• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.2
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• pp.901-908
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• 2011

For the available grid environmental realization, the resource supply PC must have to provide an appropriate security function of their operation environments. SKY@HOME is a kind of the grid computing environments. If this has not supervised by administrator handling smoothly, it is inherently vulnerable state to the security level of the grid environments, because the resource supply PC is not update a security function without delay. It is also have the troublesome problems which have to install of an additional security program for support the appropriate security. This paper proposes an integration security model on the policy-based that provides an update each level according to the situation of the resource supply PC for improving its problems as a security aspect of the SKY@HOME. This model analyzes the security state of the resource supply PC respectively, and then the result is available to provide an appropriate security of the resource supply PC using an integration security model. The proposed model is not need additionally to buy and install the software, because it is provided the security management server oriented service. It is also able to set up the suit security function of a characteristic of the each resource supply PC. As a result, this paper clearly show the participation of resource supply PC improved about 20%.

• Restorative Dentistry and Endodontics
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• v.29 no.6
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• pp.504-514
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• 2004

This study compared the dentin shear bond strengths of currently used dentin bonding agents that were irradiated with an LED (Elipar FreeLight, 3M-ESPE) and a halogen light (VIP, BISCO). The optical characteristics of two light curing units were evaluated. Extracted human third molars were prepared to expose the occlusal dentin and the bonding procedures were performed under the irradiation with each light curing unit. The dentin bonding agents used in this study were Scotchbond Multipurpose (3M ESPE), Single Bond (3M ESPE), One-Step (Bisco), Clearfil SE bond (Kuraray), and Adper Prompt (3M ESPE), The shear test was performed by employing the design of a chisel-on-iris supported with a Teflon wall. The fractured dentin surface was observed with SEM to determine the failure mode. The spectral appearance of the LED light curing unit was different from that of the halogen light curing unit in terms of maximum peak and distribution. The LED LCU (maximum peak in 465 nm) shows a narrower spectral distribution than the halogen LCU (maximum peak in 487 nm). With the exception of the Clearfil SE bond (P < 0.05), each 4 dentin bonding agents showed no significant difference between the halogen light-cured group and the LED light-cured group in the mean shear bond strength (P > 0.05). The results can be explained by the strong correlation between the absorption spectrum of camphoroquinone and the narrow emission spectrum of LED.

• Journal of the Korean Geosynthetics Society
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• v.20 no.3
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• pp.1-10
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• 2021

The purpose of this study is to present the possibility a utilization of the tertiary mudstone in Pohang as road subsoil material through pilot experiments on the road embankment structure. This mudstone is an unconsolidated rock that is distributed in the soft rock sedimentary layer, the tertiary layer of the Cenozoic, and causes physical problems such as slaking, swelling, and reduced shear strength and chemical problem like acid drainage. In order to solve various complex problems, an laboratory mixing test was conducted, and the optimal mixing conditions of the tertiary mudstone (90%), composite slag (steel making 70%, blast furnace 30%), and neutralization and coating agent treatment were derived. In order to prove its utilization, a real-scale road embankment structure was constructed and tests were conducted for each section. The pre-processing section is stable due to the design of optimal mixing conditions, while in post-processing section, natural weathering proceeded rapidly, and structural problems were concerned. Since the effect of neutralizing and coating agents was confirmed in temporary-staking section, the neutralizing and coating agents can be applied during the temporary storage period.

• Biomolecules & Therapeutics
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• v.27 no.5
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• pp.492-501
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• 2019

Nitrogen-containing heterocycles such as quinoline, quinazolinones and indole are scaffolds of natural products and have broad biological effects. During the last years those structures have been intensively synthesized and modified to yield new synthetic molecules that can specifically inhibit the activity of dysregulated protein kinases in cancer cells. Herein, a series of newly synthesized isoquinolinamine (FX-1 to 8) and isoindoloquinazolinone (FX-9, FX-42, FX-43) compounds were evaluated in regards to their anti-leukemic potential on human B- and T- acute lymphoblastic leukemia (ALL) cells. Several biological effects were observed. B-ALL cells (SEM, RS4;11) were more sensitive against isoquinolinamine compounds than T-ALL cells (Jurkat, CEM). In SEM cells, metabolic activity decreased with $10{\mu}M$ up to 26.7% (FX-3), 25.2% (FX-7) and 14.5% (FX-8). The 3-(p-Tolyl) isoquinolin-1-amine FX-9 was the most effective agent against B- and T-ALL cells with IC50 values ranging from 0.54 to $1.94{\mu}M$. None of the tested compounds displayed hemolysis on erythrocytes or cytotoxicity against healthy leukocytes. Anti-proliferative effect of FX-9 was associated with changes in cell morphology and apoptosis induction. Further, influence of FX-9 on PI3K/AKT, MAPK and JAK/STAT signaling was detected but was heterogeneous. Functional inhibition testing of 58 kinases revealed no specific inhibitory activity among cancer-related kinases. In conclusion, FX-9 displays significant antileukemic activity in B- and T-ALL cells and should be further evaluated in regards to the mechanisms of action. Further compounds of the current series might serve as templates for the design of new compounds and as basic structures for modification approaches.

