was 13.1 but the percolate pH of the furnace slag cements was shown lower. To mold proper porous planting blocks, the proper combination of additives such as the dehydrating agent, elastic agent and adhesives into the mixture of cements and soil gives better effectives. 2. After molding the porous planting blocks, it gave a better result when the grains of the filler made of peat moss, upland soil and compound fertilizer were smaller than 2 mm in size. Shaking of the filling materials also gave the better result, but it took more time and cost much more. Therefore, it was better when the filling materials were mixed with water first then flew down for stuffing. 3. It was necessary to cover with soil after seeding or planting on the porous planting blocks. The proper thickness of the soil to help root development and keep moisture is about 3~5 cm. 4. The plants for planting on the porous planting block were required stronger in the growth condition of their roots and their environmental adaptability. The average germination percentage and rate of Platycodon grandiflorum on the porous planting block were 88.8% and 85% accordingly and their rate is very uniform. The germination rates of Dianthus superbus var. longicalycinus and Taraxacum officinale were more than 50%. These grass species, Chelidonium majus var. asiaticum, Lysimachia mauritiana and Scabiosa mansenensis were the suggested biennial grasses in the planting area where exchanging of the seedling or nursery plants was not necessary because their germination rates were 59.3, 45.6 and 40.3% accordingly. Viola kapsanensis, Chrysanthemum sp., Taraxacum sp. and Iris ensata var. spontanea are the grass species that could be used by seeding for greening. However, the germination rate of Solidago virga-aurea var. asiatica, Aster scaber and Lythrum anceps were lower than 10%. The coverage ratio of Ixeris stolonifera is more than 80% after 60 days seeding and the root length of most of species are more than 10 cm except Iris ensata var. spontanea and Platycodon grandiflorum because their root developed thicker than other species.

• Korean Journal of Social Welfare Studies
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• v.47 no.4
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• pp.333-360
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• 2016

Social Impact Bonds(SIBs) has emerged as a promising way to finance proven social services programs, fund what works, and drive government accountability and has increased fast. In this context, this study examines and classifies the structure of SIB focusing key criteria of the main steps through two-step cluster analysis. Analysis results are as follows. First, the main commissioners of SIB are the ministries of the central government. And in terms of the stage of invest, there are usually two or three investors mainly consisting of social finance organizations. Second, in terms of target and age of SIB beneficiaries, it focuses on the adolescent and youth. Third, in the outcome evaluation stage, the results show that in most cases outcome payments are determined by a validation of service provider or government administrative data. However, the rate of payments are based on the comparison of the program beneficiaries to other comparable groups is 23.8%. Finally, The results of two-step cluster analysis are as; 'mix of central government and social finance organization', 'multiple agent including private organization', and 'multiple social provider'. Among three types, 'multiple agent including private organization' shows the most active participation between agents and the most systematic outcome measurement and management. The results of this study imply that the importance of the method to manage and measure outcome in SIB structure. Moreover, the consist of commissioners or investors is needed to expanded more.

• Journal of Ginseng Research
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• v.45 no.2
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• pp.264-272
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• 2021

Background: Gintonin is a ginseng-derived exogenous G-protein-coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors. A recent study demonstrated that systemic treatment with gintonin enhances paracellular permeability of the blood-brain barrier (BBB) through the LPA1/3 receptor. However, little is known about whether gintonin can enhance brain delivery of donepezil (DPZ) (Aricept), which is a representative cognition-improving drug used in AD clinics. In the present study, we examined whether systemic administration of gintonin can stimulate brain delivery of DPZ. Methods: We administered gintonin and DPZ alone or coadministered gintonin with DPZ intravenously or orally to rats. Then we collected the cerebral spinal fluid (CSF) and serum and determined the DPZ concentration through liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Results: Intravenous, but not oral, coadministration of gintonin with DPZ increased the CSF concentration of DPZ in a concentration- and time-dependent manner. Gintonin-mediated enhancement of brain delivery of DPZ was blocked by Ki16425, a LPA1/3 receptor antagonist. Coadministration of vascular endothelial growth factor (VEGF) + gintonin with DPZ similarly increased CSF DPZ concentration. However, gintonin-mediated enhancement of brain delivery of DPZ was blocked by axitinip, a VEGF receptor antagonist. Mannitol, a BBB disrupting agent that increases the BBB permeability, enhanced gintonin-mediated enhancement of brain delivery of DPZ. Conclusions: We found that intravenous, but not oral, coadministration of gintonin facilitates brain delivery of DPZ from plasma via LPA1/3 and VEGF receptors. Gintonin is a potential candidate as a ginseng-derived novel agent for the brain delivery of DPZ for treatment of patients with AD.

• Journal of Digital Convergence
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• v.14 no.10
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• pp.367-373
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• 2016

The aim of this study was to evaluate the anti-caries effect of the essential oils and chlorhexidine mouth rinse. 42 subjects were randomized allocated to the chlorhexidine (n=22) and essential oils group (n=20). Subjects were instructed to rinsing each mouthwash by 15 ml once a day during the 7 days. The CRT and Cariview scores were recorded at baseline and 4 weeks after treatment. Data was analysed by using PASW 18.0 program with independent t-test and paired t-test. After 1 month, Cariview score was shown reducing compare to baseline. However, there were no significant differences between the groups. High risk level of MS and LB was decreased to 9~15% after treatment in two groups. Both of the chlorhexidine and essential oils mouth wash showed an antiplaque effect. Although chlorhexidine continues to be the "gold standard" in terms of antiplaque effect, essential oils could be considered a reliable alternative antimicrobial agent.

• BMB Reports
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• v.33 no.5
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• pp.396-401
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• 2000

A differential display method is used to identify novel genes whose expression is affected by treatment with ferric ammonium citrate (FAC) or desferrioxamine (DFO), an iron chelating agent in the human hepatoblastoma cell line (HepG2). These chemicals are known to deplete or increase the intracellular concentration of iron, respectively. Initially, we isolated seventeen genes whose expressions are down- or up regulated by the treatment of the chemicals, as well as their four differentially expressed genes that are designated as clone-1, -2, -3, and -4. These are further characterized by cDNA sequencing and Northern blot analysis. Through the cDNA sequencing, as well as comparing them to genes published using the NCBI BLAST program, we identified the sequence of the clone-1 that is up-regulated by the treatment of DFO. It is identical to the human insulin-like growth factor binding protein-1 (IGFBP-1). This suggests that the IGFBP-1 gene in the HepG2 cell is up-regulated by an iron depletion condition. Also, the expression of the clone-3 and -4 is up-regulated by FAC treatment and their eDNA sequences are identical to the human ferritin-fight chain and human NADH-dehydrogenase, respectively. However, the sequence of the clone-2 has no significant homology to any other known gene. Therefore, we suggest that changes of the cellular iron level in the HepG2 cell affects the transcription of cellular genes. This includes human IGFBP-1, ferritin-fight chain, and NADH-dehydrogenase. Regulation of these gene expressions may have an important role in cellular functions that are related to cellular iron metabolism.