• Current Research on Agriculture and Life Sciences
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• 제4권
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• pp.109-113
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• 1986

수정란이식에 있어서 수란우의 조건에 따른 수태율을 조사하기 위하여 생수 14 ~24개월되는 젖소 처녀우 29두와 한우 처녀우 1두, 그리고 젖소 경산우 3두 계33두의 수란우에 morulae stage부터 advanced blastocyst stage의 수정란을 각각 1개씩 이식하여 이들 수란우의 연령, 이식된 계절, 반복사용 그리고 공란우와 수란우간의 발정동기화 시차 등에 따른 수태율을 조사하였으며 그 결과를 요약하면 다음과 같다. 1. 수란우의 연령에 따른 수태율은 경산우가 100%로 좋았고 18개월 이상의 처녀우가 78%로 높았다. 14개월 이하의 어린 처녀우가 가장 나쁜 67%를 보였다. 2. 이식한 계절에 따른 수란우의 수태율을 보면 겨울(11월~1월)과 봄(2월~4월)이 각각 100%, 83%로 가을(8월~10월)의 50%보다 좋았다. 3. 1차 이식 후 불임된 수란우의 재사용에 따른 수태율은 1차에 사용된 31두 수란우 중 25두가 수태, 80.7%의 수태율을 보였으나 2차례 이용된 2두는 모두 임신되지 못했다. 4. 공란우와 수란우의 발정동기화의 시차에 따른 수태율은 -(before donor) 12 시간, -6 시간, +(after donor) 6시간, +12 시간, 그리고 +12시간 이상에서 각각 100%, 86%, 67%, 79% 그리고 50%로 공란우보다 빠른편이 수태율이 늦은 우군보다 높았고 ${\pm}12$시간 이내의 동기화된 우군에서 좋은 수태율을 보였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4769-4774
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• 2016

Objective: To analyze the survival of elderly patients with breast cancer according to the type of treatment used. Methods: A cohort study of women aged 80 or over with breast cancer registered with the Brazilian National Cancer Institute (Instituto Nacional do $C{\hat{a}}ncer$ - INCA) between 2008 and 2009 was conducted. Prognosis was analyzed according to the cancer treatment performed: surgery, radiotherapy, or hormone therapy. Analysis of the overall 5-year survival rate was performed using the Kaplan - Meier method, and comparisons of curves were undertaken using the log-rank test. For multiple regression analysis, Cox regression was used, adjusting for age and clinical stage, considering values of p < 0.05 as significant. Data were all analyzed using the statistical package SPSS version 20. Results: 70 women with a mean age of $84.0{\pm}3.7years$ at diagnosis participated in the study. The median follow-up time was 37.1 months (range 0.5-75.5), and 31 deaths (44.3%) occurred during this time. The median survival time was 51.2 months (95% CI, 44.9-57.4), higher in those who underwent surgery (p = 0.012) and those who had hormone therapy (p=0.001). Treatment with surgery reduced the risk of death by 61.7% (HR 0.3; 95% CI, 0.1-0.6; p = 0.001) when adjusted for clinical stage and age at diagnosis. However, there was no significant benefit from radiotherapy (HR 1.2; 95% CI, 0.5-2.5; p = 0.694). Conclusion: Treatment with surgery and hormone therapy increased the survival of our Brazilian patients with breast cancer aged 80 or over.

• 한국산학기술학회논문지
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• 제20권4호
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• pp.303-310
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• 2019