• Journal of Life Science
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• v.29 no.8
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• pp.871-878
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• 2019

The aim of this study was to determine the anticancer activities of an 80% methanol extract and various fractions of Rhododendron brachycarpum (RB). The n-hexane fraction of RB showed the highest inhibitory activity (Inhibit concentration $50%=20.2{\pm}1.2{\mu}g/ml$) in HT-29 cells. Colony- and sphereforming abilities were significantly correlated with a decrease in the cell count and size. A TOP/FOP flash reporter assay revealed that the inhibitory activity of the n-hexane fraction of RB ($0.22{\pm}0.02$ fold change) was lower than that of the 80% methanol extract and that of other fractions. The n-hexane and ethyl acetate fractions of RB were predominantly dependent on the expression levels of intracellular ${\beta}-catenin$. Western blotting using $p-GSK3{\beta}$ with only the n-hexane fraction of RB was conducted to examine whether these secondary metabolites reduced ${\beta}-catenin$ degradation. Intracellular ${\beta}-catenin$ regulation resulted in quantitative changes in the nucleus. In summary, these results demonstrate the potential of the n-hexane fraction of RB as a natural anticancer agent.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.9
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• pp.1038-1048
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• 2019

Recently, various systems have been developed to support ship navigation safety. In order to verify the usefulness of such a system, it is most ideal to try it on a real vessel, but there are many difficulties. As an alternative, usability verification methods applied with modelling and simulation (M&S) techniques are required such as FMSS, which is closest to reality, is very expansive to construct, and there needs the specialized operator. For this reason, this paper proposes a method to verify the navigation safety support system by modeling and simulation techniques based on the Discrete Event System Specification (DEVS) formalism. As a first step, we designed the navigation simulation architecture based on the SES/MB framework, and details on modelling ship core equipment and navigator agents based on the DEVS. Through this, we are able to implement the navigation simulation system for vessels, and evaluate the effectiveness of navigation safety support elements such as collision avoidance, etc. using developed scenarios.

• Journal of radiological science and technology
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• v.28 no.4
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• pp.317-325
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• 2005

The recent medical treatment guidelines and the development of information technology make hospitals reduce the expense in surrounding environment and it requires improving the quality of medical treatment of the hospital. That is, with the new guidelines and technology, hospital business escapes simple fee calculation and insurance claim center. Moreover, MIS(Medical Information System), PACS(Picture Archiving and Communications System), OCS(Order Communicating System), EMR(Electronic Medical Record), DSS(Decision Support System) are also developing. Medical Information System is evolved toward integration of medical IT and situation si changing with increasing high speed in the ICT convergence. These changes and development of ubiquitous environment require fundamental change of medical information system. Mobile medical information system refers to construct wireless system of hospital which has constructed in existing environment. Through RFID development in existing system, anyone can log on easily to Internet whenever and wherever. RFID is one of the technologies for Automatic Identification and Data Capture(AIDC). It is the core technology to implement Automatic processing system. This paper provides a comprehensive basic review of RFID model in Korea and suggests the evolution direction for further advanced RFID application services. In addition, designed and implemented DB server's agent program and Client program of Mobile application that recognized RFID tag and patient data in the ubiquitous environments. This system implemented medical information system that performed patient data based EMR, HIS, PACS DB environments, and so reduced delay time of requisition, medical treatment, lab.

