• Journal of Animal Science and Technology
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• 제63권6호
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• pp.1376-1385
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• 2021

Foot-and-mouth disease, one of the most contagious diseases in cloven-hoofed animals, causes significant economic losses. The pathogenesis of foot-and-mouth disease virus (FMDV) infection is known to differ with age of the animals. In this study, we aimed to reveal the difference in immunological response in the initial stage of FMDV infection between piglets and adult pigs. Peripheral blood mononuclear cells (PBMCs) were isolated from 3 piglets (8 weeks old) and 3 pigs (35 weeks old) that were not vaccinated against FMDV. O-type FMDV (2 × 10² median tissue culture infectious dose) was inoculated into porcine PBMCs and the cells were incubated at 37.0℃ under 5% CO₂ for various time periods (0, 1, 3, 6, 12, 24, and 48 h). The total RNA was obtained from the FMDV-inoculated PBMCs after each time point, and the virus titer was investigated in these RNA samples. Furthermore, dynamics of mRNA expression of the six tested cytokines (interferon [IFN]-α, IFN-γ, interleukin [IL]-6, IL-8, IL-10, and tumor necrosis factor [TNF]-α) in FMDV-inoculated porcine PBMCs were evaluated by time-series analysis to determine the differences, if any, based on the age of the pigs. The PBMCs of piglets contained the highest quantity of FMDV mRNA at 6 hours post-inoculation (hpi), and the PBMCs of pigs had the highest quantity of FMDV mRNA at 3 hpi. The mean cycle threshold-value in the PBMCs steadily decreased after the peak time point in the piglets and pigs (6 and 3 hpi, respectively). The dynamics of mRNA expression of all cytokines except TNF-α showed age-dependent differences in FMDV-inoculated PBMCs. The mRNA expression of most cytokines was more pronounced in the piglets than in the pigs, implying that the immune response against FMDV showed an age-dependent difference in pigs. In conclusion, within 48 hpi, the 8-week-old piglets responded more rapidly and were more sensitive to FMDV infection than the 35-week-old pigs, which could be associated with the difference in the pathogenesis of FMDV infection among the pigs. These results provide valuable insights into the mechanisms underlying the age-dependent differences in immune response in pigs against FMDV infection.

• 한국데이터정보과학회:학술대회논문집
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• 한국데이터정보과학회 2002년도 춘계학술대회
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• pp.17-22
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• 2002

Availability is an important characteristic of a repairable component. Iyer(1992) obtained the 'limiting efficiency'(not the `steady state availability') of the age-dependent minimal repair model which was first considered by Block et al.(1985). However the existence of the steady state availability of the model has not been reported. In this note, the existence of the steady state availability of the model is shown and a brief remark on the importance of the property is given.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2003년도 봄 학술발표회 논문집
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• pp.463-468
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• 2003

A finite element formulation to predict the flexural behavior of composite girder is presented in which the early-age properties of concrete are specified including maturing of elastic modulus, creep and shrinkage. The time dependent constitutive relation accounting for the early-age concrete properties is derived in an incremental format by expanding the total form of stress-strain relation by the first order Taylor series with respect to the reference time. The total potential energy of the flexural composite member is minimized to derive the time dependent finite element equilibrium equation. Numerical applications are made for the 3-span double composite steel box girders which is a composite bridge girder filled with concrete at the bottom of the steel box in the negative moment region. The numerical analysis with considering the variation of concrete elastic modulus are performed to investigate the effect of it on the early-age behavior of composite structures. The one dimensional finite element analysis results are compared with the analytical method based on the sectional analysis. Close agreement is observed among the two methods.

• Journal of applied mathematics & informatics
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• 제24권1_2호
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• pp.49-64
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• 2007

In this paper, we investigate optimal policies for three age-dependent populations in a competition system, which is controlled by fertility. By using Dubovitskii-Milyutin's general theory, the maximum principles are obtained for problems with free terminal states, infinite horizon and target sets, respectively.

• Asian-Australasian Journal of Animal Sciences
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• 제18권5호
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• pp.682-685
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• 2005

Large White, an introduced European pig breed, and Meishan, a Chinese indigenous pig breed, were hybridized directly and reciprocally and a total of 260 pigs, including purebreds, Large White and Meishan, and their hybrids, White${\times}$Meishan (LM) and Meishan${\times}$Large White (ML) pigs, were bred in our laboratory. The mRNA differential display PCR (DD-PCR) was used to detect the age-dependent changes of differential gene expression in backfat tissue between hybrids and parents. Some measures were taken to reduce the false positives in our experiment. Among the total of 2,686 bands obtained, 1,952 bands (about 72.67%) were reproducible and eight patterns (fifteen kinds) of gene expression were observed. The percentage of differentially expressed genes between hybrids and parents is 56.86% at the age of four months and 57.71% at the age of six months. This indicated that the differences of gene expression between hybrids and their parents were very obvious. U-test was used to compare the patterns of gene expression between the age of four and six months, and results showed that bands occurring in only one hybrid and bands displayed in one hybrid and one parent were significantly different at p<0.05, and bands visualized in only two hybrids were significantly different at p<0.01. These indicated that differential gene expression between hybrids and parents changed at different ages.

