• Advances in Traditional Medicine
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• v.6 no.1
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• pp.12-20
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• 2006

Some natural products are able to inhibit radiation effects and exert an antitumor effect with fewer adverse reactions; however, their antitumor effects are less than those of widely-used synthetic drugs. Propolis is a natural material that has been attracting attention, and we extracted this material with water and investigated the effect of continuous propolis administration on radioactivity-induced reduction of hemocytes, in addition to the antioxidant and antitumor effects of propolis. Following a 1-week adjustment period, water-soluble propolis was administered intraperitoneally to male ICR mice at a dose of 100 mg/kg every other day for 2 weeks. Following administration, 2 Gy whole-body irradiation was performed and the counts of leukocytes, lymphocytes, and granulocytes and monocytes in the peripheral blood were determined 1, 3, 7, 15 and 30 days after irradiation. These cells were considered since they are closely associated with immunity to radioactivity. In a second experiment, water-soluble propolis was similarly administered to the mice for 2 weeks after a 1-week adjustment period, and 2 Gy whole-body irradiation was performed. The antioxidant effects in hemocytes were then investigated using 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), a radical generator. In a third experiment, $1\;{\times}\;10^6$ Sarcoma-180 cells were inoculated into the right thigh of mice, which were divided into four groups: control, water-soluble propolis-treated, 6 Gy irradiated and water-soluble propolis-treated + 6 Gy irradiated groups, and changes in tumor size were measured for 20 days. Statistical analysis was conducted using ANOVA for multiple groups. In the three experiments, administration of water-soluble propolis inhibited the reduction of hemocytes caused by whole-body irradiation, showed antioxidant effects against radioactivity, and inhibited tumor growth, respectively. In conclusion, our data suggest that the antioxidant effect of watersoluble propolis inhibits hemocyte reduction caused by whole-body irradiation and enhances immunological inhibition of tumor growth.

• Advances in Traditional Medicine
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• v.7 no.3
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• pp.235-243
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• 2007

Anemarrhenae Rhizoma (AR) is used in traditional oriental medicine for various medicinal purposes. However, the exact mechanism that accounts for the anti-allergy and anti-inflammatory effects of the AR is still not fully understood. The aim of The present study is to elucidate whether and how AR modulates the allergic reactions in vivo, and inflammatory reaction in vitro. In this study, we showed that AR significantly decreased compound 48/80-induced systemic anaphylaxis, paw oedema, and histamine release from preparation of rat peritoneal mast cells. Also, AR inhibited the expression of inflammatory cytokine in PMA plus A23187-stimulated human mast cells (HMC-1). In addition, we showed that anti-inflammatory mechanism of AR is through suppression of nuclear factor-${\kappa}B$ activation $I{\kappa}B-{\alpha}$degradation. These results provided new insight into the pharmacological actions of AR as a potential molecule for therapy of inflammatory allergic diseases.

• Advances in Traditional Medicine
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• v.7 no.5
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• pp.494-500
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• 2008

Ginseng has been traditionally used to recover vital energy from Qi deficiency in oriental countries. Recent reports suggested that ginseng could regulate blood pressure (BP), but much controversy still remain. Therefore, we intended to assess the anti-hypertensive effect of some ginseng species on Koreans and Chinese. This is a randomized, double blinded controlled clinical trial. The study subjects were recruited from the mild hypertensive patients who belonged prehypertension(120/80 to 139/89 mmHg) and stage I hypertension (140/90 to 159/99 mmHg) in Korea and China. After assigning the subjects into a Korean, a Chinese, and an American ginseng group by randomization, we prescribed ginseng with the dose of 4.5 g per a day for 4 w. To assess the anti-hypertensive effect, we compared the mean of systolic and diastolic BP between before and after ginseng medication by 24 h Ambulatory Blood Pressure Monitor (24 h ABPM). We also monitored adverse effect and laboratory findings to secure the subjects' safety. There were 64 subjects treated with Korean ginseng, 58 treated with Chinese ginseng, and 64 treated with American ginseng. All of the ginseng species reduced subjects' BP. Especially, Korean and Chinese ginseng showed more excellent effects. The secondary analysis on the subjects' nationality revealed that all of the ginseng species showed more significant anti-hypertensive effect in Chinese than in Koreans. We suggest ginseng could be useful for mild hypertension regardless of its species. And it would be safe within the dosage of 4.5 g per a day.

• Advances in Traditional Medicine
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• v.10 no.2
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• pp.116-122
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• 2010

Saengmaeksan (SMS) is a well known Korean traditional herbal prescription, which consists of 3 different herbs, Radix Ophiopogonis, Radix Ginseng, and Fructus Schisandrae. SMS has been commonly used in various disease including respiratory system and cardiovascular System in Korea. The objective of this study is to find out the improving effects of SMS against Dextran Sulfate Sodium (DSS)-induced ulcerative colitis. SMS reduced clinical signs of DSS-induced colitis, including body weight loss, shorten colon length, and increased disease activity index. The results showed that SMS significantly inhibited the activation of nuclear factor-${\kappa}B$ p65 in the colon tissues of DSS-treated mice. In addition, we observed that result showed that the levels of IL-6 in plasma were increased in DSS treated group compared to those of the normal group, but these increased levels were reduced by administration with SMS. Taken together, these findings suggest that SMS has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.8
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• pp.352-362
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• 2016