• Composites Research
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• v.36 no.5
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• pp.297-302
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• 2023

There are several methods for shaping foams, but the most commonly used methods involve the use of resin mixed with a foaming agent, which is then foamed under high temperature and pressure in the case of compression foaming, or foamed under high temperature without applying pressure in the case of atmospheric foaming. The polymers used for foaming require design and analysis of optimal foaming conditions in order to achieve foaming under ambient pressure. Environmentally friendly bio-based polymers face challenges when it comes to foaming on their own, which has led to ongoing research in blending them with resins capable of traditional foam production. This study investigates changes in the characteristics of bio-based polymer-EVA blend foams based on variations in the content of bio-based polymers and explores the optimal foaming conditions according to crosslinking. The correlation between foaming characteristics and mechanical properties of the foams was examined. Through this research, we gained insights into how the content of bio-based polymers affects the properties of foams containing bio-based polymers and identified differences between ambient pressure and high-pressure foaming processes. Additionally, the feasibility of commercializing bio-based polymer-EVA composite foams was confirmed.

• Atmosphere
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• v.34 no.2
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• pp.203-216
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• 2024

The National Institute of Meteorological Sciences in Korea has developed the Weather Modification Hybrid Rocket (WMHR), an advanced system that offers enhanced stability and cost-effectiveness over conventional solid-fuel rockets. Designed for precise operation, the WMHR enables accurate control over the ejection altitude of pyrotechnics by modulating the quantity of oxidizer, facilitating specific cloud seeding at various atmospheric layers. Furthermore, the rate of descent for pyrotechnic devices can be adjusted by modifying parachute sizes, allowing for controlled dispersion time and concentration of seeding agents. The rocket's configuration also supports adjustments in the pyrotechnic device's capacity, permitting tailored seeding agent deployment. This innovation reflects significant technical progression and collaborations with local manufacturers, in addition to efforts to secure testing sites and address hybrid rocket production challenges. Notable outcomes of this project include the creation of a national framework for weather modification technology utilizing hybrid rockets, enhanced cloud seeding methods, and the potential for broader meteorological application of hybrid rockets beyond precipitation augmentation. An illustrative case study confirmed the WMHR's operational effectiveness, although the impact on cloud seeding was limited by unfavorable weather conditions. This experience has provided valuable insights and affirmed the system's potential for varied uses, such as weather modification and deploying high-altitude meteorological sensors. Nevertheless, the expansion of civilian weather rocket experiments in Korea faces challenges due to inadequate infrastructure and regulatory limitations, underscoring the urgent need for advancements in these areas.

• Korean Journal of Radiology
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• v.25 no.2
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• pp.179-188
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• 2024

Objective: ¹⁷⁷Lutetium [Lu] Ludotadipep is a novel prostate-specific membrane antigen targeting therapeutic agent with an albumin motif added to increase uptake in the tumors. We assessed the biodistribution and dosimetry of [¹⁷⁷Lu]Ludotadipep in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and Methods: Data from 25 patients (median age, 73 years; range, 60-90) with mCRPC from a phase I study with activity escalation design of single administration of [¹⁷⁷Lu]Ludotadipep (1.85, 2.78, 3.70, 4.63, and 5.55 GBq) were assessed. Activity in the salivary glands, lungs, liver, kidneys, and spleen was estimated from whole-body scan and abdominal SPECT/CT images acquired at 2, 24, 48, 72, and 168 h after administration of [¹⁷⁷Lu]Ludotadipep. Red marrow activity was calculated from blood samples obtained at 3, 10, 30, 60, and 180 min, and at 24, 48, and 72 h after administration. Organand tumor-based absorbed dose calculations were performed using IDAC-Dose 2.1. Results: Absorbed dose coefficient (mean ± standard deviation) of normal organs was 1.17 ± 0.81 Gy/GBq for salivary glands, 0.05 ± 0.02 Gy/GBq for lungs, 0.14 ± 0.06 Gy/GBq for liver, 0.77 ± 0.28 Gy/GBq for kidneys, 0.12 ± 0.06 Gy/GBq for spleen, and 0.07 ± 0.02 Gy/GBq for red marrow. The absorbed dose coefficient of the tumors was 10.43 ± 7.77 Gy/GBq. Conclusion: [¹⁷⁷Lu]Ludotadipep is expected to be safe at the dose of 3.7 GBq times 6 cycles planned for a phase II clinical trial with kidneys and bone marrow being the critical organs, and shows a high tumor absorbed dose.