• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2013년도 춘계학술대회
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• pp.65-67
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• 2013

최근의 네트워크 장비들은 고성능이 요구되고, 또한 높은 네트워크 대역폭의 활용을 요구하고 있다. 이를 위해 점차 멀티 코어 프로세서를 사용한 고성능 네트워크 서버 장비를 개발 하는 추세이다. 이런 고성능과 높은 네트워크 처리율을 향상시키기 위한 방법으로 멀티 코어의 특성을 고려한 네트워크 서브시스템의 성능을 향상시키는 방법을 제시한다. 본 논문에서는 멀티 코어를 최대한 활용함으로 성능을 최적화 하고 통신 성능을 향상시키는 방법을 실험을 통해서 확인한다. 통신 프로세스의 성능 향상은 멀티 코어 프로세서 구조, 프로세스의 네트워크 집중도, 각 코어에 걸리는 오버헤드, 인터럽트 친화도에 따른 네트워크 처리량을 기반으로 해당 프로세스에 최적의 코어를 결정해 주도록 한다. 실험은 리눅스 커널에서 구현하였으며, 실험을 통해 네트워크 처리량을 30%까지 향상 시키고, 프로세서의 오버헤드는 최대 10%까지 줄여 리눅스 통신 프로세스의 성능 향상을 가져옴을 보여준다.

• Bulletin of the Korean Chemical Society
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• 제14권5호
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• pp.561-567
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• 1993

The twelve macrocycle (L) complexes of cadmium(II) nitrate have been synthesized: $CdL(NO_3)_2$. All the complexes have been indentified by elemental analysis, electric conductivity measurements, IR and NMR spectroscopic techniques. The molar electric conductivities of the complexes in water and acetonitrile solvent were in the range of 236.8-296.1 $cm^2{\cdot}mol^{-1}{\cdot}ohm^{-1}$ at 25$^{\circ}$C. The characteristic peaks of macrocycles affected from Cd(II) were shifted to lower frequencies as compared with uncomplexed macrocycles. A complex with 1,4,8,11-tetrakis(methylacetato)-1,4,8,11-tetraaza cyclodecane (L4) exhibited two characteristic bands such as strong stretching (1646 $cm^{-1})$, and weaker symmetric stretching band (1384 $cm^{-1})$. NMR studies indicated that all nitrogen donor atoms of macrocycles have greater affinity to cadmium(II) metal ion than do the oxygen atoms. The $^{13}$C-resonance lines of methylene groups neighboring the donor atom such as N and S were shifted to a direction of high magnetic field and the order of chemical shifts were $L_1 < L_2 < L_3 < L_6 < L_4$. Also the chemical shifts values were larger than those of methylene groups bridgeheaded in side-armed groups. This result seems due to not only the strong interaction of Cd(Ⅱ) with nitrogen donors according to the HSAB theory, but weak interaction of Cd(Ⅱ) and COO- ions or sulfur which is enhanced by the flexible methylene spacing group in side-armed groups. Thus, each additional gem-methyl pairs of L_3, L_4\;and\; L_6$ macrocycles relative to $L_1, L_2,\;and\;L_5$ leads to an large enhancement in Cd(II) affinity. ^{13}C$-NMR spectrum of the complex with $L_{12}$ (1,5,9,13-tetracyclothiacyclohexadecane-3,11-diol) reveals the presence of two sets of three resonance lines, and intensities of the each resonance line have the ratio of 1 : 2 : 2. This molecular conformation is predicted as structure of tetragonal complex to be formed by coordinating two sulfur atoms and the other two sulfur atoms which is affected by OH-groups.

• 정보과학회 논문지
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• 제43권11호
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• pp.1188-1200
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• 2016

추천 시스템은 개인에게 고도로 개인화된 아이템을 제공함으로써 아이템의 선택과 소비과정에서 발생하는 과부하를 줄여주고 효율성을 증대시키는 중요한 역할을 한다. 본 연구에서는 전통적인 추천 기법인 Content-Based(CB)기법과 최근 대두되는 Social Network-based(SN)기법을 접목하여 새로운 복합방식의 정보 추천 알고리즘을 제시한다. CB기법의 대표적인 한계점인 cold start problem과 SN기법에서 부족할 수 있는 추천 아이템의 전문성 문제를 상호 보완하는 형태가 되며, 특히 최근 소셜 네트워크의 특징인 비신뢰(non-trust) 기반의 영향력 있는 정보 확산자가 존재하는 환경에서 기법을 적용할 수 있도록 하였다. 또한 대부분 사람 추천 중심인 기존의 SN기법들과는 달리 사람에게 제공할 정보를 추천하는데 초점을 두며, 정보의 선정과정에서 개인의 소셜 네트워크와 실세계(real world)에서의 사회활동 정보를 모두 활용하여 더욱 더 개인화된 가치정보를 제공하고자 한다.