본 연구는 성인과 노인의 구강근기능(저작력, 혀근력, 구순력, 협근력)을 비교분석하고 구강건강 관련 삶의 질과 연하 장애에 영향을 미치는 구강근기능을 조사하였다. 2017년 12월부터 2018년 5월까지 대전과 논산시에 거주하는 20세 이상 성인 73명을 조사하였다. 수집된 검사자료는 SPSS 18.0 프로그램을 이용하여 ANOVA, 상관분석, 회귀분석을 하였다. 연령층별 저작력은 우측, 좌측 구치교합력을 평가한 결과 노년층이 (8.93, 10.80) 성인층(12.51, 14.61) 중년층 (11.63, 14.75)에 비해 감소하였다(p>0.05). 혀근력은 성인층(60.55), 중년층(50.61), 노년층(37.43) 집단간 통계적으로 유의한 차이가 있었다(p=0.000). 구순력은 노년층(8.57)이 성인층(12.01), 중년층(11.37) 보다 통계적으로 유의하게 낮았다(p=0.000). 구강건강 관련 삶의 질에 미치는 구강근기능은 혀근력이었고, 연하장애에 영향을 미치는 요인도 혀근력이었다. 혀근력은 자연치아수(r=.566, p<.05), 구순력(r=.497, p<.05)과 유의한 순상관관계가 있었다. 구강건강 관련 삶의 질과 연하장애에 영향을 미치는 요인은 혀근력이었다(p<0.05). 노화에 의한 구강근기능 저하의 위험성 인식이 필요하다. 특히 혀근력은 삶의 질과 연하장애와 관련된다. 연령증가시 치아상실로 인한 구강기능 감소뿐만 아니라 구강근기능 저하로 인한 저작, 연하 구강기능 감소의 위험성을 인식하고 고령사회에서 구강건강 관련 삶의 질 증진을 위해 정기적 구강관리 및 구강근훈련의 필요성이 제안되었다.

• 한국노년학
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• 제38권4호
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• pp.891-903
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• 2018

본 연구는 허약의 고위험군인 후기노인의 건강관련 삶의 질 향상을 위한 기초자료를 제공하고자 허약, 사회적 지지 및 건강관련 삶의 질 간의 관계를 조사하였다. 서술적 조사연구인 본 연구를 위하여 2016년 03월 01일부터 03월 31일까지 K군에 소재하는 노인복지시설에서 75세 이상 노인을 대상으로 구조화된 설문지를 이용하는 일대일 면담을 통해 총 211명의 자료를 수집하였다. 수집된 자료는 SPSS/WIN과 Amos 18.0 프로그램으로 t-test, Pearson's correlation coefficient 및 경로분석을 사용하여 분석하였다. 80세를 기준으로 한 연령집단 간 차이검정결과, 80세 이상인 경우 유의하게 허약수준이 더 높고(t=-2.51, p=.013), 건강관련 삶의 질이 낮았으나(t=3.29, p=.001), 사회적 지지는 유의한 차이를 보이지 않았다(t=1.28, p=.201). 허약, 사회적지지, 건강관련 삶의 질 간의 상관관계 분석결과, 허약수준이 높을수록 사회적 지지(r=-.21, p=.003)와 건강관련 삶의 질이 유의하게 낮았고(r=-.65, p<.001), 건강관련 삶의 질은 사회적 지지가 높을수록 유의하게 높았다(r=.18, p=.010). 사회적 지지와 건강관련 삶의 질 사이에서 허약의 매개효과를 조사한 결과, 사회적 지지는 허약에(${\beta}=-.21$, p=.016) 허약은 건강관련 삶의 질에 유의한 직접효과를 미치나(${\beta}=-.06$, p=.004), 사회적 지지는 건강관련 삶의 질에 유의한 직접효과를 미치지 않고(${\beta}=.00$, p=.562) 허약을 매개하여 유의한 간접효과를 미쳐(${\beta}=.01$, p=.012) 사회적 지지와 건강관련 삶의 질 사이에서 허약의 완전매개효과가 있었다. 사회적 지지는 허약을 예방하고 허약수준의 개선은 건강관련 삶의 질을 증진시킨다. 그러므로 후기노인의 건강관련 삶의 질 제고를 위해 연령별 사회적 지지 방안을 포함하는 다면적인 허약 예방 프로그램의 개발이 필요하다.

• 대한의생명과학회지
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• 제17권2호
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• pp.141-149
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• 2011

