• The Korean Journal of Pain
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• v.13 no.2
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• pp.218-223
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• 2000

Background: This study was conducted to evaluate the efficacy of a parenteral nonsteroidal anti-inflammatory agent for management of post-surgical pain and its effect on hospital stay and long-term surgical outcome. Methods: Total of 40 patients undergoing lumbar discectomy were randomly assigned to two groups, receiving either 1) 30 mg intravenous ketorolac upon surgical closure, every 6 hours for 36 hours, and morphine IV PCA (intravenous patient controlled analgesia), or 2) only morphine PCA. A blinded investigator recorded; the visual analog pain scores, total postoperative narcotic consumption, complications by morphine PCA, length of hospitalization (from surgery to discharge), and long-term outcome at 6 weeks. Results: The patients who received IV ketorolac and morphine PCA reported significantly lower visual analog pain scores than patients receiving only morphine PCA. Cumulative morphine doses were significantly lower in the ketorolac group (P<0.001). There was no significant difference between groups in the frequency of side effects related to morphine PCA. Mean length of hospitalization was longer for patients receiving only morphine PCA, but there was no statistical significance. Six weeks after surgery, four (20.0%) patients who received only morphine PCA suffered persistent back pain. In contrary, all those patients who received ketorolac were free of back pain at follow-up (P<0.05). Conclusions: These results suggest that intermittent IV bolus ketorolac, when used with opioid IV PCA is more effective than opioid IV PCA alone for postoperative pain following lumbar disc surgery. However, this strategy did not contribute to early discharge from hospital after lumbar disc surgery. The effect to long-term surgical outcome was not conclusive.

• Journal of KIISE:Information Networking
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• v.35 no.4
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• pp.301-310
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• 2008

In the existing literature, the handover process reveals numerous problems manifested by high movement detection latency. FMIPv6 can reduce packet loss using a tunnel-based handover mechanism. However, this mechanism may cause performance degradation due to the out-of-sequence packets. Recently. Proxy Mobile IPv6 is proposed for network-based mobility management to reduce overhead in mobile node. PMIPv6 can decrease handover latency which related overhead in MN by using network agent. In this paper, we proposed optimized fast handover scheme called Fast Proxy Mobile IPv6 (EF-PMIPv6). The proposed EF-PMIPv6 can support fast handover using fast IAPP and ND schemes. Further, a mathematical analysis is provided to show the benefits of our scheme. In the analysis, various parameters are used to compare our scheme with the current procedures, while our approach focuses on the reduction of handover latency.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.5
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• pp.880-886
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• 2016

With lots of information occurring on the Internet, the search engine plays a role in gathering the scattered information on the Internet. Some search engines show not only search result pages including search keyword but also search result numbers of the keyword. The number of keyword searching result provided by the Google search engine can be utilized to identify overall trends for this search word on the internet. This paper is aimed designing and realizing the system which can efficiently manage the number of searching result provided by Google search engine. This paper proposed system operates by Web, and consist of search agent, storage node, and search node, manage keyword and search result, numbers, and executing search. The proposed system make the results such as search keywords, the number of searching, NGD(Normalized Google Distance) that is the distance between two keywords in Google area.

• The KIPS Transactions:PartC
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• v.15C no.6
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• pp.557-566
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• 2008

NGN(Next Generation Network) is a communication network which can make use of broadband and QoS-enabled transport technologies. One of the main service issues over NGN is a multimedia service, such as IPTV, using a multicast method. And overlay multicast technology is one of the promising solutions instead of traditional multicast technology which has a few problems, and supports flexibility and scalability for multicast services. Also, the main controversial topic in NGN and overlay multicast is QoS. In the present paper, we designed an agent in each receiver's network, and a manager which is in a source network and which manages the whole multicast network. Both of them are communicating with each other and applying resource policies to their multicast network. This mechanism enables overlay multicast to support QoS, focusing on RACF(Resource and Admission Control Functions) in NGN QoS architecture.

• The KIPS Transactions:PartC
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• v.15C no.6
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• pp.455-468
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• 2008

In this paper, we propose FAS model for establishing trust based on digital certificates in Grid security framework. The existing RBAC(Role Based Access Control) model is extended to provide permissions depending on the users‘ roles. The FAS model is designed for a system independent integrated Grid security by detailing and extending the fundamental architecture of user, role, and permission. FAS decides each user’s role, allocates access right, and publishes attribute certificate. FAS is composed of three modules: RDM, PCM, and CCM. The RDM decides roles of the user during trust negotiation process and improves the existing low level Grid security in which every single user maps a single shared local name. Both PCM and CCM confirm the capability of the user based on various policies that can restrict priority of the different user groups and roles. We have analyzed the FAS strategy with the complexity of the policy graph-based strategy. In particular, we focused on the algorithm for constructing the policy graph. As a result, the total running time was significantly reduced.

