• Biomolecules & Therapeutics
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• v.4 no.4
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• pp.354-363
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• 1996

This study was conducted to investigate the repeated dose toxicity of DA-9601, an antiulcer agent of Artemisia app. extract, in rats. DA-9601 was administered orally once a day for 4 weeks to 10 males and 10 females per group at doses of 0(vehicle control), 125, 500 or 2000 mg/kg/day. Throughout the study, no treatment-related deaths and clinical signs were observed. In female rats receiving 125 mg/kg of DA-9601, water consumption increased slightly on day 4, 11 and 25. Hematological examination showed a decrease of MCV and an increase of PLT in male rats at the doses of 500 and 2000 mg/kg groups. Blood biochemistry revealed slight decreases of cholesterol, BUN and Na in male rats and decreases of total bilirubin and creatinine and slight increases of globulin and Cl in female rats. The organ weights at the end of 4 weeks showed slight changes in some organs of treated groups. But, all these changes were not considered to be of toxicological importance, because they did not show dose-response relationship and relevance to gross and microscopic findings. Histopathologically, abnormal treatment-related changes were not observed in any organ and target organs were not detected. On the basis of these results, the NOAEL(no-observed-adverse-effect level) of DA-9601 was estimated to be more than 2000 mg/kg/day under the conditions tested.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.24 no.3
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• pp.62-68
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• 2016

According to the accident/incident reports of aircraft runway overruns and excursions, it generally shows runway friction reduction and aircraft braking capability deterioration are the basic causes due to adverse weather. Although surface of paved runway gets wet, it also should give good friction capability. If runway surface is worn due to long time usage and friction capability is reduced due to rubber accumulation or weather conditions(snow, rain, ice etc.), airport authorities should rapidly measure friction coefficient and give them to relevant persons through aeronautical information system and support safe takeoff and landing. Operation wise, these information of friction coefficient reduction should be lead to aircraft performance adjustments, but the data from manufacturer(performance manual) are airplane braking coefficient and the data from airport authorities are vehicle measured braking coefficient. But these two data are considered as the same meaning although the definite relationship between them is not clarified yet. So I am trying to search for the technical background of these two data and suggest reasonable method to use them efficiently.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2004.11a
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• pp.143-152
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• 2004

Researchers seeking geological and environmental information, depend on remote sensing and aerial photographic datum from various commercial satellites and aircraft. However, adverse weather conditions as well as equipment expense limit the ability to collect data anywhere and anytime. To allow for better flexibility in geological and environmental data collection, we have developed a compact, multi-spectral automatic Aerial Photographic system (PKNU2). This system's Multi-spectral camera can record visible (RGB) and infrared (NIR) band (3032＊2008 Pixels) images Visible and infrared band images were obtained from each camera respectively and produced color-infrared composite images to be analyzed for the purpose of the environmental monitoring. However this did not provide quality data. Furthermore, it has the disadvantage of having the stereoscopic overlap area being 60% unsatisfied due to the 12 seconds of storage time of each data The PKNU2 system in contrast, photographed photos of great capacity Thus, with such results, we have been proceeding to develop the advanced PKNU2 (PKNU3) system that consists of a color-infrared spectral camera that can photograph in the visible and near-infrared bands simultaneously using a single sensor, a thermal infrared camera, two 40G computers to store images, and an MPEG board that can compress and transfer data to the computer in real time as well as be able to be mounted onto a helicopter platform.

• Fire Science and Engineering
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• v.21 no.2 s.66
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• pp.64-73
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• 2007

The absorption characteristics of hazardous materials onto human body and defense mechanism differ from each other region within the respiratory tracts, thus adverse health effects of inhaled smokes are associated with not only the concentration but also the location of the particles deposited. In this work, the deposition fraction per surface area and the deposition sites of the smoke particles in human respiratory tracts for each rest and light exercise conditions together with oral and nasal breathing were calculated by using segmental volume tracking method. The results would be used for deriving the amount of absorption of hazardous materials onto human body, thus contribute to the health risk assessments of inhaled fire smokes.

• Korean Journal of Health Education and Promotion
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• v.2 no.1
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• pp.79-95
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• 2000

The objective of this study is to stress the importance of sexuality education at school, to define its goals and to discuss ways on how to reinvigorate sexuality education. The negative conditions for adolescent sexual issues are now being expanded into all areas of Korean society. In particular, they should be regarded as one of serious social issues because of their adverse influences on adolescent groups. Various reports on juvenile sexual delinquencies have expressed serious concern over reckless and impulsive juvenile sexual deviations because they are closely related to the confusion of the youth in their sexual values and their common sexual deviations. Thus, for the youth who have attracted serious public concern, it is most important to have sound sexual awareness and attitude for the development of their healthy personality. In general, sexuality education should be conducted under individual responsibility of various levels of schools, families and communities. However, the role of schools where sexuality education should be conducted with concrete goals, that is, to interpret physical and psychological developments of youth in terms of education and teach them on the systematic goals of sexuality education, this role of schools is the most important than anything else in conducting sexuality education for youth.