The purpose of this study was to find out any difference and correlation between the cardiac structure and its function according to the level of obesity as evaluated by waist measurement and BMI (body mass index) in healthy adults. For research subjects, the study selected a final 519 subjects excluding 198 subjects aged 55 or over out of 717 subjects who received echocardiography through a medical checkup at J General Hospital. For the criteria for obesity, men were defined as being obese in case their waist measurement was over 90 cm, whereas women were defined as being obese in case their waist measurement was over 80 cm. Also, regarding the BMI criteria, in case a person's BMI was 30 kg/$m^2$, the subject was classified as belonging to an obese group, and in case a person's BMI was between 25 kg/$m^2$ and 30 kg/$m^2$, the subject was classified as belonging to an overweight group. Concerning the evaluation of cardiac structure and function, they were evaluated using two-dimensional, M-mode, doppler echocardiography. According to the stage of obesity in accordance with waist measurement and BMI, the cardiac structure showed both eccentric and centripetal changes, and the cardiac function was also discovered to show differences according to the stage of obesity. In addition, also in the overweight group, which is a prior stage to obesity, out of the criteria for obesity classification according to BMI, there were differences in the cardiac structure and function. Also, both the waist measurement and BMI were found to have a correlation with cardiac structure and diastolic function. Consequently, cardiac structure and function are correlated with BMI and waist measurement, which are anthropometrical variables, and obesity is assumed to induce not only structural change but also functional change of the heart.

• 대한임상검사과학회지
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• 제39권1호
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• pp.37-41
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• 2007

This study was carried out to investigate the cadmium level in blood by age, gender, and smoking status among 162 elderly subjects in Gyeongnam Province from September 2006 to February 2007. The cadmium level in blood was analyzed by atomic absorption spectrophotometer. Subjects were classified according to smoking status and divided into smokers and non-smokers, smoking duration, daily smoking habits, age, and gender. Mean blood cadmium levels in male and female were $0.70{\pm}0.41{\mu}g/dL$ and $0.57{\pm}0.32{\mu}g/dL$ respectively, with no significant differences between the two groups. Cadmium levels in the blood of smokers and non-smokers were $0.57{\pm}0.32{\mu}g/dL$, $0.90{\pm}0.44{\mu}g/dL$ respectively, with the cadmium level of smokers being significantly higher than that of non-smokers. In comparison by age, cadmium levels in the blood of subjects over the age 70 years and over the age 80 years were $0.91{\pm}0.44{\mu}g/dL$, $1.02{\pm}0.39{\mu}g/dL$ respectively, showing a significantly higher blood cadmium level than that of non-smokers. when compared by the amount of daily cigarette consumption, there were no significant differences in the blood cadmium level between groups. However when compared by smoking duration, the blood cadmium level for the group of smoking duration of over 10 years was $1.15{\pm}0.38{\mu}g/dL$, significantly higher than $0.67{\pm}0.31{\mu}g/dL$ for the group of smoking duration of less than 10 years. In conclusion, longer smoking duration and older aged group showed higher cadmium level in blood. For more reliable results, further study of the elements that elevate the cadmium level in blood with more subjects and study variables will be needed.

• 한국임상약학회지
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• 제33권4호
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• pp.242-253
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• 2023

Background: Arrhythmia due to QT prolongation is one of the most serious adverse events with drug interactions in the elderly. This study aimed to examine the incidence of arrhythmia in Korean elderly patients who administered both cytochrome P450 3A4 (CYP3A4) substrates and inhibitors. Methods: Patients using CYP3A4 substrate and inhibitor were selected from the 2017 elderly patient dataset (the Korean Health Insurance Review and Assessment Service - Aged Population Sample). Selection criteria were patients with a medication possession ratio over 80%, medication duration of at least 7 days, and a follow-up period of 3 months or more. The patient's basic information is age, gender, health insurance type, and comorbidities. The top 50 drug pairs and comorbidity with high-incidence arrhythmia were presented. Results: In patients with drug combinations for over 7 days, there were 981 incidences of arrhythmia, and 351 incidences in those with combinations for over 30 days. The comorbidities of congestive heart failure and myocardial infarction had a significant association with incidence of arrhythmia. Among patients with 7 days or longer, the drug pairs [substrates-inhibitors] with significant adjusted odds ratio (aOR) were [propranolol-cimetidine] (aOR, 2.25; 95% confidence interval [CI], 1.66-3.04). Among patients with 30 days or longer, the drug pairs with significant aOR were [tramadol-amiodarone] (aOR, 2.87; 95% CI, 1.97-4.19). Conclusions: In elderly patients, the incidence of arrhythmia was high with drug interactions of CYP3A4 substrates and inhibitors. The comorbidity of congestive heart failure was the risk factor.