• International Journal of Oral Biology
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• 제37권4호
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• pp.181-188
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• 2012

As the demand for large-scale analysis of gene expression using DNA arrays increases, the importance of the surface characterization of DNA arrays has emerged. We compared the efficiency of molecular biological applications on solid-phases with different surface polarities to identify the most optimal conditions. We employed thiol-gold reactions for DNA immobilization on solid surfaces. The surface polarity was controlled by creating a self-assembled monolayer (SAM) of mercaptohexanol or hepthanethiol, which create hydrophilic or hydrophobic surface properties, respectively. A hydrophilic environment was found to be much more favorable to solid-phase molecular biological manipulations. A SAM of mercaptoethanol had the highest affinity to DNA molecules in our experimetns and it showed greater efficiency in terms of DNA hybridization and polymerization. The optimal DNA concentration for immobilization was found to be 0.5 ${\mu}M$. The optimal reaction time for both thiolated DNA and matrix molecules was 10 min and for the polymerase reaction time was 150 min. Under these optimized conditions, molecular biology techniques including DNA hybridization, ligation, polymerization, PCR and multiplex PCR were shown to be feasible in solid-state conditions. We demonstrated from our present analysis the importance of surface polarity in solid-phase molecular biological applications. A hydrophilic SAM generated a far more favorable environment than hydrophobic SAM for solid-state molecular techniques. Our findings suggest that the conditions and methods identified here could be used for DNA-DNA hybridization applications such as DNA chips and for the further development of solid-phase genetic engineering applications that involve DNA-enzyme interactions.

• International Journal of Computer Science & Network Security
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• 제23권3호
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• pp.193-202
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• 2023

Numerous articles under the study and the examination of heavy metals in human teeth have been published in recent years. The heavy metal poisoning is a widespread issue emerged in toxicology area these days. It has been discovered that long-term exposure to heavy metals typically present in traces, in our everyday meals, drinking water, and in the environment as pollution causes heavy metal poisoning in human beings. Industrial effluents, Coal and Oil, as well as a variety of consumer items, such as cosmetics, can all cause this type of exposure. Teeth, which are often thought of as exoskeleton parts, store heavy metals with a high affinity and represent long-term exposure information. In this study, we have chosen and examined the sections of dentine instead, then examined the entire tooth. We have combined the work done on the examination of heavy metals in human teeth using several instrumental approaches e.g. "Optical Spectroscopic Techniques" to detect elemental profile of human teeth in the current study.

• 정보처리학회논문지C
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• 제10C권3호
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• pp.335-344
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• 2003

무선 정보 환경의 변화에 따라 다양한 정보에 대한 풍족감이 요구되고 이에 따라 많은 근거리 무선 통신 기술들이 연구 개발되어 왔으며, 그 중에서도 최근 근거리 무선 통신의 표준으로 각광받고 있는 블루투스와 무선랜은 많은 관심을 받고 있다. 그러나 근거리 무선 통신을 실제 무선 환경에 적용하기엔 많은 문제점들이 제기되고 있다. 따라서 본 논문에서는 현재 근거리 무선 통신의 보안적 취약점 뿐만 아니라 무선 환경이라는 특수한 환경에서 보안적 사항과 사용자의 프라이버시와 밀접한 관계가 있는 비보안적인 사항까지 고려한 일반화된 중앙 집중형 보안 모니터링 기법을 제안한다. 또한 제안된 방식을 근거리 무선 통신의 대표적인 기술인 블루투스와 무선랜에 적용시켜 사용자 중심으로 흩어져 있는 모바일 디바이스에 대한 안전한 보안 모니터링 기법을 제안한다.

• 한국식품위생안전성학회지
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• 제5권3호
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• pp.131-138
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• 1990