• Korean Journal of Radiology
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• 제22권7호
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• pp.1194-1202
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• 2021

Objective: To investigate the age-dependent changes in regional cerebral blood flow (CBF) in healthy adults by fitting mathematical models to imaging data. Materials and Methods: In this prospective study, 90 healthy adults underwent pseudo-continuous arterial spin labeling imaging of the brain. Regional CBF values were extracted from the arterial spin labeling images of each subject. Multivariable regression with the Akaike information criterion, link test, and F test (Ramsey's regression equation specification error test) was performed for 7 models in every brain region to determine the best mathematical model for fitting the relationship between CBF and age. Results: Of all 87 brain regions, 68 brain regions were best fitted by cubic models, 9 brain regions were best fitted by quadratic models, and 10 brain regions were best fitted by linear models. In most brain regions (global gray matter and the other 65 brain regions), CBF decreased nonlinearly with aging, and the rate of CBF reduction decreased with aging, gradually approaching 0 after approximately 60. CBF in some regions of the frontal, parietal, and occipital lobes increased nonlinearly with aging before age 30, approximately, and decreased nonlinearly with aging for the rest of life. Conclusion: In adults, the age-related perfusion patterns in most brain regions were best fitted by the cubic models, and age-dependent CBF changes were nonlinear.

• 수면정신생리
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• 제3권2호
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• pp.18-31
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• 1996

Jet-lag can be defined as the cumulative physiological and psychological effects of rapid air travel across multiple time zones. Many reports have suggested that age-related changes in sleep reflect fundamental changes in the circadian system and in significant declines in slow wave sleep. Jet lag is a dramatic situation in which the changes of the phase of circadian process and homeostatic process of sleep occur. Thus the authors evaluatead the changes of sleep-wake cycle from jet lag by age. Thirty-eight healthy travellers were studied for 3 days before and 7 days after jet-flights across seven to ten time zone. They were aged 19-70, They trareled eastbound, Seoul to North America (USA, Canada). Sleep onset time, wake-up time, sleep latency, awakening frequency on night sleep, awakening duration on night sleep, sleepiness at wake-up and nap length were evaluated. Our results suggest that by the 7 to 10 time zone shift, the old age group was significantly influenced in sleep-wake cycles. The date on which subjective physical condition was recovered was $6.23{\pm}83$ day after arrivals for old age group, while for young and middle age group, $4.46{\pm}1.50$ day and $4.83{\pm}1.52$ day, respectively. In old age group, sleep onset time was later than baselines and could not recover untill 7th day. But in other groups, the recovery was within 5th day. Nap dura fion was longer in old age group through jet lag than younger age group. In other parameters, there was no definite difference among three age groups. Our results suggested that the old age was significantly influenced by the disharmony between internal body clock and sleep-wake cycle needed at the travel site. Thus we proved that recovery ability from jet lag was age-dependent as well as travelling direction-dependent. To demonstrate more definite evidence, EEG monitoring and staging of sleep were funthun encouraged.

• 아동학회지
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• 제9권1호
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• pp.63-80
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• 1988

The main purpose of this study was to investigate the relationships of children's creativity to field independence-dependence cognitive style and demographic variables at age 5. The subjects for the present study were 86 five-year-old boys and girls selected from two kindergartens in Seoul and their parents, who replied to the questionnaire about demographic variables. Children were tested in groups, with the Torrance tests of Creative Thinking-Figural, and individually with the Preschool Embedded Figures Test. The data were analyzed by one way ANOVA, t-test, and Pearson's product-moment correlations. Children's fluency and originality in creativity showed significant positive correlations with field dependent-independent cognitive style. There were no significant differences in creativity according to sex. There were significant differences in field dependent-independent cognitive style according to sex. The score of field independent cognitive style of boys were significantly higher than those of girls. Children's creativity showed low correlations with demographic variables.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2004년도 추계 학술발표회 제16권2호
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• pp.493-496
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• 2004

The change of creep deformation mechanism due to the persistent change of stress conditions requires the constitutive relation for the analysis of long tenn behaviors considering age dependent material properties of concrete. In the present research, the process of time dependent behaviors in structure is divided into two stages; the non-mechanical deforming level which causes creep and shrinkage deformations, and the mechanical deforming level which causes mechanical deformations by the restraints of non-mechanical deformations due to internal or external factors. The incremental constitutive relation is derived by expanding the total stress-strain relation on the present time, with respect to the reference time using the Taylor series, and the modulus of elasticity in early ages of concrete was defined thru this process.

• 열처리공학회지
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• 제35권5호
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• pp.255-261
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• 2022

In this work, the strain-amplitude independent and strain-amplitude dependent damping capacities of Mg-5%Sn alloy have been investigated as a function of its age-hardening response. The hardness increased with an increase in aging time, reached a peak value after 48 h, and then it gradually decreased. The damping capacities of the Mg-5%Sn alloy exhibited a decreasing tendency in the order of solution-treated, under-aged, peakaged, and over-aged states in the strain-amplitude dependent region, whereas they increased continuously with aging time in the strain-amplitude independent region. The microstructural examination during aging revealed that the lower concentration of Sn solutes in the α-(Mg) matrix and the lower density of the Mg₂Sn precipitate particles may well be the crucial factors for better damping values in the strain-amplitude independent and strain-amplitude dependent regions, respectively.