• Archives of Plastic Surgery
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• v.36 no.3
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• pp.269-276
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• 2009

Purpose: Local skin necrosis after extravasation of adriamycin, a widely used chemotherapeutic agent, is a common problem in cancer patients. The extravasation of chemotherapeutic agents yields severe inflammatory responses, crust formation, skin necrosis, and ulceration. Even though several treatment options have been proposed for extravasation injury, there is still controversy regarding the management of such lesions. Thus the aim of this study was to compare the efficacy of saline injection(Group 1), hydrocortisone injection(Group 2), propranolol injection(Group 3) and early surgical excision as a treatment(Group 4) in a rat extravasation model. Methods: The authors planned forty mature male Sprague - Dawley rats were divided into 4 groups and each group contained 10 rats. Administration of adriamycin($1.0mg/m{\ell}$) $1.5m{\ell}$ by subcutaneous injection on the dorsal side of the rats was followed by protocol. The treatment options were applied 2 hours after adriamycin injection. At the end of the 5th days, the presence and size of ulcers at the injection site were measured. 3 weeks after injection, a histopathologic examination was performed for each treatment and control group. T - tests were used to analyze the differences between the measurements. Results: Propranolol significantly improved tissue recovery compared with control group and other groups. These data suggest that there is little role for saline and hydrocortisone in the treatment of adriamycin extravasation injury. Conclusion: In this study, we compared some treatment methods in adriamycin extravasation model. The findings support the propranolol injection may prevent extravasation injury. However this study was performed in the laboratory using rats, and the results could be different in clinical application. Thus, more needs further investigations and clinical application.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.11 no.1
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• pp.70-77
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• 2001

This study was conducted to identify the current status of occupational safety and health by checklist and to evaluate the airborne exposure to chemicals and to provide the appropriate recommendation for safety and health of laundries. A total of 20 laundries located in tile Gyungi district area were surveyed from July 20 to September 15, 2000. The prevalence of laundries having a stove and gas range were found to be 25 % and 55 %, respectively. Smoking is not allowed in 60 % of the laundries. Only 10 % of dry-cleaners were isolated. Ventilation systems in laundries had not been annually inspected. Most of the workers didn't put on respirators, MSDS were not available, and storage bottles did not contain warning labels. The bulk samples of dry cleaning agent include many chemicals that are not controlled by the MOL in Korea. The detected airborne organic solvents in the laundries were benzene, toluene, p-xylene, m-xylene, o-xylene, perchloroethylene, and 2-butoxy ethanol. The airborne concentrations of organic solvents were much less than the occupational exposure limits proposed by the Ministry of Labor(MOL) in Korea. But the concentrations of benzene exceeded the TLV of ACGIH. This study showed that the current status of occupational safety and health was not appropriate for workers in laundries. It is recommended that laundry workers should be educated for the treatment and storage of hazardous organic solvents to improve the occupational safety and health of the working environment as well as MSDS usage. Also, extended research and survey for the organic solvents that are not controlled by the MOL has to be conducted.

• Journal of Korea Technology Innovation Society
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• v.16 no.1
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• pp.346-366
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• 2013

The importance of challenging and creative research recently has been increased, risk-taking on the R&D is being needed. The settlement of policy is urgently required in order to protect the result of high-risk research. 'Honorable Failure' is statutory by 'Regulation on the National R&D Program management' to resolve this issue, however its standards and detailed guides are not provided enough or the ministerial funding agencies apply different guidelines, making the researchers on the field confused by far. Therefore this paper reviews the current state of 'Honorable Failure Policy'(saving the 'failed' research despite of its adequate process or performance) and compares with the cases of major countries, then points out following issues; the uncertainty of the criterion, the difference of the main agent performing evaluation, admission of the failure, the utilization of the result of 'failed' research, the vagueness of the range of sanctions and restriction, and the lack of method of inspection and prevention for repetitive failure of the research projects. Finally, this paper proposes the solutions for these issues to improve.

• Clinical and Experimental Pediatrics
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• v.52 no.10
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• pp.1061-1068
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• 2009

The treatment of pediatric patients with chronic renal disease comprises management of nutritional imbalance, fluid, electrolyte, and acid-base disturbances, mineral bone disease, anemia, hypertension, and growth retardation. The treatment also includes administration of appropriate renal replacement therapy, if required. Adequate dietary intake of carbohydrates, fats, and proteins and caloric intake must be encouraged in such patients to ensure proper growth and development. In addition, fluid, electrolyte, and acid-base status must be regularly monitored and should be well maintained. Serum calcium, phosphorus, and parathyroid hormone levels must be maintained at their target range, which are determined on the basis of the glomerular filtration rate, to avoid the development of mineral bone disease. This can be achieved by using phosphorus binders and vitamin D analogues. An erythropoiesis-stimulating agent must be administered along with iron supplementation to maintain the hemoglobin level of the patients between 11-12 g/dL. Hypertension must be controlled with adequate water and sodium balance and appropriate antihypertensive agents. Administration of recombinant human growth hormone is recommended to improve the final adult heights.

• The Korean Journal of Physiology and Pharmacology
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• v.8 no.6
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• pp.295-300
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• 2004

Serotonin (5-hydroxytroptamine, 5-HT) has been shown to affect the induction of long-term potentiation (LTP) in the cortex such as the hippocampus, the visual cortex and the prefrontal cortex. Fluoxetine, as a selective serotonin reuptake inhibitor, is used in the management of a wide variety of psychological diseases. To study the effect of fluoxetine on the induction of LTP, we recorded the field potential in layer II/III of the frontal cortex from 3-wk-old. LTP was induced in horizontal input by theta burst stimulation (TBS). TBS with two-folds intensity of the test stimulation induced LTP, which was blocked by application of D-AP5 $(50 {\mu}M)$, an NMDA receptor antagonist. Whereas bath application of 5-HT $(10 {\mu}M)$ inhibited the induction of LTP, treatment with the 5-HT depleting agent, para-chloroamphetamine $(PCA,\;10{\mu}M)$, for 2hr did not affect the induction of LTP. Bath application of fluoxetine (1, 3, and $10 {\mu}M)$ suppressed the induction of LTP in concentration-dependent manner, however, fluoxetine did not inhibit the induction of LTP in 5-HT-depleted slices. These results indicate that fluoxetine may inhibit the induction of LTP by modulating serotonergic mechanism in the rat frontal cortex.