• 한국의료질향상학회지
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• 제2권2호
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• pp.112-129
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• 1996

Background : A small number of high cost patients usually spend a larger proportion of scarce health resources. Aged, long-term care and readmitted patients usually belong to these high cost patient group. Among others, long length of stay and readmission can be reduced by checking its cause, and these are the areas needed most of quality improvement activity. Characteristics of high cost medical users between health insurance program and medical assistance program were reviewed. Methods : The inpatient claims of health insurance and medical assistance program were analyzed. Patients were divided by 6 groups; long-term, mid-term, short-term, readmitted, cancer and aged. We defined high cost patients as those who had spent one and half million won and over per 6 months. Characteristics of high cost patients for each group were reviewed. Results : medical assistance patients used much more resources than the insured members in the average hospital cost per case but less in daily hospital cost. The former had a longer length of stay and had much heavier diseases. Major diseases of both group were cancer, diseases of circulatory system and chronic degenerative diseases. Gallstone and schizophrenia were more in the insured program. However, pulmonary tuberculosis, asthma were more common among the medical assistance patients. Early readmission before 2 weeks were 28-30% of the total readmission. Readmission rate in the malignat neoplasm and renal failure were 80% and more. Q.A program should be installed to prevent unnecessary readmissions. Conclusion : Almost 30% of early readmissions and admissions due to complications and long length of stay should be reviewed carefully to keep cost down and to enhance the quality of hospital care.

• Journal of Korean Neurosurgical Society
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• 제62권2호
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• pp.243-255
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• 2019

Objective : Although traumatic brain injury (TBI) occurs in people of all age groups, the elderly population is at a particular risk. The proportion of elderly population in the society is markedly increasing and Korea is one of the most rapidly aging societies. Here, we analyzed the data from 904 patients older over 65 years who were registered in the Korean Neuro-Trauma Data Bank System (KNTDBS). Methods : The Korean Society of Neurotraumatology recorded data from 20 institutions between September 2010 and March 2014. This retrospective study examined the clinical epidemiology, sex difference, outcome epidemiology, sociodemographic variables, and outcomes in the geriatric population related to TBI based on data from the KNTDBS. Results : The study included 540 men and 364 women. The age distributions in the male and female groups were statistically significantly different. The most common cause of trauma was a fall and diagnosis was acute subdural hematoma. The incidence was the highest in men aged 80-84 years and in women aged 75-79 years. The most common time of arrival to hospital after TBI was within 1 hour and 119 rescue team provided first aid earliest to patients with TBI. The mortality rate stratified according to the cause of trauma was significantly different, with mortality rates of 3.77% in fall and 11.65% in traffic accident. The mortality rates according the severity of brain injury, Glasgow Coma Scale score, and treatment were statistically significant. Conclusion : To our knowledge, this study is the first to focus on elderly patients with TBI in Korea and particularly investigate mortality and characteristics related to TBI-related death based on data from the KNTDBS. Although the study has some limitations, our results may be used to obtain useful information to study targeted prevention and more effective treatment options for older TBI patients and establish novel treatment guidelines and health polish for the geriatric population.

• Journal of Trauma and Injury
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• 제36권4호
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• pp.329-336
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• 2023

Purpose: In this study, we aimed to compare the characteristics of patients with trauma by age group in a single center in Korea to identify the clinical characteristics and analyze the risk factors affecting mortality. Methods: Patients aged ≥18 years who visited the Chungbuk National University Hospital Regional Trauma Center between January 2016 and December 2022 were included. The accident mechanism, severity of the injury, and outcomes were compared by classifying the patients into group A (18-64 years), group B (65-79 years), and group C (≥80 years). In addition, logistic regression analysis was performed to identify factors affecting death. Results: The most common injury mechanism was traffic accidents in group A (40.9%) and slipping in group B (37.0%) and group C (56.2%). Although group A had the highest intensive care unit admission rate (38.0%), group C had the highest mortality rate (9.5%). In the regression analysis, 3 to 8 points on the Glasgow Coma Scale had the highest odds ratio for mortality, and red blood cell transfusion within 24 hours, intensive care unit admission, age, and Injury Severity Score were the predictors of death. Conclusions: For patients with trauma, the mechanism, injured body region, and severity of injury differed among the age groups. The high mortality rate of elderly patients suggests the need for different treatment approaches for trauma patients according to age. Identifying factors affecting clinical patterns and mortality according to age groups can help improve the prognosis of trauma patients in the future.