Aflatoxins is a chemically diverse group of toxic secondary metabolites that are produced by fungi and often occur in agricultural commodities. Because of their wide range of toxic effects, Aflatoxins cause severe economic losses to farmers and livestock producers and pose a health to human consuming contaminated foods. Long term prospects for biotechnological control of Aflatoxins require elucidation of the specific steps and regulation of their biosynthetic pathways . Aflatoxin determinations can be approached many ways. It is essential to safely handle all experimental materials associated with aflatoxin analysis or aflatoxigenic fungi Visual screening of suspect samples, base on the presence of conidial head of the aspergillus flavus group, and screening samples for the presence of bright greenish yellow flourescence are not chemical tests and such screening techniques may allow aflactoxin contaminated lots into commerce. Microcolumn screening procedures should always be used in conjunction with a quantitative method. Several thin layer chromatography(TLC) and high performance liquid chromatography(HPLC) methods are suitable for quantitation and are in general use. Immunochemical Methods such as the ELISA or affinity column chromatography methods are being rapidly developed. The chemical and immunochemical methods can be reliable if care is taken, using suitable controls and personnel that are well trained . All analytical laboratories should stress safety and include suitable analytical validation procedure. Especially a worldwide enquiry was undertaken in recent to obtain up-to-date information about aflatoxin legislation in as many countries of the world as possible. The information concerns aflatoxin in foodstuffs. aflatoxin MI in dairy products, aflatoxins in animal feedstuffs. Limits and regulations for aflatoxin have been expended in recent with more countries having legislation on subject, more products, and more aflatoxins covered by this legislation.

• 통합자연과학논문집
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• 제3권3호
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• pp.143-147
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• 2010

Since it is of great importance to know how a ligand binds to a receptor, there have been a lot of efforts to improve the quality of prediction of docking poses. Earlier efforts were focused on improving search algorithm and scoring function in a docking program resulting in a partial improvement with a lot of variations. Although these are basically very important and essential, more tangible improvements came from the reduction of search space. In a normal docking study, the approximate active site is assumed to be known. After defining active site, scoring functions and search algorithms are used to locate the expected binding pose within this search space. A good search algorithm will sample wisely toward the correct binding pose. By careful study of receptor structure, it was possible to prioritize sub-space in the active site using "receptor-based pharmacophores" or "hot spots". In a sense, these techniques reduce the search space from the beginning. Further improvements were made when the bound ligand structure is available, i.e., the searching could be directed by molecular similarity using ligand information. This could be very helpful to increase the accuracy of binding pose. In addition, if the biological activity data is available, docking program could be improved to the level of being useful in affinity prediction for a series of congeneric ligands. Since the number of co-crystal structures is increasing in protein databank, "Ligand-Guided Docking" to reduce the search space would be more important to improve the accuracy of docking pose prediction and the efficiency of virtual screening. Further improvements in this area would be useful to produce more reliable docking programs.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.44-44
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• 2003

$BK_{Ca}$ channels were suggested to contain one or more domains of the ‘regulator of K+ conductance’(RCK) in their cytosolic carboxyl termini (Jiang et al.2001). It was also shown that the RCK domain in mammalian $BK_{Ca}$ channels might sense the intracellular $Ca^{2+}$ with a low affinity (Xia et al. 2002). We aligned the amino acid sequence of the $\alpha$-subunit of rat $BK_{Ca}$ channels (rSlo) with known RCK domains and identified a second region exhibiting about 50％ homology. This putative domain, RCK2, contains the characteristic amino acids conserved in other RCK domains. We wondered whether this second domain is involved in the domain-domain interaction and the gating response to intracellular $Ca^{2+}$ for rSlo channel, as revealed in the structure of RCK domain of E. coli channel (Jiang et al.2001). In order to examine the possibility, site-directed mutations were introduced into the RCK2 domain of rSlo channel and the mutant channels were expressed in Xenopus oocytes for functional studies. One of such mutation, G772D, in the putative nucleotide-binding domain resulted in the enhanced $Ca^{2+}$ sensitivity and the channel gating of rSlo channel. These results suggest that this region of $BK_{Ca}$ channels is important for the channel gating and may form an independent domain in the cytosolic region of $BK_{Ca}$ channels. In order to obtain the mechanistic insights of these results, G772 residue was randomly mutagenized by site-directed mutagenesis and total 17 different mutant channels were constructed. We are currently investigating these mutant channels by electrophysiological techniques.ical techniques.

• KSBB Journal
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• 제27권4호
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• pp.199-206
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• 2012

Chiral crown ethers are synthetic macrocyclic polyethers that bind protonated chiral primary amines with high selectivity and affinity. They have been widely used to separate or distinguish the enantiomers of chiral compounds containing a primary amino moiety by high-performance liquid chromatography, capillary electrophoresis, and NMR spectroscopy. In this paper, two important chiral crown ethers including chiral binaphthyl unit and (18-crown-6)-2,3,11,12-tetracarboxylic acid as chiral selectors are focused. And several chiral resolution techniques and their applications in chirotechnology using these chiral crown ethers with related chiral recognition mechanism studies are reviewed. Especially, it was shown that the commercially available HPLC columns based on (18-crown-6)-2,3,11,12-tetracarboxylic acid have been developed and successfully applied for the resolution of various primary amino compounds including amino acids.