Today, it appears that the rapid advances in technology have allowed broadening both the system technology and the business opportunities in the rail industry. Owing to the developments in technology and the industry, and also due to the hearth, the latest high-speed trains and a variety of unattended operations in rail systems are being developed and are operational. In particular, this study covers the existing railway rolling stock and signaling systems that operate in an environment more complex than the concept of localized management, so the introduction of a new signaling system is needed. In addition, developments based on the existing signal system concepts for passenger railways need to minimize human injury. In this study, to participate in the development of new systems in a variety of domains and to provide an integrated common vision methodology as an engineer on the basis of efficient signal system design and safety would like to present the methodology for action. Therefore, each different linkage through the next new domain zone system design: design through to secure the integrity of safety than can secure methodology.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.223-229
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• 2020

The current technological advances are changing the way people live. In the history of war in the past, nations or people with an edge in military science and technology have always been the victor. The emergence of new technologies not only alters war patterns drastically but also affects military operational concepts and organizational systems. As the paradigm of the security environment changes, developed countries are investing heavily in defense R & D for their security. Therefore, the importance of professionalism of the defense acquisition personnel who perform their tasks from the exploration and development of weapon systems to mass production, deployment, and logistics support cannot be overemphasized. In the United States, an advanced country in this field, to improve the work efficiency of acquisition personnel in the defense field, the Directive of Ministry of Defense issued a law on education and training career development for personnel in 1990. The present study refers to related materials, such as the Desk Guide for the main education requirements for the US acquisition personnel in the military field, which contributes to the improvement of the workforce of the acquired manpower after the systematic education system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.458-465
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• 2020

Technological advances in artificial intelligence are affecting many industries, such as telecommunications, logistics, security, and healthcare, and research and development related to economic, efficiency, linkage with commercial technologies are the current focus. Predicting the changes in the future battlefield environment and ways of conducting war from a strategic point of view, as well as designing/planning the direction of military development for a leading response is not only a basic element to prepare for comprehensive future threats but also an indispensable factor that can produce an optimal effect over a limited budget/time. From this perspective, this study was conducted as part of a technology-driven plan to discover potential future technologies with high potential for use in the defense field and apply them to R&D. In this study, based on research data collected in a defense future technology investigation, the future new technology that requires further research was predicted by considering the redundancy with existing defense research projects and the feasibility of technology. In addition, an empirical study was conducted to verify the significance between the future new defense technology and the evaluation indicators in the AI field.

• Journal of KIISE:Information Networking
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• v.32 no.1
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• pp.89-99
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• 2005

Advances of Internet and rC accelerate distribution and sharing of information, which make P2P(Peer-to-Peer) computing paradigm appear P2P computing Paradigm is the computing paradigm that shares computing resources and services between users directly. A fundamental problem that confronts Peer-to-Peer applications is the efficient location of the node that stoles a desired item. P2P systems treat the majority of their components as equivalent. This purist philosophy is useful from an academic standpoint, since it simplifies algorithmic analysis. In reality, however, some peers are more equal than others. We propose the P2P protocol considering differences of capabilities of computers, which is ignored in previous researches. And we examine the possibility and applications of the protocol. Simulating the Magic Square, we estimate the performances of the protocol with the number of hop and network round time. Finally, we analyze the performance of the protocol with the numerical formula. We call our p2p protocol the Magic Square. Although the numbers that magic square contains have no meaning, the sum of the numbers in magic square is same in each row, column, and main diagonal. The design goals of our p2p protocol are similar query response time and query path length between request peer and response peer, although the network information stored in each peer is not important.

• Composites Research
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• v.25 no.4
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• pp.98-104
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• 2012

In recent years, degenerative spinal instability has been effectively treated with a cage. However, little attention is focused on the stiffness of the cage. Recent advances in the medical implant industry have resulted in the use of medical carbon fiber reinforced polymer (CFRP) cages. The biomechanical advantages of using different cage material in terms of stability and stresses in bone graft are not fully understood. A previously validated three-dimensional, nonlinear finite element model of an intact L2-L5 segment was modified to simulate posterior interbody fusion cages made of CFRP and titanium at the L4-L5 disc with pedicle screw, to investigate the effect of cage stiffness on the biomechanics of the fused segment in the lumbar region. From the results, it could be found that the use of a CFRP cage would not only reduce stress shielding, but it might also have led to increased bony fusion.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.19
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• pp.83-99
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• 1975

The earliness to flowering was completely dominant over the lateness, and the short plant height and stem length were partially dominant over the tall. The heavy stem weight, however, was recessive to the light. Heritability values for the flowering period, plant height, dry stem weight and fiber ratio were high, while those of days to initial flowering, stem length and fiber weight were low. Flowering period, plant height, stem weight, dry stem weight and fiber ratio were closely related to fiber weight or fiber yield. The selection index estimated jointly the plant height ($X_1$), dry stem weight($X_2$) and fiber weight($X_3$); that is 0.0020$X_1$-0.0047$X_2$-0.0181$X_3$, was the most efficient one for the selection practices. The plant height was the most reliable character for the increased genetic advances and the relative selection efficiences. Effects of locations and genotype-environment interactions were highly significant in most of the characters investigated.