• Journal of ILASS-Korea
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• v.14 no.4
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• pp.184-189
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• 2009

Recently, ultrafine particles emitted from internal combustion engine is main concern because of its well known adverse health effects. So Europe decided to start the regulation about diesel engine particle number emissions. The nanoparticles smaller than 50nm in diameter have the ability to penetrate deep into interstitial tissue of luge, where they may cause severe respiratory inflammation and acute pulmonary toxicity. Recent studies have showed that spark ignition engines emit particles number concentration comparable to those from diesel engines with DPF under high load and rich mixture conditions, including cold starts and acceleration. So this study investigated emission characteristics of ultrafine particles according to fuel injection type in gasoline vehicles and LPG vehicles. The test vehicles were tested on CVS-75 and NEDC vehicle test mode using the chassis dynamometer, CPC system applied as a particle measuring instrument at the end of dilution tunnel. As a result, the correlation between fuel injection type and particulate emission was determined. GDI vehicle emitted 10 times higher particles than PFI vehicles, and compared to Mixer and LPGI type LPG vehicle, LPLI vehicle emitted particles high.

• Magazine of the Korean Society of Agricultural Engineers
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• v.39 no.3
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• pp.108-114
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• 1997

Concrete is said to have a high degree of extensibility when it is subjected to large deformations without cracking. The cracking behavior of concrete in the field may even be more complex. For example, in mass concrete compressive stresses are developed during the very early period when temperatures are rising, and the tensile stresses do not develop until at a later age when the temperature begins to decline. Actual cracking and failure depend on the combination of factors and indeed it is rarely that a single adverse factor is responsible for cracking of concrete. The importance of cracking and the minimum width at which a crack is considered significant depend on the conditions of exposure of the concrete. The ultrasonic pulse measurements can be used to detect the development of cracks in structures such as dams, and to check deterioration due to frost or chemical action. An estimate of the depth of a crack visible at the surface can be obtained by measuring the transit times across the crack for two different arrangements of the transducers placed on the surface. In this paper, the concrete cracks that artificially introduced crack width is 1 and 2mm, crack depth is 2, 4, 6, 8cm were measured by Tc-To Method In consequence, the measured depth was increased with increase of measuring distance from concrete crack. The most reliable results were shown when the introduced crack width was 1mm, and the measuring distance was 10cm from concrete crack.

• Environmental Analysis Health and Toxicology
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• v.24 no.1
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• pp.33-41
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• 2009

Among the toxicants in the environment dioxin-like compounds, including TCDD(2,3,7,8-Tetrachlorodibenzo-p-Dioxin), are well known as carcinogen and teratogen. TCDD the most toxic of these compounds, may result in a wide variety of adverse health effects in humans and environment, including carconogenesis, hepatotoxicity, teratogenesis, and immunotoxicity. Also TCDD increases superoxide, peroxide radicals and induces oxidative stress that leads to breakage of DNA single-strand and mitochondrial dysfunction. Recently, there have been reports that persistent organic pollutants(POPs) may be causing metabolic disease through mitochondrial toxicity. In order to examine if dioxin brings about toxicity on mitochondria directly, we measured the change of the mitochondrial membrane potential after exposure to TCDD using JC-1 dye. After short time exposure of dioxin, mitochondrial depolarization was observed but it recovered to the control level immediately. This TCDD effect on mitochondrial membrane potential was not correlated either to the production of reactive oxygen species(ROS) or extracellular $Ca^{2+}$ by TCDD. Less than 2 hours exposure of TCDD did not show any change in ROS production but 0.25 nM TCDD for 48 hours or 0.5 nM TCDD for 12 hours exposure did increase in ROS production. Under these conditions of ROS production by TCDD, no changes in the mitochondrial membrane potential by TCDD was observed.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.44 no.6
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• pp.671-676
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• 2011

To determine the optimum light intensity for mass culture of the brackish-water cyclopoid copepod Paracyclopina nana, survival, growth, and productivity of the copepod were examined at several light intensities (0, 10, 100, 500, 1,000 lx). The survival rate of P. nana from nauplius to adult decreased with increasing light intensity. The highest survival rate was found under the dark condition, with 61.7% surviving; no significant difference was observed between 0 and 10 lx (51.7%) and the lowest survival rate was with 100 lx (26.7%). Survival rates at 500 and 1,000 lx were significantly lower in comparison with other conditions. The developmental period from nauplius to copepodid (5.8 days) and to adult (11.8 days) at 10 lx was significantly shorter than in the other treatments. Daily mean nauplius production of adult females over 7 days at 0, 10 and 100 lx was significantly higher than at 500 and 1,000 lx. In the 1,000 lx treatment, 99% of the adult females died on the $14^{th}$ day. The optimum light intensity for the mass culture of P. nana could be 10 lx, which had no adverse effects on survival, development, or reproduction.

• Journal of the Institute of Convergence Signal Processing
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• v.5 no.1
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• pp.32-39
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• 2004

Biological neurons generally have chaotic characteristics for permanent or transient period. The effects of chaotic response of biological neuron have not yet been verified by using analytical methods. Even though the transient chaos of neuron could be beneficial to overcoming the local minimum problem, the permanent chaotic response gives adverse effect on optimization problems in general. To solve optimization problems, which are needed in almost all neural network applications such as pattern recognition, identification or prediction, and control, the neuron should have one stable fixed point. In this paper, the dynamic characteristics of the chaotic dynamic neuron and the condition that produces the chaotic response are analyzed, and the convergence conditions are presented.